Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPL10P8
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:171366298-171366675  UCSC
Coordinates (T2T) chr5:171906623-171907000  UCSC
Coordinates (hg19) chr5:170793302-170793679  UCSC
Strand +
Parental Sequence NM_001256580.2
Parental seq. overlap 357 bp
Parental seq. overlap (%) 15%
Genomic Region Intergenic
Retrocopy Summary RPL10P8, located on chr5:171366298-171366675, is a retrocopy of the parental gene RPL10. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPL10
Full Name ribosomal protein L10
Also known as AUTSX5|DXS648|DXS648E|L10|MRXS35|NOV|QM
Coordinate chrX:154398065-154402339
Strand +
Gene summary This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPL10P10
Bonobo Pan paniscus RPL10P10
Gorilla Gorilla gorilla RPL10P10
Orangutan Pongo abelii RPL10P10
Gibbon Nomascus leucogenys RPL10P3
Crab-eating macaque Macaca fascicularis RPL10P16
Rhesus Macaca mulatta RPL10P17
Golden snub-nosed monkey Rhinopithecus roxellana RPSAP12
Green monkey Chlorocebus sabaeus Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPL10P8
TAGGCTCCGGACAGGCATGCGAGGTGCCTTTGGAAAGCCCCAGGGCACTGTGGCCAGGGTTCACATTGGCCAAGTTATCATGTCCATCTGTACCAAGCTGCAGAACAAGGAGCATGTGATAGAAGCCCTGCACAGGGCCAAGTTCAAGTTTCCTGGCCGCCAGAAGATCCACATCTCAAAGAAGTGGGGCTTCATCAAGTTCAATGCCAATGAATTTGAGGACATGGTGGCTGAGAAGCGGCTCATCCTAGATGGCTGTGGGGTAAAGTACATCCCCAGTCGTGGCCTTCTGGACAAGTGGCGGGCCCTGCACTCACGAGGGCTTCCACTGTGCTGCCGCCCTCTTAATATTCACCAATACATTCTACTTCCTGTCCA
>NM_001256580.2
AAATATACGTCTGTCACAGTTAACGGCAAAGCCTAGGGCAAGAGTTCTACGCCCAAGATGGCCAGCCGGAAGCGGGCTTCTCGCGACCATGTGGCGAAGCCCCATTCGTCAGCTGGCCGCCCGCGGCCCTGGTACCCGGTCACCTCTCTGATCTGCGCATGTGCTGGGCTACGCCCGGGCGCAAGCGCCAAGAGCGGCTGCGTCTATGGTCATGACGTCTGACAGAGCGTCCACCCGTCTTCGACAGGACTCTATGGTTCTTACGCGCGCAGACAGACCGCCTATATAAGCCATGCGCAGGCGGAGGAGCGCCTCTTTCCCTTCGGTGTGCCACTGAAGATCCTGGTGTCGCCATGGGCCGCCGCCCCGCCCGTTGTTACCGGTATTGTAAGAACAAGCCGTACCCAAAGTCTCGCTTCTGCCGAGGTGTCCCTGCCCTGGAGGCTGCCCGAATTTGTGCCAATAAGTACATGGTAAAAAGTTGTGGCAAAGATGGCTTCCATATCCGGGTGCGGCTCCACCCCTTCCACGTCATCCGCATCAACAAGATGTTGTCCTGTGCTGGGGCTGACAGGCTCCAAACAGGCATGCGAGGTGCCTTTGGAAAGCCCCAGGGCACTGTGGCCAGGGTTCACATTGGCCAAGTTATCATGTCCATCCGCACCAAGCTGCAGAACAAGGAGCATGTGATTGAGGCCCTGCGCAGGGCCAAGTTCAAGTTTCCTGGCCGCCAGAAGATCCACATCTCAAAGAAGTGGGGCTTCACCAAGTTCAATGCTGATGAATTTGAAGACATGGTGGCTGAAAAGCGGCTCATCCCAGATGGCTGTGGGGTCAAGTACATCCCCAGTCGTGGCCCTCTGGACAAGTGGCGGGCCCTGCACTCATGAGGGCTTCCAATGTGCTGCCCCCCTCTTAATACTCACCAATAAATTCTACTTCCTGTCCACCTATGTCTTTGTATCTACATTCTTGACGGGGAAGGAACTTCCTCTGGGAACCTTTGGGTCATTGCCCTTTCACTTCAGAAACAGGTTGACAACTCAGCCCTGCTCATGAGGCAGCAAACCCTGCAAAGGGCTGGGACTGGTGGCCTTATGTCAGTTGTCTACTCTGGAGCTTGACTTGGACCTCCCCAGGTCCTAGGCAGTAGGTTGAAAAACACTGAAGTGCTTTTCATGAAGCACAGCTGCAGCAAAGCCTTGCAATCCCAGGCTGGGGTCAGCCTACAGTTGTGTTGCTTATTACAACACATGCGGACCAAGAGGGGCTTGTGGGCTAGAGGCTGACCAGCAGCGTTTATTTAGCAAGGGTAGGTGTGCATCACATTGGGCTTGTTCTCACCCATCTGGTTTGGCCATTCCTCCTTGGTGGGAATCATCCAGGTACTGCTGAGGTCACCTGCGATTTGCCCCATTTCCTATCTCTAGCAACCTCCTGGGCCCCATGCCCCCACCCCTTCTAGAACCTGCATTCCCAGGGCCTTCACCACCTGACCAAAGGTCTAGGCTAACCTTTGGTCATTTGTAACAAGACCTCGGAACAGACACGTGTGTGGCATGGTTTGGCCTGGGGATCTTAGATGTCTGACCTGAACTATTGTAGAACAGCGCTGGCTTTTGGGGGAGCAGCAAAAATGAGAGGAGTGCTAGGTGGGTGGCCTGAGCATCTGTATCCAGGGACAGGACTCCAAAGGCTTTTGGTCCCAGAGCTGGGGTATGTTGGCCCCAGCCCCCAGCCTGTGGCTCCCAAAAGGCCTCTGGTTTTTTGTAATCTCAGTTTACAGCCATTTCTTAGGTTTTTAATTACCTTTATTTTATTTTGCCAAACATACCTGGGAATACCTTTTATTTTTTTTTTACCTTGGGGTGATGGTTCCAAACCATAAATGTGATTATAGTTAACACATGACCCTTCTAGCGTCCCAGCCAGTGTTTTTCCTGACCTCTCTTCTTTGGAGAGGAGGATGGAAGGGAGGGGTCCGGCATGCTGCTGGCATTTTGCTGTGTCCTGCAGCCCCTTTCCGGGACACCTGGGTTCACACAGCTTTTTAGCTTACATAACTGGTGCAGATTTTCTGTGTGGAGATGTTGCCTTGACCAGCCTTGGCTGGACTTTACCAGGCATGCAGAAGCCTGTACCAACACAGACTACAGCACCCAGGAGGTGCGAGTGTGGCTGCTCAGCGGTTATAACAGGCCTGACTGCATTGTTCACCGGATTATAATGAGCCAAAATGTTTCCCGGTGTTTGCTGGTTTCAGGGAAGGAGTTTGATATAGCAGATTAACCACCCTCCTTGTAGCTATTGGGGCTTAATGGTTTCctggtgattcttaccaatccacaataaacatggcccattggcatatctgc

Publications

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