Summary

Retrocopy Name	NREPP1
Species	Homo sapiens
Coordinates (hg38)	chr4:37804907-37805270  UCSC
Coordinates (T2T)	chr4:37773965-37774328  UCSC
Coordinates (hg19)	chr4:37806529-37806892  UCSC
Strand	+
Parental Sequence	NM_004772.4
Parental seq. overlap	336 bp
Parental seq. overlap (%)	17.3%
Genomic Region	Intergenic
Retrocopy Summary	NREPP1, located on chr4:37804907-37805270, is a retrocopy of the parental gene NREP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	NREP
Full Name	neuronal regeneration related protein
Also known as	C5orf13|D4S114|P311|PRO1873|PTZ17|SEZ17
Coordinate	chr5:111728802-111976932
Strand	-
Gene summary	Predicted to be involved in axon regeneration; regulation of neuron differentiation; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Homology

	Species	Scientific Name	Retrocopy
	Chimpanzee	Pan troglodytes	NREPP1
	Bonobo	Pan paniscus	NREPP1
	Orangutan	Pongo abelii	DKFZP459D0510P1
	Gibbon	Nomascus leucogenys	NREPP2
	Green monkey	Chlorocebus sabaeus	NREPP2
	Crab-eating macaque	Macaca fascicularis	NREPP1
	Rhesus	Macaca mulatta	NREPP1
	Baboon	Papio anubis	NREPP1
	Golden snub-nosed monkey	Rhinopithecus roxellana	NREPP1
	Marmoset	Callithrix jacchus	NREPP1
	Gorilla	Gorilla gorilla	Without Homology
	Mouse lemur	Microcebus murinus	Without Homology
	Mouse	Mus musculus	Without Homology
	Rat	Rattus norvegicus	Without Homology
	Chinese hamster	Cricetulus griseus	Without Homology
	Rabbit	Oryctolagus cuniculus	Without Homology
	Pig	Sus scrofa	Without Homology
	Cow	Bos taurus	Without Homology
	Sheep	Ovis aries	Without Homology
	Dolphin	Tursiops truncatus	Without Homology
	Horse	Equus caballus	Without Homology
	Dog	Canis familiaris	Without Homology
	Panda	Ailuropoda melanoleuca	Without Homology
	Cat	Felis catus	Without Homology
	Pale spear-nosed bat	Phyllostomus discolor	Without Homology
	Velvety free-tailed bat	Molossus molossus	Without Homology
	Greater mouse-eared bat	Myotis myotis	Without Homology
	Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
	Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
	Egyptian rousette	Rousettus aegyptiacus	Without Homology
	Sloth	Choloepus didactylus	Without Homology
	Tasmanian Devil	Sarcophilus harrisii	Without Homology
	Opossum	Monodelphis domestica	Without Homology
	Platypus	Ornithorhynchus anatinus	Without Homology
	Chicken	Gallus gallus	Without Homology
	Turkey	Meleagris gallopavo	Without Homology
	Zebra Finch	Taeniopygia guttata	Without Homology
	Budgerigar	Melopsittacus undulatus	Without Homology
	Painted Turtle	Chrysemys picta	Without Homology
	Lizard	Anolis Carolinensis	Without Homology
	Frog	Xenopus tropicalis	Without Homology
	Zebrafish	Danio rerio	Without Homology
	Drosophila	Drosophila melanogaster	Without Homology

Expression

This retrocopy transcript is not present in the ARCHS4 database for expression quantificationThis retrocopy transcript is not present in the GTEx database for expression quantification.

Related Sequence

>NREPP1

GACATTTGTGTTTCAGGTGTAGAGGGGAGAGTGAGTGAACAGGGAGGGGGTCTTTTGTCTATTGGTCTCCCTGGACTGAAGAGAGGGAGAATAGAAACCAAACACTAGGATTCTCAAAATGGTTTATTACCCAGAACTCTCTGTCTGGGTCAGTCAAGAACCATTTTCAAACAAGGAGATGGAGGGAATTTTTAATTTTTAATTTTTTCTTTCCATCTTCTAAGAAGGTGTTGGTACTCTGTTTCCCTGAATGTTGTTCTCTAGACTGGATTGATTTGTTTTCCTTGTGTCTTCAGTGCAGTTTTCTTCCTCAATGGTGTAGGTTGAGTGAATGCTGCCGTAGTGTGTGAGAGACTAGTGTCTC

>NM_004772.4

ACATTTGTGTTTCAGGTGTAGAGAGGAGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCTCCCTGGACTGAAGAGAGGGAGAATAGAAGCCCAAGACTAAGATTCTCAAAATGGTTTATTACCCAGAACTCTTTGTCTGGGTCAGTCAAGAACCATTTCCAAACAAGGACATGGAGGGAAGGCTTCCTAAGGGAAGACTTCCTGTCCCAAAGGAAGTGAACCGCAAGAAGAACGATGAGACAAACGCTGCCTCCCTGACTCCACTGGGCAGCAGTGAACTCCGCTCCCCAAGAATCAGTTACCTCCACTTTTTTTAATCGTAACACCTCCATTTGTATTACATATGGTGTATGGGTATTGATGAGGTCATGGTATCATATATGGGATTTTTTTCTGTGTAAATCATCAAGTATAAGAAGAAACTATGGGACTCTGAGCCTTGCTTTAGAGAATTTACAGTGGACAAATAGGTGTCATCAAACCAGTTTTTAATCATTCTGACTCAAGTGAAAACGCTCAGAATTTCACACTGTGAATCCACGTTTACAACCCTTACAGGTGGGCCTTCAGGCCTGGTTCGCTACAACAATGTCTTCCACAACTCAAACTCCCACCGCGCTCACACAACCGGTCCACTCCTGCCTTTTCACTCACACAGCTCCCGACTGCTTCTTGCAGAGGCTGAGAGTCCCCCCCCCACCTTTTTTTTCATTTAGATGTAACAAACCTAGTAGTTTATGTTCATCAATTGTCTGTATATCTCTATATTTTATCCATGTACTCTTTTGATGTATAGAAGTAGTTTGAAACTCATTGTTTCCTTGTGGTAAGTGACCGAGATGCTGCCACAGGACCTGAGACACTGATGAATGGTGCTATTTTGGACTTTCAACATGCTCCTTGGCGAGGTAGCTCTGATGGAGTTATTTTTTATTTCCATGTTCTAAGAAGGTGTTGGTACTCTGTTTCCCTGAATGTTGTTCTCTAGACTGGATTGACTTGTTTTCCTTGTGTCTTCAGTGTGGCTTTCTTCCTCAGTGTTGTAGGTTGAGCGAATGCTACCAGAGTGTGAGAGACCATTGTCTCGTTGGCTGGCGCTCACGGACATGCAGTCACGGTAGCGGGAGCAATCACAAAACTGTAATTTACTTACCAAATCTCTTCCTTTCCGTAGCCTCGCCTGCCTGACTTAGAGAAAGAAAAGCAATAATTTTACAGGCATTTTGAGGTGTCTCTTTGGGTTCTTTCTGTTTGAAAGGATATTTGTCGAAAAAAAGAGCAAAACCGTTTTAAATAAACTCCCCCTGGAAAAAAACCCAAAACACTGGCATCTGAGTGGGAATATGAAAATGACACCTTTTCCAAATATTAAATTGGAAAACAAGGTCTACAAAATCATGATACTTTTTTAAAAGGCAGAGCATTCTTTTTTCGGCAATTTTGATAAGCAAGGTGTAGATTTACATTTTTGTCCTTGCTCCCAACGAAATGGATAAACAAAAATAAATTACCATCTACTCATGGAATGTTGTTGTGTTAGCCAGTCTGAAAGCCCACCTTAATTTTTATATAACTGTCTTTAGCTCTTCTTTTGACAGGGCAGGCCTTGTTCTGAACTGTTTCGCTTCTGACTGTTAAACACCGATGACGCATGCACTGCACTTCTTCGTTTTCTTCTTGCTCCCCCATTGGCCTGAGTTTCTTGTGCATTACTCCTCTCCCTCCTTCGTTAGAATAGGTATATCAGCTGTGTAAATAGAGCAAGAAAACAGTATTCTGCATCTGTGGCATTTATGTAGAGTTGCAGTTGTGTACTGCTGAAAATGCAGGCTTTTGTAACAGTGTGATCTTTACTGATGCACTCATGACAAGTACCCAATGTATTTTAGCTATTTTAGTAGTATTTGTTCAATAAATACGCAAGCTGTAAGGTAA

Publications

PMID - Link	Title
No publications available for this retrocopy