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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ATP5MGP2
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:122859576-122860016  UCSC
Coordinates (T2T) chr6:124047869-124048309  UCSC
Coordinates (hg19) chr6:123180721-123181161  UCSC
Strand -
Parental Sequence NM_006476.5
Parental seq. overlap 421 bp
Parental seq. overlap (%) 37.5%
Genomic Region Intergenic
Retrocopy Summary ATP5MGP2, located on chr6:122859576-122860016, is a retrocopy of the parental gene ATP5MG. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ATP5MG
Full Name ATP synthase membrane subunit g
Also known as ATP5JG|ATP5L
Coordinate chr11:118401606-118409847
Strand +
Gene summary Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ATP5MGP5
Bonobo Pan paniscus ATP5MGP5
Gorilla Gorilla gorilla ATP5MGP7
Orangutan Pongo abelii ATP5MGP4
Gibbon Nomascus leucogenys ATP5MGP2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ATP5MGP2
GGGCGACAGACTTTCCATCCCAGAACCATTGGCCCAATTTTTCCGTAACCTTGTGGAAAAGACCCTGGTGCTGGTGAACGCTGCTGTGACTTACTCAAAGCCTTGATTGGCCACATTTTGGTACTACGCCAAGTTTGAGCTGGTTCCTCCCACCCCTGCTGAGATCCCTAGAGCTATTCAGAGTCTGAAAAAAATAGTCAATAGTGCTCAGACTGGTAGCTTCAAACAACTCACAGTTAAGGAAGCTGTGCTGAATGGTTTGGTGGCCACTGAGGTGTTATGTGGTTTTATGTCGGAGAGATCATAGGCAAGCGTGGCATCATTGGCTATGATGTTTGAAGACCAGTATTTAACATCTGATTATATTTGATTTATTATTTGAATGTTGTTGGACCATGTGTGATCAGACTGCTATCTGAATTAAATAAGATTTGTCAAAAT
>NM_006476.5
CCTTCCGGCGGGTGACATTCAGCCGGCGGTTCGGGGCGACGGACTCTCCATTCCAGAACCATGGCCCAATTTGTCCGTAACCTTGTGGAGAAGACCCCGGCGCTGGTGAACGCTGCTGTGACTTACTCGAAGCCTCGATTGGCCACATTTTGGTACTACGCCAAGGTTGAGCTGGTTCCTCCCACCCCTGCTGAGATCCCTAGAGCTATTCAGAGCCTGAAAAAAATAGTCAATAGTGCTCAGACTGGTAGCTTCAAACAGCTCACAGTTAAGGAAGCTGTGCTGAATGGTTTGGTGGCCACTGAGGTGTTGATGTGGTTTTATGTCGGAGAGATTATAGGCAAGCGGGGCATCATTGGCTATGATGTTTGAAGACCAATCTTTAACATCTGATTATATTTGATTTATTATTTGAGTGTTGTTGGACCATGTGTGATCAGACTGCTATCTGAATAAAATAAGATTTGTCAAAACTCAGTGTTTTCTCCATCAGATACTCCATGAAAGGTCACAATTTCTCTTGATATTAAGCTGGGTTGTCTTTAAACAACCCTAAATACACGTCTGTTTAGCCCGCAATTGGAAAGGATATATGTGGCAATATTAACCTGGTACATGAATATATGGGGATAACATTTTAATTTGAAGGTTTGGAATATATATATTTAAGCTTTATTTCCAGAACAGTGAGGGTTAGGTCTTGGGAAAACTATAACTTGCCAAAGTAGAAGAAATAGTAGTACCATATGCCAAAGTGATAGAGATGAATCATGTCAGTAGTTAGAATAACATTTCAACTGTTTTCTTTGCTAAAATCACAGAAAGACCCTATTGACAACATCTATGTCTGTAAAAATGTTAGAGTACTTGTCATCTTGAATATAGCCTCCCCAAGAGAGAACAGGGTGGTATTCTAAGTATGTTTCTTTGTAACATCTTTAGCAGTAGGACAGAGCCATACATGTGAAATCTGATTTTTATGTGTGTTATTCGTTTGTCTGGTTTTACTACCTTTGCAAAAACAAAATACCCCAAAGATATTTAAACAAGGTTATAATTTAGCATCTTCCCTGGATCTAAATAGTATATTATATCCTGAAATAAATGAAATGATTGCTATA

Publications

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