Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PRDX2P4
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:100135997-100136912  UCSC
Coordinates (T2T) chr6:101309724-101310639  UCSC
Coordinates (hg19) chr6:100583873-100584788  UCSC
Strand +
Parental Sequence NM_005809.6
Parental seq. overlap 831 bp
Parental seq. overlap (%) 89.1%
Genomic Region Intergenic
Retrocopy Summary PRDX2P4, located on chr6:100135997-100136912, is a retrocopy of the parental gene PRDX2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PRDX2
Full Name peroxiredoxin 2
Also known as HEL-S-2a|NKEF-B|NKEFB|PRP|PRX2|PRXII|PTX1|TDPX1|TPX1|TSA
Coordinate chr19:12796823-12801800
Strand -
Gene summary This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PRDX2P2
Bonobo Pan paniscus PRDX2P2
Gorilla Gorilla gorilla PRDX2P1
Orangutan Pongo abelii PRDX2P2
Gibbon Nomascus leucogenys PRDX2P2
Green monkey Chlorocebus sabaeus PRDX2P3
Crab-eating macaque Macaca fascicularis PRDX2P1
Rhesus Macaca mulatta PRDX2P1
Baboon Papio anubis PRDX2P2
Golden snub-nosed monkey Rhinopithecus roxellana PRDX2P2
Marmoset Callithrix jacchus PRDX2P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PRDX2P4
CCTGAGAACGTGAGTCCACGCGTCTGGTTGCCCGTGAGTCCAGCCTTAGCCCACGCAGCTTTCAGTCATGGCCTCCGTAATCGCGCGCATGGCATAGCCCGCCCCTGACTTCAAGGCCACCGCCGTGGTGGATGGATAGCGCTTTCAAAGAAGTGAAGCTGTAGGACTACAAAGAGAAATACGTGGTCCTCTTTTTCTACCCTCTGCACTTCACTTTTGTGTGCCCCACGGAGATCATCGCGTTCAGCGACCATGCCGAGGACTTCCGCAAGCTGGGCTGCGAAGTGCTGGGCATCTCAGTGGACTCTCAGTTCACCCACCTGGCTTGGATCAACAACCCCCAGAGGGAGGGAGACTTGGGCCCCCTGAACATCCCCCTGCTTGCTGAGGTGGCCAGTGGCTTGTCTGAGGATTACGCCGTGCTGAAAACAGATGCGGGCATTGCCTACAGGGGCCGCTTTATCAGTGATGGCAAGGGTGTCCTTTCCAGATCACTGTTAATGATTTGCCTGTGGGACGCTCCGTGGATGAGGCTCTGCGGCTGGTCCAGGCCTTCCAGTACGCAGAAGAGCACGCGGAAGTTTGTCCCGCTGGCTGGAAGCCTGGCACTGACACGATTAAGCTCAACGTGGGTGACAGCAAGGAAAATTTATCCAAACACAATTAGGCTGGCTGACGGATAGTGAGCTTGTGCCCTTACCTAGGTGCCTGTGCTGGCTGCCCACCAGTGCCGCCACCTGGGTGCCCTGTGCTGACCCAGGAAAGGCCAGACCTGCCCCTCCAAAGTCCACAGTCTGGGACACTGGAAGGCTAGACCAAGGCCGTCTCATGCCTCCACCTGGGAACTAGTAAATAGTGATGCCCTCCTACAAGCCCACCCAGCCGCACACAGGCCTAGAGTTGACCAATAAAGTAT
>NM_005809.6
GGCGCTGAGAACGCGGGTCCACGCGTGTGATCGTCCGTGCGTCTAGCCTTTGCCCACGCAGCTTTCAGTCATGGCCTCCGGTAACGCGCGCATCGGAAAGCCAGCCCCTGACTTCAAGGCCACAGCGGTGGTTGATGGCGCCTTCAAAGAGGTGAAGCTGTCGGACTACAAAGGGAAGTACGTGGTCCTCTTTTTCTACCCTCTGGACTTCACTTTTGTGTGCCCCACCGAGATCATCGCGTTCAGCAACCGTGCAGAGGACTTCCGCAAGCTGGGCTGTGAAGTGCTGGGCGTCTCGGTGGACTCTCAGTTCACCCACCTGGCTtgGATCAACACCCCCCGGAAAGAGGGAGGCTTGGGCCCCCTGAACATCCCCCTGCTTGCTGACGTGACCAGACGCTTGTCTGAGGATTACGGCGTGCTGAAAACAGATGAGGGCATTGCCTACAGGGGCCTCTTTATCATCGATGGCAAGGGTGTCCTTCGCCAGATCACTGTTAATGATTTGCCTGTGGGACGCTCCGTGGATGAGGCTCTGCGGCTGGTCCAGGCCTTCCAGTACACAGACGAGCATGGGGAAGTTTGTCCCGCTGGCTGGAAGCCTGGCAGTGACACGATTAAGCCCAACGTGGATGACAGCAAGGAATATTTCTCCAAACACAATTAGGCTGGCTAACGGATAGTGAGCTTGTGCCCCTGCCTAGGTGCCTGTGCTGGGTGTCCACCTGTGCCCCCACCTGGGTGCCCTATGCTGACCCAGGAAAGGCCAGACCTGCCCCTCCAAACTCCACAGTATGGGACCCTGGAGGGCTAGGCCAAGGCCTTCTCATGCCTCCACCTAGAAGCTGAATAGTGACGCCCTCCCCCAAGCCCACCCAGCCGCACACAGGCCTAGAGGTAACCAATAAAGTATTAGGGAAAGGTG

Publications

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