Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name UNGP5
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:158188727-158189697  UCSC
Coordinates (T2T) chr5:158712965-158713935  UCSC
Coordinates (hg19) chr5:157615735-157616705  UCSC
Strand -
Parental Sequence NM_003362.4
Parental seq. overlap 815 bp
Parental seq. overlap (%) 38.5%
Genomic Region Intergenic
Retrocopy Summary UNGP5, located on chr5:158188727-158189697, is a retrocopy of the parental gene UNG. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name UNG
Full Name uracil DNA glycosylase
Also known as DGU|HIGM4|HIGM5|UDG|UNG1|UNG15|UNG2
Coordinate chr12:109097597-109110992
Strand +
Gene summary This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes UNGP2
Bonobo Pan paniscus UNGP2
Gorilla Gorilla gorilla UNGP2
Orangutan Pongo abelii UNGP2
Gibbon Nomascus leucogenys UNGP1
Green monkey Chlorocebus sabaeus UNGP3
Crab-eating macaque Macaca fascicularis UNGP2
Rhesus Macaca mulatta UNGP2
Baboon Papio anubis UNGP2
Golden snub-nosed monkey Rhinopithecus roxellana UNGP2
Marmoset Callithrix jacchus UNGP2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>UNGP5
TCCAGAGAAACATGGCCACAGCCCTGCTCAGACTCACACCTACAACATGGTCGTGGGCTTTGGTGAGATTTGGAAGAAGCATCTCAGCAGAGAATTTGGGAAACCATATTTTATAAAGCTCATGTGATTTGTTGCAGTAGAAAGCAAGGATTACACTGTTTATCCTCTCCCACACCAAATATTCACCTGGACCTAGATGTGTGACATAAGAGATGTGAAGGATGTCATTCCAAGACAGGATCCATATCATGTACCCCCCATCAAGCTCGTGGGGTCTGCTTTAGTCTTCAAAGACCTGTTCCACCTCTGCCCAGTTTGGAAAACATTTATAAAGAGCTGTCTACAGACATAGATGGCTTTGTTCATCCCAGCCATGGAGATGTATCTGGGTGGGTCAAACAAGGTGTTTTACTCAACGCTGTCCTCACTGTTCCAGCCCATCAAGCCAATTCTCATGAGGAGAGAGGCTGGGAGCAATCTCTGCTAATGCAACTGTGTCCTGGCTAAGCCAGAACTCCAATGGCCTTGCTTTCTTGCTCTGGGGTTCTTATGCTCAGGAGAGGACAGTGCCATGGAGAGGAAGCGGCACCATGTACTGCAAACGTCTCATTCCTCCCTGTTGTCAGCGTATAGTGGTTTCTTTGGATGTAGACACTTTTCTAAGACCAATGAGCTGCTGCAGAAGTCAGGCAAGAAGCCTACTGACCGGAAGGAGCTGTGATCCTCAACTGAGAGGTAGTCTGTCTCCATTAACGGTTATTGAGAAACTGCTGTTAAAGTATTTGTCAGGTATGAAGTCGAATTGAAAATTTCCCTGTTGATTTTAAGTATTCTGCATGAGGGTGGAAAGCTTCTGTAAAGCAGCCATGAAACAGGCTGCCCAGGAATGGCCGCTTTGTCCAGGCAGACACAGCAAAGGCTATCACTTGACCAAATGACTTTCTCTGCAACACAGCTTTGGCCCAAAATAC
>NM_003362.4
GTGCAGGGTTCCCAGTCACCGCGACGCTCCTCGGGAAGCCATAGGGCGCCTCCCAGCCCGTCTCCCCGCTCCAGTTTAGAACCTAATTCCCAATTCCCGGACCGGGCCCAGCCCTGGGCTCTTACTGTCCGCTTTTGCTGGGACCTGTTCCACAAATGGGCGTCTTCTGCCTTGGGCCGTGGGGGTTGGGCCGGAAGCTGCGGACGCCTGGGAAGGGGCCGCTGCAGCTCTTGAGCCGCCTCTGCGGGGACCACTTGCAGGCCATCCCAGCCAAGAAGGCCCCGGCTGGGCAGGAGGAGCCTGGGACGCCGCCCTCCTCGCCGCTGAGTGCCGAGCAGTTGGACCGGATCCAGAGGAACAAGGCCGCGGCCCTGCTCAGACTCGCGGCCCGCAACGTGCCCGTGGGCTTTGGAGAGAGCTGGAAGAAGCACCTCAGCGGGGAGTTCGGGAAACCGTATTTTATCAAGCTAATGGGATTTGTTGCAGAAGAAAGAAAGCATTACACTGTTTATCCACCCCCACACCAAGTCTTCACCTGGACCCAGATGTGTGACATAAAAGATGTGAAGGTTGTCATCCTGGGACAGGATCCATATCATGGACCTAATCAAGCTCACGGGCTCTGCTTTAGTGTTCAAAGGCCTGTTCCGCCTCCGCCCAGTTTGGAGAACATTTATAAAGAGTTGTCTACAGACATAGAGGATTTTGTTCATCCTGGCCATGGAGATTTATCTGGGTGGGCCAAGCAAGGTGTTCTCCTTCTCAACGCTGTCCTCACGGTTCGTGCCCATCAAGCCAACTCTCATAAGGAGCGAGGCTGGGAGCAGTTCACTGATGCAGTTGTGTCCTGGCTAAATCAGAACTCGAATGGCCTTGTTTTCTTGCTCTGGGGCTCTTATGCTCAGAAGAAGGGCAGTGCCATTGATAGGAAGCGGCACCATGTACTACAGACGGCTCATCCCTCCCCTTTGTCAGTGTATAGAGGGTTCTTTGGATGTAGACACTTTTCAAAGACCAATGAGCTGCTGCAGAAGTCTGGCAAGAAGCCCATTGACTGGAAGGAGCTGTGATCATCAGCTGAGGGGTGGCCTTTGAGAAGCTGCTGTTAACGTATTTGCCAGTTACGAAGTTCCACTGAAAATTTTCCTATTAATTCTTAAGTACTCTGCATAAGGGGGAAAAGCTTCCAGAAAGCAGCCATGAACCAGGCTGTCCAGGAATGGCAGCTGTATCCAACCACAAACAACAAAGGCTACCCTTTGACCAAATGTCTTTCTCTGCAACATGGCTTCGGCCTAAAATATGCAGAAGACAGATGAGGTCAAATACTCAGTTGGCTCTCTTTATCTCCCTTGCCTTTATGGTGAAACAGGGGAGATGTGCACCTTTCAGGCACAGCCCTAGTTTGGCGCCTGCTGCTCCTTGGTTTTGCCTGGTTAGACTTTCAGTGACAGATGTTGGGGTGTTTTTGCTTAGAAAGGTCCCCTTGTCTCAGCCTTGCAGGGCAGGCATGCCAGTCTCTGCCAGTTCCACTGCCCCCTTGATCTTTGAAGGAGTCCTCAGGCCCCTCGCAGCATAAGGATGTTTTGCAACTTTCCAGAATCTGGCCCAGAAATTAGGGCTCAATTTCCTGATTGTAGTAGAGGTTAAGATTGCTGTGAGCTTTATCAGATAAGAGACCGAGAGAAGTAAGCTGGGTCTTGTTATTCCTTGGGTGTTGGTGGAATAAGCAGTGGAATTTGAACAAGGAAGAGGAGAAAAGGGAATTTTGTCTTTATGGGGTGGGGTGATTTTCTCCTAGGGTTATGTCCAGTTGGGGTTTTTAAGGCAGCACAGACTGCCAAGTACTGTTTTTTTTAACCGACTGAAATCACTTTGGGATATTTTTTCCTGCAACACTGGAAAGTTTTAGTTTTTTAAGAAGTACTCATGCAGATATATATATATATATTTTTCCCAGTCCTTTTTTTAAGAGACGGTCTTTATTGGGTCTGCACCTCCATCCTTGATCTTGTTAGCAATGCTGTTTTTGCTGTTAGTCGGGTTAGAGTTGGCTCTACGCGAGGTTTGTTAATAAAAGTTTGTTAAAAGTT

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