Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NCOA4P2
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:88508021-88509621  UCSC
Coordinates (T2T) chr4:91839677-91841277  UCSC
Coordinates (hg19) chr4:89429172-89430772  UCSC
Strand -
Parental Sequence NM_001145263.2
Parental seq. overlap 1391 bp
Parental seq. overlap (%) 39.9%
Genomic Region Intergenic
Retrocopy Summary NCOA4P2, located on chr4:88508021-88509621, is a retrocopy of the parental gene NCOA4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NCOA4
Full Name nuclear receptor coactivator 4
Also known as ARA70|ELE1|PTC3|RFG
Coordinate chr10:46005088-46030623
Strand -
Gene summary This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NCOA4P2
Bonobo Pan paniscus NCOA4P2
Gorilla Gorilla gorilla LOC101136311P1
Orangutan Pongo abelii NCOA4P2
Gibbon Nomascus leucogenys NCOA4P4
Green monkey Chlorocebus sabaeus NCOA4P1
Rhesus Macaca mulatta NCOA4P2
Baboon Papio anubis NCOA4P1
Golden snub-nosed monkey Rhinopithecus roxellana NCOA4P1
Marmoset Callithrix jacchus NCOA4P1
Crab-eating macaque Macaca fascicularis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NCOA4P2
GAAAAACCAAGTTATCCAAAGTGACAGCCATTTTACTACCAGTTCTTTCTCCATTTAATTGAAAAGGTGGAAGATCTAGAGCTTTCTGATCAAGGTGAGATGATCTATCTAGTGGCTGGTGATTCCCCAGGAATCCTGTAAGTTGGAGAAGCCTGAGAATGGCAGTTATGAAACCAGTGAGAAGTTTAAATTCTTGTTCCATTCCTACAATGTGAATGATTGGCTTGTCAAAACCAACTCCTATATCAACTGTTGGGTCAACCAGCCCAATAGTGTAGAGATTTTGAAAAACCTGGGCAATGTGAAGTGCCTGAATGACTACTTGGAAGCCAAGAAACTATTTTCTACCCTCAGCATCGTTTCTGAGGATTGACTTGTCCAGAACCATCAGGACCCATATAAAGTAGAGGACATATGCACAGCCAATGAGCCCTGCAGAAGTTTTGCAGAGTGTATGATGAGAATTGAGAAGGAAGCTCTGTGTAAGTGGCTTCTAAAGAAAGATAGACAAAATAATGGGATGCCTGAGGAAACCAAACCTGAGCCTGAGAAGCATCAAGATTCCCTGAATATGTGGTCCTGTCCTTCAAGAAAAGAACAAGCTAAGGCATCAAAGGCAACGGCTCCTTCTAGAATTGCTGATTCAAGTCATAAACAACAGTCCCTTGTCAGAGTGGCTAATCCAGCCCCCATATAAGGAAGGAATTCCCAAGGAAGTGCCTAGTACTGAGGACAGGGCTGGCCAACAAAAGCTTAAAAGCCCCACAATCACTTCCTGGTGTCCCTTTAATACAGCTGACTGGATCCTGCCAGGAAAGAAGATGGGCACCCTCAGCCAGTGATCCTCTGGAGAAGACAAGTGGCTACTTCGGAAGAAGGGCCAGGAAGTATTACTTAATCCACCCCTACAGGAGGAACATAACTTCCCCCAAGACCATGATGGCTACCCTACATTTTGTGATCTCTTTGCCTGTATGAAGCTTAAAATCGAGAAAGAGAAGTGATTATATCAAACTCCTCTACAGATGTGAAGGAACAGACAAGAGTTCAGCAGCTTTTCTGCAGATTATTACACATCCATGAGCTAAGTGACTGTGACTTGCCAAATAATTGTGTTTCTGGGTCCGACCAGTTAGCTTAGTCCCTTTCCTGCCTAAATTTGAACTAGTGAAGAAAAATACATCATCGGATTATGAGTTACTATTTAAACAAAAAATGCTGAGGTGACTCAGTTCTTTCCTTTTTACAGAAGTATTAATTCACCCCACACTAGAAATGTAGCACCTTGGTGGAGTTTTTCACAAGCCTCCCACACTCCTTAGATTGGGTTATTACTAAAAGTACATTAAAACACTGTAGTTTTAAAAAGAAGTATTTCTGTAATTGAAGTGTATTGTATTCTAAAGCTAGTAAACTTCCCTAACTTTTAATTGTTCTTTAGCTGCTTCTCTTGCTGTTTTCTTCTATTAGAGGCTGAAATAATTTTTCTCTTCTATTAATATATATTTTGCACAAAAAATTAATCCTGCCATTAGTGATTACCAAAACATGTACTAATAATCTTGGTAATTTTTGACACTAATTACCAAACATTTTAGCCT
>NM_001145263.2
GTCGCGAGAACTCTGCCTTTGGGCCGTAGGTTAGTGTGGGGCCGTGTCTCAGTCCACCCAAGGTCTCCTCGGATCGCCTGGAGAGGCACTCGGACCTGGAGCAGTGAGGAGAATGAATACCTTCCAAGACCAGAGTGGCAGCTCCAGTAATAGAGAACCCCTTTTGAGGTGTAGTGATGCACGGAGGGACTTGGAGCTTGCTATTGGTGGAGTTCTCCGGGCTGAACAGCAAATTAAAGATAACTTGCGAGAGGTCAAAGCTCAGATTCACAGTTGCATAAGCCGTCACCTGGAATGTCTTAGAAGCCGTGAGGTATGGCTGTATGAACAGGTGGACCTTATTTATCAGCTTAAAGAGGAGACACTTCAACAGCAGGCTCAGCAGCTCTACTCGTTATTGGGCCAGTTCAATTGTCTTACTCATCAACTGGAGTGTACCCAAAACAAAGATCTAGCCAATCAAGTCTCTGTGTGCCTGGAGAGACTGGGCAGTTTGACCCTTAAGCCTGAAGATTCAACTGTCCTGCTCTTTGAAGCTGACACAATTACTCTGCGCCAGACCATCACCACATTTGGGTCTCTCAAAACCATTCAAATTCCTGAGCACTTGATGGCTCATGCTAGTTCAGCAAATATTGGGCCCTTCCTGGAGAAGAGAGGCTGTATCTCCATGCCAGAGCAGAAGTCAGCATCCGGTATTGTAGCTGTCCCTTTCAGCGAATGGCTCCTTGGAAGCAAACCTGCCAGTGGTTATCAAGCTCCTTACATACCCAGCACCGACCCCCAGGACTGGCTTACCCAAAAGCAGACCTTGGAGAACAGTCAGACTTCTTCCAGAGCCTGCAATTTCTTCAATAATGTCGGGGGAAACCTAAAGGGCTTAGAAAACTGGCTCCTCAAGAGTGAAAAATCAAGTTATCAAAAGTGTAACAGCCATTCCACTACTAGTTCTTTCTCCATTGAAATGGAAAAGGTTGGAGATCAAGAGCTTCCTGATCAAGATGAGATGGACCTATCAGATTGGCTAGTGACTCCCCAGGAATCCCATAAGCTGCGGAAGCCTGAGAATGGCAGTCGTGAAACCAGTGAGAAGTTTAAGCTCTTATTCCAGTCCTATAATGTGAATGATTGGCTTGTCAAGACTGACTCCTGTACCAACTGTCAGGGAAACCAGCCCAAAGGTGTGGAGATTGAAAACCTGGGCAATCTGAAGTGCCTGAATGACCACTTGGAGGCCAAGAAACCATTGTCCACCCCCAGCATGGTTACAGAGGATTGGCTTGTCCAGAACCATCAGGACCCATGTAAGGTAGAGGAGGTGTGCAGAGCCAATGAGCCCTGCACAAGCTTTGCAGAGTGTGTGTGTGATGAGAATTGTGAGAAGGAGGCTCTGTATAAGTGGCTTCTGAAGAAAGAAGGAAAGGATAAAAATGGGATGCCTGTGGAACCCAAACCTGAGCCTGAGAAGCATAAAGATTCCCTGAATATGTGGCTCTGTCCTAGAAAAGAAGTAATAGAACAAACTAAAGCACCAAAGGCAATGACTCCTTCTAGAATTGCTGATTCCTTCCAAGTCATAAAGAACAGCCCCTTGTCGGAGTGGCTTATCAGGCCCCCATACAAAGAAGGAAGTCCCAAGGAAGTGCCTGGTACTGAAGACAGAGCTGGCAAACAGAAGTTTAAAAGCCCCATGAATACTTCCTGGTGTTCCTTTAACACAGCTGACTGGGTCCTGCCAGGAAAGAAGATGGGCAACCTCAGCCAGTTATCTTCTGGAGAAGACAAGTGGCTGCTTCGAAAGAAGGCCCAGGAAGTATTACTTAATTCACCTCTACAGGAGGAACATAACTTCCCCCCAGACCATTATGGCCTCCCTGCAGTTTGTGATCTCTTTGCCTGTATGCAGCTTAAAGTTGATAAAGAGAAGTGGTTATATCGAACTCCTCTACAGATGTGAAGGAATGGACAAGAGTTGAGCAGCCTTTCTGCTGATTATCACACATCATGAGCTGAGTGACTGCAGCTTGCCAAATCTTTGTGTTTCTGGGTCTGACCAATTAGCTTAGTTCTTCTCCTGCCTAATTTTGAACTAGTAAAGCAAAGTGAGTCATCAGATTATGAGTTACTGTTTAAAAGAAAAATGCTGTTTATTCATGCTGAGGTGATTCAGTTCCCTCCTTCTTACAGAAGTATTTTAATTCACCCCACACTAGAAATGCAGCATCTTTGTGGACGTCTTTTTCACAAGCCTCCAAGGCTCCTTAGATTGGGTCGTTACTAAAAGTACATTAAAACACTCTTGTTTATCGAAGTATATTGATGTATTCTAAAGCTAGTAAACTTCCCTAACGTTTAATTGCCCTACAGATGCTTCTCTTGCTGTGGGTTTTCTTTTGTTAGTGGTCTGAAATAATTATTTTCCTGTTCTATTAATACATAGTGTATTTTGCACAAAAAAATTAACCTGGTCAATAGTGATTACCAAAATATATATTAATAATCTTGGCAATTTTTGACATTAATTATGAAACATTTTAGCCCACGTTAGTTCTACATTATTCTTCACTTAAACTCAGCTACTGCAAATTTTGTCTTTCTGTAAATGTTATTAAAATATCCAGTGAGCTCTTTAGAAGGACTCAGTATTATTTCAAGACTATTTTTGAGGTAATTCTAGCCTTTTAAAATATTCTACAGACCTACGGGGCTTAAAAGAACCCCAGTACCGACTAAGCAAATAGGCAAAAGACATGTTGGAAATGTAGTATAGTACTTGAAACAGTCACTATCATAGGGATAATTGGTGCATCCTGTGTAAATGGAAGCTGAGCTTGACACCTGGTGCTTTTAAGTAGGGATAAAGTCATCCTCTCACTGCAAGCACAGCATACCTGTACCTCCAAAAGTGACGTTTTAGTGAACAGGCCGTTTTCAACACTTGTGCCTTGGGGTGTTCATTGAAGCTTTGTGAAAACTACTGATGTTTTCTCAGTCTCCTTAAAGTTACGTCCATGCTTTAAAATGTCTGTGTAGGAGAGAAGTGGGGTTTATAATGTTTTCTCTAAGATATCTTTGCTGCTTTCCAGACTTTGAAACTATTAAGCTTCTTAACTGCCTCTTACCGGAAATACTTCTGGGGAAACTTCATGGTCCCAAAATGTCATTGCCATACAGCTTCACTAGAGTTCTTTGAACCACAGCTGAAAAGAGCTTTGTATTATTTTTTAATTCCCTCCCCAGATATCATTTAGGAGTATTATATAAAGGTGGTGGGCAAAAACAATGTAAGGAGCCTTTCCAGTTATCTTGAGTTGCAGCTCTGTAGTTTCTTGAGGCCAAACACACTGTATTTTACAAGTCAAAATATAATTTACATTAATCACTATGTTAATGAGTATGTAAAACATTCTTTTGCATTGATGAATTTTGTATCTGCTTCCATTAAAAGCATAACAGCCATA

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