Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TMEM126AP1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:38763812-38764227  UCSC
Coordinates (T2T) chr5:39012882-39013297  UCSC
Coordinates (hg19) chr5:38763914-38764329  UCSC
Strand -
Parental Sequence NM_032273.4
Parental seq. overlap 347 bp
Parental seq. overlap (%) 45.7%
Genomic Region Intergenic
Retrocopy Summary TMEM126AP1, located on chr5:38763812-38764227, is a retrocopy of the parental gene TMEM126A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TMEM126A
Full Name transmembrane protein 126A
Also known as OPA7
Coordinate chr11:85647967-85656542
Strand +
Gene summary The protein encoded by this gene is a mitochondrial membrane protein of unknown function. Defects in this gene are a cause of optic atrophy type 7 (OPA7). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TMEM126AP1
Bonobo Pan paniscus TMEM126AP1
Gorilla Gorilla gorilla TMEM126AP2
Orangutan Pongo abelii TMEM126AP1
Gibbon Nomascus leucogenys TMEM126AP1
Crab-eating macaque Macaca fascicularis TMEM126AP1
Rhesus Macaca mulatta TMEM126AP1
Baboon Papio anubis TMEM126AP1
Golden snub-nosed monkey Rhinopithecus roxellana TMEM126AP1
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TMEM126AP1
AGAAAAATTAACCAGCTTCCAGAAGCAGAAAGGAAACTACTTGAACATGGATCAATATATGTTGAACTTAATGCTGTTCTCCGTGGCCTAATAGCAAACAGTCTTTTTCTATGCATCTTGAACATGACACAGGCTCATATAGCTGTCGGCTCACCAATGGCAGAGAACCCATTTCTGATAGTACATGTATTTTACAGAAGTTTTGTAAATTTACCTTTGAATTGAGGTCATTGGAATTTGAAACCCATACCATAAAATGAGGTGGATTGGTTGGTCTTGTTTTTGGTGGTCTTTTCTTGACTATACCTATGAATGGTGGCTTAGAAGCCAGATATGAATCAACTCTGTTATCAGAGAAAGGAAACATCTTAAGTTACTGGATTAGAATTTCTAAGCCTGACTTTAGAAAGATGTTG
>NM_032273.4
ACGCCGCGTCACGAGTCAGCCAAAGATGGCTGCGCCCAGGTAATTTGAGCAAAGGCCACAGTGAACTCCGGCGTGGCTGAGGAAGGAGGAGGCACCCACAGGCTGCTGGGAGGAGAGCATAAGGCTCAAAATGGAAAATCATAAATCCAATAATAAGGAAAACATAACAATTGTTGATATATCCAGAAAAATTAACCAGCTTCCAGAAGCAGAAAGGAATCTACTTGAAAATGGATCGGTTTATGTTGGATTAAATGCTGCTCTTTGTGGCCTCATAGCAAACAGTCTTTTTCGACGCATCTTGAATGTGACAAAGGCTCGCATAGCTGCTGGCTTACCAATGGCAGGGATACCTTTTCTTACAACAGACTTAACTTACAGATGTTTTGTAAGTTTTCCTTTGAATACAGGTGATTTGGATTGTGAAACCTGTACCATAACACGGAGTGGACTGACTGGTCTTGTTATTGGTGGTCTATACCCTGTTTTCTTGGCTATACCTGTAAATGGTGGTCTAGCAGCCAGGTATCAATCAGCTCTGTTACCACACAAAGGGAACATCTTAAGTTACTGGATTAGAACTTCTAAGCCTGTCTTTAGAAAGATGTTATTTCCTATTTTGCTCCAGACTATGTTTTCAGCATACCTTGGGTCTGAACAATATAAACTACTTATAAAGGCCCTTCAGTTATCTGAACCTGGCAAAGAAATTCACTGATTTTAAACAAATATGTAAACAAAAATAAAATGGTAAAAACA

Publications

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