RCPedia: Rtcs

Summary

Retrocopy Name	GAPDHP40	Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr5:159950294-159951569 UCSC
Coordinates (T2T)	chr5:160478871-160480146 UCSC
Coordinates (hg19)	chr5:159377301-159378576 UCSC
Strand	-
Parental Sequence	NM_002046.7
Parental seq. overlap	1146 bp
Parental seq. overlap (%)	89%
Genomic Region	Intergenic
Retrocopy Summary	GAPDHP40, located on chr5:159950294-159951569, is a retrocopy of the parental gene GAPDH. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	GAPDH
Full Name	glyceraldehyde-3-phosphate dehydrogenase
Also known as	G3PD\|GAPD\|HEL-S-162eP
Coordinate	chr12:6534517-6538371
Strand	+
Gene summary	This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	GAPDHP19
Bonobo	Pan paniscus	GAPDHP20
Gorilla	Gorilla gorilla	GAPDHP19
Orangutan	Pongo abelii	GAPDHP18
Gibbon	Nomascus leucogenys	GAPDHP2
Green monkey	Chlorocebus sabaeus	GAPDHP44
Crab-eating macaque	Macaca fascicularis	GAPDHP23
Rhesus	Macaca mulatta	GAPDHP22
Baboon	Papio anubis	GAPDHP17
Golden snub-nosed monkey	Rhinopithecus roxellana	GAPDHP9
Marmoset	Callithrix jacchus	GAPDHP7
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>GAPDHP40
GCTCTCTGCTCCTCCCGTTCGACAGACAGCTGCATCTTCTCGTGCATTGCCAGCTGCATCCCCAAGACACCGTGGTGAAGGTGAAGGCTGGAGTCAACGGATTTGGATGTATTGGGCACCTGCTCACCAGGGCAGCTTTTAACTCTAGTAAAGTGGATATTGTTGCCATTAATGACCCTTCATTGACCTCAACTACATGGTTTACATGTTCGAGTATGATTCCACCCATGGCAAATTCCATGGCACTGTCAAGGCTGAGAAAGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCAAGATCCCTCCAAAATCAAATGGGGCGATGCTGGCGCTGAATATGTTGTGAAGTCCACCAGCGTCTTTCACCATGGAGAAGGCTGGGGCTGACTTGCAGGGAGGAGCTACAAGGGTCATCATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTGATGGGCATGAACCACAAGAAGTATGACAACAGACTCAATATCGTCAGCTATGCCTCCTGCACCACCAACTGCTTAGTGCCCCTGGGCGAGGTCATCCATGACAACTTTGGTATTGTGGAAAGATTCCAGAATACAGTCCACGCCATCACTGCCACCCAGAAGATTGTGGATGGCCTCTCTGGGAAACTGTGGTGCGACGGCTGCGGGGCTCTCCAGAACATCACCCCTGCCTCTACTGGCACTGCCAAGGCTGTGGGTAGGGGTCATCTCTAAGCTGAACAAGAAGCTCACTGACATGGGCTTCTGTGTCCACATCACCAACGTGTCAGTCATGGACCTCACCTGCCGTCTCGAAAAACCTGCCAAATATGATGACATTAAGAAGGTGGTGAAGTGAGCATTGGAGTGTCCCCCCAAGGGCATCTGGGGCGACACTGAGCACCAGGTTGTCTCCTCTGACTTCAACAGAGACACCCACTCCTCCACCTTTGATGCTGGGGCCGGCATTGCCCTCAAAGACCATTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTACAGCAACAGGGTGGTGGACCTCATGGCCCACATAGCCTCCAAGGAGTAACACCCCTGGACCACCAGCCCCAGTGAGAGCATGAGAGGAAGCGAGAAGCCCTCACTGATGGGGAGTCCCTGCCACACACAGTCCCCCATGACACTGAGACTCTCCCCTCCTCACAGTTTCCATACAGACCCCCTGAAGAGGGAGGGGCCTAGGGAGCCCCACCTTGTCATGTACTATCAATAAAGTCCCCTGTGCTCAG

>NM_002046.7
GCTCTCTGCTCCTCCTGTTCGACAGTCAGCCGCATCTTCTTTTGCGTCGCCAGCCGAGCCACATCGCTCAGACACCATGGGGAAGGTGAAGGTCGGAGTCAACGGATTTGGTCGTATTGGGCGCCTGGTCACCAGGGCTGCTTTTAACTCTGGTAAAGTGGATATTGTTGCCATCAATGACCCCTTCATTGACCTCAACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAAATTCCATGGCACCGTCAAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCGAGATCCCTCCAAAATCAAGTGGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGGCGTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGAGCCAAAAGGGTCATCATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTATGACAACAGCCTCAAGATCATCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTGGCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCATGACCACAGTCCATGCCATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGCGGGGCTCTCCAGAACATCATCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGTCATCCCTGAGCTGAACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCCACTGCCAACGTGTCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAGGTGGTGAAGCAGGCGTCGGAGGGCCCCCTCAAGGGCATCCTGGGCTACACTGAGCACCAGGTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTTGACGCTGGGGCTGGCATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTACAGCAACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGAGTAAGACCCCTGGACCACCAGCCCCAGCAAGAGCACAAGAGGAAGAGAGAGACCCTCACTGCTGGGGAGTCCCTGCCACACTCAGTCCCCCACCACACTGAATCTCCCCTCCTCACAGTTGCCATGTAGACCCCTTGAAGAGGGGAGGGGCCTAGGGAGCCGCACCTTGTCATGTACCATCAATAAAGTACCCTGTGCTCAACCA

>NM_002046.7 

GCTCTCTGCTCCTCCTGTTCGACAGTCAGCCGCATCTTCTTTTGCGTCGCCAGCCGAGCCACATCGCTCAGACACCATGGGGAAGGTGAAGGTCGGAGTCAACGGATTTGGTCGTATTGGGCGCCTGGTCACCAGGGCTGCTTTTAACTCTGGTAAAGTGGATATTGTTGCCATCAATGACCCCTTCATTGACCTCAACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAAATTCCATGGCACCGTCAAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCGAGATCCCTCCAAAATCAAGTGGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGGCGTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGAGCCAAAAGGGTCATCATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTATGACAACAGCCTCAAGATCATCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTGGCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCATGACCACAGTCCATGCCATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGCGGGGCTCTCCAGAACATCATCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGTCATCCCTGAGCTGAACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCCACTGCCAACGTGTCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAGGTGGTGAAGCAGGCGTCGGAGGGCCCCCTCAAGGGCATCCTGGGCTACACTGAGCACCAGGTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTTGACGCTGGGGCTGGCATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTACAGCAACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGAGTAAGACCCCTGGACCACCAGCCCCAGCAAGAGCACAAGAGGAAGAGAGAGACCCTCACTGCTGGGGAGTCCCTGCCACACTCAGTCCCCCACCACACTGAATCTCCCCTCCTCACAGTTGCCATGTAGACCCCTTGAAGAGGGGAGGGGCCTAGGGAGCCGCACCTTGTCATGTACCATCAATAAAGTACCCTGTGCTCAACCA

Publications

PMID - Link	Title