Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CD53P1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:88527560-88528887  UCSC
Coordinates (T2T) chr4:91859205-91860532  UCSC
Coordinates (hg19) chr4:89448711-89450038  UCSC
Strand +
Parental Sequence NM_001040033.2
Parental seq. overlap 1120 bp
Parental seq. overlap (%) 71.8%
Genomic Region Intragenic (HERC3)
Retrocopy Summary CD53P1, located on chr4:88527560-88528887, is a retrocopy of the parental gene CD53. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CD53
Full Name CD53 molecule
Also known as MOX44|TSPAN25
Coordinate chr1:110871167-110899928
Strand +
Gene summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CD53P1
Bonobo Pan paniscus CD53P1
Gorilla Gorilla gorilla CD53P1
Orangutan Pongo abelii CD53P1
Gibbon Nomascus leucogenys CD53P1
Green monkey Chlorocebus sabaeus CD53P1
Crab-eating macaque Macaca fascicularis CD53P1
Rhesus Macaca mulatta CD53P1
Baboon Papio anubis CD53P1
Golden snub-nosed monkey Rhinopithecus roxellana CD53P1
Marmoset Callithrix jacchus CD53P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CD53P1
cCAACTTGCTCTTTTGGTTCTGTGGCTGCTGCAGTTATGGGGATGTACCCGCTGATCCACAACAGTTTGGGAGTGCTCTTCCATAAGCTCCCCTCCCTCATGCCGGGCAATGTGCTTGTCATCGTGGTCTCCATTATCACGGTGGTTGCCTTCCTGGGCTGCATAGGTTCTGTCAAGAAAAACAGGTGCCTGCTTATGTCCTTGTTCATTCTGCTGCCGGTTATCCTCCTTGCTGAGGTGATCTTGGCCATCCTGCACTTTGTTTACGAACGGAAGCTGAATGTATAGGTAGCTGAGGGCCTGACGGACAGCATCTACCATTACCACTGGGACAACAGCACCAAGGCGATGTGGGACTCCATCCAGTCATTTCTGCACTGCTGTGGCGTAAATGGCATGAGTGATTGGTCCAGCGGATAGCAAGCATCTTGCCCCTCAGATCCAAAAGTGAAAGGTTGCTATGCAAAAGCGAGACTGTAGTTTCACGCCAATTTCCTGTATATCAGAATCATCACCATCTGTGTATATGTGCAATCCAGGTGGTGAGGATGTCCTTTGCACTGACCCCAAACAGCCAGATTGATAAAACCAGTCAGGCCCTGGGGGTGTGACCTGCAACTGCCCTGTGCTGGGGAGACTCGTTTCATCTTTGGAAATCCAAAACCATTTATAGCACGAAGTTCTAAATGGTCACCTGCTGGACTGCCTGTCCTCCTCCCAACCCTTTGCTTTTTGGGTCGCTGTCTTATACAGCCAGAAAATAAGGTGTTGGCTAGGGACTTTCCATCTCAGGCAGCAAGACAACCTTTCACCTACTGATGGCAGCAGCCACGTCTCTCAAGGTGGTAACAGTAATACTTGGACATTTTTTTAGACATGAAAGGCCAAGAGAAACTGTGGAACTAATGGCTCAAGATCAAAGAGTGGGCCCAGGATATGAAGTTTTTAACCTTCCCATTGTCAAATTAGTCTCTGGCCTCTGTGTCATGCCCAGTCTGCTCTCCAAAGTCAAGCAAGAGACAAGCTGAAGAGGGTCCTAGGTCCAGGCTCATGGGACCATTGTCACAACCCTGTTTCTCTTTGACGAAGAGTGGTGGCTATAGGAATTACAGAGTGCTCTTTCTCCAAAGGGCAAGGTTTCATTTCCATTTCTTTATTAAGGGCCTCATCAATTTATTCTGTCTTTCCACAAAAAATTATCCAGTGATTTATATCCTGACTTCAACCAGTTACTTAGTTGATAATCACATGCACAAGACTTCCGGTGTTATTTCTCTATCAGCTAAGGTTTTGTTAATTTACTATTTTGCTCTTCGATAAATAAAAGT
>NM_001040033.2
gaagaaacatccaaggtggtcttgaaggacactgggatcctgtaacacagCCCCGGATATCTGTGTTACCAGCCTTGTCTCGGCCACCTCAAGGATAATCACTAAATTCTGCCGAAAGGACTGAGGAACGGTGCCTGGAAAAGGGCAAGAATATCACGGCATGGGCATGAGTAGCTTGAAACTGCTGAAGTATGTCCTGTTTTTCTTCAACTTGCTCTTTTGGATCTGTGGCTGCTGCATTTTGGGCTTTGGGATCTACCTGCTGATCCACAACAACTTCGGAGTGCTCTTCCATAACCTCCCCTCCCTCACGCTGGGCAATGTGTTTGTCATCGTGGGCTCTATTATCATGGTAGTTGCCTTCCTGGGCTGCATGGGCTCTATCAAGGAAAACAAGTGTCTGCTTATGTCGTTCTTCATCCTGCTGCTGATTATCCTCCTTGCTGAGGTGACCTTGGCCATCCTGCTCTTTGTATATGAACAGAAGCTGAATGAGTATGTGGCTAAGGGTCTGACCGACAGCATCCACCGTTACCACTCAGACAATAGCACCAAGGCAGCGTGGGACTCCATCCAGTCATTTCTGCAGTGTTGTGGTATAAATGGCACGAGTGATTGGACCAGTGGCCCACCAGCATCTTGCCCCTCAGATCGAAAAGTGGAGGGTTGCTATGCGAAAGCAAGACTGTGGTTTCATTCCAATTTCCTGTATATCGGAATCATCACCATCTGTGTATGTGTGATTGAGGTGTTGGGGATGTCCTTTGCACTGACCCTGAACTGCCAGATTGACAAAACCAGCCAGACCATAGGGCTATGATCTGCAGTAGTCCTGTGGTGAAGAGACTTGTTTCATCTCCGGAAATGCAAAACCATTTATAGCATGAAGCCCTACATGATCACTGCAGGATGATCCTCCTCCCATCCTTTCCCTTTTTAGGTCCCTGTCTTATACAACCAGAGAAGTGGGTGTTGGCCAGGCACATCCCATCTCAGGCAGCAAGACAATCTTTCACTCACTGACGGCAGCAGCCATGTCTCTCAAAGTGGTGAAACTAATATCTGAGCATCTTTTAGACAAGAGAGGCAAAGACAAACTGGATTTAATGGCCCAACATCAAAGGGTGAACCCAGGATATGAATTTTTGCATCTTCCCATTGTCGAATTAGTCTCCAGCCTCTAAATAATGCCCAGTCTTCTCCCCAAAGTCAAGCAAGAGACTAGTTGAAGGGAGTTCTGGGGCCAGGCTCACTGGACCATTGTCACAACCCTCTGTTTCTCTTTGACTAAGTGCCCTGGCTACAGGAATTACACAGTTCTCTTTCTCCAAAGGGCAAGATCTCATTTCAATTTCTTTATTAGAGGGCCTTATTGATGTGTTCTAAGTCTTTCCAGAAAAAAACTATCCAGTGATTTATATCCTGATTTCAACCAGTCACTTAGCTGATAATCACAGTAAGAAGACTTCTGGTATTATCTCTCTATCAGATAAGATTTTGTTAATGTACTATTTTACTCTTCAATAAATAAAAGTTTATTATCTCAA

Publications

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