Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name KPNA7P1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:75831122-75832793  UCSC
Coordinates (T2T) chr5:76312228-76313899  UCSC
Coordinates (hg19) chr5:75126947-75128618  UCSC
Strand -
Parental Sequence NM_001145715.3_2
Parental seq. overlap 1484 bp
Parental seq. overlap (%) 82.4%
Genomic Region Intergenic
Retrocopy Summary KPNA7P1, located on chr5:75831122-75832793, is a retrocopy of the parental gene KPNA7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name KPNA7
Full Name karyopherin subunit alpha 7
Also known as IPOA8
Coordinate chr7:99145467-99219417
Strand -
Gene summary The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import, but exhibits different nuclear localization signal binding specificity compared to other members of the family. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Jul 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes KPNA7P1
Bonobo Pan paniscus KPNA7P1
Gorilla Gorilla gorilla KPNA7P1
Orangutan Pongo abelii KPNA7P1
Gibbon Nomascus leucogenys KPNA7P1
Green monkey Chlorocebus sabaeus KPNA7P1
Rhesus Macaca mulatta KPNA7P1
Baboon Papio anubis KPNA7P1
Golden snub-nosed monkey Rhinopithecus roxellana KPNA7P1
Crab-eating macaque Macaca fascicularis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>KPNA7P1
GTACTGAGGCAAAGATGCATCTCGGAGGCGACAGCAGAGGATAGCAGTCAGCCTGGAGCTCCGAAAGGCCAAGAAAGATGAACGGATCTTAAAGAAAAAGAATATCACCAGCTTCTGCCCTGATACAGCTTCCGAAAAACCAGCCAAAGAGGTGGCAGTCAGCTTCACTCTGGTGAAATAATCAAAGGTGTGAATAGCTCAGATTCAGTCCCACGTTTCCAGGCCACCCAGACAGCCAGGAAAATGCTATCCCAGGAAAAGAACCCCCTTCTGAAATTGATCATTGAAGCGGGCCTCATTCCCAGGATGGTAGAGTTCCTGAAGTCATCACTTTACCCCTGCTTGCAGTTTGAGGCTGCCTGGGCCCTGACCAACATTGCTTCAGGGACTTCCGAGCAGATTTGAGCCGTGGTAGAAGGGGGACCCATCCAGCCCTTGATCAAGCTCCTGTCTTCCCCCAACGTGGCTGTGTGTGAACAGGCAATGTGGGCTCTTGGTAATATACCCAGTGACGGCCTGGAGTTCAGAGATAATGTCATCTCAAGCAATGCCATCCCACATCTGCGGGCCTTGATTTCACCCACCCTACCAATCACATTTATGCGGAACATCACGTGGACCTGGTCGAACCTATGCCGAAAAAAGACCCCGTACCCTTGCGAAACTGCAGTGAAGCAGATGCTGCGTGCCCTCTCACTCCTGCAGCGCCACCACAGCGAGGTTCTCTCAGAAGCCTGCTGGTCACTGTCCTACCTCACCTACGGCTGCAAAGAGCTCATCGGCCAAGTGGATGACACAGGGGTCCTGCTCAGGCTAGTAGCCCTCATGACCATCTCAGAACTCAATGTCTGGACCCCTTCTCTCCCGTACCATGGGGAACATTATCACAGGCACAAATGAACAGAAGCAGATGGCCATTGACGCGGGCATGCTGAACGTGCTGCCCCAGTTCCTGCAGCACAACAAGTCCTCCATCCAGGAGGCGGCCTGGGCCCTGAGCAACGTGGCGGCAGGGCCCTCTCACCACACCCAGCAGCTGCTTGCCTACAACGTCTTGCCTCCCGTGGTGGCTCTGCTAAAAAAAATGGAGAATTTAAAGTCCAGAAAGAGGCTGTCTGGACGGTGGCTAACTTTGCAATGTGGGTCACCGTGGATAAGTTGATCCTCCACTCTGGGGTCCTGGAGCCACTGGCAAATCTGCTCATTGCCCCAGATGTTAAAATTGTTCTCATCATCCTCGATGTAATCTCTTGCATCCTCCAGGCGGCAGAGAAACGGTCTGAGAAGGAAATCCTATGTTTTCTGATAGAACAACTCGGTGGGATCGATAGAATTGAGGCTTTACAACTGCATGAGAACTGTCAGATTGGCCAGTCTGCTTTGAACATCATTGAGAAGCACTTTGGTGAGGAAGAAGATGAGAGTCTAACTTTACTGAGCCAAGTCCTAGACCAAGATTGTGAATTTATAGATTGTGAATGCTTAGCAAAAAATAGCCAAGCTCCATAACTCCTAAACCAACAACCCAATGCTAAAGGATAACTTCTTTAAGCAGCAGTAGTCCTATATCTTAGTGTATCCCAAATGTGAAGCTTTCAAAACTTAACATTAATAAAACGTTCAATACTTTCAA
>NM_001145715.3_2
gacagagtgagactctgATGCCAACAAGCAGGTCTTGCAGAAATAGGACATGGAGCTGAGAAGTCCAGACTGTTGTTCTTGCTGCCAGGTAACTTACTACTTCCAGTCAATATGCCGACCTTAGATGCTCCAGAAGAGAGGCGGAGAAAATTTAAGTACCGAGGCAAAGATGTGTCTCTGAGGCGACAGCAGAGGATGGCGGTCAGTCTGGAGCTCCGAAAGGCCAAGAAAGATGAACAGACCTTAAAGAGAAGGAATATCACGAGCTTCTGCCCTGACACACCTTCTGAAAAAACAGCCAAAGGGGTGGCGGTCAGCCTCACTCTGGGTGAAATAATCAAAGGTGTGAATAGCTCAGATCCAGTCCTATGTTTCCAGGCCACCCAGACAGCCAGGAAAATGCTATCCCAGGAAAAGAACCCCCCTCTGAAACTGGTCATTGAAGCGGGCCTCATTCCCAGGATGGTGGAGTTCCTGAAGTCATCACTTTACCCCTGCTTGCAGTTTGAGGCTGCCTGGGCCCTGACCAACATCGCTTCAGGGACTTCGGAGCAGACTCGTGCCGTGGTAGAAGGGGGAGCCATCCAGCCCTTGATTGAGCTCCTGTCTTCCTCCAACGTGGCTGTGTGTGAACAGGCAGTGTGGGCTCTTGGTAATATAGCCGGTGATGGCCCAGAGTTCAGAGATAACGTCATCACAAGCAATGCCATCCCACATCTCCTAGCCTTGATTTCACCCACCCTGCCGATCACATTTCTGCGGAACATCACGTGGACCTTGTCGAATCTGTGCCGAAACAAGAACCCATACCCTTGCGACACTGCGGTGAAGCAGATACTGCCGGCCCTCCTTCACCTCCTGCAGCACCAGGACAGTGAGGTTCTCTCGGATGCCTGCTGGGCACTGTCCTACCTCACCGACGGCTCCAACAAGCGCATCGGCCAAGTGGTTAACACGGGGGTCCTGCCCAGGCTGGTAGTGCTCATGACCAGCTCAGAACTCAATGTCTTGACTCCTTCTCTCCGCACCGTGGGGAACATTGTCACGGGCACAGATGAGCAGACGCAGATGGCCATTGATGCGGGTATGCTGAACGTGCTCCCCCAGCTCCTGCAACACAACAAGCCCTCCATCCAGAAGGAGGCAGCCTGGGCCCTGAGCAACGTAGCAGCGGGGCCTTGTCACCACATCCAGCAGCTGCTTGCCTACGACGTCTTGCCTCCCTTGGTGGCTCTGCTAAAAAACGGAGAATTTAAAGTCCAGAAAGAGGCTGTCTGGATGGTGGCGAACTTTGCAACAGGGGCCACCATGGATCAGCTGATCCAGCTCGTCCACTCTGGGGTCCTGGAGCCACTGGTGAATCTGCTCACTGCCCCAGATGTTAAAATTGTTCTCATCATCCTTGATGTCATCTCTTGCATCCTCCAGGCGGCAGAGAAACGGTCTGAGAAGGAAAACCTGTGTCTTCTGATAGAAGAACTTGGTGGGATCGATAGAATTGAGGCTTTACAGCTGCATGAGAACCGTCAAATTGGCCAGTCGGCTTTGAACATCATCGAGAAGCACTTTGGTGAGGAAGAAGATGAGAGCCAAACTTTACTGAGCCAAGTCATAGACCAAGATTATGAATTTATAGATTATGAATGCTTAGCAAAAAAATAGCCAAGCTCCCTACCTCCTAAACCAACAACCCAGTGCTAAAGGATAACTTCTTTAAGAAGCAGCAGTCCTCTATCTTAGTGTAACCCAAATGTGAAGCTTTTAAAACTTGACATTAATAAAATGTTCAACACTTTCA

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