Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ARPC1AP1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:86912927-86914917  UCSC
Coordinates (T2T) chr4:90242348-90244338  UCSC
Coordinates (hg19) chr4:87834080-87836070  UCSC
Strand -
Parental Sequence NM_006409.4
Parental seq. overlap 832 bp
Parental seq. overlap (%) 37.2%
Genomic Region Intergenic
Retrocopy Summary ARPC1AP1, located on chr4:86912927-86914917, is a retrocopy of the parental gene ARPC1A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ARPC1A
Full Name actin related protein 2/3 complex subunit 1A
Also known as Arc40|HEL-68|HEL-S-307|SOP2Hs|SOP2L
Coordinate chr7:99325898-99366262
Strand +
Gene summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ARPC1AP1
Bonobo Pan paniscus ARPC1AP1
Gorilla Gorilla gorilla ARPC1AP1
Orangutan Pongo abelii ARPC1AP1
Gibbon Nomascus leucogenys ARPC1AP1
Crab-eating macaque Macaca fascicularis ARPC1AP1
Rhesus Macaca mulatta ARPC1AP1
Baboon Papio anubis ARPC1AP1
Golden snub-nosed monkey Rhinopithecus roxellana ARPC1AP1
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ARPC1AP1
GTGGATGAAAAGCCAGTCAGTATGCACTGGGGCAGCAAGATGCCCTTTGGGCAGCTGATGTCAGAGTTAGGTGGCAGTGGCACTGGTGGCTGGGTCCACAGGGTCAGCTTCTCTGCCAGTGGGAGCCGCCTGGCCTGGGTCAGCCACAACAGCACCATGTCTGTTGCTGATGCCTCAAAAAGTGTGCAGGTCTCACACAGAGTTCCTGCTGCTCCTAAGTGTTTCATTTGTCTCAGAGAACAGAGTGGTGGCTGCTGGCCATGACTGCTGCCCAACGCTCTTTTCGATGACCGAGGCTGCCTGACCTTCATCTCCAGGTTGGACGTTCCAAAACAGAGCATCCAACGCAACATGTCTGTCATGAATGCTTTTGCAACATGGACAAGAGGGCCACGACTGAGGACCGCAACACGGTGTTGGAGATGCTGCACCCGAATAGCATCACTCAAGTCTCTATTTATGAGGTGGGCAAGCAAGATTGTCGCAAATTTTGCACTACTGACATCGGTGGAGCCATGACAATTTAGGATTTCAAGACTCTCGAGTCTTCCATCCAGGGCCTCTGGATGTGAAGCTGAGTGAGCTTCCGCCATCCAGCACAACAAACTGTGGAAGATCACAGCTGTGCTGTGGCACGATGGCAAGGAAGCCAGCCCCAAGGAAACACTGAGAACATATATCACGCCAATACCATGTGGTTTTGTTTGAATATAAAATTGGTTAAAGTGTTGGTTTTTTAAAAGCAGTACTTTTTTTTTTTTATTGCGACTTCATTCCATTTTTGACCAAAGCTTCTTTAAGCAGTTTATTATGGAAAATTGTGACACTAACTTAAAAGACAGTGTGAGGGAGATATGTAAATTGCCCAGTGGAAAATTAAATTAAAAACTGAATGTGGTGGAAGAAGAAGAACGGGAGCCGGGGGGTGAAAGCTCATGAACTCAAGGAGCACAACGGACATATCACAGGTATTGACTGGGCTCCCAAGAGCGACCGCATCGTCACTTGTGGGGCAGACCACAATGCCTATGTCTGGAGTCAGAAAGATGGTGTCTGTAAGCCAACCCTGGTGATCCTGAGAATTAACTGTGCAGCTACTTTTGTGAAGTAGTCCCCACTAGGGAACAAATTTGCTGTGGGAAGTGGAGCACGATTCATTTCTGTTTGTTACTTTGAGTCTGAAAATGACTGGTGGGTGAGCAAGCACATTAAAAAGCCAATTCGCTCCACAGTCCTCAGCTTGGATTGCCATCCCAACGACGTTTTGCTGGCAGCAGGATCATGTGACTTCAAATGCAGACTGTTTTCTGCCTACATTAAAGAAGTGGATGAGCCTGTTTGCATTGACTGCCCAGAGTCCATGAATCCTCCACTCCAAGCCCGTCCGGACTCCCCCGACCCCAGCTTTCTCTCCTTTGAAAACACTAAGAATAATGTCACTGCACCAGTTTTTATTAGAGCCAATCACCTATCGTGCCTGGAACAGGGATCATACCCAGATTGCCCTCAGTTCCAATAATCACCAAGTGCACATCTATAAGAAGAACGGAg
>NM_006409.4
CTCTGGGCTTCCGTCCTCCGCCCGCGCCCGACGGAGCCTGTTCGCGTCGACTGCCCAGAGTCCGCGAATCCTCCGCTCCGAGCCCGTCCGGACTCCCCCGATCCCAGCTTTCTCTCCTTTGAAAACACTAAGAATAATGTCACTGCATCAGTTTTTACTAGAGCCAATCACCTGTCATGCCTGGAACAGGGATCGTACTCAGATTGCCCTCAGTCCCAATAATCACGAAGTGCACATCTATAAGAAGAACGGGAGCCAGTGGGTGAAAGCTCATGAACTCAAGGAGCACAACGGACACATCACAGGTATTGACTGGGCTCCCAAGAGCGACCGCATTGTCACTTGTGGGGCAGACCGCAATGCCTATGTCTGGAGTCAGAAAGATGGTGTTTGGAAGCCAACCCTGGTGATCCTGAGAATTAATCGCGCAGCTACTTTTGTGAAGTGGTCCCCCCTAGAGAACAAATTTGCTGTGGGAAGTGGAGCACGACTCATTTCTGTTTGTTACTTTGAGTCTGAAAATGACTGGTGGGTGAGCAAGCACATTAAAAAGCCGATTCGCTCCACAGTCCTCAGCTTGGATTGGCATCCCAACAACGTTTTGCTGGCAGCAGGATCATGTGACTTCAAATGCAGAGTGTTTTCTGCCTACATTAAAGAAGTGGATGAAAAGCCAGCCAGCACGCCCTGGGGCAGCAAGATGCCTTTTGGGCAGCTGATGTCAGAGTTTGGTGGCAGTGGCACTGGTGGCTGGGTCCACGGGGTAAGCTTCTCTGCCAGTGGGAGCCGCCTGGCCTGGGTCAGCCACGACAGCACCGTGTCTGTTGCTGATGCCTCAAAAAGTGTGCAGGTCTCGACTCTGAAGACAGAGTTCCTGCCGCTCCTAAGTGTGTCATTTGTCTCAGAGAACAGCGTCGTGGCTGCTGGCCATGACTGCTGCCCAATGCTCTTTAACTACGATGACCGCGGCTGCCTGACCTTCGTCTCCAAGTTAGATATTCCAAAACAGAGCATCCAACGCAACATGTCTGCCATGGAACGCTTCCGCAACATGGACAAGAGAGCCACAACTGAGGACCGCAACACGGCCTTGGAGACGCTGCACCAGAATAGCATCACTCAAGTCTCTATTTATGAGGTGGACAAGCAAGATTGTCGCAAATTTTGCACTACTGGCATCGATGGAGCCATGACAATTTGGGATTTCAAGACCCTCGAGTCTTCCATCCAGGGCCTCCGGATAATGTGAAGCTGAGTGAGCCTCCGCCATCCAGCATGACAAACTGTGGCCGACCGCAGCTGTGCCGTGGCACGATGGCGAGGAAGCCAGCCCCAAGGAAACACTGAAAACACATATCACGCCAATGCCGTGTGGTTTTGTTTGAATATAAAATTGGTGAAAGTGTTGGTTTTTTTAAGGCAGTAATTTTTTTGTTTGTTTTTTTGCGATTTCATTCCATTCTTGACCAAAGCTTCTCTTTAAGTAGTTTATTATGGAAAATTGTCACACTAACTTAAAAGACAGGGTGAGGGAGATATGTAAATTGTCCACTAGAAAATTAAATAAAAGAACTGAATGTGG

Publications

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