Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MAPRE1P2
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:33009270-33011811  UCSC
Coordinates (T2T) chr4:32978254-32980795  UCSC
Coordinates (hg19) chr4:33010892-33013433  UCSC
Strand -
Parental Sequence NM_012325.3
Parental seq. overlap 2380 bp
Parental seq. overlap (%) 92.4%
Genomic Region Intergenic
Retrocopy Summary MAPRE1P2, located on chr4:33009270-33011811, is a retrocopy of the parental gene MAPRE1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MAPRE1
Full Name microtubule associated protein RP/EB family member 1
Also known as EB1
Coordinate chr20:32819780-32850405
Strand +
Gene summary The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MAPRE1P2
Bonobo Pan paniscus MAPRE1P2
Gorilla Gorilla gorilla MAPRE1P2
Orangutan Pongo abelii MAPRE1P2
Gibbon Nomascus leucogenys MAPRE1P3
Green monkey Chlorocebus sabaeus MAPRE1P3
Crab-eating macaque Macaca fascicularis MAPRE1P1
Rhesus Macaca mulatta MAPRE1P1
Baboon Papio anubis MAPRE1P1
Golden snub-nosed monkey Rhinopithecus roxellana MAPRE1P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MAPRE1P2
GTCTGGCAGTTTGAATGAGATGAAGAAACTGGAGCCGGGTGAGGGCAGCGGACGCGAGAGCCGAAGATGGCAGTGAATGTATACTTAACGTCAGTGACCAGTGATAACCTAAGTCATCATGACGTGCTGGCCTGGATCAATGAGTCTCTGCAGTTGAATCTGACAAAGATCAAACAGTTGTTCTCAATATCCATAAACTGGATATTGTCAGTTTATGGACATGCTGTTCCCTGGCTCCATTGACTTGAAGAAAGTAAAATTCCAGGCTAAGCTAGAACATGAGTGCATCCAGAACTTCAAAATACTACAAGCAGGTTTTAAGAAGCTGGGTGTTGACAAAATAATTCCTGTCGACAAATCAGTAAAAGGAAAGTTTCAGGACAATTTTGAATTTGTTCAGTGGTTCAAGAAGTTTTTTGATGCAAACTATGATGGAAAAATCTATGACCCTGTGGCTGCCAGACAAGGTCAAGAAATTGCAGTGGCTCACTCCCTCCTTGCTCCAGCTCCGAATAAACCCAAGTTCTAGCAATGCAACTCCCCAGATGCCCATCTCAACACAGAGAACTGCTGTGGCTCCTAAGACTGGCCCTGGCGTGGTGTGAAAGAACCCTGGTGTGGGCAATGGGAATGACGAGGCAGCTGAGTTGATGCGGCAGGTCAACGTATTGAAATTTACTGTTGAAAACTTGGAGAAAGAAGGATTTCTACTTCGGAAAGCTACGGAACATTGAATTGATTTGCCAGGAGAATGAGGGGGAAAACAACCCTGTATTGCAGAGGACTGTAGACATTCTGTATGCCACAGATGAAGGCTTTGTGATACCTGATGAAGGCGGCACACAGGAGGAACAAAAAGAGTATTAACAGCCTGGACCAGCAGAGCAACATCCAAATTCTTCACTCCAAATCATGTGCTTAACTGTAAAATACTCCCTTTTATTATCCTTAGAGGACTCACTGGTTTCTTTTCATAAGCAAAAAGTACCTCTTCTTAAAGTGCACTTTGCAGACGTTTCACTCCTTTTCAAATAAGTTTGAATTAGGAGCGTTTACATTGTAGCAGAGCAGTATTAACATCTAGTTGGTTCACCTGGGAAACAAAGAGGCTGACGTTGGGGCTTACCCTGTGGATGCGGGTCACACTGAGTGCTGGAGAAGGTGTTGTGTAATATGCTGAGGCGGCGACCTTAGTGGAGAAATGGAAAGACTGAATTGAATTTTAAGCTAATGTGAAATCGGAGAATGTTGTAATAAATAAATGCCTTATGAGTATTTAAAATATGCTTCCATATTTCAAAATACAAAATGTAACATGACAGAGGATTTTGCGTTTGATGTTGTATCTGGGAAGGAAGGACCAGACCTTGGAACCTTTGGAACTTGCTGTCACAAGTCTTAGAGGGCTGCTTGAATCCTCATAGGCCTAGGCTTTGGTCTAAAAGGAACATTTAAAAAGTTGCCCTGTAAAGCCATTTGGTGCCATTGACCAATTGCATCCCTGCTAAAAAGCAAGAGGCATTGTTGACTGGATAATAGAGGATGTGTTTCAGCCCTGAGATGTTCGAGGTGAAGAGCTTGGTTTTCACTGAGCATTTCTCTATTTTTCCAGTTATCCCCAAAATTTCTATGTATTATATTTTTGGGGAAGTGAGGTGTGTCCAGTTTTTTTGGTCTAAAAACTACTTTTGGGAACTTGCCCACATCTCTGGGATTTGAATGGGGATTGTATCCCATTTTACTGTCTTTTAGGTTTGCATTTACCATCTTTCTCTTCTCTGCTCCCCTTTCCCACTGGGGACTCCTCTTTGGCTCCTTGAAGTTTGCTGCTTAGAGATGGAAGTGAAGCATGCAGGTGACCATGCTGCAAGTTTTCTGGACCTCTGGCAAAGGGAGTGGTCAATGAAGGCCATTGTTACCTTGGGATCTGCAAGACTGGGGTGTTTTCGGTATGTGCTGTCCACAGCTCTCCACTGTAATCTGCATACTTTGCCAGTGCACTAATCTCTTTGGAGATAAAGTTCATTAGTGTGTTGCTAAATGTTAATTTTCTTTTGCAGAAAATACAGTATCATGTCTGAATTAATTATTAATATTTAAAATATTTCATTCTTTAACTTTCCCTCATTTGCTTTGCCCACAGTCTTTTCAGTTCCTTTGTTTGGCAGGATTCTGCAAAATGTGTCTCACCCACTATTGAGATTGTTCAGCCCCTGATGTATTTATATTGATTTGTTTCTGGTGGTAGCTTGTCTTAAAATGTGTGTAGAAAGAAAGCATTTTCTGATAAAATTGTTGTGTAGTGCATGCTCTGTGTGGAATTCAGAGGAAAACCCAGATTCAGAGATTAACAATGCCAAAAAATGCAAGTAACTAGCCATTGTTCAAATGACAGTGGTGCTATTTCTCTTTTGTGGCCTTTTAGACTTTCGTTGCCCTAAAATTACATTTTTTGGGAACCCATTTTCCACCTGGTCTTTCTTGACAGGGTTTTTTTCTACTTTAAACAGTTTCTAAATAAAATTCTGTATTTCAAGAGTAA
>NM_012325.3
GTCTGGCGGTTTGAACGAGACGAAGACGGAACCGGAGCCGGTTGCGGGCAGTGGACGCGGTTCTGCCGAGAGCCGAAGATGGCAGTGAACGTATACTCAACGTCAGTGACCAGTGATAACCTAAGTCGACATGACATGCTGGCCTGGATCAATGAGTCTCTGCAGTTGAATCTGACAAAGATCGAACAGTTGTGCTCAGGGGCTGCGTATTGTCAGTTTATGGACATGCTGTTCCCTGGCTCCATTGCCTTGAAGAAAGTGAAATTCCAAGCTAAGCTAGAACACGAGTACATCCAGAACTTCAAAATACTACAAGCAGGTTTTAAGAGAATGGGTGTTGACAAAATAATTCCTGTGGACAAATTAGTAAAAGGAAAGTTTCAGGACAATTTTGAATTCGTTCAGTGGTTCAAGAAGTTTTTCGATGCAAACTATGATGGAAAAGACTATGACCCTGTGGCTGCCAGACAAGGTCAAGAAACTGCAGTGGCTCCTTCCCTTGTTGCTCCAGCTCTGAATAAACCGAAGAAACCTCTCACTTCTAGCAGTGCAGCTCCCCAGAGGCCCATCTCAACACAGAGAACCGCTGCGGCTCCTAAGGCTGGCCCTGGTGTGGTGCGAAAGAACCCTGGTGTGGGCAACGGAGACGACGAGGCAGCTGAGTTGATGCAGCAGGTCAACGTATTGAAACTTACTGTTGAAGACTTGGAGAAAGAGAGGGATTTCTACTTCGGAAAGCTACGGAACATTGAATTGATTTGCCAGGAGAACGAGGGGGAAAACGACCCTGTATTGCAGAGGATTGTAGACATTCTGTATGCCACAGATGAAGGCTTTGTGATACCTGATGAAGGGGGCCCACAGGAGGAGCAAGAAGAGTATTAACAGCCTGGACCAGCAGAGCAACATCGGAATTCTTCACTCCAAATCATGTGCTTAACTGTAAAATACTCCCTTTTGTTATCCTTAGAGGACTCACTGGTTTCTTTTCATAAGCAAAAAGTACCTCTTCTTAAAGTGCACTTTGCAGACGTTTCACTCCTTTTCCAATAAGTTTGAGTTAGGAGCTTTTACCTTGTAGCAGAGCAGTATTAACACCTAGTTGGTTCACCTGGAAAACAGAGAGGCTGACCGTGGGGCTCACCATGCGGATGCGGGTCACACTGAATGCTGGAGAGATGTTATGTAATATGCTGAGGTGGCGACCTCAGTGGAGAAATGTAAAGACTGAATTGAATTTTAAGCTAATGTGAAATCAGAGAATGTTGTAATAAGTAAATGCCTTAAGAGTATTTAAAATATGCTTCCACATTTCAAAATATAAAATGTAACATGACAAGAGATTTTGCGTTTGACATTGTGTCTGGGAAGGAAGGGCCAGACCTTGGAACCTTTGGAACCTGCTGTCAACAGGTCTTACAGGGCTGCTTGAACCCTCATAGGCCTAGGCTTTGGTCTAAAAGGAACATTTAAAAAGTTGCCCTGTAAAGTTATTTGGTGTCATTGACCAATTGCATCCCAGCTAAAAAGCAAGAGGCATCGTTGCCTGGATAATAGAGGATGTGTTTCAGCCCTGAGATGTTACAGTTGAAGAGCTTGGTTTTCATTGAGCATTTCTCTATTTTTCCAGTTATCCCCGAAATTTCTATGTATTATATTTTTTGGGGAAGTGAGGTGTGCCCAGTTTTTTAATCTAACAACTACTTTTGGGGACTTGCCCACATCTCTGGGATTTGAATGGGGATTGTATCCCATTTTACTGTCTTTTAGGTTTACATTTACCACGTTTCTCTTCTCTGCTCCCCTTGCCCACTGGGGACTCCTCTTTGGCTCCTTGAAGTTTGCTGCTTAGAGTTGGAAGTGCAGCAGGCAGGTGATCATGCTGCAAGTTCTTTCTGGACCTCTGGCAAAGGGAGTGGTCAGTGAAGGCCATCGTTACCTTGGGATCTGCCAGGCTGGGGTGTTTTCGGTATCTGCTGTTCACAGCTCTCCACTGTAATCCGAATACTTTGCCAGTGCACTAATCTCTTTGGAGATAAAATTCATTAGTGTGTTACTAAATGTTAATTTTCTTTTGCGGAAAATACAGTACCGTGTCTGAATTAATTATTAATATTTAAAATACTTCATTCCTTAACTCTCCCTCATTTGCTTTGCCCACAGCCTATTCAGTTCCTTTGTTTGGCAGGATTCTGCAAAATGTGTCTCACCCACTACTGAGATTGTTCAGCCCCTGATGTATTTGTATTGATTTGTTTCTGGTGGTAGCTTGTCCTGAAATGTGTGTAGAAAGCAAGTATTTTATGATAAAAATGTTGTGTAGTGCATGCTCTGTGTGGAATTCAGAGGAAAACCCAGATTCAGTGATTAACAATGCCAAAAAATGCAAGTAACTAGCCATTGTTCAAATGACAGTGGTGCTATTTCTCTTTTGTGGCCTTTTAGACTTTTGTTGCCCTAAAATTCCATTTTATTGGGAACCCATTTTCCACCTGGTCTTTCTTGACAGGGTTTTTTTCTACTTTAAACAGTTTCTAAATAAAATTCTGTATTTCAAGAGTA

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