Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name XAGE2P1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:3312505-3312912  UCSC
Coordinates (T2T) chr4:3311682-3312089  UCSC
Coordinates (hg19) chr4:3314232-3314639  UCSC
Strand +
Parental Sequence NM_130777.3
Parental seq. overlap 338 bp
Parental seq. overlap (%) 53.9%
Genomic Region Intragenic (RGS12)
Retrocopy Summary XAGE2P1, located on chr4:3312505-3312912, is a retrocopy of the parental gene XAGE2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name XAGE2
Full Name X antigen family member 2
Also known as CT12.2|GAGED3|XAGE-2|XAGE2B
Coordinate chrX:52368996-52375683
Strand +
Gene summary This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in normal testis, and in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer and a germ cell tumor. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes XAGE2P1
Bonobo Pan paniscus LOC100976927P1
Orangutan Pongo abelii LOC100448176P1
Gibbon Nomascus leucogenys LOC100587005P1
Green monkey Chlorocebus sabaeus LOC103247426P1
Crab-eating macaque Macaca fascicularis XAGE3P1
Rhesus Macaca mulatta XAGE3P1
Baboon Papio anubis XAGE5P1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104671982P1
Gorilla Gorilla gorilla Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>XAGE2P1
TTGAAATATGAGTTGGCAAGGAAGATCAGCATGTAGGCTTAGACCAAGACGGTATGTGCAGCCTCCTGAGCTAACTGGGCCTGTGCTTGAGCCCAGTGATGAGCAGCCTCAGCAAGAGGAACCACCACCTGAAAGTCGGGGTCTTACCTGGCCAGGAGAGAGAGGAAGATCACGGTGCTGCTGAGATTCTTGTGCTTGACCAGGAAGCTGATCTCCGGGAGCTGTCTCAAAGACTGGGATGAATGTGGAGATGGTCCTGATGTCCGGGGAATATTCTGCCGAAATCAGAGCAATTTAAATTGCCAGAAGGAGGTGAAGGGCAACCACAGGTTCCAAGGAAGACAAGCTGAAACAATGCAAACTGGTTTTATATTAGATACGTGACTTAAAATATCTCAATACAGTTTT
>NM_130777.3
AGTGTGCATGTTCCTTGGACACCTGCCTCAGTGTGCATGTTCACTGGGCATCTTCCCTTCGACCCCTTTGCCCACGTGGTGACCGCTGGGGAGCTGTGAGAGTGTGAGGGGCACGTTCCAGCCGTCTGGACTCTTTCTCTCCTACTGAGACGCAGCCTATAGGTCCGCAGGCCAGTCCTCCCAGGAACTGAAATAGTGAAATATGAGTTGGCGAGGAAGATCAACATATAGGCCTAGGCCAAGAAGAAGTTTACAGCCTCCTGAGCTGATTGGGGCTATGCTTGAACCCACTGATGAAGAGCCTAAAGAAGAGAAACCACCCACTAAAAGTCGGAATCCTACACCTGATCAGAAGAGAGAAGATGATCAGGGTGCAGCTGAGATTCAAGTGCCTGACCTGGAAGCCGATCTCCAGGAGCTATGTCAGACAAAGACTGGGGATGGATGTGAAGGTGGTACTGATGTCAAGGGGAAGATTCTACCAAAAGCAGAGCACTTTAAAATGCCAGAAGCAGGTGAAGGGAAATCACAGGTTTAAAGGAAGATAAGCTGAAACAACACAAACTGTTTTTATATTAGATATTTTACTTTAAAATATCTTAATAAAGTTTTAAGCTTTTCTCCAAA

Publications

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