Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ARG2P1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:100177175-100178132  UCSC
Coordinates (T2T) chr6:101350928-101351885  UCSC
Coordinates (hg19) chr6:100625051-100626008  UCSC
Strand +
Parental Sequence NM_001172.4
Parental seq. overlap 814 bp
Parental seq. overlap (%) 42.6%
Genomic Region Intergenic
Retrocopy Summary ARG2P1, located on chr6:100177175-100178132, is a retrocopy of the parental gene ARG2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ARG2
Full Name arginase 2
Also known as -
Coordinate chr14:67619920-67651708
Strand +
Gene summary Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ARG2P1
Bonobo Pan paniscus ARG2P1
Gorilla Gorilla gorilla ARG2P1
Orangutan Pongo abelii ARG2P1
Gibbon Nomascus leucogenys ARG2P1
Green monkey Chlorocebus sabaeus ARG2P1
Crab-eating macaque Macaca fascicularis ARG2P1
Rhesus Macaca mulatta ARG2P2
Baboon Papio anubis ARG2P1
Golden snub-nosed monkey Rhinopithecus roxellana ARG2P1
Marmoset Callithrix jacchus ARG2P2
Mouse lemur Microcebus murinus ARG2P1
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ARG2P1
TGTCTCCTCCAGACGCAAGTGCATTCTATCCTGAAGAAGTCTGGTTGTGATAGGAGCCCCGTTCTTGTAGGGACAGAAAAGAAAAGGAGTGGAACATGGTCCAGCTGCCAGAAGAAAAATTGGATTGATGAAAAGGGTCTCCAATTTGGGCTGCTGCCTGAAAGACTTTGAAAAGTTTAGTTTTACTCCAGTCCCCACAGATGAGCTCTTCAACAACCCTACAGTGAATCTGTGCTCAGTGGCCCAGCCAACCAGCAACTGGCTGAGTTGGTTAGCAGAGCAGTGTTGTCTGGCTACAGCTGCGTCACGGTGAGAGGAGACCCCAGCCTGGCAATTAGTACCATTAGTGGTCATGCCTGGAACTGCCCAGACCTTTGTGTCACTTGGGTTGATGCCCAGAAGACATCAGTACACCCCTTACCACTTCATCAGGAAATCTCCATGGACTATCAGTTTCATTTCTCCTCACAGAACTACAGGGAAAGGTACCAGAACTTCCAGGATTTCCCTGGACAAACCTTGTATCTCCTCCCCAAGTATAGCGTATTCTGATCTAGGAGACATGGACCCTCTGGAACATTTTTTTAAAAGAACAATGATATCTAGTATTTTTCCGTGAGAGACATCAATCCATTTGGCACCCAGGAGGTCATGCAACAGAAATTTGATCTGCTGATTGGCAAAAGACAAAGGTCTGTCCATCTGAGTTTTGATATTGATGTATTTGACTGTACACTGGCTCCAGCTGCAGGAATCCCTATTGTAGGGGGACTGACCTTTCAAGAAGGCATCTATATTACTGGGGAAATACATAGTACAGGGTTGCTGTCAGCACTGGATCTTGTTGAAGTCAATCCTCAACTGGGCACTTTAGAGGAAAGGGCAAAGGCCACAGCTAGCCTGCCAGTAGATGTAACTGCTTTATGTTTGGGTCAGACAAGGGAAGGAGGGCACATTG
>NM_001172.4
ACTCCCGGCTTCCAACCGCGCGGAGCCTCTGCCTTGGAGATTCTCAGTGCTGCGGATCATGTCCCTAAGGGGCAGCCTCTCGCGTCTCCTCCAGACGCGAGTGCATTCCATCCTGAAGAAATCCGTCCACTCCGTGGCTGTGATAGGAGCCCCGTTCTCACAAGGGCAGAAAAGAAAAGGAGTGGAGCATGGTCCCGCTGCCATAAGAGAAGCTGGCTTGATGAAAAGGCTCTCCAGTTTGGGCTGCCACCTAAAAGACTTTGGAGATTTGAGTTTTACTCCAGTCCCCAAAGATGATCTCTACAACAACCTGATAGTGAATCCACGCTCAGTGGGTCTTGCCAACCAGGAACTGGCTGAGGTGGTTAGCAGAGCTGTGTCAGATGGCTACAGCTGTGTCACACTGGGAGGAGACCACAGCCTGGCAATCGGTACCATTAGTGGCCATGCCCGACACTGCCCAGACCTTTGTGTTGTCTGGGTTGATGCCCATGCTGACATCAACACACCCCTTACCACTTCATCAGGAAATCTCCATGGACAGCCAGTTTCATTTCTCCTCAGAGAACTACAGGATAAGGTACCACAACTCCCAGGATTTTCCTGGATCAAACCTTGTATCTCTTCTGCAAGTATTGTGTATATTGGTCTGAGAGACGTGGACCCTCCTGAACATTTTATTTTAAAGAACTATGATATCCAGTATTTTTCCATGAGAGATATTGATCGACTTGGTATCCAGAAGGTCATGGAACGAACATTTGATCTGCTGATTGGCAAGAGACAAAGACCAATCCATTTGAGTTTTGATATTGATGCATTTGACCCTACACTGGCTCCAGCCACAGGAACTCCTGTTGTCGGGGGACTAACCTATCGAGAAGGCATGTATATTGCTGAGGAAATACACAATACAGGGTTGCTATCAGCACTGGATCTTGTTGAAGTCAATCCTCAGTTGGCCACCTCAGAGGAAGAGGCGAAGACTACAGCTAACCTGGCAGTAGATGTGATTGCTTCAAGCTTTGGTCAGACAAGAGAAGGAGGGCATATTGTCTATGACCAACTTCCTACTCCCAGTTCACCAGATGAATCAGAAAATCAAGCACGTGTGAGAATTTAGGAGACACTGTGCACTGACATGTTTCACAACAGGCATTCCAGAATTATGAGGCATTGAGGGGATAGATGAATACTAAATGGTTGTCTGGGTCAATACTGCCTTAATGAGAACATTTACACATTCTCACAATTGTAAAGTTTCCCCTCTATTTTGGTGACCAATACTACTGTAAATGTATTTGGTTTTTTGCAGTTCACAGGGTATTAATATGCTACAGTACTATGTAAATTTAAAGAAGTCATAAACAGCATTTATTACCTTGGTATATCATACTGGTCTTGTTGCTGTTGTTCCTTCACATTTAAGTGGTTTTTCATCTTTCCTCCCTCCTCCCACAGCCTGGCTATACAGTGCATCCTTGAACTGTCAGCCCACAGCAGCAATATGCTTATTCTATCCACATCCCTAACATCATGCATTCACAAGGTCAAAGTTCTGGTCCACAAACCCTTCCCTATAGAAGTTCAATGGCTGCGAAAGAATTTGTAGTAAACCAGGCCTCCCAGGATGGCGAGCTCCAGTAAGATGATAATGGAAAGCAGCAGCTTGTTGGTTGTCACTCTACAAAGAGAAGCAAAGTGGGGAGTAGTCAGAAGTTTGGATAACCTTCCTTCTAAACATTTTGGGGTTAGACCTGGGACCACGGCTGGATACTCTGAGGCTGTATGTTTGATCACACAGCCACTTAGCAGGAAGTACTCATAaggttctttagctgtcacttagggataacactgtctacctcacagaaatgttAAACTGAGACAATAAAAACCAAAGCATAAAAA

Publications

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