Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HPF1P3
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:180085611-180087051  UCSC
Coordinates (T2T) chr5:180640712-180642152  UCSC
Coordinates (hg19) chr5:179512611-179514051  UCSC
Strand -
Parental Sequence NM_017867.3
Parental seq. overlap 552 bp
Parental seq. overlap (%) 31.3%
Genomic Region Intergenic
Retrocopy Summary HPF1P3, located on chr5:180085611-180087051, is a retrocopy of the parental gene HPF1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HPF1
Full Name histone PARylation factor 1
Also known as C4orf27
Coordinate chr4:169729470-169757944
Strand -
Gene summary Enables chromatin binding activity and histone binding activity. Involved in double-strand break repair; peptidyl-serine ADP-ribosylation; and regulation of protein modification process. Located in chromatin; nucleus; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HPF1P1
Bonobo Pan paniscus LOC100991754P1
Gorilla Gorilla gorilla LOC101147097P1
Orangutan Pongo abelii LOC100433735P1
Green monkey Chlorocebus sabaeus C7H4orf27P4
Crab-eating macaque Macaca fascicularis C5H4orf27P1
Rhesus Macaca mulatta C5H4orf27P1
Baboon Papio anubis LOC101023020P1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104662874P2
Marmoset Callithrix jacchus LOC100399369P2
Gibbon Nomascus leucogenys Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HPF1P3
CTAATCTCTTGAAAAACATAGATGAAAAACTCGCAGAAGCAGCCAGAGAAATGGGGTCCTCACTGGAACAGACAACCACGAAGATGAAACCGATAAGAAAGTTGTGACGAAGGCCTTTCATGGTGCAGGCTTGGCTGTTCCAGCAGATAAAAATGATGTTGGGTACAGAGAGCTCCCTGAAACAGATGCTGACGTCAACAGAATTTGCAAGACAATAGTTGAGGCTGCAAGTGAGGAGAGACTGAAAGCTTTTGTTCCCATTCAGGAAATGATGACTTTCGTGCAGTTTGCTAGTGATGAATGTAATTGTGGGAAGGGGCGTGAGTTGGGAATGGAGCTCTTTTGCTGTGGCTCACATTATTTTCATAAAGTTGCTGCTCAGCATTTACCTCTTGCATATAATCTGTTGAAGAGGAATCTGCAGAAATTATTGAGGATCATTTGGCAAACAGAAGTAAAGAGAACATAGAGCAACTTGCTGCATGAGTCAGGTGGCTTTGTTTGGTGTACAGTATTTCAAAGGATTAGTATTAAACTTGTGATTTTTGTTTTGTTTTTAAGGAATATAAAAAATAAACATTTACTAAAAACACTGCGGCTGCAGAATGGTCGGCGGTGGGAGGAAGTGCAAGCCCAGCGGGGAGGGGCCTGTGAAAAAATGGTTAATGTGAAGAAAAGTAAATTCTATGAAGCTGATGTGGTCTTCGACAAGAAGTAGAAAATCATTATAAGCTCTCTTCACCTGAAGATTCCGATCGTTTCTGGAAGTTCTTTGAAGAACTTGATCCTGAAAAGCCAGCTGATCACTTTCTGCAAGCCTCGGACTTCAGTTAGGTGGTCCTTATGATATCCTTGCTGGAAAACATAAAATTAAGAAAAATTCAACAGGCCTGAATGTTAGCCTTCATTGGAGGTTTTACCATGATCCTCCTGAGTTCCAGACCGTCATTATTGGAGATAATAAAACTCAGTACCACATGGGGTATTTCAGGGATTCTTCTGATGAACTTCCTGCATATGTTGGTATAAATGAAGCAAAGAAAAAGTGTACAATTGTTCCAAATGGAGATAATGTATTTGTGGCAGTCAAATTATTTTTGATGAAAAAACTTAAAGAAGTAACGCATAAAAAGAAAACTAg
>NM_017867.3
GGAAGCGGTTGGCGGCGCTCGGAAGCGGCCGCGGATCGGGGAATTCTGCTGGCGCTGCAGCTGCAGAATGGTCGGCGGTGGCGGGAAGCGCAGGCCCGGCGGAGAGGGGCCGCAGTGTGAAAAAACAACTGATGTGAAGAAAAGTAAATTCTGTGAAGCTGATGTCTCCAGTGACCTTCGAAAAGAAGTAGAAAATCATTATAAGCTTTCTTTACCTGAAGATTTCTATCACTTCTGGAAGTTCTGTGAAGAACTTGATCCTGAAAAGCCATCTGATTCACTTTCTGCAAGCCTTGGACTTCAATTAGTTGGTCCTTATGATATCCTTGCTGGAAAACATAAAACGAAGAAAAAATCAACAGGCCTGAATTTTAACCTTCACTGGAGGTTTTACTATGATCCTCCTGAGTTCCAGACCATTATTATTGGAGATAATAAAACTCAGTACCACATGGGGTATTTCAGGGATTCTCCTGATGAATTTCCTGTATATGTTGGTATAAATGAAGCAAAGAAAAATTGTATAATTGTTCCAAATGGAGATAATGTATTTGCTGCAGTCAAATTATTTTTGACGAAAAAACTTAGAGAAATAACGGATAAAAAGAAAATCAATCTCTTGAAAAACATAGATGAAAAACTCACAGAAGCAGCCAGAGAATTGGGGTACTCGCTTGAACAGAGAACCGTGAAGATGAAACAGAGAGATAAGAAAGTTGTGACAAAGACCTTTCATGGTGCAGGCTTGGTTGTTCCAGTAGATAAAAATGATGTTGGGTACCGAGAGCTCCCTGAAACAGATGCTGACCTCAAGAGAATTTGCAAGACAATAGTTGAGGCTGCAAGTGATGAGGAGAGACTAAAAGCTTTTGCTCCCATTCAGGAAATGATGACTTTTGTGCAGTTTGCTAATGATGAATGTGATTATGGCATGGGGCTTGAATTGGGAATGGATCTCTTTTGCTATGGCTCACATTATTTTCATAAAGTTGCTGGCCAGCTTTTACCTCTTGCATATAATCTGTTGAAGAGGAATCTGTTTGCAGAAATTATTGAGGAGCATCTGGCAAACAGAAGTCAAGAGAACATAGACCAACTTGCTGCATGAGTAAGGTGGCTTTGATTGGTGTACAGTATTTCAAAGGACTAGTATTAAACTTGTGATTTTTGTTTTGTTTTTAAGGAATACAAAAAATAAACATTTACTAAAAACGTT

Publications

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