Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HSP90AB1P2
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:78041888-78044143  UCSC
Coordinates (T2T) chr5:78523680-78525935  UCSC
Coordinates (hg19) chr5:77337712-77339967  UCSC
Strand -
Parental Sequence NM_001271971.2
Parental seq. overlap 1224 bp
Parental seq. overlap (%) 47.3%
Genomic Region Intragenic (AP3B1)
Retrocopy Summary HSP90AB1P2, located on chr5:78041888-78044143, is a retrocopy of the parental gene HSP90AB1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HSP90AB1
Full Name heat shock protein 90 alpha family class B member 1
Also known as D6S182|HSP84|HSP90B|HSPC2|HSPCB
Coordinate chr6:44246194-44253883
Strand +
Gene summary This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HSP90AB1P4
Bonobo Pan paniscus HSP90AB1P4
Gorilla Gorilla gorilla HSP90AB1P7
Orangutan Pongo abelii HSP90AB1P4
Green monkey Chlorocebus sabaeus HSP90AB1P2
Crab-eating macaque Macaca fascicularis HSP90AB1P3
Rhesus Macaca mulatta HSP90AB1P3
Baboon Papio anubis HSP90AB1P3
Golden snub-nosed monkey Rhinopithecus roxellana HSP90AB1P3
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HSP90AB1P2
TTTTAGAATTTCAAAAATTAAAATCTAAAGCTTGGAATCCACAAAGACTCCACTAGCCAGTGACGCATGTCCTAGCTGCTGCAGTATCACACTTCCCAGTCTGGAGATGAGATGACATCTGTGTCAAAATATGTCTCCTGCATGAAAGAGGCACAGAAATCCATCTATAGCATCACTGGTGAGAGCAAAGAGCAGGTGGCCAGCTCTGTGTTTGTGGAGCAAGTGCAGAAGTGGGGCTTTGAATTAGTATATACAGCCAAGCCCACTGATGAGTACTGCGTGCAGCAGCTCAAGGAGTTTGATGGGAAAAGCCTGGTCTCAGTTACCAAGGAGAGTCTGCAGCTGCCTGGGCAGATAGAGATGATGAGAAAAAGTCCAAGATTGAAGAAGATGTGGGTGGGTTCAGATGAAGAGGAGGACAATGGTAAGGATAAGAAAAAGAAAACCAACAAGATCAAGGAGAAATCATTGATTGGGAAGAACTAAACAAGATCAAGAACATTTGGATCAGAAACTCTGATGACATTCACCCAGGAGGAGTATAGAGAATTCTACAAGAGCTTCACCAGTGACTAGGAAGACCATTTGGCAGTCAAGCACTTCTCTGTAGAAGGTTGGTTGGAATTCAGAGCATTGCTGTTCATCCCTTGTTTGGCTCCCTTTGACTTCTTTGAGAATGAGAAGAAAAAAAGAACAACAAACTCTGTGTCCATCATGTGTTCATCATGGACAGCCATGATGATATAAGAGTATCTCAACTTTAATCCTTGGTGTGGTTGACTTGGGATCTGCCCCTGAACATCTCTCGAGAAATGCTCCAACAGAGCAGAATCTTAACAGTCATTCACAGAAACATTGTTAAGAAGTGCCTTGAGCTGTTCTCTGAGGTGGCAGAAGACAAGGAGAATTGCAAGAAATTCAATGAGGCCTTATCTAAAAATCTAAAGCTTGTTTCGAGATGCCTGAGAAAGTGCACGTGGAGCGGAGGAGCTGGAAACTTGCCTTTCAGGCAGATATTGCCCAACTCATGTCTCTCGTCATCAATACCTTCTATTCTAACAAGGAGATTTTCCTTCAGGGGTTGATCTAATGTTTCTGATGCATTGGACAAGATTTCCTGTAAGAGCCTGACAAACCCTTCCAAGTTGGACAATGGTAAAGAGCTGGAAGTTAACATCATCCCCAACCCATGGTAATGGTTCCCAAATTAGGAGATCAGCCTTGGTCATGTCAATGCCTGTGTCTACCAAAGTCAGGGTGTATTCCCTGGTACTAAAGGATTTATGGAGGCTCTTCAGGCTAGTGTAGATATCTCCATGATTGGGCAGTTTGGTGCTGCCTTTTTTTCTGCCTACCTTGTGGCAGAGAAAGTAGTTGTGATCACAAAGCACAACAATGATGAAGAGTATGCCTGGGAGTCTCTGCTGGGGGTTCCTTCACTGTATGTGCTGACCATGGAGAGCCCATTGGCAGGGGTACCAAAGTGACCCTCCACCTTAAAGAAGACCAGACAGAGTACTTAGAAGAGAGGAAGGTCAAAGAAGTAGTGAAGAGCACTTACAGTTCATAGCCTATCCCATTACCCTTTCTTTGGAGAAGGAAAGAGAGGAGAAAATCAGTGATGATAGGCAGAGGAAGAGAAAGGTGAGAAAGAAGAGGAAGATAg
>NM_001271971.2
CTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTATAATCCTTTTCTTTTCAAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAGAAATTGCCCAACTCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATGCCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGGCAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTGACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAGAAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATTTGGAGAAGGAACGAGAGAAGGAAATTAGTgatgatgaggcagaggaagagaaaggtgagaaagaagaggaagataaagatgatgaagaaAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTACAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGCACTTTTCTGTAGAAGGTCAGTTGGAATTCAGGGCATTGCTATTTATTCCTCGTCGGGCTCCCTTTGACCTTTTTGAGAACAAGAAGAAAAAGAACAACATCAAACTCTATGTCCGCCGTGTGTTCATCATGGACAGCTGTGATGAGTTGATACCAGAGTATCTCAATTTTATCCGTGGTGTGGTTGACTCTGAGGATCTGCCCCTGAACATCTCCCGAGAAATGCTCCAGCAGAGCAAAATCTTGAAAGTCATTCGCAAAAACATTGTTAAGAAGTGCCTTGAGCTCTTCTCTGAGCTGGCAGAAGACAAGGAGAATTACAAGAAATTCTATGAGGCATTCTCTAAAAATCTCAAGCTTGGAATCCACGAAGACTCCACTAACCGCCGCCGCCTGTCTGAGCTGCTGCGCTATCATACCTCCCAGTCTGGAGATGAGATGACATCTCTGTCAGAGTATGTTTCTCGCATGAAGGAGACACAGAAGTCCATCTATTACATCACTGGTGAGAGCAAAGAGCAGGTGGCCAACTCAGCTTTTGTGGAGCGAGTGCGGAAACGGGGCTTCGAGGTGGTATATATGACCGAGCCCATTGACGAGTACTGTGTGCAGCAGCTCAAGGAATTTGATGGGAAGAGCCTGGTCTCAGTTACCAAGGAGGGTCTGGAGCTGCCTgaggatgaggaggagaagaagaagatggaagagAGCAAGGCAAAGTTTGAGAACCTCTGCAAGCTCATGAAAGAAATCTTAGATAAGAAGGTTGAGAAGGTGACAATCTCCAATAGACTTGTGTCTTCACCTTGCTGCATTGTGACCAGCACCTACGGCTGGACAGCCAATATGGAGCGGATCATGAAAGCCCAGGCACTTCGGGACAACTCCACCATGGGCTATATGATGGCCAAAAAGCACCTGGAGATCAACCCTGACCACCCCATTGTGGAGACGCTGCGGCAGAAGGCTGAGGCCGACAAGAATGATAAGGCAGTTAAGGACCTGGTGGTGCTGCTGTTTGAAACCGCCCTGCTATCTTCTGGCTTTTCCCTTGAGGATCCCCAGACCCACTCCAACCGCATCTATCGCATGATCAAGCTAGGTCTAGGTATTGATGAAGATGAAGTGGCAGCAGAGGAACCCAATGCTGCAGTTCCTGATGAGATCCCCCCTCTCGAGGGCGATGAGGATGCGTCTCGCATGGAAGAAGTCGATTAGGTTAGGAGTTCATAGTTGGAAAACTTGTGCCCTTGTATAGTGTCCCCATGGGCTCCCACTGCAGCCTCGAGTGCCCCTGTCCCACCTGGCTCCCCCTGCTGGTGTCTAGTGTTTTTTTCCCTCTCCTGTCCTTGTGTTGAAGGCAGTAAACTAAGGGTGTCAAGCCCCATTCCCTCTCTACTCTTGACAGCAGGATTGGATGTTGTGTATTGTGGTTTATTTTATTTTCTTCATTTTGTTCTGAAATTAAAGTATGCAAAATAAAGAATATGCCGTTTTTATACA

Publications

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