Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TBCAP3
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:98909380-98909812  UCSC
Coordinates (T2T) chr4:102224332-102224764  UCSC
Coordinates (hg19) chr4:99830531-99830963  UCSC
Strand -
Parental Sequence NM_001297738.2
Parental seq. overlap 360 bp
Parental seq. overlap (%) 14.8%
Genomic Region Intergenic
Retrocopy Summary TBCAP3, located on chr4:98909380-98909812, is a retrocopy of the parental gene TBCA. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TBCA
Full Name tubulin folding cofactor A
Also known as -
Coordinate chr5:77691166-77776339
Strand -
Gene summary The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TBCAP3
Bonobo Pan paniscus TBCAP3
Gorilla Gorilla gorilla TBCAP2
Orangutan Pongo abelii TBCAP2
Gibbon Nomascus leucogenys TBCAP1
Green monkey Chlorocebus sabaeus TBCAP2
Crab-eating macaque Macaca fascicularis TBCAP3
Rhesus Macaca mulatta TBCAP3
Baboon Papio anubis TBCAP2
Golden snub-nosed monkey Rhinopithecus roxellana TBCAP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TBCAP3
GTGGTGAAGCAGTTGGTCGAGAAAAAGTGATGCATGAAAAAGAAGCAAAACAAGAAGGAAAGAAAAAAAATGAGAGCTGAAGATGGTGAAAATGATGCCATTAAAAAGCAGGCAGAAAGTCTGCGAGAATCCCAGGTGATAAGCCTTGTTTGCCAGCACAGGTTGGAAGCTGCATATACTGTTCTTTGGCAGATTTTAGAAAGTGAAAAGGACTTGGAAGAAGCTGAGGAATATAAAGAACATTTAGTACTGGATTCAGTGGAGTTAGAAGCCTGAAACTTTTATGTACAGGGTGTTTTTTGCATTAAATCATGGGGTCCAGTTTACATTTCATTATTTTTGACCACTGCTGTGTGTTCAAGTGTGAGAACGTGATTCTTTTTATGTGATTGTGTACATTTCTTTGCCTGATTTAATTTGTCAAATGAATGAC
>NM_001297738.2
CTAAATAGCCGCAGCCTCTGCGCGTCGCCCTCCACGGTTACCCCGGCTCTCCGCCCCTCCTTCTCGCGGCGCTCGAGGGACCATGGCCGATCCTCGCGTGAGACAGATCAAGATCAAGACCGGCGTGGTGAAGCGGTTGGTCAAAGAAAAAGTGATGTATGAAAAAGAGGCAAAACAACAAGAAGAAAAGATTGAAAAAATGAGAGCTGAAGACGGTGAAAATTATGACATTAAAAAGCAGGCAGAGATCCTACAAGAATCCAGGATGATGATCCCAGATTGCCAGCGCAGGTTGGAAGCCGCATATTTGGATCTTCAACGGATACTAGTAAGCAAAGACTTCTGTGTCATGTTTAAATTTTTTTTTTCAATCCAATACATGGAAAGCCAAAAGTTTAAATATTTAACACTGAGAACTAGTTGGCAGTATTTCTTATTCACTTGCCCTTTATACCGCTATATTTTAAAATAATTAATGGAGTTTAAATTGTGTTTTGAATTATGCCTCCAGTAAAAGTACTGTTTTCTAGCATGTTTGTTCAGTTTATTAAAATTTAGCTAGTTAAATTTATTTAAGTTATGATAGTACCAGTATTGTCCAGCAATGTCTTGATTATTTGGTTTTCATACATAAAGATCTTTTGAGACATTGAGGATGAGTTGACTGATTAAAATTTTAAAAGATCTAATGTTTCAAAAGAATTTGGGATCTTATTAAAAGGATCTTGAATTCTTTCACATTCAAACCTAGATCAGTTTGAGAGGGGGAAAAAACCTGGTAATCTATGTAGTCCCCTCATACTAACTTGGAGCTGAATAACACTTATACTTGCTGGTATAAATGCCTTGTGATACAGAAGGTAGATAAAGCAGGAAATAATAACTGTTAAAATACTATCTAAGACAGGAAGCATCATTTGTATTTCTTGACAGTTTAAATGCTTTTTTCTCTCATGAATCTAGTAGCTGAGAAAGTAATAGAAATTGCTTGGAAAAAAATAATGTTGGCCgccaggtgcagtggctcatgcctgtaatcccagcactttgggaggctgaggtgggtggatcacgagtcaggagttcaagaccagcctgaccaacatggtgaaatcctgtctctactaaaaataccaaaataataataataataataatGTATTTGGATGATATATTTGTATGTGAAGATGTATTCAACAATATCTCTGCCCTTGAAGAGCTTGTATTTACTAACAGAGAACAAAGATGTGTTTAAGGTATAACATGGAGGTTTAAGAAATTCTTACGTATAGTTTGAGCTAAGCAAATTCTCAGTCGTTTTGCTTTCAGTTTTCATATTAAATACACACATACTTTATTTCCTCTACTGTTTGTATATCTCCATCTTTTATTGACCTGACATAAATTGCTAACCATAGCTTCATTTAAAAATCAAACAAAATTTCCTGTGTACTTTAGATAATATTATTTCATTTGTCTGTTATCATTACAATATATTAGTAAAAGTTGCCTGTATATCAGTATTATGGAAAAACTCAATCTTTAAATATCAGAAAATGAAAGATGTATTTTGTTTCCTTTAGTGTAGGGTATGTAATACCCATTAGCAAGCAGGCAATTCATTTGTTTAATTCAAAGATTATATTTAACTCTGTTGTGACATCAGAAGCCTTCTTTGTCATTGTGAATAGTCAGTGGATTATTTTGGCCTGAATGCTGTCATATATGTAACATGTTAGTAAATCTTCCTTTTTACTTTTCTCTTTTGTATGATGATGATGGGTCAACAAAATGAGAATAAACTTTTTCTGAGGTTTTTATTTAATTAATGCTGGTAGCTTTAGAAGACTGTTATTCACTTATTTTATGAGAATATATACAGTGAAACAAAACCACCAGTTATTTCTTCCTTTCCTTGTAAAGAAGGAACAGAATGTGGGAAACCTGTGGAATTACAATATATTTAGATGAGGCTTGGGATTTTTTACTTTTAATTTTTTAGTTATTAACATTAATGGTTTGTAATATTTGAGTAAATAACAAAGTACTGAAACTTGAAAAGGATAAACTTAATTTTTATTGTATTTCATTTTAGGAAAATGAAAAAGACTTGGAAGAAGCTGAGGAATATAAAGAAGCACGTTTAGTACTGGATTCAGTGAAGTTAGAAGCCTGAAACTTTTCTCGTATGGGGTGGTTTTTGCATTAAATCCTGGGGTCCATTTTACAATCCATTATTTTTGACCACTGCTATGTGTTCAAGTAGTATGAGAATGTGATTGTTTTTATCTGGTTACATATATATTTCTTTGTCTAATTTAATATGTCAAATAAATGAGTTCATCTAATAAAATTGTTTATTTTATACTTTACAAAATTTTTAAATTAACCTTTTATCATTAAACCACATAGACTTTATGACAGAGAA

Publications

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