Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PRMT1P1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:177265364-177266598  UCSC
Coordinates (T2T) chr5:177808603-177809837  UCSC
Coordinates (hg19) chr5:176692365-176693599  UCSC
Strand -
Parental Sequence NM_198318.5
Parental seq. overlap 1008 bp
Parental seq. overlap (%) 72.1%
Genomic Region Intragenic (NSD1)
Retrocopy Summary PRMT1P1, located on chr5:177265364-177266598, is a retrocopy of the parental gene PRMT1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PRMT1
Full Name protein arginine methyltransferase 1
Also known as ANM1|HCP1|HRMT1L2|IR1B4
Coordinate chr19:49676166-49688447
Strand +
Gene summary This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PRMT1P1
Bonobo Pan paniscus PRMT1P1
Gorilla Gorilla gorilla PRMT1P1
Orangutan Pongo abelii PRMT1P1
Green monkey Chlorocebus sabaeus PRMT1P1
Crab-eating macaque Macaca fascicularis PRMT1P1
Rhesus Macaca mulatta PRMT1P1
Baboon Papio anubis PRMT1P1
Golden snub-nosed monkey Rhinopithecus roxellana PRMT1P1
Marmoset Callithrix jacchus PRMT1P2
Gibbon Nomascus leucogenys Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PRMT1P1
CCAGAGGAGGTTTTAGGGGCCTGGGCTGGGGGGATGGGGAGGGCACATCATGACTGTTTTTCATAACTTATGTTTTTAGATGGCTGCATTTATGCCAATAAATCTTCAGCTGGGAGCGGGTGAAGATGGCGGCCGCCGAGGTCGTGAACTGCATCATGGAGGTGTCCTGTGGCCAGGCGGAAAGCAGCGAGAAGCCGAACGTCGAGGGCATGACGTCCAAAGATTACTACTTTGACTCCTACGCCCACTTCGGCAACTCCATGTTTCACAACCGCCACCTCTTTAAAGACAAGGTGGTGCTGGATGTGGGCTCGGACACAAGCATCCTCTGCATGTTCGCCGCCAAGGCCGGGCCCGCAAGGTCATCGGCATCGAGTGTTCCAGTAGCTCTGATTATGCGGTGAAGATTGTCAAAGCCAACAAGTTAGACCACTTGGTGACCATCACCAAGGGGAAGGTGGAGGAGATAGAGCTCCCGGTGGAAAAGGTGAACATCATCATCAGCAAGTGGATGGGCTAACTGCCTCTTCTACGAGTCCATGCTCAACACTGTGCTCTATGCCCGGACAAGTGGCTGGCGCCCAATAGCCTCATCTTCCCAGAACGGGCCACACTGTATGTGACGGCCACCGAGGACCGGCAGTACAAAGACTACAAGATCCACTGGTGGGAGAACGTTTATGGCTTCGATATATCTTGCATCAAAGATGTGGCCATCAAGGAAACCCTAGTGGATGTGGTGGACCTCAAACAGCTGGTTACCAACGCCTGCCTCATAAAGGAGGTAGACATCTACACCGTCAAGGTGGAAGACCTGACCTTCACCTCCCCGTTCTGCCTGCAAGTGAAGCAGAATGACTACGTGCACACCCAGGTGGCCTACTTCAACATCGAGTTTACGCACTGCCACAAGAGGACCGGAGGGACCGGCTTCTCCACCATACCCGAGTCCCTGTACACGCACTGGAAGCAGACGGTGTTCTACATGGAGGACTACCTGACCTTGAAGACGGGCGAGGAGATCTTCGGCACCATCGGCATGCGGCCCAACGCCAAGAACTGGGACCGGGACTTCACCATCAACCTAGATTTCAGGGGCCATCTGTGCGACCTGTCCTGCTCCACAGACTACAGGATGTGCTGAGGCCCGGCTCTCCCGCCCTGCACGGGCCCAGGGGCTGAGCATTCCTAGACGGTTGTGGGGCTCCc
>NM_198318.5
GCGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGGAGATGCTGAAGGACGAGGTGCGCACCCTCACTTACCGCAACTCCATGTTTCATAACCGGCACCTCTTCAAGGACAAGGTGGTGCTGGACGTCGGCTCGGGCACCGGCATCCTCTGCATGTTTGCTGCCAAGGCCGGGGCCCGCAAGGTCATCGGGATCGAGTGTTCCAGTATCTCTGATTATGCGGTGAAGATCGTCAAAGCCAACAAGTTAGACCACGTGGTGACCATCATCAAGGGGAAGGTGGAGGAGGTGGAGCTCCCAGTGGAGAAGGTGGACATCATCATCAGCGAGTGGATGGGCTACTGCCTCTTCTACGAGTCCATGCTCAACACCGTGCTCTATGCCCGGGACAAGTGGCTGGCGCCCGATGGCCTCATCTTCCCAGACCGGGCCACGCTGTATGTGACGGCCATCGAGGACCGGCAGTACAAAGACTACAAGATCCACTGGTGGGAGAACGTGTATGGCTTCGACATGTCTTGCATCAAAGATGTGGCCATTAAGGAGCCCCTAGTGGATGTCGTGGACCCCAAACAGCTGGTCACCAACGCCTGCCTCATAAAGGAGGTGGACATCTATACCGTCAAGGTGGAAGACCTGACCTTCACCTCCCCGTTCTGCCTGCAAGTGAAGCGGAATGACTACGTGCACGCCCTGGTGGCCTACTTCAACATCGAGTTCACACGCTGCCACAAGAGGACCGGCTTCTCCACCAGCCCCGAGTCCCCGTACACGCACTGGAAGCAGACGGTGTTCTACATGGAGGACTACCTGACCGTGAAGACGGGCGAGGAGATCTTCGGCACCATCGGCATGCGGCCCAACGCCAAGAACAACCGGGACCTGGACTTCACCATCGACCTGGACTTCAAGGGCCAGCTGTGCGAGCTGTCCTGCTCCACCGACTACCGGATGCGCTGAGGCCCGGCTCTCCCGCCCTGCACGAGCCCAGGGGCTGAGCGTTCCTAGGCGGTTTCGGGGctcccccttcctctccctccctcccGCAGAAGGGGGTTTTAGGGGCCTGGGCTGGGGGGATGGGGAGGGCACATCGTGACTGTGTTTTTCATAACTTATGTTTTTATATGGTTGCATTTACGCCAATAAATCCTCAGCTGGG

Publications

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