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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TUBAP15
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr13). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:119652565-119653001  UCSC
Coordinates (T2T) chr5:120173420-120173856  UCSC
Coordinates (hg19) chr5:118988260-118988696  UCSC
Strand -
Parental Sequence NM_006001.3
Parental seq. overlap 350 bp
Parental seq. overlap (%) 23%
Genomic Region Intergenic
Retrocopy Summary TUBAP15, located on chr5:119652565-119653001, is a retrocopy of the parental gene TUBA3C. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TUBA3C
Full Name tubulin alpha 3c
Also known as TUBA2|bA408E5.3
Coordinate chr13:19173772-19181824
Strand -
Gene summary Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TUBA3CP2
Bonobo Pan paniscus LOC100973193P1
Gorilla Gorilla gorilla LOC101135000P1
Orangutan Pongo abelii TUBA3EP1
Gibbon Nomascus leucogenys LOC100587604P1
Green monkey Chlorocebus sabaeus TUBA3EP2
Crab-eating macaque Macaca fascicularis LOC102121218P1
Rhesus Macaca mulatta LOC707215P1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104676885P1
Marmoset Callithrix jacchus LOC100390144P1
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TUBAP15
AGATCACCAGTGCTTGCTTTGAGCCAGCCATCCAGGTAGTGAAATGTGACCCTCACCATGGTAAATACATGGCTTGCTGTCTGTCATACCATGGTGACATGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGTGTACTATCCAGTTTGTGGATTAGTGCCCCACTGGCTTCAGGGTTGGTATTAACTACCAACCTCCCACTGTGGTGCCTAGTGGAGACCTAGCCAAAGTACAGAAAGTTGTGTGCATGTTGAACAACACCACAGCTGTCGCTGAGGCCTGGGCTCACCTGGACCAAAACTTTGACCTGATGTATGCAAAGCATGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGAAGAGTTTTCTGGAGCCCCTGAGGACATGGCTGCCCTTGAAAAGGATTATGAGGAGGTT
>NM_006001.3
GTCGTTGGGCGTGCGCAGCTGCAGCGGCGGTTGAGGTCAAGTAGTAGCGTTGGGCTGCGGCAGCGGAGGAGCTCAACATGCGTGAGTGTATCTCTATCCACGTGGGGCAGGCAGGAGTCCAGATCGGCAATGCCTGCTGGGAACTGTACTGCCTGGAACATGGAATTCAGCCCGATGGTCAGATGCCAAGTGATAAAACCATTGGTGGTGGGGACGACTCCTTCAACACGTTCTTCAGTGAGACTGGAGCTGGCAAGCACGTGCCCAGAGCAGTGTTTGTGGACCTGGAGCCCACTGTGGTCGATGAAGTGCGCACAGGAACCTATAGGCAGCTCTTCCACCCAGAGCAGCTGATCACCGGGAAGGAAGATGCGGCCAATAATTACGCCAGAGGCCATTACACCATCGGCAAGGAGATCGTCGACCTGGTCCTGGACCGGATCCGCAAACTGGCGGATCTGTGCACGGGACTGCAGGGCTTCCTCATCTTCCACAGTTTTGGGGGTGGCACTGGCTCTGGGTTCGCATCTCTGCTCATGGAGCGGCTCTCAGTGGATTACGGCAAGAAGTCCAAGCTAGAATTTGCCATTTACCCAGCCCCCCAGGTCTCCACGGCCGTGGTGGAGCCCTACAACTCCATCCTGACCACCCACACGACCCTGGAACATTCTGACTGTGCCTTCATGGTCGACAATGAAGCCATCTATGACATATGTCGGCGCAACCTGGACATCGAGCGTCCCACGTACACCAACCTCAATCGCCTGATTGGGCAGATCGTGTCCTCCATCACGGCCTCCCTGCGATTTGACGGGGCCCTGAATGTGGACTTGACGGAATTCCAGACCAACCTAGTGCCGTACCCCCGCATCCACTTCCCCCTGGCCACCTACGCCCCGGTCATCTCAGCCGAGAAGGCCTACCACGAGCAGCTGTCCGTGGCTGAGATCACCAATGCCTGCTTCGAGCCAGCCAATCAGATGGTCAAGTGTGACCCTCGCCACGGCAAGTACATGGCCTGCTGCATGTTGTACAGGGGGGATGTGGTCCCGAAAGATGTCAACGCGGCCATCGCCACCATCAAGACCAAGCGCACCATCCAGTTTGTAGATTGGTGCCCAACTGGATTTAAGGTGGGCATTAACTACCAGCCCCCCACGGTGGTCCCTGGGGGAGACCTGGCCAAGGTGCAGCGGGCTGTGTGCATGCTGAGCAACACCACGGCCATCGCGGAGGCCTGGGCTCGCCTGGACCATAAGTTCGATCTCATGTATGCCAAGCGGGCCTTTGTGCACTGGTACGTGGGAGAAGGCATGGAGGAGGGGGAGTTCTCTGAGGCCCGCGAGGACCTGGCAGCTCTGGAGAAGGATTATGAAGAGGTGGGCGTGGATTCCGTGGAAGCCGAGGCTGAAGAAGGTGAAGAATACTGAGGGGAGGGTGTGGTGGGTTCTCCACTCCACTGCCACCCCCAGCGTGGCTGCTTTCAAGTTCTTTGCAATTAAAGGTTCTGTATAAAACCAA

Publications

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