Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name APOOP1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:156924107-156924999  UCSC
Coordinates (T2T) chr5:157443128-157444020  UCSC
Coordinates (hg19) chr5:156351118-156352010  UCSC
Strand +
Parental Sequence NM_024122.5
Parental seq. overlap 749 bp
Parental seq. overlap (%) 66.7%
Genomic Region Intragenic (TIMD4)
Retrocopy Summary APOOP1, located on chr5:156924107-156924999, is a retrocopy of the parental gene APOO. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name APOO
Full Name apolipoprotein O
Also known as FAM121B|MIC26|MICOS26|Mic23|My025
Coordinate chrX:23833348-23907938
Strand -
Gene summary This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes APOOP3
Bonobo Pan paniscus APOOP3
Gorilla Gorilla gorilla APOOP3
Orangutan Pongo abelii APOOP3
Gibbon Nomascus leucogenys APOOP1
Green monkey Chlorocebus sabaeus APOOP5
Crab-eating macaque Macaca fascicularis APOOP3
Rhesus Macaca mulatta APOOP3
Baboon Papio anubis APOOP2
Marmoset Callithrix jacchus APOOP3
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>APOOP1
ACTGCCAGTAACATGTTCAAGGTGGTTTAGAGGTCCATGGGGCTGACCAGCCTGAGCCTACTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTTCCCTCCCCAAAATCCCATGAAGGTTTATGAGTTTTACTCTACTAAGTTCTCGAGGGCTAATCTAAACATGCAGATGAGTCAAGGACCCAGCTTAGGAAAGCATCTCTCAGCTTTGACATTATCAAGAGCTATATAAAAGTTGGTGTCAGGAAAGGTACTCCTAAATGAAGCCAAAGATGTAAAGTTTGGTTCAATGGGGGTGAGACAGCTATGAATATCTCCAAAATGCACCTGCTGGATTTTTTCCAGGACTGGGTGTTATTGGTTTTGCTGGCCTTGTTGGACTTGTTTTGGCTAGAGGTTCAAAAATAAAGAAGCAGGCATTTCTACCCAGTTTCATAGGATTAGCAGCCTCTATCCATTATCCACAGCAAGCCATCGAGTTTGTGCAGGTCAGAAAGGAGATATTATATGACCAGGGTTTATGAGGATACATAGTCGTGGAAGATTTTTGGAAGGAGAACTTTCTAAAGCCAGGAAATGTGAGGAATTCATCTGAAAATAAATAGAAAATTTCATGCTCTACACATTTTAATCAGTTACAGGTAAGCAACAGAAACTTCAAATGGTCAATCATTATTTTTACAGAAAAATAGCAGAGAAGTCAGTATTGAATATATTAAACTGGCTTTCTTCTTCAGGAAAAACTATACTAGGTCTCTGTTATCTTGGGTGATGCCATCCTACAAGCAAACAAATCTGAAATCCTTTCACTTAGAGATAAGGCACAAGGCTTAGAACTCCCTGTACTCATGTTGCTATTTACATACATGATTAAAATCCAAGTTAAAAAA
>NM_024122.5
GTTTGCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCGCACCGAGTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCTCTATAGTGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCCAGCCAGCCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTCACTCTACTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTGCGAGCCATACACAACCTGGTGTCAGGAAACGTACTCCCAAACTAAGCCCAAGATGCAAAGTTTGGTTCAATGGGGGTTAGACAGCTATGACTATCTCCAAAATGCACCTCCTGGATTTTTTCCGAGACTTGGTGTTATTGGTTTTGCTGGCCTTATTGGACTCCTTTTGGCTAGAGGTTCAAAAATAAAGAAGCTAGTGTATCCGCCTGGTTTCATGGGATTAGCTGCCTCCCTCTATTATCCACAACAAGCCATCGTGTTTGCCCAGgtcAGTGGGGAGAGATTATATGACTGGGGTTTACGAGGATATATAGTCATAGAAGATTTGTGGAAGGAGAACTTTCAAAAGCCAGGAAATGTGAAGAATTCACCTGGAACTAAGTAGAAAACTCCATGCTCTGCCATCTTAATCAGTTATAGGTAAACATTGGAAACTCCATAGAATAAATCAGTATTTCTACAGAAAAATGGCATAGAAGTCAGTATTGAATGTATTAAATTGGCTTTCTTCTTCAGGAAAAACTAGACCAGACCTCTGTTATCTTCTGTGAAATCATCCTACAAGCAAACTAACCTGGAATCCCTTCACCTAGAGATAATGTACAAGCCTTAGAACTCCTCATTCTCATGTTGCTATTTATGTACCTAATTAAAACCCAAGTTAAAAAAAAAAA

Publications

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