Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name CRTC2P1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:62333398-62335737  UCSC
Coordinates (T2T) chr5:63152649-63154988  UCSC
Coordinates (hg19) chr5:61629225-61631564  UCSC
Strand +
Parental Sequence XM_005244946.1
Parental seq. overlap 1925 bp
Parental seq. overlap (%) 71.2%
Genomic Region Intragenic (KIF2A)
Retrocopy Summary CRTC2P1, located on chr5:62333398-62335737, is a retrocopy of the parental gene CRTC2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CRTC2
Full Name CREB regulated transcription coactivator 2
Also known as TORC-2|TORC2
Coordinate chr1:153947675-153958643
Strand -
Gene summary This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]

Homology

Species Scientific Name Retrocopy
Bonobo Pan paniscus CRTC2P1
Gorilla Gorilla gorilla CRTC2P1
Orangutan Pongo abelii CRTC2P1
Gibbon Nomascus leucogenys CRTC2P1
Green monkey Chlorocebus sabaeus CRTC2P1
Crab-eating macaque Macaca fascicularis CRTC2P1
Rhesus Macaca mulatta CRTC2P1
Baboon Papio anubis CRTC2P1
Golden snub-nosed monkey Rhinopithecus roxellana CRTC2P1
Marmoset Callithrix jacchus CRTC2P1
Chimpanzee Pan troglodytes Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CRTC2P1
TGGCTTGTACTGGGAGGGTGTCAGGAAGGAACGGGAGGAAGATGGCGACATCAGGGGCAGGGCAAATGAGCCTTGTTCGGCCACAGCCTTGGCTTTCAATCTGTGCAAGTTTAGTGAGATCACGCTGCAGAAGCAGTGTCAGGCTGAGGACACAGTGGCCCTCGAGGAAATGATAATGGACATCAGCTCCACCCAGTTACACACCCAAAAACTGCAACTGCCATACACAAGGAGCTCCCGTTATGGTGGTTCTCTGCCAACACCCTACCACACTGACAGCTCTCCCTATAGTCCTGCCTACTTATCTCCTCCCCAAGTGTCCAGCTGGTGAAGGACTATCTCCTGGGACAATTTCCCTGCAGAGAAGGGGTACCTGTTTTGCCCAGCATCTGCATTTAACAGGACAAGCTCTGACTCTGCCCTTCACACAAGTATGATGAACCCCAGTCCCCAGGATACTTATTCAGGCCCCACACCTCCCAGCATCCTGCCCAGCCAACATTTCAGGTTGGTAAAATGGACTCCAAAGTACCTGCTATTGAGGAGAAGTTCTCCTAGGTGACAAGCATTTGCTGAAGCCATGGGATACTTAGAAGCTGTCGTCACCCTCCTCCTGACCCCGGTCCTAATGAAGTCCCTGGAATTAATATCTTTCCATTTCCTGGCCAGCTTGCCAATGTTCCTGTCCTCCCACCTGCCATGAAGACTGGATGTGGCAGGAGGTCCCTACCTGACCTCATCAATTTGTACTTTCTGCCAGCACTGCCCACCCCCCGGACCCTGAGGAGACAGCCTACTCTAGCCTGAATAGGGGCAACAGTACCTCCAATTTGACTCACATCATGACTCACCTGGGCATTAGTGAGGGCCTGAGCCTGGACTTGGGTCCAGGTCATGATGCCCCAGGACTTTGTTCACCTCTCAGCCACCCATCCCTGCAGTCCTCCCTAAGCAATCCCGATCTCCAGACTTCCCTGAGCAGTCCTCAGCTCCATCTTCAGGGCATCCACAGTCTCCCCTCACTATCTCCCTCTTCCTTGGCCCACCATGCCCTGCCTACTACCTTCCTGGGCCAGCCCTCACTAAGTACCCTGCCCCCCAtTACTCAACCTCTACTCCTGGGGCCTCCCCACCACCACTGCCTTGTACCCCTCAGCCCCCTAAGTTTGCTCACAGGTCCAGCCGATGCCAGAAGGTCGCAACAGCAGCTACCCAAACAGTTTTTGCCAGTGTCACCCACCCTGTCTTCCATCGTTCAGGGTGTCCCCCTGGAGACCAGTAATCTGCACACCCAGCCACACACCCCAAAGTCTCTACAGCAGCCAGAGCTGCCCTCTCAGGCCTGCTCAGCGCAGCCCTCAGGTGGGTAGCCCCTGAGCAGGCAATTGGATTATGGAATACTCCCCGCCTCGGCCCACTGGGCTTGGGCAAGTCTTCACTGGCCGATGAGTGACTTCAGCCTGGGGAACTGGAGCAGTTCAGCATGGAGAGCCCATAAATCAGCCTGGTGATGGGTCCCCCTGGCTTTTCTGAAGGGCCTGGATTTTTAGAAGGTGAGGGACCAGTGGCTGGCCCTCAGGATTCCCACACCCTCAACCACCAGAACTTGACCCACCACTGCTCCTGCTGTGGCTCAAGGCTGAACATCATCCTCATAGGAGACTCCTTCCCAGGTTTCTCTAAGGAGATTGCAGCAACCCTGGCTGGAGTGCCTGGCTTTGAGGTGTCAGTAGCAGGGTTGGAGTTGGGGCTAGGGCTAGAAGATGAGCTGCGCATGGAGCTATTGGGCCTGGAAGGGCTATACATGCTGAGAGACCCAGTGCCCTGCTACCCGATCCTGCTCTGGAGTATTCATCACCATCCCTCTTCTTGGCCCTGTCCCCCATTACTGTCCATTTCCTCCCTTACCCCAGCTAGTAGAGACGCCACTCTGTCCCTCAGATCCTCTTTGTAGCATGAACGAAGGAGCCCAAAAATGAGAAAAAGCAAGGAGTTTGTTCAGGTGGCCCTTGAATTCTGTACAGGGGTGGGCCTGGAGGAGCTCAAGGGAGGGTCACAAGCACTTGTAACTTTGAACCAACTGCCTGGAGGTCAGAACCTGTTGGAAAGTTGGGGATATAAACGGGAACCTGGGAGGCAGGGCTTGTCCGGATTCCTAGAGATGGGCATTGCCAGCTCCTCCTCACCACCTTTTCACCTCTCAATGGAGGACAGTGCCACAGTGGGTATTATTTTTAATTAAATAT
>XM_005244946.1
AACAGGTCAGGGCTAGGCTGGGGCCGGGTTCGCGGTGCTCGCTGAggcggcggtggctacggctggaggagccgggccgaggccgcggcggaggccgcggcTGGTACTgggagggtggcagggagggacggggaaggaagATGGCGACGTCGGGGGCGAACGGGCCTGGTTCGGCCACGGCCTCGGCTTCCAATCCGCGCAAATTTAGTGAGAAGATTGCGCTGCAGAAGCAGCGTCAGGCCGAGGAGACGGCGGCCTTCGAGGAGGTGATGATGGACATCGGCTCCACCCGGTTACAGGCCCAAAAACTGCGACTGGCATACACAAGGAGCTCTCATTATGGTGGGTCTCTGCCCAATGTTAACCAGATTGGCTCTGGCCTGGCCGAGTTCCAGAGCCCCCTCCACTCACCTTTGGATTCATCTCGGAGCACTCGGCACCATGGGCTGGTGGAACGGGTGCAGCGAGATCCTCGAAGAATGGTGTCCCCACTTCGCCGATACACCCGCCACATTGACAGCTCTCCCTATAGTCCTGCCTACTTATCTCCTCCCCCAGAGTCTAGCTGGCGAAGGACGATGGCCTGGGGCAATTTCCCTGCAGAGAAGGGGCAGTTGTTTCGACTACCATCTGCACTTAACAGGACAAGCTCTGACTCTGCCCTTCATACAAGTGTGATGAACCCCAGTCCCCAGGATACCTACCCAGGCCCCACACCTCCCAGCATCCTGCCCAGCCGACGTGGGGGTATTCTGGATGGTGAAATGGACCCCAAAGTCTTTCTCTTTCAAGTACCTGCTATTGAGGAGAACTTGCTAGATGACAAGCATTTGCTGAAGCCATGGGATGCTAAGAAGCTATCCTCATCCTCTTCCCGACCTCGGTCCTGTGAAGTCCCTGGAATTAACATCTTTCCATCTCCTGACCAGCCTGCCAATGTGCCTGTCCTCCCACCTGCCATGAACACGGGGGGCTCCCTACCTGACCTCACCAACCTGCACTTTCCCCCACCACTGCCCACCCCCCTGGACCCTGAAGAGACAGCCTACCCTAGCCTGAGTGGGGGCAACAGTACCTCCAATTTGACCCACACCATGACTCAcctgggcatcagcaggggcatgggcctgggccCAGGCTATGATGCACCAGGACTTCATTCACCTCTCAGCCACCCATCCCTGCAGTCCTCCCTAAGCAATCCCAACCTCCAGGCTTCCCTGAGCAGTCCTCAGCCCCAGCTTCAGGGCTCCCACAGCCACCCCTCTCTGCCTGCCTCCTCCTTGGCCCGCCATGTACTGCCCACCACCTCCCTGGGCCACCCCTCACTCAGTGctccggctctctcctcctcctcttcctcctcctccacttcatctcctGTTTTGGGCGCCCCCTCTTACCCTGCTTCTACCCCTGGGGCCTCCCCCCACCACCGCCGTGTGCCCCTCAGCCCCCTGAGTTTGCTCGCGGGCCCAGCCGACGCCAGAAGGTCCCAACAGCAGCTGCCCAAACAGTTTTCGCCAACAATGTCACCCACCTTGTCTTCCATCACTCAGGGCGTCCCCCTGGATACCAGTAAACTGTCCACTGACCAGCGGTTACCCCCATACCCATACAGCTCCCCAAGTCTGGTTCTGCCTACCCAGCCCCACACCCCAAAGTCTCTACAGCAGCCAGGGCTGCCCTCTCAGTCTTGTTCAGTGCAGTCCTCAGGTGGGCAGCCCCCAGGCAGGCAGTCTCATTATGGGACACCGTACCCACCTGGGCCCAGTGGGCATGGGCAACAGTCTTACCACCGGCCAATGAGTGACTTCAACCTGGGGAATCTGGAGCAGTTCAGCATGGAGAGCCCATCAGCCAGCCTGGTGCTGGATCCCCCTGGCTTTTCTGAAGGGCCTGGATTTTTAGGGGGTGAGGGGCCAATGGGTGGCCCCCAGGATCCCCACACCTTCAACCACCAGAACTTGACCCACTGTTCCCGCCATGGCTCAGGGCCTAACATCATCCTCACAGGGGACTCCTCTCCAGGTTTCTCTAAGGAGATTGCAGCAGCCCTGGCCGGAGTGCCTGGCTTTGAGGTGTCAGCAGCTGGATTGGAGCTAGGGCTTGGGCTAGAAGATGAGCTGCGCATGGAGCCACTGGGCCTGGAAGGGCTAAACATGCTGAGTGACCCCTGTGCCCTGCTGCCTGATCCTGCTGTGGAGGAGTCATTCCGCAGTGACCGGCTCCAATGAGGGCACCTCATCACCATCCCTCTTCTTGGccccatcccccaccaccattcctttcctcccttcccccTGGCAGGTAGAGACTCTACTCTCTGTCCCCAGATCCTCTTTCTAGCATGAATGAAGGATGCCAAGAATGAGAAAAAGCAAGGGGTTTGTCCAGGTGGCCCCTGAATTCTGCGCAAGGGATGGGCCTGGGGGAACTCAAGGGAGGGCCTAAAGCACTTGTAACTTTGAACCGTCTGTCTGGAGGTCAGAGCCTGTTGGAAAGCAGGGGTAGAGGGGAGCCCTGGAAGCAGGGCTTTTCCGGATGCCTAGGGGTGGGCAGTGCCAGCCCCTCCTCACCACTCTTCCCCTTGCAGTGGAGGAGAGAGCCAGAGTGGATACTATTTTTTATTAAATATATTATTATATGTTAATAAAAAAATCATATCAAA

Publications

PMID - Link Title