Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LDHAL6EP
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:71434389-71437724  UCSC
Coordinates (T2T) chr4:74776687-74780022  UCSC
Coordinates (hg19) chr4:72300106-72303441  UCSC
Strand -
Parental Sequence XM_011519923.2
Parental seq. overlap 1029 bp
Parental seq. overlap (%) 48.5%
Genomic Region Intragenic (SLC4A4)
Retrocopy Summary LDHAL6EP, located on chr4:71434389-71437724, is a retrocopy of the parental gene LDHAL6A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LDHAL6A
Full Name lactate dehydrogenase A like 6A
Also known as LDH6A
Coordinate chr11:18455856-18479601
Strand +
Gene summary Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in carbohydrate metabolic process and carboxylic acid metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LDHAL6AP1
Bonobo Pan paniscus LDHAL6AP1
Gorilla Gorilla gorilla LDHAL6AP1
Orangutan Pongo abelii LDHAL6AP1
Gibbon Nomascus leucogenys LDHAL6AP3
Green monkey Chlorocebus sabaeus LDHAL6AP2
Crab-eating macaque Macaca fascicularis LDHAL6AP2
Rhesus Macaca mulatta LDHAL6AP2
Baboon Papio anubis LDHAL6AP1
Golden snub-nosed monkey Rhinopithecus roxellana LDHAL6AP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LDHAL6EP
GAATAATCTTAAGAGGGTGCATCCAGTTTCCATCATAATTGAGAGCTTTTATGGGATAAATGAAGTAACATTCCTTAGCATTCCTTGTATCCTAGGACAGAATAGTACTACAGATCTTATAAAGATAAAGGTGACTTCTGAAGAGGAGGCCCAGTTGAAAGAGAGTGCTGAAAGACTTTGGGAAATTTAGAAGGAGCTCAAGCTTTAAAGTTGTTTAAAGCTACTCATCCCAATAAGATCTCCATTATAGGAACTGGATCAGTTGGCATGGCCTGTGCTCTCAGCATCTTATTAAAAGGTTTGGGTGATAAACTTGCCTTTGTGGATGTTGACGAAGGCAAATTGAAGGGTGAGACAACGGATCTTCAACATGGCAGCCCTTCCATAAAAATGCCAAGCATTGTTTTCAGCAAAGACTACAGTGTCACTGCAAAGTCCAACTTAGTCATTATTACAGCAGGTGTTCCAGCAAAAGGAGAAACACACCTTGATATAGTCCAGTGAAATGTGATCATTTTTAAATTAATTATTTCCAGTATTACCCGATGCAATCCCCACCACAAACTGATAGTAGTTTCTAATTTACTGGATATTGTAACTTATGTATTCTGGAAATTGAGTGTATTTCCCCAAAACCGTGTTATTGGAAGTGGCTGTAATCTGGACACTCCCCATTTCCGTTTCTTCACTGGGCAAAGGCTTGATATCCACTCTGAAAGCTGTCATAGGTGGATTCTTGGACAGCATAGGGACTCAAGTATTCCTGTGTGGAGTGGAGTCAATATTGCTGGCATCCCTCTGACGGATCTGAACTCAGATATAGGAACTGATAAAGATCCTGAACAGTGGGAAAAAGTCCACAAAGAAGTGATTGCCTGTGGCTATGAGATAGTTAAAATGAAAGGTTGTACTAATTGGACCATTGGCCTATCTGTAGCTGATTTAACAGAAAGTATTTTGAAGAATCTTTTTTTTTAATAGAAAACAACAGTAAACATTTTTTAATAGGCAAACTCATTTCCCATTGAAATGTCTTTCACTGCAGTGGGAAAGAGCAGCCACACATAGCCTGGGTTTTAATGACATGACACTGTCAATGGGAAGTTACAAGGAGAAAAAAAAAAGGTGCATTTGATTTATTACTGAATTCTGGAAGGATTATGGACAACTTGTCAGAATTTATTTCAAATGAATATTTGTTGAGAATTAATTATCTCTAAGTCATTAAGCAATTAAATGAATCTAGAAATCCATCAGAGGAATTATCTTTGCATCTCCTAAGTAGTAGCCAGCACTGACTTTGGTCTCTGTTTCATACTGGTCAATAATTCACATTGTATGAGCTGATTAATCTAGTCATGTTTTACTATTAGGTTAGTGCAAAAGTATTTTt
>XM_011519923.2
GCTTCCGGCCTCACACCTGCCAAGCATCACACCTGCCAAGCATCACACCTGCCAAGCATCACACCTGCCAAGCATCACACCTGCGATGCCTGCACGAGCTGGGTGCGGTCCGCGCAGCTGCAGTAAGGGGGCGACCCGGCGTCTGTTAGTCGGCGGTTCATCTCCTTCGTGCCTCGATGAGCTTTAACGCCATTTTCCTCCATTCTCTTTCTTCACCTCTTGAGTTTCCAAGATGGCAACTATCAAGAGTGAACTTATTAAGAATTTCGCGGAAGAGGAGGCCATTCATCACAATAAGATCTCCATTGTAGGAACTGGATCGGTTGGTGTGGCTTGTGCTATCAGCATCTTATTAAAAGGTTTGAGTGATGAACTTGTCCTTGTGGATGTTGATGAAGGCAAACTGAAGGGTGAGACAATGGATCTTCAACATGGCAGCCCTTTTATGAAAATGCCAAATATTGTCTCCAGCAAAGATTACCTGGTCACTGCAAACTCCAATCTAGTGATTATCACAGCAGGTGCACGCCAGAAAAAAGGAGAAACACGCCTTGATTTAGTCCAGCGAAATGTATCCATCTTTAAATTAATGATTCCCAATATTACCCAGTACAGTCCTCACTGCAAACTGCTTATTGTTACTAATCCAGCTTTATGTATGAGGAAACTTAAAGACATTTCTACCATACTTCTCTCCATCTCAGTGGATATCTTAACTTATGTAGCCTGGAAGTTGAGTGGATTTCCCAAAAACCGTGTTATTGGAAGTGGTTGTAATCTGGACTCTGCTCGTTTTCGTTACTTTATTGGGCAAAGGCTTGGCATCCACTCTGAAAGCTGTCATGGGCTGATCCTTGGAGAGCATGGCGACTCAAGTGTTCCTGTGTGGAGTGGTGTGAACATTGCTGGCGTCCCTCTGAAGGATCTGAACCCAGATATAGGAACTGATAAAGATCCTGAGCAGTGGGAAAATGTCCACAAAAAAGTGATTTCCAGTGGCTATGAGATGGTCAAAATGAAAGGTTATACTTCTTGGGGCATTAGCCTATCTGTAGCTGATTTAACAGAAAGTATTTTGAAGAATCTTAGGAGAGTGCATCCAGTTTCTACCCTAAGTAAGGGCCTCTATGGAATAAATGAAGACATATTCCTTAGTGTCCCATGTATCCTGGGAGAGAATGGTATCACAGACCTCATAAAAGTAAAACTGACTCTTGAAGAGGAGGCCTGCTTGCAAAAGAGTGCAGAAACACTTTGGGAAATTCAGAAGGAGCTCAAGCTTTAAAGTTGCTTAAAGCTAATTCTGTAGATTGAAGATGAAATAGTAGTTATGGAATTGTATATGTCAAACTTTTGAATAAATTTGAATTTCTAAAAGTTGGAAAAATAGAGGAAAGAGTGACCTATTTAGTATAGCCTTCCAGCttttttttttttcttttttgggagggtctcattctgtcacccaggctggagtgcagtggcacaatcatggctcactgcaaccttgacctcccgagctcaggtgagcctcccacttcagcctccagagtaggtgggaccacatgcgtgtgcctccatgcctgcctaatttttgtatctttttgtagagatggggttttgccatgtcatccaagctggttttgaactcccaaagtgctgagattacaggggtgagccactgtgcctggccTTAGCTTTGATTTAGTATCCAGATGATAGATGACACttttttttttttttttttAAAGTGACGGCATCAAAGATGTTTTTGGTACTTCTCAGTACTTGCCTTGTATGTATACGTAATTGCCATCTGGTCCACAAGAATGTGTTTACTGTGTTACACAAATCCTGATTCTTTTCATCAGGTGCATAGTAATTCTTCTCTATGGCTTAATACCTATGTTCATTTACATGCTATCTCTACAATGTAAAAATAAAAGTGTATATATATACACACA

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