Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MED27P1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:80350604-80351973  UCSC
Coordinates (T2T) chr5:80834579-80835947  UCSC
Coordinates (hg19) chr5:79646423-79647792  UCSC
Strand -
Parental Sequence NM_004269.4
Parental seq. overlap 1337 bp
Parental seq. overlap (%) 96.4%
Genomic Region Intergenic
Retrocopy Summary MED27P1, located on chr5:80350604-80351973, is a retrocopy of the parental gene MED27. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MED27
Full Name mediator complex subunit 27
Also known as CRAP34|CRSP34|CRSP8|MED3|NEDSCAC|TRAP37
Coordinate chr9:131860110-132079867
Strand -
Gene summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MED27P1
Bonobo Pan paniscus MED27P1
Gorilla Gorilla gorilla MED27P1
Orangutan Pongo abelii MED27P1
Gibbon Nomascus leucogenys MED27P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MED27P1
GCTGTGGCGGCGGCAACATGGCGGACGTGATAAATGTCAGTGTGAACCTGGAGGCCTTTTCCCAGGCCATTAGTGCCATCCAGGCGCTGCGCTCCAGCGTGAGCAGGTTGTTCGACTGCCTGAAGGATGGGATGCGGAACAAGGAGACGCTGGAGGGCCGGGAGAAGGCCTTCATTGCGCACTTCCAGGACAACTTACATTCGGTCAACCGGGACCTCAATGAGCTGGAACGTCTGAGCAATCTGGTAGGCAAGCCATCTGAGAACCATCCTCTTCATAACAGTGGGCTGTTAAGCCTGGATCCTGTGCAGGACAAAACTCCTCTCTATAGTCAACTCCTTCAAGCATATAAGTGGTCAAACAAGTTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGTAGTCGTTGAAGCGTTCCGCTAATCAGATGGGAGTATCTGCCAAAAGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTGAAAGTGATCGTCATCATGCGGAGCCTGTTCATTGATCGAACAATAGTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTTGATATATGGTCCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCACGCCACCACGGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTAGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCATGCCAGCACTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCGACATGGAGGGATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAAGCCCCCACGCTGGCCCCAGCGTGAGACCCCACCCGGCAACTTCCCAGACACTCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCCGCTCCTCCCTTTCAGCGCCATGTGTGCTGAGGCCACTCTTGAGGAGCAGACCCCCCCTGTGGCTGATGAGACTAATTATTCCCACTAGCCAGTGGACTGAAGGCAAAGAAGACTTTTCTAGAACCTGATAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCGTGTGTGTCGGCAGTGCTGGTGTCTTGTCGTTTCCGCGAGCTATTACTAGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGGTTTGGTAACTTATTTTTATAAGCAATAAACCTTTTGTAC
>NM_004269.4
AGAGCTGCTGTGGCGGCGGCAACATGGCGGACGTGATAAATGTCAGTGTGAACCTGGAGGCCTTTTCCCAGGCCATTAGTGCCATCCAGGCGCTGCGCTCCAGCGTGAGCAGGGTGTTCGACTGCCTGAAGGATGGGATGCGGAACAAGGAGACGCTGGAGGGCCGGGAGAAGGCCTTTATTGCGCACTTCCAGGACAACTTACATTCGGTCAACCGGGACCTCAATGAGCTGGAACGTCTGAGCAATCTGGTAGGCAAGCCATCTGAGAACCATCCTCTTCATAACAGTGGGCTGTTAAGCCTGGATCCTGTGCAGGACAAAACTCCTCTCTATAGTCAACTCCTTCAAGCATATAAGTGGTCAAACAAGTTGCAGTACCATGCAGGACTAGCATCTGGCCTTTTAAATCAGCAGTCATTGAAGCGTTCCGCTAATCAGATGGGAGTATCTGCCAAACGTAGACCAAAGGCTCAGCCCACAACTCTTGTCCTACCACCTCAATATGTTGATGATGTGATCAGCCGCATTGACAGGATGTTTCCTGAAATGTCCATCCACTTATCCAGACCCAATGGAACATCAGCAATGCTTCTGGTGACCTTGGGAAAGGTGTTGAAAGTGATCGTCGTCATGCGGAGCCTGTTCATTGATCGAACAATAGTAAAGGGATATAACGAGAATGTCTACACAGAAGATGGCAAGCTTGATATATGGTCCAAATCCAACTATCAAGTATTCCAGAAGGTGACAGACCATGCCACCACTGCCCTGCTCCACTATCAGCTGCCCCAGATGCCGGATGTCGTGGTCCGATCCTTCATGACCTGGTTAAGAAGTTACATAAAGCTGTTCCAGGCCCCGTGCCAGCGCTGCGGGAAGTTTCTGCAGGACGGCCTTCCCCCGACATGGAGGGATTTCCGAACCCTCGAAGCCTTCCATGACACCTGCCGGCAGTAGCCCCCACGCTGGCCCCAGCCTCAGACCCCACCCAGCACCTTCCCAGACACGCAGGAAGCCCACAGAAGGCTCAGCTGGTTCCTCACTGCCCAGATGTGTACAGCTGCTCCTCCCTTTCATAAAGCAGCGCCATGTGTGCAGAGGCCACTCTTGAAGAGCAGACTCCCTCTGTGGCTGATGGGACTAATTATTCCCACTAGCCAGCGGACTGAAGGCAAAGAAGACCTTTCTAGAACCTGGTAGAAGGAAGCTGTGCAGCATGCTCCTCGTCCATGTGTGTCGGCAGTGCTGGTGTCTGTCGTCTCCGCGAGCTGTTACTGGAATGAGCCCTTGTGTTCATGGGTATCGTCATGCGGGGTTCTTGTGTTTTGTGGGGCTTGGGTTTTGGTAACTTATTTTTATAAGCAATAAACCTTTTGTATCCTG

Publications

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