RCPedia: Rtcs

Summary

Retrocopy Name	INTS6P1	Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr13). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr5:39718737-39721510 UCSC
Coordinates (T2T)	chr5:39968928-39971701 UCSC
Coordinates (hg19)	chr5:39718839-39721612 UCSC
Strand	-
Parental Sequence	XM_011535041.2
Parental seq. overlap	2526 bp
Parental seq. overlap (%)	38.6%
Genomic Region	Intergenic
Retrocopy Summary	INTS6P1, located on chr5:39718737-39721510, is a retrocopy of the parental gene INTS6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	INTS6
Full Name	integrator complex subunit 6
Also known as	DBI-1\|DDX26\|DDX26A\|DICE1\|HDB\|INT6\|Notchl2
Coordinate	chr13:51353171-51453333
Strand	-
Gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	INTS6P1
Bonobo	Pan paniscus	INTS6P1
Gorilla	Gorilla gorilla	INTS6P1
Orangutan	Pongo abelii	INTS6P1
Gibbon	Nomascus leucogenys	INTS6P1
Green monkey	Chlorocebus sabaeus	INTS6P1
Crab-eating macaque	Macaca fascicularis	INTS6P1
Rhesus	Macaca mulatta	INTS6P1
Baboon	Papio anubis	INTS6P1
Golden snub-nosed monkey	Rhinopithecus roxellana	INTS6P1
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>INTS6P1
GCTCCGTGCCCGGGACCCTGCCAGCAGAGGAGACAGGTATATGCTCGTCACTTTCGAAGAGCCGCCCTGTGCTATCAAGGCTGGATGGAAAGAAAACCATGCAACGTTTATGAATGAACTGAAAAACCTTCAGGCTGAAGGACTTAGGACTCTTGGCCAATCCCTAAGGACAGCTTTTGATTTATTAAATTTAAATAGATTAGCAACTGGCATAGACAACTATGGGCAGGGAAGAAACCCTTTTTTCTTGGAGCCAGCAATAATTATCACAATTACTGATGGGAGCAAGTTGACTACCACCAGTGGAGTCCAGGATGAGCTTCATTTACCTCTTAATTCTCCTTTGCCTGGAAGTGAATTGACCAAGGAACCTTTTCCTTGGGATCAGAGATTCTTTGCATTAGTGTTGCAGTTGCCTGGCACCATGTCAGTAGAATCAGAACAGTTGACAGGTGTGCCTTTAGATGACCCTGCAATCACACCAGACGGCTGGTCGTATTTTGTGTGTTCTCCAAGAATGCTTAATCAGTGTCTGGAGTCCTTGGTGCAGAAAGTACAAAGTTGGGTGGTAATAAACTTTCAAAAAGCAGGACCGGATCCTTCCCCTGTAGAAGATGGGCAGCCAGATATATCAAGGCCTTTTGGATCTCAGCCTTGGCATAACTGTCACAAACTCATATGTGTCAGACCAAATCCTAAAACTGGGGTTCCTATAGGTCATTGGCCTGTTCCAGAGTCTTTTTGGCCAGATCAAAATTCGCCAACACCACCACTTCGTACATCTCATCCTGTAGTGAAGTTTTCCTGTACAGACTGAACCAATGGTTATTGATAAACTTCCTTTTGACAAATACGAGTTGGAACCTTCATCACTGACTCAATTTATCCTGGAAAGGAAATCTCCTCAAACATGTTGGCAGGTGTACGTCAGCAATAGTGCAAAATACAGTGAACTTGGTCATCCTTTTGGTTACTTGAAAGCCAGTATGGCACTGAACTGTGTCAATGTATTTGTGATGCCTTACAATTACCCAGTCCTTCCCCTCTTAGATGACTTGCTTAAAGTGCATAAAGCAAAACCAACACTGAAGTGGAGACAGTCATTTGAAAGTTATTTGAAGACCGTGCCTCCCTACTATCTCGGGCCCTTCAAGAAAGCTGTTAGTATGATGGGAGCACCTAACCTAATAGCAGACAGTATGGAATATGGACTTAGTTACAGTGTCATTTCATACCTCAAAAAACTGAGTCAACAGGCCAAAATAGAATCTGATCGAGTCATTGGATCTGTAGGCAAAAAAGGAGTACAGGAAACTGAAATAAAAGTCTGGAGCCAATCACATGGTTTATCAAGGGCATATAGGAAAGATTTTCAACAGCTCCTCCAGGGAATTTCAGATGTCCCTCACAGACTGCTAGACCTTAATATGAAGGAATACGCTGGGTTCCACGTTGCTTTGCTGAATAAGGATTTGAAGCCACAGACATTTAGAAATGCTTATGACATTCCAAGACGAAATCTTTTGGATCACTTAACAAGAATGAGATCTAATCTTTTGAAGCACACTCGCAGATTTCTTAAAGGACAGGACGAAGATCAAGTGCAGTGTTCCTATAGCACAAATGGGGAACTACCAGGAATACCTCAAGCAAGTTACCTTCTCCACTAAGAGAACTTGATCCTGATCAGCCGCAAAGGTTACATACATTTGGCAATTCCTTTAAGCTGGATAAAAAGGGTATGATGACAGATGAAGCAGATGAATTTGTGGCTGGACCTCAAAATAAACATAAATGACCTGGAGAATCAAATATGCAAGGGATCCCTAAAAGACGTCAGTGTATGTCTCCACTACTAAGAGGCAGACAGCAGAATCCTGTTGTAAACAATCATATCGGGGGAAAAGGACCACCTGCACCTACAACTCAAGCACAGCCAGATCTTATTAAGCTTCTTCCTCTTCATAAAATTTCAGAAACCACTAATGATTCGATAATACATGATGTGGTTGAAAATCATGTTGCAGACCAACTTTCGTCAGACATTACACCAAATGCTATGGATACTGAATTTTCAACATCTTCTCCAGCCAGTTTACTGGAAGGGCCAACCAATCATATGGAGGCTCCTGGTCATGACAATTTAGGAACGAATGACCTCACTGTTGGTGGATTTTTAGAAAATCATGAGGAGCCAAGAGATAAAGAACAATGTGCTGAAGAGAACATACCAGCATCTTCACTCAACAAAGGAAAGAAATTGATCCATTGCAGAAGCCATGAAGAGGTCAATATCGAACTAAAACCACAAATAATGAAAGAGATCTGAAAGCCAGGGAGAAAATATGAAAGAATCTTCACTTTACTGAAGCATGTGCAAGGCAGTTTACAAACAAGACTAATATTTTTACAAAATGTTATTAAAGAAGCATCAAGGTTTTAAAAACGAATGCTAATAGAACAACTGGAGAACTTCTTGGATGAAATTCATCGAAGAGCCAATCAGATCAACCATATTAATAGCAATTAAAAGAAAATAGAATGTGGCCACTTCACTATCTTCTTCAAATACAAAGTAAATACAAGACTGTTGTGATCTTGCATTCATTTTCTGACATGCATTGTCGGCTATTTGAAATACTAAAAGCAAATCTACAGATCATTTTCCGTCATTTTACAGTGACCTTTTCTTCATTTTGGTTTATTTTTGTAATGTGAAAAGTATCACTCTAAAAAACATTTTTATTTAACAAACTGAAAATATTCCTCCAAAG

>XM_011535041.2
CCCACCTCGCGGTCCTTCCGCAGTCCGGCCCCGCCCCTTCCCGAAGCCCGCCTCCGGGTCGGCCCGCCCGCCCGCTCGCGCGCACCCGACGCCCCGCCTCTGCGCGTGCTCAATAACTGTCCCCGGAGCCGGCCTACAAGCTTCCCCCGCCCCTGAGCTGTTTAAATATGCTAATGAAAGGATAGGGCCTGACCAGTAGAACGGCGAGGCGGTGTATCACGTGGCTCGGGGACGTGTCAGGGGCGGAGCCTCCGCAGCCCCTGCCCGAGTTAAAACCGGAGTGTGAGAGAGAAAAGCGCTTCAGTAGCGAGAGGGGCTGAGAAAGTGGTGACACCGCCGGGGTGCGGAGGGAGTCCCTGAAACTTctcccaacagccccagggccaatcttccctcagcccactcccctcttcgccagctcccaggtccccactccTGTACCGGGGGTGGGGTGGGGAGCCAGGCCCGTCTCCCGCTGGGACACACACAGGGGCCGGGAGCGGGGACGGGACCCCCGAGGCGGGGGGGACGAACCGACAGACAGACGGCTGGGCGCCCGCCCCAgcgggcaggcaggcaggaggaggcggaggcgggGGTACGACGGGGAGCACTGGGTCTGGGGAGTTTCCTCTCAACTATCGGGGGAGAAACTCCCCGCAGCCGGAGGAAAGACCCAGACAGTGTTTTCCTCCCGGGGGCCGTGCTCCCCCGCCCCGCGTAGCGGCGGTCGccgccaccggcgcctccacctctaccatctcctctttctccaccaccTCGGGCCCCGGTGTCCCCGGCCAGCACTATGCCCATCTTACTGTTCCTGATAGACACGTCTGCCTCTATGAACCAGCGCAGCCATCTGGGCACCACCTACCTGGACACGGCCAAAGGCGCGGTAGAGACCTTCATGAAGCTCCGTGCCCGGGACCCTGCCAGCAGAGGAGACAGGTATATGCTGGTCACTTTCGAAGAGCCGCCCTATGCTATCAAGGCTGGATGGAAAGAAAACCATGCAACGTTTATGAATGAATTGAAAAACCTTCAGGCTGAAGGACTTACGACTCTTGGCCAATCCCTAAGGACAGCTTTTGATTTATTAAATTTAAATAGATTAGTAACTGGCATAGACAACTATGGGCAGGGAAGAAACCCTTTTTTCTTGGAGCCAGCAATAATTATCACAATTACTGATGGGAGCAAGTTGACTACCACCAGTGGAGTCCAGGATGAGGCCGTTCATATTCTGTGTGTTCTCCAAGAATGCTTAATCAGTGTCTGGAGTCCTTGGTGCAGAAAGTACAAAGTGGGGTGGTAATAAACTTTGAAAAAGCAGGACCAGATCCTTCCCCTGTAGAAGATGGGCAGCCAGATATATCAAGGCCTTTTGGATCTCAGCCTTGGCATAGCTGTCACAAACTCATATATGTCAGACCAAATCCTAAAACTGGGGTTCCTATAGGTCATTGGCCTGTTCCAGAGTCTTTTTGGCCAGATCAAAATTCGCCAACACTACCACCTCGTACATCTCATCCTGTAGTGAAGTTTTCCTGTACAGACTGTGAACCAATGGTTATTGATAAACTTCCTTTTGACAAATATGAGTTGGAACCTTCACCACTGACTCAATTTATCCTGGAAAGGAAATCTCCTCAAACATGTTGGCAGGTGTACGTGAGCAATAGTGCAAAATACAGTGAACTTGGTCATCCTTTTGGTTACTTGAAAGCCAGTACAGCACTGAACTGTGTCAACTTATTTGTGATGCCTTACAATTATCCAGTCCTTCTTCCCCTCTTAGATGACTTGTTTAAAGTGCATAAAGCAAAACCAACATTGAAGTGGAGACAGTCATTTGAAAGTTATTTGAAGACAATGCCTCCCTACTATCTTGGGCCCTTGAAGAAAGCTGTTAGGATGATGGGAGCACCTAACCTAATAGCAGACAGTATGGAATATGGACTTAGTTACAGTGTCATTTCATACCTCAAAAAACTGAGTCAACAGGCCAAAATAGAATCTGATCGAGTCATTGGATCTGTAGGCAAAAAAGTAGTACAGGAGACTGGAATAAAAGTCCGGAGCCGATCACATGGTTTATCAATGGCATATAGGAAAGATTTTCAACAACTCCTCCAGGGAATTTCAGAGGATGTCCCTCACAGACTGCTAGACCTTAATATGAAGGAATACACTGGGTTCCAAGTTGCTTTGCTGAATAAGGATTTGAAGCCACAGACATTTAGAAATGCTTATGACATACCAAGACGAAATCTTTTGGATCACTTAACAAGAATGAGATCTAATCTTTTGAAGAGCACTCGCAGATTTCTGAAAGGACAGGACGAAGATCAAGTGCACAGTGTTCCTATAGCACAAATGGGGAACTACCAGGAATACCTCAAGCAAGTACCTTCTCCACTAAGAGAACTTGATCCTGATCAGCCACGAAGGTTGCATACATTTGGCAACCCCTTTAAGCTGGATAAGAAGGGTATGATGATAGATGAAGCAGATGAATTTGTGGCTGGACCTCAAAATAAACATAAACGACCCGGAGAACCAAATATGCAAGGGATCCCTAAAAGACGTCGGTGTATGTCTCCACTACTAAGAGGCAGACAGCAGAATCCTGTTGTAAACAATCATATTGGGGGAAAAGGACCACCTGCACCTACAACTCAAGCACAGCCAGATCTTATTAAACCTCTTCCTCTTCATAAAATTTCAGAAACCACTAATGATTCGATAATACATGATGTGGTTGAAAATCATGTTGCAGACCAACTTTCATCAGACATTACACCAAATGCTATGGATACGGAATTTTCAGCATCTTCTCCAGCCAGTTTACTGGAACGGCCAACCAATCATATGGAGGCTCTTGGTCATGACCATTTAGGAACCAATGACCTCACTGTTGGTGGATTTTTAGAAAATCATGAGGAGCCAAGAGATAAAGAACAATGTGCTGAAGAGAACATACCAGCATCTTCACTCAACAAAGGAAAGAAATTGATGCATTGCAGAAGCCATGAAGAGGTCAATACTGAACTAAAAGCACAAATAATGAAAGAGATCCGAAAGCCAGGAAGAAAATATGAAAGAATCTTCACTTTACTGAAGCATGTGCAAGGCAGTTTACAAACAAGACTAATATTTTTACAAAATGTCATTAAAGAAGCATCAAGGTTTAAAAAACGAATGCTAATAGAACAACTGGAGAACTTCTTGGATGAAATTCATCGAAGAGCCAATCAGATCAACCATATTAATAGCAATTAAAAGAAAATAGAATGTGGCCACTTATTTCACTATCTTCTTCAAATACAAAGTAAATACAAGACTGTTGTGATCTTGCATTCATTTTCTGACATGCATTGTTGGCTATTTGAAATACTAAAAGCAAATCTACAGATCCTTTTTCCATCATTTTACAGTGACCTTTTCTTCATTTTGGTTTATTTTTGTAATGTGAAAAGTATCACTCTAAAAAACATTTTTAATTTAACAAACTAAAAATATTCCTCCAAATCTCTTGCTTGTCATTGACTCTTGCGTGTCAATTTCCCTCAGGTTCTATTTTCTTAAACCAACCTTTAAAATTGTCACCTCTGTTAAGGTTGAACTTTGCCAAAAAAAAAAGAAGTTACTTTGTAATTTTTGGGGAAAAAAGCACATACATTAAAACTAGGTAATGTTTTGTATATACAGTTATTTTGGATATATTATTGTAAGTTGTACAAATGTATTTTGAAGAATATTTAAGAAAAGCACTTTTGTTATTCCATCAATAAATGCTCTATTTTACTCTTGTGTGGTTTAGGAAATAATCACATTTAAAGTAATCATTTAAAAACATCCTAAGATAATGGAATTTTAAAGGCCTTGCTTTTTAGCATTGGAAAAATACACCACTTGAAGTTCATGTTTGTTAAGCCTAACTGTAATTACATGTTACATAATCTGCATTGCCTTTTTACTATATGTTCGTAGTTTTTGTTGGCCATGCCAACATACTCCCATTTCTGCCTAGATTATGGGAATGACTTTGTATGGGGCAGATAGACAGATACTTTAAAAGCTATTTAAAAAGCAAACAACTTTGGATATTATTGGTTTCCTTACTTCAACACCTTTTCCTTTATCACTAGGATTGTGGATGGCACGAAGCTGAAGCTGTTAGGGAGTGGTAGGTTTGGAGTACAGTACATGCTCTGAAATATCTAGCCTTTAGCAGCTTCATGCCATGCTTGCAAAAGCCCACAACAAATTGGAGGCCTCCTTGTTCTGCTCTGCTGTTCTCACACTTAAACTCTGTTTTATTTATAAGCTAAATGGAAAGGAAACACCTTTAAGATGACTTTGCTCATTTTGCATCCCCCCTGAGTTTCACAGGATAAGGAAAACCACGCTATTCATTCTCCACCCTCAATTCAACATGGCCTAGAGTATCCGTACTGAGGAAGCAATCTTATGGCCTGACTCACTCACCATTCATGATCACTGCTGTGCCTTTTAGTGGTTTGGGGGGTAAGCAGTAGAAAAGAAGGTCAAAATAGATTTGGATTAAGAGTAGGCAAAATAAACTTATAACATTTAAAAACTGAAGTATTTTTAGGTTTATAATATTGAAAATCACATACCCTTAGCTTTTTACACTTTATCAGACATTTTTTTAAATTTCAAGGGTATAGCAAAATGAAATTATAACTTTATGAAGAAAAGCATTGATGAAAGTGGAGAACATGCATTTAGTCTAGGGGATTTGAAACTCTCCCAATACTGAAGACAAACCCTGTCAAGAAAAAGAAGAATTTAATATTATATAGTATTTTCATATGCAGTTCTTTAAGCTTTGTTTACTTCTATACAAATACTTTTAAGTAATGCAAGATAACATTTAATAGATGGAATTGTTAAGGTAATTGCCTGTAGTCACATTGCTAAATTCATTGAGAGTTACACAAAATCCAGAATATATTGTCTGTTCCTAAATTATATATATTTAGATTCTGGAATTActaggaggaattagaagtcattcagataaaaattcatacttaacaagagtatctaggaaagagattcagcccatcccaatattgagcagctttccttatcagaaagttttattttctgtttcacagattgctcatgACCTTTAATACATTTTTCTGAATGAACCCTGGAGGGAGGTGAGAAGTAGCAGTTTTGTTCATCTCTTCTTTTTGTCCTTTATCTCTCTGCCACTGTTCTCACCTCATCCTAAAACCTGGTCAGGAGGGTTTGAAACCTATCAGAACTAAAGGTTAATATCTCATCTCCCTCAGGCTTTTTTCATTTAAAAAAAAAATGGGTATATTAGTTAAATTAGAATACTTGTTGTAGAATTATTGTCAAAGGGGAAGGGAAATACATCTAGGGGAAACATCATGTCTTTTAGGCCCTTTATGTCACTGAATGACTTAAGGCTCGACAAATGATATTCTTGGAAAGTTTAATCTTGAGGTTTTCAAATCTTTTTTTTTAATGTCTCCCATGTTTCTCATTTGCTGATTGATTCATTAGTTGCTCTTAGTAAGATTTGTCAGTTGGAAATAATGAAGGCTGAGACTCATTTCTAAACTCTTCCATAACCATCACCAGAAGAGCAGCCACTGTGTTGTGTGATGTAGGCTAATGCCTCCCAGATAGAGGTAAAGTCACAAGGACTATTAGAATTCCAGTGGATTGTGGAACTGGTTTTGGATTATCCTTATATTTTCATTCTGATTACTGAGGCAGTTCTGAAAACTCCTACCATTGAAATAGTGGTGTGTCTTTTCCTTGTTTAAGGATTTTACATCATTTTTATGCACTTGAATTCCAAAATCAGAATCTCTCTTTTACCTATCAACCTTTATTGGCTATTGGCTTTTGGCAATGACCTTTCTGTTCAAATGTAGTCCTGTCTCTTTGTTTCCTTAGGGAGTAGAACCTGTCCTTTTTCTCATCTTTCATTTTTTTGACGTGTCCTTTCTAAGAGAAGGCTCTCTGCCGCCTGTTCTGGGTGATAAGTGATATTTTCATCTAATCGTTATGTGGTTGGGATGATCATGGTGAAATACTAGGAAGACATACTCTGTTGATGGACTTTTTCTCTCCAAATAATCCCAAATAGATTATTTTCTAGTGAATGGTTTATATCTTTCTCGTCACAAAAATGTTCCTTTGATTTCTAGCACAAGGTACAGCAGGATGCAAATGATTCTCAGATAAAATGATGTTGACAGTATTTCCTTAACAATTTATGTAAAACTATGCATAATTTTCATTCTAACTTTTGACATTTTTCTCCATAAATAAAAGTAATGCCTGATGTTTAGTTAAAGTA

>XM_011535041.2 

CCCACCTCGCGGTCCTTCCGCAGTCCGGCCCCGCCCCTTCCCGAAGCCCGCCTCCGGGTCGGCCCGCCCGCCCGCTCGCGCGCACCCGACGCCCCGCCTCTGCGCGTGCTCAATAACTGTCCCCGGAGCCGGCCTACAAGCTTCCCCCGCCCCTGAGCTGTTTAAATATGCTAATGAAAGGATAGGGCCTGACCAGTAGAACGGCGAGGCGGTGTATCACGTGGCTCGGGGACGTGTCAGGGGCGGAGCCTCCGCAGCCCCTGCCCGAGTTAAAACCGGAGTGTGAGAGAGAAAAGCGCTTCAGTAGCGAGAGGGGCTGAGAAAGTGGTGACACCGCCGGGGTGCGGAGGGAGTCCCTGAAACTTctcccaacagccccagggccaatcttccctcagcccactcccctcttcgccagctcccaggtccccactccTGTACCGGGGGTGGGGTGGGGAGCCAGGCCCGTCTCCCGCTGGGACACACACAGGGGCCGGGAGCGGGGACGGGACCCCCGAGGCGGGGGGGACGAACCGACAGACAGACGGCTGGGCGCCCGCCCCAgcgggcaggcaggcaggaggaggcggaggcgggGGTACGACGGGGAGCACTGGGTCTGGGGAGTTTCCTCTCAACTATCGGGGGAGAAACTCCCCGCAGCCGGAGGAAAGACCCAGACAGTGTTTTCCTCCCGGGGGCCGTGCTCCCCCGCCCCGCGTAGCGGCGGTCGccgccaccggcgcctccacctctaccatctcctctttctccaccaccTCGGGCCCCGGTGTCCCCGGCCAGCACTATGCCCATCTTACTGTTCCTGATAGACACGTCTGCCTCTATGAACCAGCGCAGCCATCTGGGCACCACCTACCTGGACACGGCCAAAGGCGCGGTAGAGACCTTCATGAAGCTCCGTGCCCGGGACCCTGCCAGCAGAGGAGACAGGTATATGCTGGTCACTTTCGAAGAGCCGCCCTATGCTATCAAGGCTGGATGGAAAGAAAACCATGCAACGTTTATGAATGAATTGAAAAACCTTCAGGCTGAAGGACTTACGACTCTTGGCCAATCCCTAAGGACAGCTTTTGATTTATTAAATTTAAATAGATTAGTAACTGGCATAGACAACTATGGGCAGGGAAGAAACCCTTTTTTCTTGGAGCCAGCAATAATTATCACAATTACTGATGGGAGCAAGTTGACTACCACCAGTGGAGTCCAGGATGAGGCCGTTCATATTCTGTGTGTTCTCCAAGAATGCTTAATCAGTGTCTGGAGTCCTTGGTGCAGAAAGTACAAAGTGGGGTGGTAATAAACTTTGAAAAAGCAGGACCAGATCCTTCCCCTGTAGAAGATGGGCAGCCAGATATATCAAGGCCTTTTGGATCTCAGCCTTGGCATAGCTGTCACAAACTCATATATGTCAGACCAAATCCTAAAACTGGGGTTCCTATAGGTCATTGGCCTGTTCCAGAGTCTTTTTGGCCAGATCAAAATTCGCCAACACTACCACCTCGTACATCTCATCCTGTAGTGAAGTTTTCCTGTACAGACTGTGAACCAATGGTTATTGATAAACTTCCTTTTGACAAATATGAGTTGGAACCTTCACCACTGACTCAATTTATCCTGGAAAGGAAATCTCCTCAAACATGTTGGCAGGTGTACGTGAGCAATAGTGCAAAATACAGTGAACTTGGTCATCCTTTTGGTTACTTGAAAGCCAGTACAGCACTGAACTGTGTCAACTTATTTGTGATGCCTTACAATTATCCAGTCCTTCTTCCCCTCTTAGATGACTTGTTTAAAGTGCATAAAGCAAAACCAACATTGAAGTGGAGACAGTCATTTGAAAGTTATTTGAAGACAATGCCTCCCTACTATCTTGGGCCCTTGAAGAAAGCTGTTAGGATGATGGGAGCACCTAACCTAATAGCAGACAGTATGGAATATGGACTTAGTTACAGTGTCATTTCATACCTCAAAAAACTGAGTCAACAGGCCAAAATAGAATCTGATCGAGTCATTGGATCTGTAGGCAAAAAAGTAGTACAGGAGACTGGAATAAAAGTCCGGAGCCGATCACATGGTTTATCAATGGCATATAGGAAAGATTTTCAACAACTCCTCCAGGGAATTTCAGAGGATGTCCCTCACAGACTGCTAGACCTTAATATGAAGGAATACACTGGGTTCCAAGTTGCTTTGCTGAATAAGGATTTGAAGCCACAGACATTTAGAAATGCTTATGACATACCAAGACGAAATCTTTTGGATCACTTAACAAGAATGAGATCTAATCTTTTGAAGAGCACTCGCAGATTTCTGAAAGGACAGGACGAAGATCAAGTGCACAGTGTTCCTATAGCACAAATGGGGAACTACCAGGAATACCTCAAGCAAGTACCTTCTCCACTAAGAGAACTTGATCCTGATCAGCCACGAAGGTTGCATACATTTGGCAACCCCTTTAAGCTGGATAAGAAGGGTATGATGATAGATGAAGCAGATGAATTTGTGGCTGGACCTCAAAATAAACATAAACGACCCGGAGAACCAAATATGCAAGGGATCCCTAAAAGACGTCGGTGTATGTCTCCACTACTAAGAGGCAGACAGCAGAATCCTGTTGTAAACAATCATATTGGGGGAAAAGGACCACCTGCACCTACAACTCAAGCACAGCCAGATCTTATTAAACCTCTTCCTCTTCATAAAATTTCAGAAACCACTAATGATTCGATAATACATGATGTGGTTGAAAATCATGTTGCAGACCAACTTTCATCAGACATTACACCAAATGCTATGGATACGGAATTTTCAGCATCTTCTCCAGCCAGTTTACTGGAACGGCCAACCAATCATATGGAGGCTCTTGGTCATGACCATTTAGGAACCAATGACCTCACTGTTGGTGGATTTTTAGAAAATCATGAGGAGCCAAGAGATAAAGAACAATGTGCTGAAGAGAACATACCAGCATCTTCACTCAACAAAGGAAAGAAATTGATGCATTGCAGAAGCCATGAAGAGGTCAATACTGAACTAAAAGCACAAATAATGAAAGAGATCCGAAAGCCAGGAAGAAAATATGAAAGAATCTTCACTTTACTGAAGCATGTGCAAGGCAGTTTACAAACAAGACTAATATTTTTACAAAATGTCATTAAAGAAGCATCAAGGTTTAAAAAACGAATGCTAATAGAACAACTGGAGAACTTCTTGGATGAAATTCATCGAAGAGCCAATCAGATCAACCATATTAATAGCAATTAAAAGAAAATAGAATGTGGCCACTTATTTCACTATCTTCTTCAAATACAAAGTAAATACAAGACTGTTGTGATCTTGCATTCATTTTCTGACATGCATTGTTGGCTATTTGAAATACTAAAAGCAAATCTACAGATCCTTTTTCCATCATTTTACAGTGACCTTTTCTTCATTTTGGTTTATTTTTGTAATGTGAAAAGTATCACTCTAAAAAACATTTTTAATTTAACAAACTAAAAATATTCCTCCAAATCTCTTGCTTGTCATTGACTCTTGCGTGTCAATTTCCCTCAGGTTCTATTTTCTTAAACCAACCTTTAAAATTGTCACCTCTGTTAAGGTTGAACTTTGCCAAAAAAAAAAGAAGTTACTTTGTAATTTTTGGGGAAAAAAGCACATACATTAAAACTAGGTAATGTTTTGTATATACAGTTATTTTGGATATATTATTGTAAGTTGTACAAATGTATTTTGAAGAATATTTAAGAAAAGCACTTTTGTTATTCCATCAATAAATGCTCTATTTTACTCTTGTGTGGTTTAGGAAATAATCACATTTAAAGTAATCATTTAAAAACATCCTAAGATAATGGAATTTTAAAGGCCTTGCTTTTTAGCATTGGAAAAATACACCACTTGAAGTTCATGTTTGTTAAGCCTAACTGTAATTACATGTTACATAATCTGCATTGCCTTTTTACTATATGTTCGTAGTTTTTGTTGGCCATGCCAACATACTCCCATTTCTGCCTAGATTATGGGAATGACTTTGTATGGGGCAGATAGACAGATACTTTAAAAGCTATTTAAAAAGCAAACAACTTTGGATATTATTGGTTTCCTTACTTCAACACCTTTTCCTTTATCACTAGGATTGTGGATGGCACGAAGCTGAAGCTGTTAGGGAGTGGTAGGTTTGGAGTACAGTACATGCTCTGAAATATCTAGCCTTTAGCAGCTTCATGCCATGCTTGCAAAAGCCCACAACAAATTGGAGGCCTCCTTGTTCTGCTCTGCTGTTCTCACACTTAAACTCTGTTTTATTTATAAGCTAAATGGAAAGGAAACACCTTTAAGATGACTTTGCTCATTTTGCATCCCCCCTGAGTTTCACAGGATAAGGAAAACCACGCTATTCATTCTCCACCCTCAATTCAACATGGCCTAGAGTATCCGTACTGAGGAAGCAATCTTATGGCCTGACTCACTCACCATTCATGATCACTGCTGTGCCTTTTAGTGGTTTGGGGGGTAAGCAGTAGAAAAGAAGGTCAAAATAGATTTGGATTAAGAGTAGGCAAAATAAACTTATAACATTTAAAAACTGAAGTATTTTTAGGTTTATAATATTGAAAATCACATACCCTTAGCTTTTTACACTTTATCAGACATTTTTTTAAATTTCAAGGGTATAGCAAAATGAAATTATAACTTTATGAAGAAAAGCATTGATGAAAGTGGAGAACATGCATTTAGTCTAGGGGATTTGAAACTCTCCCAATACTGAAGACAAACCCTGTCAAGAAAAAGAAGAATTTAATATTATATAGTATTTTCATATGCAGTTCTTTAAGCTTTGTTTACTTCTATACAAATACTTTTAAGTAATGCAAGATAACATTTAATAGATGGAATTGTTAAGGTAATTGCCTGTAGTCACATTGCTAAATTCATTGAGAGTTACACAAAATCCAGAATATATTGTCTGTTCCTAAATTATATATATTTAGATTCTGGAATTActaggaggaattagaagtcattcagataaaaattcatacttaacaagagtatctaggaaagagattcagcccatcccaatattgagcagctttccttatcagaaagttttattttctgtttcacagattgctcatgACCTTTAATACATTTTTCTGAATGAACCCTGGAGGGAGGTGAGAAGTAGCAGTTTTGTTCATCTCTTCTTTTTGTCCTTTATCTCTCTGCCACTGTTCTCACCTCATCCTAAAACCTGGTCAGGAGGGTTTGAAACCTATCAGAACTAAAGGTTAATATCTCATCTCCCTCAGGCTTTTTTCATTTAAAAAAAAAATGGGTATATTAGTTAAATTAGAATACTTGTTGTAGAATTATTGTCAAAGGGGAAGGGAAATACATCTAGGGGAAACATCATGTCTTTTAGGCCCTTTATGTCACTGAATGACTTAAGGCTCGACAAATGATATTCTTGGAAAGTTTAATCTTGAGGTTTTCAAATCTTTTTTTTTAATGTCTCCCATGTTTCTCATTTGCTGATTGATTCATTAGTTGCTCTTAGTAAGATTTGTCAGTTGGAAATAATGAAGGCTGAGACTCATTTCTAAACTCTTCCATAACCATCACCAGAAGAGCAGCCACTGTGTTGTGTGATGTAGGCTAATGCCTCCCAGATAGAGGTAAAGTCACAAGGACTATTAGAATTCCAGTGGATTGTGGAACTGGTTTTGGATTATCCTTATATTTTCATTCTGATTACTGAGGCAGTTCTGAAAACTCCTACCATTGAAATAGTGGTGTGTCTTTTCCTTGTTTAAGGATTTTACATCATTTTTATGCACTTGAATTCCAAAATCAGAATCTCTCTTTTACCTATCAACCTTTATTGGCTATTGGCTTTTGGCAATGACCTTTCTGTTCAAATGTAGTCCTGTCTCTTTGTTTCCTTAGGGAGTAGAACCTGTCCTTTTTCTCATCTTTCATTTTTTTGACGTGTCCTTTCTAAGAGAAGGCTCTCTGCCGCCTGTTCTGGGTGATAAGTGATATTTTCATCTAATCGTTATGTGGTTGGGATGATCATGGTGAAATACTAGGAAGACATACTCTGTTGATGGACTTTTTCTCTCCAAATAATCCCAAATAGATTATTTTCTAGTGAATGGTTTATATCTTTCTCGTCACAAAAATGTTCCTTTGATTTCTAGCACAAGGTACAGCAGGATGCAAATGATTCTCAGATAAAATGATGTTGACAGTATTTCCTTAACAATTTATGTAAAACTATGCATAATTTTCATTCTAACTTTTGACATTTTTCTCCATAAATAAAAGTAATGCCTGATGTTTAGTTAAAGTA

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