Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DNAJC24P1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:133720064-133720967  UCSC
Coordinates (T2T) chr5:134243641-134244544  UCSC
Coordinates (hg19) chr5:133055755-133056658  UCSC
Strand -
Parental Sequence NM_181706.5
Parental seq. overlap 743 bp
Parental seq. overlap (%) 24.8%
Genomic Region Intragenic (FSTL4)
Retrocopy Summary DNAJC24P1, located on chr5:133720064-133720967, is a retrocopy of the parental gene DNAJC24. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DNAJC24
Full Name DnaJ heat shock protein family (Hsp40) member C24
Also known as DPH4|JJJ3|ZCSL3
Coordinate chr11:31369860-31432835
Strand +
Gene summary Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DNAJC24P1
Bonobo Pan paniscus DNAJC24P1
Gorilla Gorilla gorilla DNAJC24P1
Orangutan Pongo abelii DNAJC24P1
Gibbon Nomascus leucogenys DNAJC24P1
Green monkey Chlorocebus sabaeus DNAJC24P1
Crab-eating macaque Macaca fascicularis DNAJC24P1
Rhesus Macaca mulatta DNAJC24P1
Baboon Papio anubis DNAJC24P1
Marmoset Callithrix jacchus DNAJC24P1
Mouse lemur Microcebus murinus DNAJC24P3
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DNAJC24P1
ATCTGAGAAGGCCCAGTTCTTATTCAATGGATAATGGCATTTGAGCTGATGCCAAAAAATAATTGGTATAGCATTTTTGGGGGCACACCCAAATGTGTCAAACCTAAAACAAAAGTATAAAAAACTTACATTAAAGCAGCATTCAGATTAACAAAGTACAGATGTGCCAGCAGGAATAGTGGAGGACTGTATACAGAAATTCATTGAAATTGATCAGGCGTGGAAAATTCTAGGGAATGAAGAGAAAAAAAGAGTATGATCCTCAGTGGCATGAAGATGATCTAAGAAATATGGAACCAGTAGATGCTCAACTATACCTTGAAAAAGTGCCTTGGAAAAAAGATGATGACTCTTTTTCCCCAAGTAGCCAATGTGGTAGAAAACACAGTGTTTCCAAGGATGAAGCAGAGGAAGTTAACCTATTTTCTTGTGATACATGTTCACTAATTACAGAACTTCTTCATTATTGGTAAAATTCTTCACTACTTGGAATCCTTGTCCTGTGTATTTGGACATGGTGAGGAGAGGCCATCTGAGCTTTGACAATTCAAGGGAATACATTCTATTGTTGTTAGCCCTATCATTTTCAATGAAAATATGATTGTCAAGCAAAGTCCACCTCAGATTAATAGAAAACTAATTTAGTTATTTACATGTATTGATAGTTTGTATTTACAGGTTGCCACAAAAAGAACTTGAATTACAAATTATATTTAGTGCATTCCAAAGGACTTTATTATTTCATTTTCTCCTTGATACAAAATGAGAATTTTCTTTTTCCTACTATGAGCATCTCCTTTTTTAGTGGGTAACAGTATCATTGCATTCCTTTATAGTTACTAAGTTTCTGATCTAACAGATGATATTTCTTGCTGCTAAAGTTATAGGCCTGTTATACACCTAT
>NM_181706.5
AGTTCTGGCCGACAGCAGGCGAGGAGTGGGTAGCAGCGCCTATGTGAAGTTAGCTAATCTGAGAAGGCCCACTTCTGGTTCCATGGATGATGGCGGTTGAGCAGATGCCAAAAAAGGATTGGTACAGCATCCTGGGAGCAGACCCATCTGCAAATATATCAGACCTAAAACAAAAATATCAAAAACTCATATTAATGTATCATCCAGATAAACAAAGTACAGATGTACCAGCAGGAACAGTGGAGGAATGTGTACAGAAGTTCATCGAAATTGATCAAGCATGGAAAATTCTAGGAAATGAAGAGACAAAAAGAGAGTATGACCTGCAGCGGTGTGAAGATGATCTAAGAAATGTAGGACCAGTAGATGCTCAAGTATATCTTGAAGAAATGTCTTGGAATGAAGGTGATCACTCTTTTTATCTGAGTTGCAGATGTGGTGGAAAATACAGTGTTTCCAAGGATGAAGCGGAAGAAGTTAGCCTGATTTCTTGTGATACATGTTCACTAATTATAGAACTCCTTCATTATAACTAAAATTGTTCACAACTTGAAATGCTTTAACTGTGGTATTGAGACATGATGAGAAGCCGTTGAGCTTTGTCCATTCAAGGAAATGGATTATTTGTCAGCCCGATTATTTGCAAAGAAAATATACAATTATCAAGCAGAGACCACCTCAGATTAATAGAGAATGAAtataattatttatttgtatttataatttatatttaCAAGTTGTCACAAAAATAGATTTGATTATATTTGGTGAATTCCCATCTGAGAACTTTATTATGTCATTTTTTTCCATGACACAAAATAAGAATTTTCTTAATATGAGCATGTCTCCTCTTTTCAGTGGGTAACAGTATCATCATATTCCTTTATAGTTACTAAGTTTCTGGTCTAACCGATAACGTTTCTAGTTGCTAAAGTTATGGGGCTGTTGTACACCTAGAATCTTTGTGAATAATGTGAGGCCAGTTCTTCCATAAGGAAGGCTGGTTATGGATATTCATAAGGTTATTTCAAAGTTAATAAAGACAAAGTGGCAACTGTAGAAAGTGTTGCCTCCAATCTTGGTCCGTATTTCCAAAGCTTGTAAACACTGCCATCTTCAAATTTAAATGTAATTTAGGAAATGGAAGCTTTTAATTTTAAtttcttttttctaagacagagtctcactctgtcgcgccagctggagtgcagtgccatgatctcaggtcgctgtaacctccgtctcctgggttcaagtgattctccagcctcagcctcccgaatagctgggattacacgtgcccaccaccatgcccagctaatttttgtatttttagtagagatggggttccaccatgttggccaggctggtctcaaactcctgacctcaggtgatccacctgcctcgacctcccaaagtgctaggattacaggtttgagccaccgtgcctggccTAAGTTTTGttaatagagatgggatttcatcatgttggctaggctggtcttgaactcctggcctcaaatgatccgcccacctcaacctcccaaagtgctgggattgcaggcgtgagccaccatgcctggccAGAAGCTTTTTTAAAAATAATGACTTGGAAGTTGGTGCATTATTTCCCCTTTTATTTTGGAGTGTTGATATAATATTGGggccaggcatggtggctcacatctgtaatcccagcactttgggagactaaggcaggcggatcacctttggtcaggagttcaagaccaccctggccaacatggtgaaaccccatatctactaaaaataatttttttaaaaattagccagtcacgttggtgtctgcctgtggtcccagctactcgggaggctgaggcacaagaatcacttgaacccaggaggcagagtgagccgaggttgtgccactgcactgcagcctgggctacagagagcaagactctgtctcaaaaaaaataaaataaaataaataaaaaaaGATATAGTATTAATGCCTGTATTTATGAAGACAGGGCCATTGCACTGCTGCTATGCTGAAATGAACTTTTATAAAGTATTATTGACTATAGCCAACTACAGATGGCATATGCCTTAAAGATGCATTTTTCTATGTATTTAATATTTTGTGTACAGTAAAAGTCAGAACTCATTTAAAGAACTTTAAGGGATCCTTTAGAAACATTTTTACTTAATTTCAAATGAGTGGGCTGAGCATGTAGACTAGCAGCTTTTTATCAAACCTGGCATTGTCAGGTTGAACTTATAAATACGAATAGTTACTACTCTGACTTGTAAATGTAGCTGCTAAAGTATGAGGTATATTTAAGAAGAATAGATTAGTTTCATTATACCTATAAGAACAAGAATTCAAAAGTGAGGTAGTCATCCAGGTTCCCCCTCCCACAATATTTTTGTATCATAAAATTTAGATGACTTTTTTGGGTTACATTTTTATCCATATATTTTGAACTAACAGAACTTGGCAGAATGTGTGTTGAATATTCTTTACATTTAACAATTAAAAACAACTAAAACTGAATAGCAAATAGTTTATTGGTAAGTACACGGTTTCAACGGGAGTAATAAATTCACATGAAAAGGAGACAATAATCAAGTCAAAAGAATAAATGCTTACTAATCATCAGAAAATCTGTGGCCATTAGGGCTGGCACGTAAAAATCCAAAATCACTCAGAGGCCAAATCTGTAAAATCAAAATGAGGTTGAAGACAATTAGTGAAAGTAATGTTATAGTATCATCATATTCCCTTTTGCTATCTGTCCCTTTTCTCTATGCCAGATAAACACTTTCTCCTTACTCATCAATCAAGAATAAAATTTTCTACATCAAAGTAAGACTTGAGAAAATAAACTTATGTGTATATATGTTTAAACTCCAAAGTTTGGGACATTCAAACAATGTACATGAAATTATATGTGTGTGGTGTGTGAATAAATATGTATGAATATA

Publications

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