Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ARL2BPP5
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:162761862-162762545  UCSC
Coordinates (T2T) chr5:163296162-163296845  UCSC
Coordinates (hg19) chr5:162188868-162189551  UCSC
Strand +
Parental Sequence NM_012106.4
Parental seq. overlap 568 bp
Parental seq. overlap (%) 28.6%
Genomic Region Intergenic
Retrocopy Summary ARL2BPP5, located on chr5:162761862-162762545, is a retrocopy of the parental gene ARL2BP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ARL2BP
Full Name ADP ribosylation factor like GTPase 2 binding protein
Also known as BART|BART1|RP66
Coordinate chr16:57245259-57253635
Strand +
Gene summary ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ARL2BPP2
Bonobo Pan paniscus ARL2BPP2
Gorilla Gorilla gorilla ARL2BPP2
Orangutan Pongo abelii ARL2BPP2
Gibbon Nomascus leucogenys ARL2BPP3
Green monkey Chlorocebus sabaeus ARL2BPP7
Crab-eating macaque Macaca fascicularis ARL2BPP2
Rhesus Macaca mulatta ARL2BPP2
Baboon Papio anubis ARL2BPP2
Golden snub-nosed monkey Rhinopithecus roxellana ARL2BPP2
Marmoset Callithrix jacchus ARL2BPP2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ARL2BPP5
ACTGTCTTTCTCCTCCACCTCTGCTGAACAATTTTATTCTGTAGCTGGATATTTATACTACATTATGGTGGATAACGAGTTGTAGTTATTACAGAGAAATTTCTTGGACATATACTGTCAGGAATTTGAAGACAAGTTAAAGAATAAACTCACCTACATGACTACTTTTAATGAATATATTTATTTGGTGGAAAAGTATATTAAAGACCAGCTGCTGGGGCAGATGCTTGGATTTAACATGGCAGCCTTATGACATTACAGCACCATAAAGATGAAGCGGTTGGTGACATATTTGACATACTGTTCACATTTACAGGTTTGATAGCATTTAAAGAATGATTTCTGGACCACAAAGAAGAAAAACAAGGCTGGGGTTGGACTTAAGCAGTGGTTTACTGGTGACTTCATTGTGTAAATCATCTTCTATGTTAGCTTCCCAGAACGATCTGAAGCACTAGGTCCTACCTCCAGCCAACGAATGAGATCATTCTGGATGTCACCAGGCCAAAAGGCCAATAGGCTCAGCTAATAATGACTTAAGAATAAATTTCGGAAAGACTTACTGTGTTCTGCAACTATTCCCTCACGTTATGTATTGATGGGCCAAAACCAAAATGACCTAACCCTCCTGGACATATTTCTCCTGAAACACCTTCTTGTATTCATTAACCTTAGTACGCCTCC
>NM_012106.4
AGTGAGCTGGCCGCGGCCTTGGCTGAGAGGCCTTAACCCCGCCGGGCGGCCGCGCCCTGCATGCGAGTTGGGCCGCGGGCGGGGTTGGAGCCTACTCGGGGCGACTGCGATGGACGCCTTAGAAGGAGAGAGCTTTGCGCTGTCTTTCTCCTCCGCCTCTGATGCAGAATTTGATGCTGTGGTTGGATATTTAGAGGACATTATCATGGATGACGAGTTCCAGTTATTACAGAGAAATTTCATGGACAAGTACTACCTGGAGTTTGAAGACACAGAAGAGAATAAACTCATCTACACACCTATTTTTAATGAATACATTTCTTTGGTAGAAAAATACATTGAAGAACAGCTGCTGCAGCGGATTCCTGAGTTCAACATGGCAGCCTTCACCACAACATTACAGCACCATAAGGATGAAGTGGCTGGTGACATATTCGACATGCTGCTCACCTTCACAGATTTTCTGGCTTTTAAAGAAATGTTTTTGGACTACAGAGCAGAAAAAGAAGGCCGAGGACTGGACTTAAGCAGTGGCTTAGTGGTGACTTCATTGTGCAAATCATCTTCTCTGCCAGCTTCCCAGAACAATCTGCGGCACTAGGTCCTACCTCCAGCCAATGAATGGGATCATTCTGGATGTCACCAGCCCAATAGGCTCAGCTCATGATGACAGAACACATCTTGGAAAGACTGACTCTGTTATGTAACTCTTCATTTATGTTAAGTATTAATAGGTCAAAACCAAAATGACCTAACCCTCCTGGACCTATTTATCCTGAAACACCTTCTTGTATTCATTAACCATAGTACTCCTCCCCACCTCAAGTAGACACCTCTCTCAGGAGCTTCTGAGTCAGACGCCTCTGGAGCGAGCCCTATGTCAGGCACTCCACCTGGGGGGCCCTTCCCCAGCATACCTGCTGGTGTGTAAGTGTGGACTAACCCGCCGCCACCACCCTCTGTTCCAGCAGGCTCTGCATGAATCTTTGTGCACTTGCACCTCTTTTTCACATGGGCCACAGTTTCAGTACTTCAGCCTCAGTGGGGTTCCTGATGTTTATCTAGGGTGTTACTCAAGCCCAGTTTGAGATTTTGGAGTCTCCTGTGATCACATCTTGTCTCGGCTGTAGGAATCAACAGAAGGAGACGTCCTCTACATAAAAGCTCCATGTGAAAAGCTACTCCTAGTCTTAACATTTGCAGTCCTTGTGTCACTGTCTTCTGGTCCTGATGTAGTCCCACTGTTTCTAGAAGTCTCTTTTAAGCATTATTTTTGAAAAAAAAAATATTTTTATAGATGAATACTCAGGCTAACCTAGTGGATGTGATCTTGGAACTTCCATGATTATCCACTTAAAGATCAAAGTATTATATGCTGTGTGCTTTTTAGGTGTTTGTTAGTACTGTGAAGGCAAAAATGCTTTCTACATTGACATTCATTCCTATTTTACTGGGCACCTATGAATGTATGCTGTGTGCTAGAAATAGACTAAAACATATTCCTATAGCATGTTAGTGTGTTTGCATGTTTGCTGAAAATCCTTTGTGTATAAACCAGTTTGTAAGGTTCTCTGGGTTAGGTAGGGACTCTGCAGTTTCTTCCTGTCAAAATCTCTCCTACCAAGATGGTGTTCCACTGTCCAGCCCAGCATGAGTAGCAGGTAGAGCACAGCTTTACTGGCTGTTTGTATGCTTTGGTTTAGTGCAATGTGTGGTAGATTACTTATCAGAAAACATATATGTCATCTCTAGAACGAAGAAAAAGCATAGTAGTTCAATTCCCAGTGTGTCCCTTTGATTTTTTTTTTTTAATAGTAAAAATAAGAATCTGTACTGACTTTTCACTTGGCCATTCTGGTTTTAAAGGACAAGCTACAAGCTCTGTGTTTCTGTACTGATGTGTCACTTATTAAATACTTTTGTACCATGAGTAAAACTTCAGGTGTTTCGCAAGAACCACCATTCTCAA

Publications

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