Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name ZP3P1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:83875481-83875652  UCSC
Coordinates (T2T) chr5:84363991-84364162  UCSC
Coordinates (hg19) chr5:83171300-83171471  UCSC
Strand -
Parental Sequence NM_012230.5_2
Parental seq. overlap 146 bp
Parental seq. overlap (%) 9.5%
Genomic Region Intergenic
Retrocopy Summary ZP3P1, located on chr5:83875481-83875652, is a retrocopy of the parental gene POMZP3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name POMZP3
Full Name POM121 and ZP3 fusion
Also known as POM-ZP3
Coordinate chr7:76609986-76627279
Strand -
Gene summary This gene appears to have resulted from a fusion of DNA sequences derived from 2 distinct loci, specifically through the duplication of two internal exons from the POM121 gene and four 3' exons from the ZP3 gene. The 5' end of this gene is similar to the 5` coding region of the POM121 gene which encodes an integral nuclear pore membrane protein. However, the protein encoded by this gene lacks the nuclear pore localization motif. The 3' end of this gene is similar to the last 4 exons of the zona pellucida glycoprotein 3 (ZP3) gene and the encoded protein retains one zona pellucida domain. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes POMZP3P1
Bonobo Pan paniscus POMZP3P1
Gorilla Gorilla gorilla LOC101143607P1
Orangutan Pongo abelii ZP3P1
Gibbon Nomascus leucogenys ZP3P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ZP3P1
TTCACAGTGAATGTCTTCCACTTTGCTAATGTCTCCAGAAACACAATATATATCACCTGTTATCTGAAGGTCAATCTGGTTGACCAAGTCCCAGATCAACTAAACAAAGCCTGTTCCTTCAGCAAGTTTTCCAATAGCTGGTCCCCAGTAGAAGACACTGCTGACATCTGTG
>NM_012230.5_2
AAGTCTCCTCCGCGGCGCGGAGCCGCGATGTCTCCGGCGGCTGCGGCGGCTGGAGCAGGCGAGCGGCGGCGGCCGATAGCGAGTGTCAGGGCCGGCCGGGGCGGCGCTTCTCGGCCTGTCGCTGGTCGGCCTCCTACTGTACCTCGTGCCTGCTGCGGCTGCGCTGGCCTGGCTGGCCGTGGGGACTACCGCGGCCTGGTGGGGACTGAGCCGCGAGCCCCGAGGTTCGCGCCCCTTGTCCTCCTTCGTTCAGAAGGCGCGACATCGGCGAACACTGTTCGCTTCGCCTCCGGCCAAGTCGACAGCCAACGGAAACCTCCTAGAGCCGCGGACCCTGCTCGAAGGACCTGACCCTGCCGAACTGCTCCTCATGGGCAGTTACCTGGGCAAGCCCGGGCCGCCGCAGCCCGCCCCCGCTCCGGAGGGCCAGGACCTGCGGAATAGGCCTGGccgccgcccgcccgcccggcgccgcgctccacaccgccctccccgccgaccCATCGCGTTCACCACTTTTACCCCTCTCTCCCCACTCCTCTTCTCCGACCCTCCGGGAGGCCTTCCCCACGGGATCGTGGGACTTTACCAGATCGGTTTGTAATAACACCTCGAAGACGCTATCCGATCCATCAGGCCCAGTATTCCTGTCCGGGGGTACTTCCCACAGTGTGCTGGAATGGTTATCACAAGAAGGCTGTGCTGTCCCCTCGCAACTCCAGGATGGTGTGTAGCCCAGTGACTCTGAGGATCGCCCCTCCTGACAGAAGATTTTCGCGTTCTGCGATACCAGAGCAGATAATCAGCTCAACACTGTCCTCACCATCAAGTAATGCCCCAGACCCATGTGCAAAGGAGACTGTACTGAGTGCCCTCAaagagaagaagaagaaaaggacagtggaggaagaagaCCAAATATTCCTTGATGGCCAGGAAAATAAAAGAAGCTGTCTTGTCGACGGTCTCACTGATGCCTCTTCTGCATTCAAAGTTCCTCGACCCGGGCCAGATACACTCCAGTTCACAGTGGATGTCTTCCACTTTGCTAATGACTCCAGAAACATGATATACATCACCTGCCACCTGAAGGTCACCCTAGCTGAGCAGGACCCAGATGAACTCAACAAGGCCTGTTCCTTCAGCAAGCCTTCCAACAGCTGGTTCCCAGTGGAAGGCCTGGCTGACATCTGTCAATGCTGTAACAAAGGTGACTGTGGCACTCCAAGCCATTCCAGGAGGCAGCCTCGTGTCGTGAGCCAGTGGTCCACGTCTGCTTCCCTGTAACCGCAGGCATGTGACAGAAGAAGCAGATGTCACCGTGGGGCCACTGATCTTCCTGGACAGGAGGGGTGACCATGAAGTAGAGCAGTGGGCTTTGCCTTCTGACACCTCAGTGGTGCTGCTGGGCGTAGGCCTGGCTGTGGTGGTGTCCCTGACTCTGACTGCTGTTATCCTGGTTCTCACCAGGAGGTGTCGCACTGCCTCCCACCCTGTGTCTGCTTCCGAATAAAAGAAGAAAGCAATA

Publications

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