Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name COMMD6P2
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr13). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:45014618-45014810  UCSC
Coordinates (T2T) chr4:44981649-44981840  UCSC
Coordinates (hg19) chr4:45016635-45016827  UCSC
Strand -
Parental Sequence NM_001287394.2
Parental seq. overlap 159 bp
Parental seq. overlap (%) 9.4%
Genomic Region Intergenic
Retrocopy Summary COMMD6P2, located on chr4:45014618-45014810, is a retrocopy of the parental gene COMMD6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name COMMD6
Full Name COMM domain containing 6
Also known as Acrg
Coordinate chr13:75525214-75549439
Strand -
Gene summary COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes COMMD6P2
Bonobo Pan paniscus COMMD6P2
Gorilla Gorilla gorilla COMMD6P3
Orangutan Pongo abelii COMMD6P2
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>COMMD6P2
CACAGTTTCAGAATTTCTATAGAAAGATGAAGAAAATTTCTGAAGTTATTGAAACTGTGTGAAGACGAATTATTTGGTTGAAAAATTACTATCATTCTAAATGGACTTCACTTTCTGCAAAAAAAAAAATAAGGATGAAATATGTATTGGATGAAAATTATATTTTGTTTTTCCATTTTTACa
>NM_001287394.2
ATTCTTGCAGTGTCAACCGACTGCGCTAGGAGGCGTGCCGCGGAGTCCTATTCTGAGACAGACGCCAGGTGGCTACCCATTGCCAGGCAGCAAGGCCGGAGGACGCCGTGCAGCACGCTTGTAGATTTTCAGTGGAAACTGGGTATGGCTGTGAGCTCAGACACTTGCAGATCTCTTAAGTATCCTTACGTTGCAGTGATGCTAAAAGTGGCAGATCATTCAGGCCAAGTAAAGACCAAGTGCTTTGAAATGACGATTCCACAGTTTCAGAATTTCTACAGACAGTTCAAGGAAATTGCTGCAGTTATTGAAACGGTGTGAAGACGGATTCTTTGGTTGATAAATTGCTATCATTCTAAAGTCATGGACTTCACTTTCGGCAACAAAACTAAATAAGGATGGAACATTTATTGAATGAAAAATGCACTTTTGTTTTTCCATTTTTTTAAATAATAAAAATCAGACAAACAggaactgggtagtggtgatgaatgcaaaactttgtgaatgtgctttataaaagtgataattagacactttagaggatatacttggtgataatgtgaatgatgtAATCAGACTAACAGTTGAATCATTGCTGTTGGAGGCAGCACAAATTTATGTGTTACAACAGTAGTTTAAAAACTTGTACTGGATGGAACCCATTTTATAAACAGTCTTATTTGGAGTCATGTATATAAAAATatatataaattagaaaagtagtatttgattaggataactttacaaattcaatagtatagccatcacttattataatggcaatcagaagagtgaggcttcttttttcaaacttttgtaatcagattaagattgaccattgctcctttacacagtattagtctagcattcaattatttctgtTATTAATGGTTGTAGAaagttcaaatacatacgcagagttggaaagacgagttttagtctgagttctgtacgacggagttaacccgttagcacaagttattgcattagatgatctctgttgaatttaaatacataaacctgttgttaaacgcttttatactataaagccaccacattgtatggcatttgtttagaagtaagcaaatagaccaccggaatagaatagatggcctagaaatagatcAAGACATTCTGGTCCGCCATATTAGAAATTTAAACCCTCTTCACACCCTGTCTGCATTTCTGCAGGTCTGTGTGAGTCCACTTTCTTTTTTGTTCCCTGCTAGGTAGCACACAGCTGTGAGGAGCCCAGGACTGCTGCCTGCCGCAGCCCACCTGTGCGCTCAGATTCCTACCAGCTTGATGAGTTAGCTGATGGGCCATTTGTGCATACCAACTACCCACAGACATTTCTATTACCCACCCTCTGGATGCCAGTGCATTAATGATTCTAGAATTAGGAGAAACCAAAGATCCCTTCTCTCTCCCTCCCACAACCAGTGTCGTCGTGTTCCTAGAAATAAGAGTAGAAACCCCTCTATCTGGGTTAAAACAGCAAACCTGCCTTCTGTAACTGTGCATGAGGTTCCTCTGTCTCCCACTTACTTCGGATTAACACCTTCCTCTTTCCCCTTCCCTGTTTGCAGGGTAGCATTTCTAGGTTTAAGGCAATATGCAAAAAGACCCAAAGTTAGGCCCTGGCTCAAACACTGTGGGTAGCAGATTTGAAATAAATTTAAATTGCATGTTT

Publications

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