Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CSNK1A1P3
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:98833523-98834004  UCSC
Coordinates (T2T) chr5:99336812-99337293  UCSC
Coordinates (hg19) chr5:98169227-98169708  UCSC
Strand +
Parental Sequence NM_001271742.2
Parental seq. overlap 453 bp
Parental seq. overlap (%) 9%
Genomic Region Intergenic
Retrocopy Summary CSNK1A1P3, located on chr5:98833523-98834004, is a retrocopy of the parental gene CSNK1A1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CSNK1A1
Full Name casein kinase 1 alpha 1
Also known as CK1|CK1a|CKIa|HEL-S-77p|HLCDGP1|PRO2975
Coordinate chr5:149492982-149551439
Strand -
Gene summary Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CSNK1A1P1
Bonobo Pan paniscus CSNK1A1P1
Gorilla Gorilla gorilla CSNK1A1P1
Orangutan Pongo abelii CSNK1A1P1
Gibbon Nomascus leucogenys CSNK1A1P1
Green monkey Chlorocebus sabaeus CSNK1A1P4
Crab-eating macaque Macaca fascicularis CSNK1A1P2
Rhesus Macaca mulatta CSNK1A1P2
Baboon Papio anubis CSNK1A1P2
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CSNK1A1P3
CATCTGAAGCAGCTATTCCGCATTCTTTTCAGGACCGTGAACCATCAATATGACTACACATTTGATTGGACAATGTAAAAGCAGAAAGTAGCACAGCAAGCAGCCTCTTCCAGTGGGCAGGGTCAGCAGGCCCAAACTCCCACAGGCAAGCAAACTGATAAAAGCAAGAGTAACATGAAAGGTTTCTAAGCATGAATTGAGGAACAGAAGAAGCAGAGCAGACGATCAGAGCAGCATTGGTTTCTCTCCAAATCTAGAATTTTTAGTTCATATGTACACTAGCCAGTGGTTATGGACAGTGTTGATGTAAAGAACTTAATTTCAGTATAAACGGACTCTGAGCAGCATTGGTGATGTTGTATCCTGAGTTGTAGCCACTGTAACTGTGACTATTAACTGAGAGAGTGAAACATGGTGTCTGGTTTTCTACTGCATTTTTTCAAGTGGAAAAGTTAACTAAATGGTTGACACACACAAATTGG
>NM_001271742.2
CTACCCCCTGAAGAGGCCTTTGAGGCTGGTTGCCTCGTTTTATAATTACCGAGAGCTTTCTCTTTCCAGCTTTTCACTTCTTCTTGTAGTCGCGACTTGGAGTTTTGCTAATGTCTCCCTCCTTTCCTAAGTGACATTGAATCCGTAGGGATGTTGATGCCATCATCCCCTCTTTCCCCTGCAGGAAGTGGCAGTGAAGCTAGAATCTCAGAAGGCCAGGCATCCCCAGTTGCTGTACGAGAGCAAGCTCTATAAGATTCTTCAAGGTGGGGTTGGCATCCCCCACATACGGTGGTATGGTCAGGAAAAAGACTACAATGTACTAGTCATGGATCTTCTGGGACCTAGCCTCGAAGACCTCTTCAATTTCTGTTCAAGAAGGTTCACAATGAAAACTGTACTTATGTTAGCTGACCAGATGATCAGTAGAATTGAATATGTGCATACAAAGAATTTTATACACAGAGACATTAAACCAGATAACTTCCTAATGGGTATTGGGCGTCACTGTAATAAGTGTTTAGAATCTCCAGTGGGGAAGAGGAAAAGAAGCATGACTGTTAGTACTTCTCAGGACCCATCTTTCTCAGGATTAAACCAGTTATTCCTTATTGATTTTGGTTTGGCCAAAAAGTACAGAGACAACAGGACAAGGCAACACATACCATACAGAGAAGATAAAAACCTCACTGGCACTGCCCGATATGCTAGCATCAATGCACATCTTGGTATTGAGCAGAGTCGCCGAGATGACATGGAATCATTAGGATATGTTTTGATGTATTTTAATAGAACCAGCCTGCCATGGCAAGGGCTAAAGGCTGCAACAAAGAAACAAAAATATGAAAAGATTAGTGAAAAGAAGATGTCCACGCCTGTTGAAGTTTTATGTAAGGGGTTTCCTGCAGAATTTGCGATGTACTTAAACTATTGTCGTGGGCTACGCTTTGAGGAAGCCCCAGATTACATGTATCTGAGGCAGCTATTCCGCATTCTTTTCAGGACCCTGAACCATCAATATGACTACACATTTGATTGGACAATGTTAAAGCAGAAAGCAGCACAGCAGGCAGCCTCTTCCAGTGGGCAGGGTCAGCAGGCCCAAACCCCCACAGGCAAGCAAACTGACAAAACCAAGAGTAACATGAAAGGTTTCTAAGCATGAATTGAGGAACAGAAGAAGCAGAGCAGATGATCGGAGCAGCATTTGTTTCTCCCCAAATCTAGAAATTTTAGTTCATATGTACACTAGCCAGTGGTTGTGGACAACCATTTACTTGGTGTAAAGAACTTAATTTCAGTATAAACTGACTCTGGGCAGCATTGGTGATGCTGTATCCTGAGTTGTAGCCTCTGTAATTGTGAATATTAACTGAGATAGTGAAACATGGTGTCCGGTTTTCTATTGCATTTTTTCAAGTGGAAAAGTTAACTAAATGGTTGACACACAAAAATTGGTGGAGAAATTGTGCATATGCCAATTTTTTGTTAAAACCTTTTGTTTTGAACTATACTGCTTTGAGATCTCATTTCAGAAGAACGGCATGAACAGTCTTCAGCCACAGTTGTGATGGTTGTTAAATGCTCACAATTGTGCATTCTTAGGGTTTTTCCATCCCTGGGGTTTGCAAGTTGTTCACTTAAAACATTCTTAAAATGGTTGGCTTCTTGTCTGCAAGCCAGCTGATATGGTAGCAACCAAAGATTCCAGTGTTTGAGCATATGAAAGACTCTGCCTGCTTAATTGTGCTAGAAATAACAGCATCTAAAGTGAAGACTTAAGAAAAACTTAGTGACTACTAGATTATCCTTAGGACTCTGCATTAACTCTATAATGTTCTTGGTATTAAAAAAAAAGCATATTTGTCACAGAAATTTAGTTAACATCTTACAACTGAACATGTATGTATGTTGCTTAGATAAATGTAATCACTGTAAACATCTATATGATCTGGGATTTTGTTTTTATTTTGAAATGGGAGCTTTTTTGTTTACAAGTTCATTAAAAACTAAAAACTGTTTCTGTAAGGAAATGAGATTTTTTTTAAACAACAAAAAATGCCTTGCTGACTCACTATTAAATAAAAATCTCCCCAATTTTTTGATAGACTACTTCAAGCCATTTGTTACATGGTATTCCTTTGCAAGTCAATTTAGGTTTCGTGTTATAACTTTTCCTCTTTTTTTAAGAAAAATGAAAAAAGTAATTCTTTTGTCTGAAGGGGAAAGGCAttctttcatttttttctttttttttttttttttttATGACTTGCAGGCACAATATCTAGTACTGCAACTGCCAGAACTTGGTATTGTAGCTGCTGCCCGCTGACTAGCAGCTGGACTGATTTTGAATAAAAATGAAAGCATTAAAGGGTTTCCCTACAAAACATTTTTCTTTAAAATACTTTTGAAATGGCTATAAGCAGTTGACTTTCACCCTTGGAGAGCATCACACTGTGTGAGGTTCAGTGATTGTTGACCCTCCCCAGCCCCTCCTGCTTCTTTAAGTTATCTGTGTGCGTGCGCTTCCTCTCAATCTTCTTTGCACGCTCATTTCTTTTTCTCTGACCCATGAGAAAGGAAAACTTACTGATGATAATTTTTAAATAGTGTAATTTATTCATTTATAGCATGTCAGGATAAATTAAAAGAACATTTGTCTGGAAATGCTGCCGGGAGCCTATTGTGTAAATGTAGGTATTTTGTAAAATAACCTTGAAATTGTAAATTGACACGTGTTTGGTCAGATTGTGTCAAGTTTAAtttgttttgttttcttttttcttttttttatttGAAAACTACTTTAGCAATAATTAATTCCATGATTATCACATTCTGCCATTAAGGGATATTAGTACCGTAATACTGAAGAAATTTTATTAAGTCTGAACTTCTGGGGTAGGCAGCTTCTTTGTTTCTTTTCTATCCACCCTTGTCGGTTGAGGTATTTGTTTCTTGACTAATAAACCCTTTGATACTTTTAGCCAGAAATCAGTCTCATAAAGCTATTTTTGAGTATAGTTTGTGTAAAATAAAAATGTTTAGCTTTGGTAATAACTTCCAAGCTGAACTCCCTCTAGCAAGATATTTTTCAGTGCTTTTATTTACTATGCACTTAGACTATGCACTTTTTCTGAAATATTTTTGTAACACTTTTTTGTATTTTTGCCATTTGAAAAGGTTGTGGTGTAGTTGGTCTGTAATTAAGTTGCAGATTTAAAACTGCTGTTAGCTTTGTAAATCAAAATATAGGTGTTTTTTGTCCTGGTATATCGTCATTCCATCTGCAGCTGGAGCTGGAATCCCATTGATCTTCTAGCTACCATTCATTTTCTTCACTGTTCACAAAAGAAGAGTGTGAAATTCAGTGAATGCTGTTACTAATCCTGTTACGAGATGAATCTCATTTCACCAAAATTAAATTATGTTTTTCCGCTAAAATGATGATACAAGTTGAAGACACATCACTCTGAAATTGGAAGACCTCACCACTTAAGGCTCCACAGTGGCTTACTCAGCTGAACTCTAGGTTACTACTCTTTACTTTGTTCACCCATTGGGGGGTGCAGTTTTTTTAAAATGTTGGGAGATGGCCATTCTAACTACTGTTGAATGTCTCTGTTTTGGGAAGGTATAACAAGAAATAAAAAAGAATATATATGAAGGGAGAGACTGGTTATCTCCTCCCATATGGTTGTGCTTATCCTCTTATGGCTTACAAATGAATATTTGGAGGTTTGCTTTCACAATGATTTCCCATCAACAAATATTTTTAGTAGGATTTTTCCTGTTTCTGTTAGTCCTTGCAGTACTCATAAATGTTTTAAGCTGAGCATACTGTAATAGTCATAAGTTTAATTTCATTATAATAAAAATAATCAAACAAAAGGACTTTAGAACCCAAGACAATGAGCTAGTTTTCCCTAAAGTTTGCTGAACTATTAAGGAATATGTTCTTATAGCTTTTGACTAGAATGAGTCATGGGAATTCTAAGAAGGGATGGCCTAGACATTTTTAGCTCAGTTAAATTCAGCATTTAATGCAGGTGAGTTCCTGGGTCGTTTTCCAACTAGTCTGGAACAGTCTGGTTCTGACTCAAACTGGTATAAAGCATTATTTTAGGTTTTCTCTTTGCCAGTTTTTAAGCAGTTATAACCATGTAAATCAAGATGTGAGGACATCTATATGAAGTATAGTAAAGAAGTGGTGTCAGCAGATCAATATGTGTGTCCTGGGTGTGCTGCTCTCTTAAGTGAGACTTTGTGAGACTATACTTTAAATGCATTATTACCATTGCTTACATTTTGGGGGATTTTCTTCCTCCTCAAAACTTCCATTTCTATTGTAATATTCTTAATGACAATCTTTTTTTTTTTTTAGCAGTGTATGTTTGAAACAGCCAAAGATGGCGATGAACCAAGTGTAAATTGATCTAAGCAGCCCATGCAGTTTGTGTTGAATCAACAAACAGTGTATTGTTGAAGTGAAATTATTTTCTGAAATGACTTGTTAGACCAGTTTTGAGGACATACTCAAAAGTAGAGTAATAATGGCTCctgggatggagaaatatgagatgaacctggaacattctattatggtgccacaaaggaaatctaaaaaaaaaaaaaaaaaaaaaagtggttggctaggagcagtggcacacgcctgtgattccagcactttgggaggccgaagtgggcaggagttcaagaccagcctggccaacatagtgaaaccctgtctctactaaaaatacaaaaattagccgggtgtggtggcgggcgcctgtaatcccagcttttcaagaggctgaggcagaagaatcgcttgaacccgggagatggaggttgcagtgagctgagatcgtgccactgcactccagcctgggcgttgcagtgagactccgtctcaacaacaacaaaaaggtggatacatgtcaaaagggcacaggagccacttgaaggattatacttgctaaatctgtgtcaattatcaaaataaactggtagcaacgtta

Publications

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