Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name WDR5P2
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Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:39480386-39481765  UCSC
Coordinates (T2T) chr4:39450036-39451415  UCSC
Coordinates (hg19) chr4:39482006-39483385  UCSC
Strand +
Parental Sequence NM_017588.3
Parental seq. overlap 1280 bp
Parental seq. overlap (%) 40.5%
Genomic Region Intergenic
Retrocopy Summary WDR5P2, located on chr4:39480386-39481765, is a retrocopy of the parental gene WDR5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name WDR5
Full Name WD repeat domain 5
Also known as BIG-3|BIG3|CFAP89|SWD3
Coordinate chr9:134135199-134159968
Strand +
Gene summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes WDR5P2
Bonobo Pan paniscus WDR5P2
Gorilla Gorilla gorilla WDR5P2
Orangutan Pongo abelii WDR5P2
Green monkey Chlorocebus sabaeus WDR5P2
Crab-eating macaque Macaca fascicularis WDR5P2
Rhesus Macaca mulatta WDR5P2
Baboon Papio anubis WDR5P2
Golden snub-nosed monkey Rhinopithecus roxellana WDR5P2
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>WDR5P2
CCGACGCCCCGAGCGCCCGGCCCTCCGCAGCAGCCCGGCAGACTGCCTCTGTCATCAGGACCCTCCGTCCACGTCCCCTGTGCGGCCAGCGTCAGAGCCATGGCGATGGAGGAGAGGAAGCCCGAGACCGAGGCAACGAGAGCACAGCCGACCCCTTCGTCATCCACCACTCAGAGCAAGCCTACGCCCGTGAAGCCAAACTATGCTCTCTAAAGTTCACCCTTGCTGGCCACACCAAAGCAGTGTCCTCCGTGAAATTCAGCCCGAATGGAGAGTGGCTGGCAAGTTCATCTGCTGATAAACTCATTAAAATTTGGGGGACTCATATGATGGGAAATTTGAGAAAACCGTCTGGTCACAGCCTGGTCGTCAGATTCTAACCTTTTTGTTTCCGCCTCAGATGACAAAACCTTGAAGATACGGGACGTGAGCTCGGGAAAGTGTCTGAAAACCCTGAAGGGACACAGTAATTATGTCTTTTGCTGTAACTTCAATCCCCAGTCCAGCCTTACTGTCTCAGGATCCTTTGATGAAAGTGTGAGGATATGGGTTGTGAAAACAGGGAAGTGCCACAAGACTGCTAGCTCACTCCGATCCAGTCTCGGCCATTCATTTTAATCGTGATGGATTCTTGATAGTTTCAAGTAGCTATGATGGTCTCTGTCACATCTGGGACACAGCCTCAGGCCAGTGCCTGAAAACGCTCACTGATGATGACAACCCCTGGTGTCTTTCGTGAAGCTCTCCCCGAAGGGTGGATACATCGTGGCTGCCACGCTGGGCAACACTCAAGCTCTGGGACTACAGCAAGGGGAAGTGCCTGAAGACATACACTGGCCACAAGAACGAGAAATACTGCATATTTGCTAATTTCTCTGTTACTGGCGGGAAGTGGATTGTGTCTGGCTCGGAGGATAACCTTCTTTACATCTGGAAACTTCAGACGAAAGAGATTGTACAGAAATTAGAAGGCCACACAGATGTTGTGACCTCAACAGCTTGTCACCCAACAGAAAACATCATCACCTCTGCCGCGCTAGAAAATGACAAAACAATTAAACTGTGGAAGAGTGACTGTTAAGTCCCTTTGCTCCCACATGCGATAGACCATCAGGAAGTTGACCCGGATTGGCAAGAAACATGATGTCTCGGAGGCGGTCCCCTGGGTCTGTGCCTGGGGGTCAGGACCGGGCCTGATTTGAGCCTCCTTTTTGAAGATGATTTGGCCGAGTGTGGACCACCGGAAAGTTCTAAAAGTTGCTGGTGACATTTCTTGCCAATTCTCTAACACTGTCTAGGGAAGAGTTCCTAGTCTGTTGTGTTCAAACAGAGTCAACAAAAATTTTTAATTTTTTGTTACAAAAGGGTGAAGTTCAATTT
>NM_017588.3
GCCCCCGCCGCCTGGCGCCCGCCCGAGCTGCCGCCTTGTCGAGCTGAGTCCGCGCTCCCGCCCAGGCGGCGGCCGACGCGACGCCCCGAGCGCCCGGCCCCGCCGCCGCGGCCCGGCAGACTGCCTCTGTCACCGGGTCCCTCCACCCTTGTCTCCTGTGCGGCCAGCGTCAGAGCCATGGCGACGGAGGAGAAGAAGCCCGAGACCGAGGCCGCCAGAGCACAGCCAACCCCTTCGTCATCCGCCACTCAGAGCAAGCCTACACCTGTGAAGCCAAACTATGCTCTAAAGTTCACCCTTGCTGGCCACACCAAAGCAGTGTCCTCCGTGAAATTCAGCCCGAATGGAGAGTGGCTGGCAAGTTCATCTGCTGATAAACTTATTAAAATTTGGGGCGCGTATGATGGGAAATTTGAGAAAACCATATCTGGTCACAAGCTGGGAATATCCGATGTAGCCTGGTCGTCAGATTCTAACCTTCTTGTTTCTGCCTCAGATGACAAAACCTTGAAGATATGGGACGTGAGCTCGGGCAAGTGTCTGAAAACCCTGAAGGGACACAGTAATTATGTCTTTTGCTGCAACTTCAATCCCCAGTCCAACCTTATTGTCTCAGGATCCTTTGACGAAAGCGTGAGGATATGGGATGTGAAAACAGGGAAGTGCCTCAAGACTTTGCCAGCTCACTCGGATCCAGTCTCGGCCGTTCATTTTAATCGTGATGGATCCTTGATAGTTTCAAGTAGCTATGATGGTCTCTGTCGCATCTGGGACACCGCCTCAGGCCAGTGCCTGAAGACGCTCATCGATGACGACAACCCCCCCGTGTCTTTTGTGAAGTTCTCCCCGAACGGCAAATACATCCTGGCCGCCACGCTGGACAACACTCTGAAGCTCTGGGACTACAGCAAGGGGAAGTGCCTGAAGACGTACACTGGCCACAAGAATGAGAAATACTGCATATTTGCCAATTTCTCTGTTACTGGTGGGAAGTGGATTGTGTCTGGCTCAGAGGATAACCTTGTTTACATCTGGAACCTTCAGACGAAAGAGATTGTACAGAAACTACAAGGCCACACAGATGTCGTGATCTCAACAGCTTGTCACCCAACAGAAAACATCATCGCCTCTGCTGCGCTAGAAAATGACAAAACAATTAAACTGTGGAAGAGTGACTGCTAAGTCCCTTTGCTCCTGCCCGCGAGAGACTGTCGGGAAGTTGACCCGGATTGGCAAGAAACAGGGTGTCTTGGAGGTGGTCCCCCAGATCTGCGCCTGGGGGTCAGGACAGGGCCTGATTTGAGCCTCCTCTCTGAAGATGATTTGGCCGAGCGGAAGGTGTGGACCACCGGAAAGTTCTTAAAAGTTGCTGGTGACATTTCTTGCCAATTCTAACACTGTCTAGGGAAGAGTTCCTAGTCTATTGTGTTCAAACAGAGTCAACAAAAGTTTTTAATTTTTTATTACAGAAGGGTGAAGTTCAATTTAACATGCGTTGTGTTTTTTCAGTAAACGTTCTGTATCTTTTTGATATTCCATGACCCAGTGCACGCTGTGGCCTGTCACCGCCACCGTGGCCCCGCCAGCTGGCCTCCCCTTTGGCCCACGCCGGCCGCCCCCATTCTCTGCTGCGTAGATGCCCTGGCCCAGGGCCCTGACTCCTCCATTCCCGCCAGTAGCTGTTCCTAGTGTATTTTCGTCTTTCTGGAAAACAGCATTGAGTGGTTGTTTTCTGTGTAAAGAGCCGTTTGTGTCTTGGGAGTTTGTGGCCCACATGCCGATAGCACGGTCATCGCACATGACTCTCCCGTTTGTCTCAGTGTCCCTGCAACAAGCAGCACCGCAGACTGTAATAAAAGGTGGGGTTTTGTGAATGGTTGTGGCAAGTGCGTCCTTGTGAAGCTCGTCTCCATGTGGCTTTCTTGGAGAAAGGCTCCCCTGGGGCAAGAGGGTGGAAGGTTTCTTTGGACAGGAGGTGCTGAGGCTGGCTGCACCTGCTCTCTGAAGACGCCTTCCTCTCTAGGTTCATTGTTCAGTGTTGCTGGGGGCGGGGAACGGGGGTGGGGAGGTTCTTAGTTGCGAAGGAGCCAAGCTCCTGATGGACTTGCGTTGGGATGTGGGGGACACCTGTGGCATGGTAAGGCTCCCTGAGTCCCTTACTCCAGGTCAGATGCCAGTGGGACTCATGCGCCCTATGAGGGCTGCAGGGCCAGTGCTGCCCCTCGGACTCCTCGAGGGGTTGGGTGCTAAGCGCGAGCCTCGCCGTCCCTGCTGGAGCCCTCGCCTGCCTGCCCCTCTGCCTGTGCTCCTGGCAGTGTGGCTTCCCGGTGCTCACCTGCACAGCAGTTAACAGCAGAGGCCGAGCGGGAGCCTCTGGGGAGCGAGGCTGAAACCTGAACCTGCCCATGGAGACAGTTGTGGTGAGGGTTGCCACACACAGTGAGGGCGGAGCAGGGTGGCTGAGGGCACAGGTGCCTGGGTCTGTCCCACGGGGCAGGGCTTTGGGGCTGTGATGCTCTGGGAAGCCAGCTTGGGTCCTGGGTCTACAGAGGGCCCTGGCCCCGGAGCCCAGCCAGCTCTGCCTCTCTCAGGGCCTGGAGTCCTGGGGGAGCTCAGCCAGCTCTGCCTTTCTCAGGGCCTGGAGTCCTGGATGAATCCTGCAGGTTTTTGGTTGCACCGGCCCAGGGAGGAAGCGGGGGGTTTGTCAGGTGGGCTCTCCTGGAGGTCCTCGAGTGGCAGGGGTGAGGAGGGGATTATCTGAGGCATCTGGAGATGTATATCCTGTGGTTTCCCCTGCCCCTCTGTTTCCGATGAGGTGTACGGATGAGTGACCTGCACTAAGAAGTGAGTTGCCACAGTGAAAATGGGTTGGTTTTTGTCTTCGACGCTCAGGGTCTGGGCGCCTCGCATTTGCAGTCTGTTGTGACAGACACGGGGAGCTCCGCGTGCCAGCCTGTGGCTGCCCTGCTGTGGGGGTCCTGGGGCCGGCGAGGCCCCTTCAGTCTTGTTCTGGGGGGACGGCCCACTCCGGGGAGGGGGTGTGCTGTGCTGAGCGCTGTATCCCTGAATATAGTTTATTTTTTCTACATTTGAATTCTGTTGTAGATTTATGTAAAAATACATTCTTTTTGAAAATAAAAATTTTCATGTCTTCTAA

Publications

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