Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RBX1P2
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr22). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:80019656-80020869  UCSC
Coordinates (T2T) chr5:80503507-80504720  UCSC
Coordinates (hg19) chr5:79315479-79316692  UCSC
Strand +
Parental Sequence NM_014248.4
Parental seq. overlap 657 bp
Parental seq. overlap (%) 55%
Genomic Region Intragenic (THBS4)
Retrocopy Summary RBX1P2, located on chr5:80019656-80020869, is a retrocopy of the parental gene RBX1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RBX1
Full Name ring-box 1
Also known as BA554C12.1|RNF75|ROC1
Coordinate chr22:40951378-40973309
Strand +
Gene summary This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RBX1P2
Bonobo Pan paniscus RBX1P3
Gorilla Gorilla gorilla RBX1P2
Orangutan Pongo abelii RBX1P2
Gibbon Nomascus leucogenys RBX1P1
Green monkey Chlorocebus sabaeus RBX1P1
Crab-eating macaque Macaca fascicularis RBX1P1
Rhesus Macaca mulatta RBX1P1
Baboon Papio anubis RBX1P2
Golden snub-nosed monkey Rhinopithecus roxellana RBX1P1
Marmoset Callithrix jacchus RBX1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RBX1P2
TGCTTTGAAGTAAAAAAGTGAAATGCAGTAGCTAGCCCTCTGGGCTTGGGATGTTGTGGTTAATAACTGTGCCATCTGCAGGAATCACAGCATGGATCTGCATTGAATGTCAAGCTAACCAAGAGTCTGCCACTTCAGAAGTGTGTACCGTTGCACGGGGAGCCTGTAACCGTGCTTTTCACTTCACTGTCTCTCTCACTGGCTCAAAACACAACAGCTGTGCCTGTTGGACAACAGACAATAGGAATTCCCAAAGTATGGACACCAGAAAAAGAATTCTTCCATCAAGCTTAACTGTTTTGTGATTCATTTAATGACTTGCCCTTCTGTCACTTAATTATAAATTAGATAGAACTGTGTCTTTTCTGCTTTGTCTTTGCCATTTGCTGTTCTCGCAGCCACATTGTATTCTGTGTCAAATAAAGTCCAGTTGGATTCTAGAGCGAATGCTGTCTCCTGTGTATGTGAACAAAAGTGAACGTAAATGAAGGGTCCCCTCTTCCAAGGCTGAAAAGCCACCTTTTAAAAGTGAAATGTAAAGAAAGTGAAATGTGTGTCCATTAGAGCCAGAACAGGATTGTCCTGTGAGTGCATCGCTTAGTCAGAGGACTCCAACTGTACAAGGGGGAATGTGGATCGCTGACCCTGAAAACAGCAGTCAGCCCTGTCTTCCTCTGGTGTGATAGCAGCAGGCAGCTGAATGAaTGCAGGCTTCTAAGGACTACATGGCATTACATGGGGCACAGAAAGAGGCTTTATAAAATGCAAAACCACTATAGAAATGT
>NM_014248.4
GACAGACCGTGTGTTTCCAAAATGGCGGCAGCGATGGATGTGGATACCCCGAGCGGCACCAACAGCGGCGCGGGCAAGAAGCGCTTTGAAGTGAAAAAGTGGAATGCAGTAGCCCTCTGGGCCTGGGATATTGTGGTTGATAACTGTGCCATCTGCAGGAACCACATTATGGATCTTTGCATAGAATGTCAAGCTAACCAGGCGTCCGCTACTTCAGAAGAGTGTACTGTCGCATGGGGAGTCTGTAACCATGCTTTTCACTTCCACTGCATCTCTCGCTGGCTCAAAACACGACAGGTGTGTCCATTGGACAACAGAGAGTGGGAATTCCAAAAGTATGGGCACTAGGAAAAGACTTCTTCCATCAAGCTTAATTGTTTTGTTATTCATTTAATGACTTTCCCTGCTGTTACCTAATTACAAATTGGATGGAActgtgtttttttctgctttgttttttcagtttgctgtttctgtAGCCATATTGTATTCTGTGTCAAATAAAGTCCAGTTGGATTCTGGAACGGATGCTCTCTCTTGTGTATGTGAACAAAGTGAACATAAATGAAGAGTCTCCCCTTCCAAGGCTGAAAACTCAGCTTTTGAAAGTGAAATGTTTGTTCATCGGGGCCAGAGCAGGGTTGTCCTCTGAGCGCATCACTTAGTGACGAGGAATCCAACAGCTCAAGGCAGAGTGTGGATCACCGGCTCCCGAAAACAGCAGTCAGCCCTTCTTTCTCCTGTGTgacagcagtgggcagctgaaagagggaagaatgtgggattcagtcatcaaacccagttctgagtcctggttccacagcttgggtactgatggcaatcttggccaagttgtctctctactctgaactttcctcctctgtactgtgggcttctgaggactaagtggcatcatgtgggcacagagagaagctttgtaaaatgtaaaaccgctatacaaatgtgaCCTTTGGTTGTGTATGAcagcagtccccaacctttttgccaccagggattggtttcatggaagacgatttttccatggaccgggggtggggcgggggtgtgcttggggatggttttggaactgttccacctgagatcatgaggcagtagatggaccgcgcaacctagatccctcacatgcacggttcgccaatagggttgaa

Publications

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