RCPedia: Rtcs

Summary

Retrocopy Name	PTPRDP1	Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr5:117719443-117722097 UCSC
Coordinates (T2T)	chr5:118231815-118234469 UCSC
Coordinates (hg19)	chr5:117055138-117057792 UCSC
Strand	-
Parental Sequence	NM_130393.3
Parental seq. overlap	663 bp
Parental seq. overlap (%)	8%
Genomic Region	Intergenic
Retrocopy Summary	PTPRDP1, located on chr5:117719443-117722097, is a retrocopy of the parental gene PTPRD. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	PTPRD
Full Name	protein tyrosine phosphatase receptor type D
Also known as	HPTP\|HPTPD\|HPTPDELTA\|PTPD\|R-PTP-delta\|RPTPDELTA
Coordinate	chr9:8314246-10613002
Strand	-
Gene summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	PTPRDP1
Bonobo	Pan paniscus	PTPRDP1
Gorilla	Gorilla gorilla	PTPRDP1
Orangutan	Pongo abelii	PTPRDP1
Gibbon	Nomascus leucogenys	Without Homology
Green monkey	Chlorocebus sabaeus	Without Homology
Crab-eating macaque	Macaca fascicularis	Without Homology
Rhesus	Macaca mulatta	Without Homology
Baboon	Papio anubis	Without Homology
Golden snub-nosed monkey	Rhinopithecus roxellana	Without Homology
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>PTPRDP1
CCATGCAATAATTTCAAAAATCACCTTGTTAATATTACACCATATAAATCCACAAGGTTGTACTTGCAGCCTATCCATGGAGTAGAAGTATCTGGTTACATTAATGCCAGTTTTATTGATGAGTAAAGACAATAGAAAGCTTACATTAGGGACCCTTGAAAGAGATCACTGAGGACTTCCAGTGGATGCTCTGGAAACACAATTTCACCAAGCTGTGTGAAATGGGCAGAGAAAAATGTCACCAATACTGGCCAGCAGAATAATCCACAAGATACCAGTACTTTGTTGTAGATCCTGTGGCTGAGTACAACATGCCATAGTTTATCACAAGGGAATTTAAAGTCATAGATGCCAAGGACAGCCAGTCCTGAACAGTGAGACAGCTCCAGTTCACTGACTGCCCAGATTAAAAAGTGCCAAAGTCTGGAAAAAGATTTATTGACTTAATTGGCCAAGTGCATAAAACAAAAGAGTACTGTGGTCAAGATGGACCCAGTTCAGTTGGAGTTGGCTGGACTGGTTGTTTCATTGTCATAGATGCCATGTTGGAAAGAATCAAGCATGAAAAAACTGTAGGTAATTATGCCTATGCAACTTTAATGAGAACCCAGAGGAATTACATGGTTCAAGCAGGAGACCAGTGTATCTCTGTCCATGATGCACTGTTAGAGGCAGTTACTTGTGTAAATACCAAAGTTCCAGCTAGAAACTTGTATGCCTATATTAGAAACTGACACAAATAGAGAGGGGACAGAATGTCATAGGAGTGGTGCTCAAATTTAAGCATCTAATCAGCTCAAAAGCTCACATCTCAGGTTTCCTCAGTGCCAATCTTCCATGCAATAATTTCTTTTTATATATATATAt

>NM_130393.3
GCTCTGAAAGTGTTCCAGCTGAAATTTCAGATCGGACAGACTCGCTGCGGCTCCGGAGGCAGTGATTCCAAGCTGCTCGCGCACGCTGCTGCCAAGCTGCAGGATGGTGCACGTAGCCAGGCTGCTGCTGCTGCTCCTCACTTTCTTCCTCCGCACGGATGCTGAGACACCTCCAAGGTTTACACGAACACCCGTTGATCAGACAGGGGTCTCTGGCGGAGTTGCCTCTTTCATCTGCCAAGCTACGGGAGACCCAAGACCTAAAATTGTCTGGAACAAAAAAGGAAAGAAAGTCAGCAATCAGAGATTTGAGGTAATAGAGTTTGACGATGGGTCTGGATCAGTTCTCAGAATACAACCCTTACGGACTCCGAGGGATGAGGCCATTTATGAATGTGTGGCCTCAAATAATGTGGGAGAAATAAGTGTATCCACCAGACTCACAGTTTTGCGGGAAGATCAAATTCCCAGGGGCTTCCCTACCATTGACATGGGCCCACAGTTGAAGGTGGTTGAGCGTACTCGCACGGCCACCATGCTTTGTGCAGCCAGTGGTAATCCGGATCCAGAAATCACTTGGTTTAAAGATTTCTTACCTGTGGACACAAGCAACAACAATGGTCGTATTAAGCAGTTACGATCAGAATCTATTGGAGCCCTTCAGATTGAGCAGAGTGAAGAGTCTGACCAAGGAAAATATGAGTGTGTTGCCACCAACAGCGCGGGCACTCGCTATTCCGCTCCTGCCAATTTATATGTCAGAGAGCTGCGAGAAGTTCGCCGTGTCCCACCAAGATTCTCTATCCCACCCACTAATCATGAAATCATGCCAGGCGGAAGCGTTAATATCACCTGTGTGGCCGTGGGGTCACCAATGCCTTATGTAAAGTGGATGTTGGGGGCAGAAGATCTGACACCTGAAGATGATATGCCAATAGGAAGAAATGTGCTAGAACTGAATGATGTAAGACAGTCAGCAAATTACACCTGTGTTGCTATGTCAACACTGGGTGTCATTGAAGCAATAGCACAGATCACTGTCAAAGCCTTACCCAAACCTCCAGGAACTCCTGTAGTGACCGAGAGCACAGCTACAAGCATCACACTGACGTGGGACTCTGGGAACCCTGAGCCTGTTTCTTATTACATAATTCAGCATAAACCTAAAAACTCTGAGGAACTTTACAAAGAAATTGATGGGGTGGCGACCACACGCTACAGTGTCGCTGGACTAAGTCCCTACTCGGATTATGAATTCAGGGTTGTTGCTGTCAATAACATTGGGCGGGGGCCTCCCAGCGAACCTGTGCTAACACAAACCTCAGAGCAAGCACCATCCAGTGCCCCGAGGGATGTCCAGGCACGAATGTTGAGTTCGACCACCATTTTGGTACAGTGGAAGGAACCTGAAGAGCCAAATGGACAGATCCAAGGATATAGAGTTTATTATACAATGGATCCCACTCAACATGTCAACAACTGGATGAAACACAATGTAGCTGACAGCCAAATCACTACTATTGGCAACTTAGTGCCCCAGAAAACATATTCTGTCAAAGTCCTGGCTTTTACCTCAATTGGAGATGGTCCCCTTTCAAGTGACATACAAGTCATCACTCAGACAGGAGTACCAGGGCAGCCACTAAACTTCAAAGCAGAACCTGAGTCTGAAACAAGTATTTTGCTCTCTTGGACACCTCCACGTTCAGATACCATTGCCAACTATGAACTGGTCTACAAAGATGGGGAGCATGGAGAGGAGCAACGAATTACCATTGAGCCAGGGACATCATATAGGCTGCAAGGACTGAAACCAAACAGCTTATACTATTTCCGTCTGGCTGCACGCTCCCCTCAAGGCCTGGGTGCTTCTACTGCAGAAATATCAGCTAGAACCATGCAGTCAACAGTGTTTGCAAAAAATTTTCATGTCAAAGCAGTAATGAAGACTTCCGTGTTGCTGTCTTGGGAGATTCCAGAGAATTATAACTCCGCCATGCCTTTCAAAATTCTTTATGATGATGGGAAAATGGTAGAAGAAGTGGATGGCCGAGCCACACAGAAGTTAATTGTCAACCTGAAGCCTGAGAAATCATATTCATTTGTGCTGACAAATCGTGGAAACAGTGCTGGTGGGCTGCAGCACAGGGTCACGGCAAAGACTGCACCAGATGTATTACGTACCAAGCCTGCCTTCATTGGGAAGACCAACTTGGATGGCATGATTACTGTGCAACTGCCTGAAGTACCTGCAAATGAGAATATAAAAGGTTACTACATAATAATTGTGCCTTTGAAGAAATCTCGCGGGAAATTTATCAAGCCATGGGAGAGTCCAGATGAAATGGAATTAGATGAGCTGCTTAAGGAGATATCTAGGAAGCGCAGAAGCATCCGTTATGGGAGAGAAGTTGAATTAAAGCCATATATTGCCGCTCACTTTGATGTCCTTCCCACTGAGTTCACCCTGGGGGATGACAAGCATTATGGTGGATTTACAAACAAGCAACTCCAAAGTGGTCAAGAATATGTCTTCTTTGTGTTAGCAGTAATGGAACATGCAGAGTCTAAGATGTATGCAACCAGCCCTTACTCCGACCCCGTGGTGTCAATGGATCTGGATCCGCAGCCAATCACGGATGAAGAAGAAGGCTTGATCTGGGTTGTAGGTCCTGTCCTTGCAGTGGTCTTTATCATCTGCATTGTCATTGCTATTCTTCTTTATAAAAGGAAGAGGGCAGAGTCCGACTCTAGAAAAAGCAGCATACCGAACAATAAGGAGATCCCTTCACACCACCCAACAGACCCTGTAGAACTGAGGCGCCTTAACTTTCAAACACCGGGTATGGCTAGCCATCCTCCAATACCCATCTTGGAACTTGCAGACCACATTGAAAGATTGAAAGCAAATGACAACTTGAAGTTTTCCCAGGAATATGAGTCAATTGACCCTGGCCAGCAGTTCACTTGGGAACATTCAAACTTGGAAGTAAACAAACCAAAGAATAGATACGCGAATGTAATCGCATATGATCATTCCCGGGTTCTCCTATCAGCTATAGAAGGGATCCCAGGAAGTGACTATGTGAATGCCAACTACATAGATGGGTATAGGAAGCAAAATGCCTATATTGCAACACAGGGATCTCTCCCCGAAACATTTGGGGACTTTTGGAGAATGATATGGGAACAACGGAGTGCCACAGTTGTCATGATGACAAAACTAGAAGAAAGATCAAGGGTGAAGTGTGACCAGTATTGGCCTAGCAGAGGCACAGAAACCCACGGACTCGTTCAAGTAACGCTGCTTGATACTGTGGAGCTGGCCACATATTGTGTTCGAACATTTGCACTTTACAAGAATGGTTCAAGTGAGAAGAGAGAAGTGAGACAATTCCAGTTCACCGCCTGGCCTGATCATGGTGTTCCAGAACACCCTACACCTTTTCTAGCTTTCTTACGTAGAGTCAAAACCTGTAACCCTCCCGATGCTGGTCCGATGGTTGTGCACTGCAGTGCGGGAGTTGGCCGGACTGGTTGCTTCATCGTCATAGATGCCATGTTAGAAAGAATAAAGCATGAAAAAACTGTAGATATTTATGGCCATGTAACTTTAATGAGAGCCCAGAGGAACTATATGGTTCAAACAGAAGACCAATACATCTTTATCCATGATGCACTGTTAGAAGCAGTGACTTGTGGAAATACCGAAGTGCCAGCTAGAAACTTGTATGCCTACATTCAGAAGCTGACACAAATAGAAACGGGAGAGAATGTCACAGGAATGGAGCTCGAATTTAAGCGTCTAGCCAGCTCAAAAGCTCACACCTCAAGGTTTATCAGTGCCAATCTTCCATGTAATAAATTCAAAAATCGCCTTGTTAATATTATGCCATATGAATCCACAAGGGTATGCCTGCAGCCTATCCGTGGAGTAGAAGGATCTGATTACATCAATGCCAGTTTTATTGATGGATACAGACAACAGAAAGCCTACATCGCTACCCAGGGGCCCTTGGCAGAGACCACTGAAGACTTCTGGCGGATGCTCTGGGAACACAATTCCACCATAGTTGTGATGCTCACCAAGCTGCGTGAAATGGGCAGAGAGAAATGTCACCAATACTGGCCAGCAGAACGGTCTGCAAGATACCAGTACTTTGTTGTAGATCCCATGGCTGAGTACAACATGCCACAGTATATCCTAAGGGAATTCAAGGTCACAGATGCCAGGGACGGCCAGTCCCGAACAGTAAGGCAGTTCCAGTTCACTGACTGGCCAGAGCAAGGAGTGCCAAAGTCCGGAGAAGGATTTATTGACTTCATCGGCCAAGTCCATAAAACAAAAGAACAGTTTGGCCAAGATGGACCCATTTCAGTCCATTGCAGCGCGGGCGTTGGAAGAACTGGAGTCTTCATAACGCTAAGCATTGTTTTGGAAAGAATGAGATATGAAGGAGTTGTAGATATCTTCCAGACTGTCAAAATGTTAAGAACACAACGACCAGCTATGGTACAGACAGAGGATCAATATCAGTTTTCCTATCGTGCCGCACTAGAGTACCTGGGCAGCTTTGACCACTATGCAACGTAGAAACCCCTGACCCATTCTGGATTTTTACTACAGGCCCTTCAATATCCATGGAGTCTCTTCTGAGCCATACAGGGCACTTGAGAAGTCCTTCTTAACTTCTAGCTAACAACTACTTAGTGGGACTATTACACACAAAACAAATTAAAAACAAATTATTCCAGGTGGACCAAGAATTCACAGTTTAATAATCTAACCTGAAAAATAATGAAGAGAATCCTGACTGATGAGGCATCTGAAGGATTTTATTTACAGATACCTCAAGGATTCAAAATCAAGGGAAGAAGAAATCACAGCAAAGAACCACCATCTTATTCAGGATTGCTTGAAAGGTGCAAGGAGAAATTGCCAGAATGCTGCAGTTCAGCACAAGATATGTGCTGGTGTGGCTTCTCACAATGAAACGGACTCTGCTTTGACATCGCCCCTTCCCACCATACTGCTCATAATAACATTTTAGGGGGAAAGGGGAGGGAATGTTTAAAAAGAAAGTCCTTGATTTAGTTTTTTAGTATTGTAAAGATACTGCTGACCTGTGCTTCATTTCTAACTGTGTAAACTTTTTTTTAACAAAATGTATCATTCGATAAAGTGAATTTTAAAAAAGTTACATAACTCTTCATTTTTTTATTTCCAAATCGTAGGTTTTTTTAAGCTGTAGAACTGTTATCTGTAATATCTTGCTGTAGAAATATCAAATCATTTGAAAATTTGCACATTTTTGTGCAAAACTCAATCTACAGTATCAGTCTCGTCAGATATATTAATTTTACACTTCAGTTTTGATTGGTGAGAAAGTACCCATTCTCTTCAAATAATCAAAGATAATTATTATTTTGTTTTGTTTTTGGAATCAACAGGGAGGCGCAAAGTATAAAGTTGCTGCTAACatatatacatatatatccatattttataagggtgtctatgtatatataGACAGTGTGTCCACACAAAAAATAGATACAGTTATCAGTCAGTCAGTTCTTCCATGATTTAGTTTTTTTAAACGTAGAAAAGCTATTGTAAACATCTCTTTCCATTTATTCTTAATTTTTTGACATATTGGTATTTCTTTAAAGGGAAATGAGGAATGCACATCAGTGATTGATTGTCAAACCTCACCCCCTGATTTCCTACCTAATCTACCCCCACCTAACCAATCAATCACATCCACAAATTGTTTTGTTTGTTTGTTAGTCAGGCTTCCAACAAAGTTCAATATTTCTAACACTCTAGTGCAATAAAAATTATTATTAAATAGCTAAGAGGTGTGCATGTGGGAAAGGTCAGTGCATATCCCTTTAGGAGGGGAGAATGTTGTAATATATCAGCTATCGAGTTGTTTAAAAAAAGTGTATTCAATCGTATATTGTCTATAGTATGTGCTATGAAATTTGCATTTATGATATGTAACAGGGGCAAAGCCAAATTCATGTTACTCTGTTCAGTCAGAAACATTTTGTGGCATACAGCATTCCTGGGAAGTGCTGTACTTTGTTTCGTTTTGGTTTTAGTTTTGCATTTAGAGTGCCTTATAATTGATGCCTATTTTAATAGCATTTCTTTTTAGCTTTTGGTTCGTATTTCCATTCACTGTTCGTATCTGTTACTTTCTATTAAAGCATTATCTGTTTACCACATGTACAAAAACTCTTTGAATAATATGCATTCCTAGTTTTCAGCCAAGTCGGGGATGTTAGTGATTGTACCAGCCCAAAGCACTTGGATAATCAGGGCCCTTCTTCCTTTTATAATCAATCATCAACATCAGAAAAAGCTACTTGTTTTATTTATATTCCCTTCCAAATCCGCTCTGGAACATGCAGTAACTGCACCAAACTTATTTTAGTAACAAATATCATTGGCAACTTTGGAATATATTTGATATTCCATTAGGATTTTTCTAAAAGGGGAAATAAACTATATATATATATGTATCTTACCCCCAATTCTTCCAACAGAATTTCTATAGGAAGCCATGGATGATGGCATAAGTTTGCCACATATTACATGATTTTAAATAATCCTCAAAATACCCAAGGAACTCTTAAAGAGTTTTGGTATGAGTATACTACTTTGGTTTAATTTTAGCTTCATGGATGTTCTGCATGGAAGGATTTTTGTTTTCCACATTTTCCCATTGCTAGCAGAGTGAAATCCAAGAGACCAAACATTTGCAAGCATTGTATTTGAGCACTTTTGTaaaaaacaaagaaaaagaaaaaaaagaaaatatatataatactaaaaaaaaGTATCTAGAAGGCTACCTCAGAATGAGACTCTCTAACCTACATCAGAACCAGAGAAGAATGTGCACTATGTGGGTCTGTTATCATTATTTTCTTTTAGTTTGTATCTTTTTGGAGATTTATCCAAGTGCCAGATTACTCAGTGCTATAATTTTCTTTTAGTTAAACAAAGGGGGTCAGACAGACATTGCATCATCCAGACATGCCTTGTTGGACATGTAGAATCCGATGGAGCACTGCACACCAGAATGATTGGCCAATGAGCAGCTTCTCTCCCTGAAACAATAACTGCCCATTTGGCAAAGGGAAAGATGACAATAATCAGAAGAAGAAAATGAATGGGATGCATACCATAGACGAACGAGGCGGAGACTATTGCGGGAATCTTACTGTTCAGGAGCTGTTCCTAGAACTAACTCCCTTACTGTCATTGATGTGCATTCCACTCTGTGCTTTTCTGTACAACCATTCAAGTTTTAATTTCCCAGGTGAACCATCTTTATCTGCCATTACCACAAGCTTTCAAGTTTCCAGTTATTTTCATCATCATAACCAGTACGGTGCTATTATTTACCTATGTACGTGTAGTTATGTATAATTTTGTAATTAGTTACAATGGTAAAAAAAATCAAAATATATAAAAAGTGATTTGTACAGAACTTTATTTTAGCTCTTTTTTAAAAATGATTTGCATGGTTAGAAAACGGCGAGGACAGCCAGGGGAGGGAAGGGCCTCTAGGGAACTTTGCACTTTCTATACCTTTGTACTATGCACTGCCCTATTGATTCTACACCCAATAATGATATTACTTGAACCCATCTGTAAGAAACTGCTTCGGAAATTCATTTGTGTGTATGTAAATAACACAACATAGAAACAGGAAGGGAAAAAAGTCTGCAGTAATGCACGTATTttttttctttcctgtttattttcggttttgctttaagtccttttatttttaattccctttttgtttttctttttgggttttggttCCTTTTGGGTTTATGGGTGCCCTGATACTCCAGCAGAGATCAGAAGGCTACAGATCCATTCTATCCATCCGTTATGTGGCTTTGCCATCCCAGCTTGGAGTGTCTTTACAAAGATAATAACAGTTGTGTTCTTTGCTCTCGTTTTGGATGCATAGACTGAAAAATTAAAACAAATAACTTGTAAAATGGCTTGTTAAAAAATACAATTACCTCTAATTAGTAGTACGCGTAAATGTTTTACAGAATGAAAGGCGTGCTTTTTATTTTCTTACTTCGTTACATTGGTGGCGAAAGAAGTCTGTATGAAAATCAGTTCTTTGCTGACACAAGTTCCATTTGTTACAAATGAATTCTAATAAAAATGTCAGTGTTATGCA

>NM_130393.3 

GCTCTGAAAGTGTTCCAGCTGAAATTTCAGATCGGACAGACTCGCTGCGGCTCCGGAGGCAGTGATTCCAAGCTGCTCGCGCACGCTGCTGCCAAGCTGCAGGATGGTGCACGTAGCCAGGCTGCTGCTGCTGCTCCTCACTTTCTTCCTCCGCACGGATGCTGAGACACCTCCAAGGTTTACACGAACACCCGTTGATCAGACAGGGGTCTCTGGCGGAGTTGCCTCTTTCATCTGCCAAGCTACGGGAGACCCAAGACCTAAAATTGTCTGGAACAAAAAAGGAAAGAAAGTCAGCAATCAGAGATTTGAGGTAATAGAGTTTGACGATGGGTCTGGATCAGTTCTCAGAATACAACCCTTACGGACTCCGAGGGATGAGGCCATTTATGAATGTGTGGCCTCAAATAATGTGGGAGAAATAAGTGTATCCACCAGACTCACAGTTTTGCGGGAAGATCAAATTCCCAGGGGCTTCCCTACCATTGACATGGGCCCACAGTTGAAGGTGGTTGAGCGTACTCGCACGGCCACCATGCTTTGTGCAGCCAGTGGTAATCCGGATCCAGAAATCACTTGGTTTAAAGATTTCTTACCTGTGGACACAAGCAACAACAATGGTCGTATTAAGCAGTTACGATCAGAATCTATTGGAGCCCTTCAGATTGAGCAGAGTGAAGAGTCTGACCAAGGAAAATATGAGTGTGTTGCCACCAACAGCGCGGGCACTCGCTATTCCGCTCCTGCCAATTTATATGTCAGAGAGCTGCGAGAAGTTCGCCGTGTCCCACCAAGATTCTCTATCCCACCCACTAATCATGAAATCATGCCAGGCGGAAGCGTTAATATCACCTGTGTGGCCGTGGGGTCACCAATGCCTTATGTAAAGTGGATGTTGGGGGCAGAAGATCTGACACCTGAAGATGATATGCCAATAGGAAGAAATGTGCTAGAACTGAATGATGTAAGACAGTCAGCAAATTACACCTGTGTTGCTATGTCAACACTGGGTGTCATTGAAGCAATAGCACAGATCACTGTCAAAGCCTTACCCAAACCTCCAGGAACTCCTGTAGTGACCGAGAGCACAGCTACAAGCATCACACTGACGTGGGACTCTGGGAACCCTGAGCCTGTTTCTTATTACATAATTCAGCATAAACCTAAAAACTCTGAGGAACTTTACAAAGAAATTGATGGGGTGGCGACCACACGCTACAGTGTCGCTGGACTAAGTCCCTACTCGGATTATGAATTCAGGGTTGTTGCTGTCAATAACATTGGGCGGGGGCCTCCCAGCGAACCTGTGCTAACACAAACCTCAGAGCAAGCACCATCCAGTGCCCCGAGGGATGTCCAGGCACGAATGTTGAGTTCGACCACCATTTTGGTACAGTGGAAGGAACCTGAAGAGCCAAATGGACAGATCCAAGGATATAGAGTTTATTATACAATGGATCCCACTCAACATGTCAACAACTGGATGAAACACAATGTAGCTGACAGCCAAATCACTACTATTGGCAACTTAGTGCCCCAGAAAACATATTCTGTCAAAGTCCTGGCTTTTACCTCAATTGGAGATGGTCCCCTTTCAAGTGACATACAAGTCATCACTCAGACAGGAGTACCAGGGCAGCCACTAAACTTCAAAGCAGAACCTGAGTCTGAAACAAGTATTTTGCTCTCTTGGACACCTCCACGTTCAGATACCATTGCCAACTATGAACTGGTCTACAAAGATGGGGAGCATGGAGAGGAGCAACGAATTACCATTGAGCCAGGGACATCATATAGGCTGCAAGGACTGAAACCAAACAGCTTATACTATTTCCGTCTGGCTGCACGCTCCCCTCAAGGCCTGGGTGCTTCTACTGCAGAAATATCAGCTAGAACCATGCAGTCAACAGTGTTTGCAAAAAATTTTCATGTCAAAGCAGTAATGAAGACTTCCGTGTTGCTGTCTTGGGAGATTCCAGAGAATTATAACTCCGCCATGCCTTTCAAAATTCTTTATGATGATGGGAAAATGGTAGAAGAAGTGGATGGCCGAGCCACACAGAAGTTAATTGTCAACCTGAAGCCTGAGAAATCATATTCATTTGTGCTGACAAATCGTGGAAACAGTGCTGGTGGGCTGCAGCACAGGGTCACGGCAAAGACTGCACCAGATGTATTACGTACCAAGCCTGCCTTCATTGGGAAGACCAACTTGGATGGCATGATTACTGTGCAACTGCCTGAAGTACCTGCAAATGAGAATATAAAAGGTTACTACATAATAATTGTGCCTTTGAAGAAATCTCGCGGGAAATTTATCAAGCCATGGGAGAGTCCAGATGAAATGGAATTAGATGAGCTGCTTAAGGAGATATCTAGGAAGCGCAGAAGCATCCGTTATGGGAGAGAAGTTGAATTAAAGCCATATATTGCCGCTCACTTTGATGTCCTTCCCACTGAGTTCACCCTGGGGGATGACAAGCATTATGGTGGATTTACAAACAAGCAACTCCAAAGTGGTCAAGAATATGTCTTCTTTGTGTTAGCAGTAATGGAACATGCAGAGTCTAAGATGTATGCAACCAGCCCTTACTCCGACCCCGTGGTGTCAATGGATCTGGATCCGCAGCCAATCACGGATGAAGAAGAAGGCTTGATCTGGGTTGTAGGTCCTGTCCTTGCAGTGGTCTTTATCATCTGCATTGTCATTGCTATTCTTCTTTATAAAAGGAAGAGGGCAGAGTCCGACTCTAGAAAAAGCAGCATACCGAACAATAAGGAGATCCCTTCACACCACCCAACAGACCCTGTAGAACTGAGGCGCCTTAACTTTCAAACACCGGGTATGGCTAGCCATCCTCCAATACCCATCTTGGAACTTGCAGACCACATTGAAAGATTGAAAGCAAATGACAACTTGAAGTTTTCCCAGGAATATGAGTCAATTGACCCTGGCCAGCAGTTCACTTGGGAACATTCAAACTTGGAAGTAAACAAACCAAAGAATAGATACGCGAATGTAATCGCATATGATCATTCCCGGGTTCTCCTATCAGCTATAGAAGGGATCCCAGGAAGTGACTATGTGAATGCCAACTACATAGATGGGTATAGGAAGCAAAATGCCTATATTGCAACACAGGGATCTCTCCCCGAAACATTTGGGGACTTTTGGAGAATGATATGGGAACAACGGAGTGCCACAGTTGTCATGATGACAAAACTAGAAGAAAGATCAAGGGTGAAGTGTGACCAGTATTGGCCTAGCAGAGGCACAGAAACCCACGGACTCGTTCAAGTAACGCTGCTTGATACTGTGGAGCTGGCCACATATTGTGTTCGAACATTTGCACTTTACAAGAATGGTTCAAGTGAGAAGAGAGAAGTGAGACAATTCCAGTTCACCGCCTGGCCTGATCATGGTGTTCCAGAACACCCTACACCTTTTCTAGCTTTCTTACGTAGAGTCAAAACCTGTAACCCTCCCGATGCTGGTCCGATGGTTGTGCACTGCAGTGCGGGAGTTGGCCGGACTGGTTGCTTCATCGTCATAGATGCCATGTTAGAAAGAATAAAGCATGAAAAAACTGTAGATATTTATGGCCATGTAACTTTAATGAGAGCCCAGAGGAACTATATGGTTCAAACAGAAGACCAATACATCTTTATCCATGATGCACTGTTAGAAGCAGTGACTTGTGGAAATACCGAAGTGCCAGCTAGAAACTTGTATGCCTACATTCAGAAGCTGACACAAATAGAAACGGGAGAGAATGTCACAGGAATGGAGCTCGAATTTAAGCGTCTAGCCAGCTCAAAAGCTCACACCTCAAGGTTTATCAGTGCCAATCTTCCATGTAATAAATTCAAAAATCGCCTTGTTAATATTATGCCATATGAATCCACAAGGGTATGCCTGCAGCCTATCCGTGGAGTAGAAGGATCTGATTACATCAATGCCAGTTTTATTGATGGATACAGACAACAGAAAGCCTACATCGCTACCCAGGGGCCCTTGGCAGAGACCACTGAAGACTTCTGGCGGATGCTCTGGGAACACAATTCCACCATAGTTGTGATGCTCACCAAGCTGCGTGAAATGGGCAGAGAGAAATGTCACCAATACTGGCCAGCAGAACGGTCTGCAAGATACCAGTACTTTGTTGTAGATCCCATGGCTGAGTACAACATGCCACAGTATATCCTAAGGGAATTCAAGGTCACAGATGCCAGGGACGGCCAGTCCCGAACAGTAAGGCAGTTCCAGTTCACTGACTGGCCAGAGCAAGGAGTGCCAAAGTCCGGAGAAGGATTTATTGACTTCATCGGCCAAGTCCATAAAACAAAAGAACAGTTTGGCCAAGATGGACCCATTTCAGTCCATTGCAGCGCGGGCGTTGGAAGAACTGGAGTCTTCATAACGCTAAGCATTGTTTTGGAAAGAATGAGATATGAAGGAGTTGTAGATATCTTCCAGACTGTCAAAATGTTAAGAACACAACGACCAGCTATGGTACAGACAGAGGATCAATATCAGTTTTCCTATCGTGCCGCACTAGAGTACCTGGGCAGCTTTGACCACTATGCAACGTAGAAACCCCTGACCCATTCTGGATTTTTACTACAGGCCCTTCAATATCCATGGAGTCTCTTCTGAGCCATACAGGGCACTTGAGAAGTCCTTCTTAACTTCTAGCTAACAACTACTTAGTGGGACTATTACACACAAAACAAATTAAAAACAAATTATTCCAGGTGGACCAAGAATTCACAGTTTAATAATCTAACCTGAAAAATAATGAAGAGAATCCTGACTGATGAGGCATCTGAAGGATTTTATTTACAGATACCTCAAGGATTCAAAATCAAGGGAAGAAGAAATCACAGCAAAGAACCACCATCTTATTCAGGATTGCTTGAAAGGTGCAAGGAGAAATTGCCAGAATGCTGCAGTTCAGCACAAGATATGTGCTGGTGTGGCTTCTCACAATGAAACGGACTCTGCTTTGACATCGCCCCTTCCCACCATACTGCTCATAATAACATTTTAGGGGGAAAGGGGAGGGAATGTTTAAAAAGAAAGTCCTTGATTTAGTTTTTTAGTATTGTAAAGATACTGCTGACCTGTGCTTCATTTCTAACTGTGTAAACTTTTTTTTAACAAAATGTATCATTCGATAAAGTGAATTTTAAAAAAGTTACATAACTCTTCATTTTTTTATTTCCAAATCGTAGGTTTTTTTAAGCTGTAGAACTGTTATCTGTAATATCTTGCTGTAGAAATATCAAATCATTTGAAAATTTGCACATTTTTGTGCAAAACTCAATCTACAGTATCAGTCTCGTCAGATATATTAATTTTACACTTCAGTTTTGATTGGTGAGAAAGTACCCATTCTCTTCAAATAATCAAAGATAATTATTATTTTGTTTTGTTTTTGGAATCAACAGGGAGGCGCAAAGTATAAAGTTGCTGCTAACatatatacatatatatccatattttataagggtgtctatgtatatataGACAGTGTGTCCACACAAAAAATAGATACAGTTATCAGTCAGTCAGTTCTTCCATGATTTAGTTTTTTTAAACGTAGAAAAGCTATTGTAAACATCTCTTTCCATTTATTCTTAATTTTTTGACATATTGGTATTTCTTTAAAGGGAAATGAGGAATGCACATCAGTGATTGATTGTCAAACCTCACCCCCTGATTTCCTACCTAATCTACCCCCACCTAACCAATCAATCACATCCACAAATTGTTTTGTTTGTTTGTTAGTCAGGCTTCCAACAAAGTTCAATATTTCTAACACTCTAGTGCAATAAAAATTATTATTAAATAGCTAAGAGGTGTGCATGTGGGAAAGGTCAGTGCATATCCCTTTAGGAGGGGAGAATGTTGTAATATATCAGCTATCGAGTTGTTTAAAAAAAGTGTATTCAATCGTATATTGTCTATAGTATGTGCTATGAAATTTGCATTTATGATATGTAACAGGGGCAAAGCCAAATTCATGTTACTCTGTTCAGTCAGAAACATTTTGTGGCATACAGCATTCCTGGGAAGTGCTGTACTTTGTTTCGTTTTGGTTTTAGTTTTGCATTTAGAGTGCCTTATAATTGATGCCTATTTTAATAGCATTTCTTTTTAGCTTTTGGTTCGTATTTCCATTCACTGTTCGTATCTGTTACTTTCTATTAAAGCATTATCTGTTTACCACATGTACAAAAACTCTTTGAATAATATGCATTCCTAGTTTTCAGCCAAGTCGGGGATGTTAGTGATTGTACCAGCCCAAAGCACTTGGATAATCAGGGCCCTTCTTCCTTTTATAATCAATCATCAACATCAGAAAAAGCTACTTGTTTTATTTATATTCCCTTCCAAATCCGCTCTGGAACATGCAGTAACTGCACCAAACTTATTTTAGTAACAAATATCATTGGCAACTTTGGAATATATTTGATATTCCATTAGGATTTTTCTAAAAGGGGAAATAAACTATATATATATATGTATCTTACCCCCAATTCTTCCAACAGAATTTCTATAGGAAGCCATGGATGATGGCATAAGTTTGCCACATATTACATGATTTTAAATAATCCTCAAAATACCCAAGGAACTCTTAAAGAGTTTTGGTATGAGTATACTACTTTGGTTTAATTTTAGCTTCATGGATGTTCTGCATGGAAGGATTTTTGTTTTCCACATTTTCCCATTGCTAGCAGAGTGAAATCCAAGAGACCAAACATTTGCAAGCATTGTATTTGAGCACTTTTGTaaaaaacaaagaaaaagaaaaaaaagaaaatatatataatactaaaaaaaaGTATCTAGAAGGCTACCTCAGAATGAGACTCTCTAACCTACATCAGAACCAGAGAAGAATGTGCACTATGTGGGTCTGTTATCATTATTTTCTTTTAGTTTGTATCTTTTTGGAGATTTATCCAAGTGCCAGATTACTCAGTGCTATAATTTTCTTTTAGTTAAACAAAGGGGGTCAGACAGACATTGCATCATCCAGACATGCCTTGTTGGACATGTAGAATCCGATGGAGCACTGCACACCAGAATGATTGGCCAATGAGCAGCTTCTCTCCCTGAAACAATAACTGCCCATTTGGCAAAGGGAAAGATGACAATAATCAGAAGAAGAAAATGAATGGGATGCATACCATAGACGAACGAGGCGGAGACTATTGCGGGAATCTTACTGTTCAGGAGCTGTTCCTAGAACTAACTCCCTTACTGTCATTGATGTGCATTCCACTCTGTGCTTTTCTGTACAACCATTCAAGTTTTAATTTCCCAGGTGAACCATCTTTATCTGCCATTACCACAAGCTTTCAAGTTTCCAGTTATTTTCATCATCATAACCAGTACGGTGCTATTATTTACCTATGTACGTGTAGTTATGTATAATTTTGTAATTAGTTACAATGGTAAAAAAAATCAAAATATATAAAAAGTGATTTGTACAGAACTTTATTTTAGCTCTTTTTTAAAAATGATTTGCATGGTTAGAAAACGGCGAGGACAGCCAGGGGAGGGAAGGGCCTCTAGGGAACTTTGCACTTTCTATACCTTTGTACTATGCACTGCCCTATTGATTCTACACCCAATAATGATATTACTTGAACCCATCTGTAAGAAACTGCTTCGGAAATTCATTTGTGTGTATGTAAATAACACAACATAGAAACAGGAAGGGAAAAAAGTCTGCAGTAATGCACGTATTttttttctttcctgtttattttcggttttgctttaagtccttttatttttaattccctttttgtttttctttttgggttttggttCCTTTTGGGTTTATGGGTGCCCTGATACTCCAGCAGAGATCAGAAGGCTACAGATCCATTCTATCCATCCGTTATGTGGCTTTGCCATCCCAGCTTGGAGTGTCTTTACAAAGATAATAACAGTTGTGTTCTTTGCTCTCGTTTTGGATGCATAGACTGAAAAATTAAAACAAATAACTTGTAAAATGGCTTGTTAAAAAATACAATTACCTCTAATTAGTAGTACGCGTAAATGTTTTACAGAATGAAAGGCGTGCTTTTTATTTTCTTACTTCGTTACATTGGTGGCGAAAGAAGTCTGTATGAAAATCAGTTCTTTGCTGACACAAGTTCCATTTGTTACAAATGAATTCTAATAAAAATGTCAGTGTTATGCA

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