Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LSP1P3
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:28926819-28927026  UCSC
Coordinates (T2T) chr5:29032036-29032243  UCSC
Coordinates (hg19) chr5:28926926-28927133  UCSC
Strand +
Parental Sequence NM_001013255.1
Parental seq. overlap 200 bp
Parental seq. overlap (%) 13.1%
Genomic Region Intergenic
Retrocopy Summary LSP1P3, located on chr5:28926819-28927026, is a retrocopy of the parental gene LSP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LSP1
Full Name lymphocyte specific protein 1
Also known as WP34|pp52
Coordinate chr11:1853084-1892263
Strand +
Gene summary This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LSP1P1
Bonobo Pan paniscus LOC100971766P2
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LSP1P3
ACTGGCAGGACACCCAAGCTAGCCCGCCAGGCCTCCATAGAGCTGCCCAGCATGGCCGTGGCCAGTACCAAGAGTCGGTGGGAGACGGGTGAGGTACAGGCTCAGTCTGCAGCCAAGACTCTGTCCTGCAAGGATATTGTGGCTGGAGACATGAGCAACAAAAGCTTCTGGGAGCAGAAGGGAGGCTCCAAGACCTCATCAACAATTA
>NM_001013255.1
GAGGGCCGTCGAGCAAAGGCGGGAGGCGCAGCCGGGCTGTCGGTGGACCTGCCCACTGCTCAGTGGAGCGTGGAGGACGAGGAGGAGGCCGTCCACGAGCAATGCCAGCATGAGAGAGACAGGCAGCTTCAGGCCCAGGACGAGGAGGGAGGCGGCCATGTCCCCGAGCGGCCGAAGCAGGAGATGCTCCTCAGCCTGAAGCCCTCGGAGGCCCCTGAACTGGATGAGGACGAGGGCTTTGGCGACTGGTCCCAGAGGCCAGAGCAGCGGCAGCAGCACGAGGGGGCGCAGGGCGCCTTGGACAGCGGAGAGCCCCCCCAGTGCAGGAGTCCTGAGGGGGAGCAAGAGGACAGGCCCGGCCTGCATGCCTACGAAAAGGAGGACAGTGATGAAGTCCACCTGGAGGAGTTGAGTCTGAGCAAGGAGGGGCCAGGCCCAGAGGACACTGTCCAGGACAACCTGGGGGCCGCAGGGGCTGAGGAGGAACAGGAGGAGCACCAGAAATGTCAGCAGCCCAGGACACCCAGCCCCTTGGTCTTGGAGGGGACCATCGAACAGAGCTCGCCTCCCCTGAGCCCTACCACCAAACTCATCGACAGGACCGAGTCCCTAAACCGCTCCATAGAGAAGAGTAACAGTGTGAAGAAATCCCAGCCAGACTTGCCCATCTCCAAGATTGATCAGTGGCTGGAACAATACACCCAGGCCATCGAGACCGCTGGCCGGACCCCCAAGCTAGCCCGCCAGGCCTCCATAGAGCTGCCCAGCATGGCTGTGGCCAGTACCAAGAGTCGGTGGGAGACGGGTGAGGTACAGGCTCAGTCTGCGGCCAAGACTCCGTCCTGCAAGGATATTGTGGCTGGAGACATGAGCAAGAAAAGCCTCTGGGAGCAGAAGGGAGGCTCCAAGACCTCATCAACAATTAAGAGCACCCCATCTGGGAAGAGGTATAAGTTTGTGGCCACCGGGCATGGGAAGTATGAGAAGGTGCTTGTGGAAGGGGGCCCGGCTCCCTAGGCGTCCCATCTCGCTTCCTGGGTCTGCAGGTCCAGCCGGCTGGCACCCTCCATGTACCCAGGGGAGATTCCAGCCAGACACCCGCCCCCCGGCCCTGGCTAAGAAGTTGCTTCCTGTTGCCAGCATGACCTACCCTCGCCTCTTTGATGCCATCCGCTGCCACCTCCTTTTGCTCCTGGACCCTTTAGCCTCTCTGCCCTTCCACTCTCTGACCACCGCCCCCGCCCTCCCCACCCAGCTCCGCTTCTTGTTACTTGGGGGAGGAAAGAAACTCCTGATCATTGGCCAAAGGGACTTACCCCTGGAGAGGCCAAGTGCCTTCTAGGAAGTTAGGAGGTTGAGGCACAGCCTGTGCAGAGAGGGTGGGTCACCCCCCCAGATCCAAGGAGAAACTGCAGGTCAAGGGCTGATAACGGCCATGCAGGATGCTTGATGCTGCGTCCCCCGCTGCTTGCCGCCCCCCACCCCGCCATTTTGTATAATAAAGCTCCCTGTGTATTCTCA

Publications

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