Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RASGRP2P1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:68614519-68615240  UCSC
Coordinates (T2T) chr4:72055552-72056273  UCSC
Coordinates (hg19) chr4:69480237-69480958  UCSC
Strand +
Parental Sequence NM_001098671.2
Parental seq. overlap 608 bp
Parental seq. overlap (%) 26.8%
Genomic Region Intergenic
Retrocopy Summary RASGRP2P1, located on chr4:68614519-68615240, is a retrocopy of the parental gene RASGRP2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RASGRP2
Full Name RAS guanyl releasing protein 2
Also known as CALDAG-GEFI|CDC25L
Coordinate chr11:64726911-64745481
Strand -
Gene summary The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla RASGRP2P1
Orangutan Pongo abelii RASGRP2P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RASGRP2P1
aTCTCACAGGAAAAATTCCAGATCATCCATGGGAACTTCCCCTTACCTCAGCGCCTTTGGGGACTTTGACCAAAACTAGGAAGGCTGCATCAGTAGGGAAAAGATGCTTTCCTTTTCCTGTGCTTCAGCTCCTTGCTGGGAGTCTACATGGGTTTTGTACACAGTTTCCAGGAGGGCAACTCCTAGAGTGCAGTAGCCTGCTGCCACTGCGAAGCCCTGATCCTGGGCATCTATAAGCAGGGCCTCAACTGCCAAGCCAGTGGTATGAGCTGCCACCAGCAGTGCAAGGATTGCCTGTAAGTTGAGCACCAGTGCAGGCCCCAGAGTGTGGGCCTGGAGGAGTCTCCACGTCACCCTCACACACTCATACCCACCATCATCCCACCTTCAGCTTCTCCCTGCCCTGCCATGGCAAACGAGACTCCCAGCCTCCAGAGATTCATGAGGAGGAGATGCAGATGGTGAAGGATGGGGTGTTTGACAACTGCTTGTAATTGATGCTATGATTGGATCAAGGACTCATTCCTGCCTTGGAGAAAAGACTTGAACCAGAGCAGGGAGCCTGGGGGTGCTGGGACAGAAGGTTGGGGCTGAGGGCAGAATGTGATGGTGGCATGCAGCTAAGGGCAGGGCCAGGGCAGGCGTCCCTAAGGTTGTACCAACTTTTGTGAATATTTGTATTTTCCTCATGGAATAAAAAGGCTCATGTAATTAA
>NM_001098671.2
ACTGCCTTGCGTGTGTGCACACGTGTGAGGATGTCAGCGCCTGTGTGGCCGCGGGACTCAAGGCTGGCCTGGCTCAAGTGAACAGCACGTCCAGGAGGCGACCTCGTCCGCGGGTTTGCATTCTGGGGTGGACGAGCTGGGGGTTCGGTCCGAGCCCGGTGGGAGGCTCCCGGAGCGCAGCCTGGGCCCAGCCCACCCCGCGCCGGCGGCCATGGCAGGCACCCTGGACCTGGACAAGGGCTGCACGGTGGAGGAGCTGCTCCGCGGGTGCATCGAAGCCTTCGATGACTCCGGGAAGGTGCGGGACCCGCAGCTGGTGCGCATGTTCCTCATGATGCACCCCTGGTACATCCCCTCCTCTCAGCTGGCGGCCAAGCTGCTCCACATCTACCAACAATCCCGGAAGGACAACTCCAATTCCCTGCAGGTGAAAACGTGCCACCTGGTCAGGTACTGGATCTCCGCCTTCCCAGCGGAGTTTGACTTGAACCCGGAGTTGGCTGAGCAGATCAAGGAGCTGAAGGCTCTGCTAGACCAAGAAGGGAACCGACGGCACAGCAGCCTAATCGACATAGACAGCGTCCCTACCTACAAGTGGAAGCGGCAGGTGACTCAGCGGAACCCTGTGGGACAGAAAAAGCGCAAGATGTCCCTGTTGTTTGACCACCTGGAGCCCATGGAGCTGGCGGAGCATCTCACCTACTTGGAGTATCGCTCCTTCTGCAAGATCCTGTTTCAGGACTATCACAGTTTCGTGACTCATGGCTGCACTGTGGACAACCCCGTCCTGGAGCGGTTCATCTCCCTCTTCAACAGCGTCTCACAGTGGGTGCAGCTCATGATCCTCAGCAAACCCACAGCCCCGCAGCGGGCCCTGGTCATCACACACTTTGTCCACGTGGCGGAGAAGCTGCTACAGCTGCAGAACTTCAACACGCTGATGGCAGTGGTCGGGGGCCTGAGCCACAGCTCCATCTCCCGCCTCAAGGAGACCCACAGCCACGTTAGCCCTGAGACCATCAAGCTCTGGGAGGGTCTCACGGAACTAGTGACGGCGACAGGCAACTATGGCAACTACCGGCGTCGGCTGGCAGCCTGTGTGGGCTTCCGCTTCCCGATCCTGGGTGTGCACCTCAAGGACCTGGTGGCCCTGCAGCTGGCACTGCCTGACTGGCTGGACCCAGCCCGGACCCGGCTCAACGGGGCCAAGATGAAGCAGCTCTTTAGCATCCTGGAGGAGCTGGCCATGGTGACCAGCCTGCGGCCACCAGTACAGGCCAACCCCGACCTGCTGAGCCTGCTCACGGTGTCTCTGGATCAGTATCAGACGGAGGATGAGCTGTACCAGCTGTCCCTGCAGCGGGAGCCGCGCTCCAAGTCCTCGCCAACCAGCCCCACGAGTTGCACCCCACCACCCCGGCCCCCGGTACTGGAGGAGTGGACCTCGGCTGCCAAACCCAAGCTGGATCAGGCCCTCGTGGTGGAGCACATCGAGAAGATGGTGGAGTCTGTGTTCCGGAACTTTGACGTCGATGGGGATGGCCACATCTCACAGGAAGAATTCCAGATCATCCGTGGGAACTTCCCTTACCTCAGCGCCTTTGGGGACCTCGACCAGAACCAGGATGGCTGCATCAGCAGGGAGGAGATGGTTTCCTATTTCCTGCGCTCCAGCTCTGTGTTGGGGGGGCGCATGGGCTTCGTACACAACTTCCAGGAGAGCAACTCCTTGCGCCCCGTCGCCTGCCGCCACTGCAAAGCCCTGATCCTGGGCATCTACAAGCAGGGCCTCAAATGCCGAGCCTGTGGAGTGAACTGCCACAAGCAGTGCAAGGATCGCCTGTCAGTTGAGTGTCGGCGCAGGGCCCAGAGTGTGAGCCTGGAGGGGTCTGcaccctcaccctcacccatgcacagccaccatcaccGCGCCTTCAGCTTCTCTCTGCCCCGCCCTGGCAGGCGAGGCTCCAGGCCTCCAGAGATCCGTGAGGAGGAGGTACAGACGGTGGAGGATGGGGTGTTTGACATCCACTTGTAATAGATGCTGTGGTTGGATCAAGGACTCATTCCTGCCTTGGAGAAAATACTTCAACCAGAGCAGGGAGCCTGGGGGTGTCGGGGCAGGAGGCTGGGGATGGGGGTGGGATATGAGGGTGGCATGCAGCTGAGGGCAGGGCCAGGGCTGGTGTCCCTAAGGTTGTACAGACTCTTGTGAATATTTGTATTTTCCAGATGGAATAAAAAGGCCCGTGTAATTAACCTTCA

Publications

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