Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MFFP2
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:149931366-149932977  UCSC
Coordinates (T2T) chr5:150467910-150469521  UCSC
Coordinates (hg19) chr5:149310929-149312540  UCSC
Strand -
Parental Sequence NM_001277065.2
Parental seq. overlap 1533 bp
Parental seq. overlap (%) 89.9%
Genomic Region Intragenic (PDE6A)
Retrocopy Summary MFFP2, located on chr5:149931366-149932977, is a retrocopy of the parental gene MFF. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MFF
Full Name mitochondrial fission factor
Also known as C2orf33|EMPF2|GL004
Coordinate chr2:227325233-227357836
Strand +
Gene summary This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MFFP3
Bonobo Pan paniscus MFFP3
Gorilla Gorilla gorilla MFFP3
Orangutan Pongo abelii MFFP3
Gibbon Nomascus leucogenys MFFP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MFFP2
CTTTTGCGCTTCTGCCCTGGCCCTCTGCTGGCCACTCCGCCGGTGCTGTGCCTGGGCGCCTCCGTGCTCTCGGCCAACTGCCTCTGAGAGCGCCCACTTGAGCGCCCTGGGAGCCGGAGGGCGGCGGTCCTCACCGGGACCCTCCTGTGGGCGGAGGGGGACAAAAGTGTCTCTCAATCCAGCACATGCACATTGAAGCAAGTTAAAGGATTTAATATGAAGCACAGAAGCCGACAGTGCCAAACAGCAAGCAGTAGTTGGTACACATTTGGTGAGTGGGGCAGCATTTCCTTCTCCCACTGCTGCTGAGATGGCAGAAATTAGTCGAATTCGTACGAAATGGAATATACTGAAGGCATTAGTCAGCGAATGAGGGTCCCAGAAAAGTTAAAAGTAGCACCGCCAAACGCCAACCTGGAACAGGGATTCCAAAAAGGAGTTCCAAATGCTAGCGTGATAATAATGCAAGTTCCAGAGAGGATTGTTGTAGCAGGAAATAATGAGGATGTTTCATTTTCAAGACCAGCAGATCTTGACCTTATTCAGTCAACTCCCTTTAAACTCCTCGCACTAAAAACAGCACCTCGTGTACTTAGGCTAAGTGAAAGACCACTAGATTTTCTGGATTTAGAAAGACCTCCTACAACCCCTCAAAATGAAGAAATCCGTGCAGTTGGCCGACTAAAAAGAGAGCGGTCTACGAGTGAAACTGCTGTTCGCCAAAATGGACAGCTGGTCAGAAATGATTCTCTTTATGGCATTTCAAATACAGATACAACAATTGAAGGAACATCAGATGACCTGACTGTTGTAGATGCAGCTTCACTAAGACGACAGATAATCAAACTAAATAGACGTCTACAACTTCCGGACGAGGAGAACAAAGAACGTGCTAAAAGAGAAATGGTCGTGTATTCAATTACTGTAGCTTTCTGGCTGCTTAATAGCTGGCTCTGGTTTTGCCGCTAGAGGTAACATCAGCTCTCAAAAATATTATCTCAACAGCTGGAAATATAAAAGATTTGCAAACTTCTTTGTTTCTGTCTCTTCATTGTACGCCATTTTATAGTCCACAACCTGAAAATATATTTCTTCCAGAAACTCTGGAGGTAACACCTGCTTAAAATTCTCCTTTTGCATGTTTTGTAAATAGGCTCCAGTTTTGTTTTTTAAAAGGAATTCATCTTTTGCCTCATCGGTCCACACAACTGATTCTGAATGGGAGAGAGTCTGTAGAGAATTGATTTAGAAAAATGTCTGTGAAAGAAAAACAATTATTTTGTCGTGTTTCTCAAACACTGTAAGCAGTTTTGTTAATAGACATTTTTCCATCAACACTTCAACATTAACACTTTCAAAGTCATGGTCTGTTGCCAGATTTGAGAAACTCGAACCACCTAATATTTCATAACCTTCTTCATTAGGTACTTGTACAGATTAATTTCTAACATTTCAGCAGTTTAATATGTGTGCAATAAGTGCATTCTTTCATTTTAGTTTTGTACTTGGTTTTCTATAAAGTACGTTTTTACTCAGTTCATGTGTGAACAATTTTTAAAAACTACAGAATAAGGTACAAATGTAGTGTATTTAATAAACTGTCAACCAAAGC
>NM_001277065.2
AGAAGGGGCCAGCCCGCGCCTTTCGCGCTTCTGCCCTGGCCCTCTGCGGGCCGCTCCGCCGGTGCTGTCCCTGGGCGCCTCCGTGCTCTCAGCCAACCACCTCTGAGAGCGCCCACTCGAGCGCCCCGGGAGCCAGAGGGCGGGGGTCCTCGCCGGGACCCTCCTGTGGGCCCAGGGGGACAAAAGTGGCTCTCAATCCAGCACATGCACATTGAAGCAAGTTAAAGGATTTAATATGAAGCACAGAAGCAGATAGTGCCAAATAGCAAGCAGTAGTTGTTACACATTTGGTGAGCAGGGCAGCATTTCCTTCTCCCACTGCTGCTGAGATGGCAGAAATTAGTCGAATTCAGTACGAAATGGAATATACTGAAGGCATTAGTCAGCGAATGAGGGTCCCAGAAAAGTTAAAAGTAGCACCGCCAAACGCTGACCTGGAACAAGGATTCCAAGAAGGAGTTCCAAATGCTAGTGTGATAATGCAAGTTCCGGAGAGGATTGTTGTAGCAGGAAATAATGAAGATGTTTCATTTTCAAGACCAGCAGATCTTGACCTTATTCAGTCAACTCCCTTTAAACCCCTGGCACTGAAAACACCACCTCGTGTACTTACGCTGAGTGAAAGACCACTAGATTTTCTGGATTTAGAAAGACCTCCTACAACCCCTCAAAATGAAGAAATCCGAGCAGTTGGCAGACTAAAAAGAGAGCGGTCTATGAGTGAAAATGCTGTTCGCCAAAATGGACAGCTGGTCAGAAATGATTCTCTGTATGGCATTTCAAATATAGATACAACCATTGAAGGAACGTCAGATGACCTGACTGTTGTAGATGCAGCTTCACTAAGACGACAGATAATCAAACTAAATAGACGTCTACAACTTCTGGAAGAGGAGAACAAAGAACGTGCTAAAAGAGAAATGGTCATGTATTCAATTACTGTAGCTTTCTGGCTGCTTAATAGCTGGCTCTGGTTTCGCCGCTAGAGGTAACATCAGCCCTCAAAAATACTGTCTCAACAGCTGGAAATATAAAAGATTTGCAAACTTCTTTGTTTCTGTCTCTGCATTGTATGCCATTTTATAGTCCACACCCTGAAAATGTATTTCTTCCAGAAAGTCTGGAGGAAGGACCTATATTTGTAGAAGTAAAGGTATATTCTGTCACTCAGCTGTATTCACGTCTGAGCAGTTCTGCAGTAACACCTGCTTAAAATTCTCCCTTTGCATGTTTTGTAAATAGGCTCCAGTTTTGTTTTTTAAAAGGAATTTATTTTTTGCCTCATCAGTCCACCCAACTGATTCTGAATGGGAGAGAGTCTGTAGAGAATTGATTCAGAAAAGTGTCTGTGAAAGAAAAACAATTATTTTGTCCTGTTTCTCAAACAGTGTTAAGCAGTTTTGTTAATAGACATTTTTGCATCGACACTTCAACATTAACACTTTCAAAGTCATGGTCTGGTGCCAGATTTAAGAAACTCGAACCACCTAATATTTCATAACCTTCTTCATTAGGTACTTGTACAGATTAATTTCTAACATTGCAGCAGTTTCATATGTGTGCAATATGTGCATTCTTTCATTTTAGTTTTGCACTTGGTTTTCTATAAAGTACGTTTTTACTCAGTTCATGCGTGAACAATTTAAAAAACGACAGAATAAGGTACAAATGTAGTGTATTTAATAAACTGTCAACCAAAGAA

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