Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name BMPR1AP1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:129156535-129159507  UCSC
Coordinates (T2T) chr6:130349741-130352713  UCSC
Coordinates (hg19) chr6:129477680-129480652  UCSC
Strand -
Parental Sequence XM_011540103.2
Parental seq. overlap 2929 bp
Parental seq. overlap (%) 46.5%
Genomic Region Intragenic (LAMA2)
Retrocopy Summary BMPR1AP1, located on chr6:129156535-129159507, is a retrocopy of the parental gene BMPR1A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name BMPR1A
Full Name bone morphogenetic protein receptor type 1A
Also known as 10q23del|ACVRLK3|ALK-3|ALK3|BMPR-1A|CD292|SKR5
Coordinate chr10:86755786-86927969
Strand +
Gene summary The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes BMPR1AP1
Bonobo Pan paniscus BMPR1AP1
Gorilla Gorilla gorilla BMPR1AP1
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>BMPR1AP1
GCTCCCGAATCGATGAGGAAAGCCGCTCTCCCCGGCAGATCCTCCCGGCCGGGGCGCCTCCATCACCCTGCCTGCGCCTCGGCACGCTGGCAAGGAGCCCGGGAAGAGACGCCGGGAGCGACTTATGAAAATATGCATCAGTTTAATACTGTCTTGGAATTCATGAGATGGAAGCATAGGTCAAAGCTGTTTGGAGAAAATCGGAAGTACAGTTTTATCTAGCCACATCTTGGAGGAGTCGTAAGAAAGCAGTGGGAGTTGAAGTCATTGTCAAGTGCTTGCGATCTTTTACAAGAAAATCTCACTGAATGACAGTCATTTAAATTGGTGAAGTAGCAAGACCAATTACTAAAGGTGACAGTACACAGGAAACATTACAATTGAACAATGACTCAGCTATACATTTACATCAGATTATTGGGAGCCTATTTGTTCATCATTTCTCGTGTTCAAGGACAGAATCTGGATAGTATGCTCCACGGCACTGGGATGAAATCAGACTCCGACCAGAAAAAGTCAGAAAATGGAGTAACCTTAGCACCAGAGGATACCTTGCCTTTTTTCAAGTGCTATTGCTGAGGGCACTGCCCAGATGATGCTATTAATAACACATGCATAACTAATGGACGTTGCTTTGCCATCATAGAAGAAGATGACCAGGGAGAAACCACATTAGCTTCAGGGTGTATGAAATATGAAGGATCTGATTTTCAGTGCAAAGATTCTCCAAAAGCCCAGCTACGCCGGACAATAGAATGTTGTCGGACCAATTTATGTAACCAGTATTTGCAACCCACATGCCCCCTGTTGTCATAGGTCCGTTTTTTGATGGCAGCATTCGATGGCTGGTTTTGCTCATTTCTATGGCTGTCTGCATAATTGCTATGATCATCTTCTCCAGCTGCTTTTGTTACAAACATTATTGCAAGAGCATCTCAAGCAGACGTCGTTACAATCGTGATTTGGAACAGGATGAAGCATTTATTCCAGTTGGAAAATCACTAAAAGACCTTATTGACCAGTCACAAAGTTCTGGTAGTGGGTCTGGACTACCTTTATTGGTTCAGCGAACTATTGCCAAACAGATTCAGATGGTCCGGCAAGTTGGTAAAGGCCGATATGGAGAAGTACGGATGGGCAAATGGCATGGCGAAAGAGTGGCGGTGAAAGTATTCTTTACCACTGAAGAAGCCAGCTGGTTTCGAGAAACAGAAATCTACCAAACTGTGCTAATGCGCCATGAAAACATACTTGGTTTCATAGCGGCAGATATTAAAGGTACAGGTTCCTGGACTCAGCTCTATTTGATTACTGATTACCATGAAAATGGATCTCTCTATGACTTCCTGAAATGTGCTACGCTGGACACCAGAGCCCTGCTTAAATTGGCTTATTCAGCTGCCTGTGGTCTGTGCCACCTGCACACAGAAACGTATGGCACCCAAGGAAAGCCCGCAATTGCTCATCGAGACCTAAAGAGCAAAAACATCCTCATCAAGAAAAATGGGAGTTGCTGCATTGCTGACCTGGGCCTTGCTGTTAAATTCAACAGTGACACAAATGAAGTTGATGTGCCCTTGAATACCAGGGTGGGCACCAAACGCTACCTGGCTCCAGAAGTGCTGGACGAAAGCCTGAACAAAAACCACTTCCAGCCCTACATCATGGCTGATATCTACAGCTTCGGCCTAATCATTTGGGAGATGGCTCGTCGTTGTATCACAGGAGGGATCGTGGAAGACTACCAATTGCCATATTATAACATGGTACCGAGTGATCCGTCATACGAAGATATGCGTGAGGTTGTGTGTGTCAAACGTTTGCGGCCAATTGTGTCTAATCGGTGGAACAGTGATGAATGTCTACGAGCAGTTTTGAAGCTAATGTCAGAATGCTGGGCCCACAATCCAGCCCCCAGACTCACAGCGTTGAGAATTAAGAAGACGCTTGCCAAGATGGTTGAATCCCAAGATGTAAAAATCTGACGGTTAAACCATCGGAGGAGAAACTCTAGACTGCAAGAACTGTTTTTACCCATGGCATGGGTGGAATTAGAGTGGAATAAGGATGTTAACTTGGTTCTCAGACTCTTTCTTCACTACGTGTTCACAGGCTGCTAATATTAAACCTTTCAGTACTCTTATTAGGATACAAGCTGGGAACTTCTAAACACTTCATTCTTTATATATGGACAACTTTATTTTAAATGTGGTTTTTGATGCCTTTTTTTAAATGGGTTTTTATGAACTGCATCAAGACTTCAATCCTGATTAGTGTCTCCAGTCAAGCTCTGGGTACTGAATTGCCTGTTCATAAAACGGTGCTTTCTGTGAAAGCCTTAAGAAGATAAATGAGTGCAGCAGAGTTGGAGAAATAGACTTTGCCTTTTACCTGAGACATTCAGTTCGTTTGTATTCCACCTTTGTAAAACAGCCTATAGATGATGATGTGTTTGGGATACTGCTTAGTTTATGATAGTTTGTCCTGTCTCCTTAGTGATGTGTGTGTGTCTCCATGCACATGCACGCCAGGATTCCTCTGTTGCCATTTGAATTAGAAGAAAATAATTTATATGCATGCACAGGAAGATATTGGTGGCCGGTGGTTTTGTGCTTTAAAAATGCAATATCTGACCAAGATTCGCCAATCTCATACAAGCCATTTACTTTGCAAGTGAGATAGCTTCCCCACCAGCTTTATTTTTTAACATGAAAGCTGATGCCAAGGCCAAAAGAAGTTTAAAGCATCTGTAAATTTGGACTGTTTTCCTTCAACCACCATTTTTTTTGTTGTTATTATTTTTGTCACGGAAAACATCCTCTCCTAAGTTGGAGCTTCTATTGCCATGAACCATGCTTACAGAGAAAGCACTTCTTATTGAAGTGAATTCCTGCATTTGATAGCAATGTAAGTGCCTATAACCATGTTCTGTATTCTTTATTCTCAGTAACTTTTAAAAGGGAAGTTATTTAA
>XM_011540103.2
ATGCCGCTGGAATTCGCGGGCTCGCAGGTCACAGGAGCCCGGGCGCGCCGGGCCTGGCGCTCCCGAATCGATGAGGGAAGCCGCTCTCCCCGGCAGATCCTCCCGGCCGGGGAGCCTCCATCACCCTGCCTGCGCCTCGGCACGCTGGCAAGGAGCCCGGGAAGAGACGCCGGGAGCGACTTATGAAAATATGCATCAGTTTAATACTGTCTTGGAATTCATGAGATGGAAGCATAGGTCAAAGCTGTTTGGAGAAAATCAGAAGTACAGTTTTATCTAGCCACATCTTGGAGGAGTCGTAAGAAAGCAGTGGGAGTTGAAGTCATTGTCAAGTGCTTGCGATCTTTTACAAGAAAATCTCACTGAATGATAGTCATTTAAATTGGTGAAGTAGCAAGACCAATTATTAAAGGTGACAGTACACAGGAAACATTACAATTGAACAATGCCTCAGCTATACATTTACATCAGATTATTGGGAGCCTATTTGTTCATCATTTCTCGTGTTCAAGGACAGAATCTGGATAGTATGCTTCATGGCACTGGGATGAAATCAGACTCCGACCAGAAAAAGTCAGAAAATGGAGTAACCTTAGCACCAGAGGATACCTTGCCTTTTTTAAAGTGCTATTGCTCAGGGCACTGTCCAGATGATGCTATTAATAACACATGCATAACTAATGGACATTGCTTTGCCATCATAGAAGAAGATGACCAGGGAGAAACCACATTAGCTTCAGGGTGTATGAAATATGAAGGATCTGATTTTCAGTGCAAAGATTCTCCAAAAGCCCAGCTACGCCGGACAATAGAATGTTGTCGGACCAATTTATGTAACCAGTATTTGCAACCCACACTGCCCCCTGTTGTCATAGGTCCGTTTTTTGATGGCAGCATTCGATGGCTGGTTTTGCTCATTTCTATGGCTGTCTGCATAATTGCTATGATCATCTTCTCCAGCTGCTTTTGTTACAAACATTATTGCAAGAGCATCTCAAGCAGACGTCGTTACAATCGTGATTTGGAACAGGATGAAGCATTTATTCCAGTTGGAGAATCACTAAAAGACCTTATTGACCAGTCACAAAGTTCTGGTAGTGGGTCTGGACTACCTTTATTGGTTCAGCGAACTATTGCCAAACAGATTCAGATGGTCCGGCAAGTTGGTAAAGGCCGATATGGAGAAGTATGGATGGGCAAATGGCGTGGCGAAAAAGTGGCGGTGAAAGTATTCTTTACCACTGAAGAAGCCAGCTGGTTTCGAGAAACAGAAATCTACCAAACTGTGCTAATGCGCCATGAAAACATACTTGGTTTCATAGCGGCAGACATTAAAGGTACAGGTTCCTGGACTCAGCTCTATTTGATTACTGATTACCATGAAAATGGATCTCTCTATGACTTCCTGAAATGTGCTACACTGGACACCAGAGCCCTGCTTAAATTGGCTTATTCAGCTGCCTGTGGTCTGTGCCACCTGCACACAGAAATTTATGGCACCCAAGGAAAGCCCGCAATTGCTCATCGAGACCTAAAGAGCAAAAACATCCTCATCAAGAAAAATGGGAGTTGCTGCATTGCTGACCTGGGCCTTGCTGTTAAATTCAACAGTGACACAAATGAAGTTGATGTGCCCTTGAATACCAGGGTGGGCACCAAACGCTACATGGCTCCCGAAGTGCTGGACGAAAGCCTGAACAAAAACCACTTCCAGCCCTACATCATGGCTGACATCTACAGCTTCGGCCTAATCATTTGGGAGATGGCTCGTCGTTGTATCACAGGAGGGATCGTGGAAGAATACCAATTGCCATATTACAACATGGTACCGAGTGATCCGTCATACGAAGATATGCGTGAGGTTGTGTGTGTCAAACGTTTGCGGCCAATTGTGTCTAATCGGTGGAACAGTGATGAATGTCTACGAGCAGTTTTGAAGCTAATGTCAGAATGCTGGGCCCACAATCCAGCCTCCAGACTCACAGCATTGAGAATTAAGAAGACGCTTGCCAAGATGGTTGAATCCCAAGATGTAAAAATCTGATGGTTAAACCATCGGAGGAGAAACTCTAGACTGCAAGAACTGTTTTTACCCATGGCATGGGTGGAATTAGAGTGGAATAAGGATGTTAACTTGGTTCTCAGACTCTTTCTTCACTACGTGTTCACAGGCTGCTAATATTAAACCTTTCAGTACTCTTATTAGGATACAAGCTGGGAACTTCTAAACACTTCATTCTTTATATATGGACAGCTTTATTTTAAATGTGGTTTTTGATGCCTTTTTTTAAGTGGGTTTTTATGAACTGCATCAAGACTTCAATCCTGATTAGTGTCTCCAGTCAAGCTCTGGGTACTGAATTGCCTGTTCATAAAACGGTGCTTTCTGTGAAAGCCTTAAGAAGATAAATGAGCGCAGCAGAGATGGAGAAATAGACTTTGCCTTTTACCTGAGACTTTCAGTTCGTTTGTATTCTACCTTTGTAAAACAGCCTATAGATGATGATGTGTTTGGGATACTGCTTATTTTATGATAGTTTGTCCTGTGTCCTTAGTGATGTGTGTGTGTCTCCATGCACATGCACGCCGGGATTCCTCTGCTGCCATTTGAATTAGAAGAAAATAATTTATATGCATGCACAGGAAGATATTGGTGGCCGGTGGTTTTGTGCTTTAAAAATGCAATATCTGACCAAGATTCGCCAATCTCATACAAGCCATTTACTTTGCAAGTGAGATAGCTTCCCCACCAGCTTTATTTTTTAACATGAAAGCTGATGCCAAGGCCAAAAGAAGTTTAAAGCATCTGTAAATTTGGACTGTTTTCCTTCAACCACCATTTTTTTTGTGGTTATTATTTTTGTCACGGAAAGCATCCTCTCCAAAGTTGGAGCTTCTATTGCCATGAACCATGCTTACAAAGAAAGCACTTCTTATTGAAGTGAATTCCTGCATTTGATAGCAATGTAAGTGCCTATAACCATGTTCTATATTCTTTATTCTCAGTAACTTTTAAAAGGGAAGTTATTTATATTTTGTGTATAATGTGCTTTATTTGCAAATCACCCACTCCTTTACAACCATACTTTATATATGTACATACATTCATACTGTAGAAACCAGCTCATGTGTACCTCATATCCCATCCTTAAGAGAAGAAATGTTATAAAGTAGAACTAAATATAAATTTTCAGAATTAATGCATTCAAAGTAATATATCAAATCCAGGACTTTGTTAACTTCAGGTAAAAACTTCATTAGGGTAATATCATCTCAATTTTTTCAAATGAAAGGATTCTCTAATTAGAAATTTATATGTCAGAGCTGTTATAAATTTATCAACTGTCAAATATGTTCTGGACAGCTAAATCATTTGAGATTTTTGGTTTTTTGATTTCTATTCCCTAACTTGTGAAGACAATGAAAAATCAGGCAGAAATATTTAGTATCTAGTCAGTATCTGTAGCTACACTGTATAACTGTTCTTCAATAAAATGGTTCATATTTTATAGATGCCTTGTTATCTCAAGAAATCTGATTTACATAAACTTATACTTCTTTAATGCTTTTTAAATATTTATTCTGAGCAAACAATTCATGAGTACATCAAGTGAGATAGTTTTATTTGATTATAACATAAAATAAATGTGATTATATCACATCATCATCAAAAAGGTTTAAATTAAATGGGAGGAAATCAGCATATGTCCACCCATTACCAAAATTTGACTATCATTTAAGGTTAAAACTTACAAATTTGTCTGCACATCAAATTTCACAAATTTGAAAATTGCCTTAACCATTTTGATTAATAAGTTTCATCTGCCATAATTAAAGTCTGAAGTGTTCATCAAGATAAGTAAATTTGCATATGGATAATACCCAATAACTTGTTTTTTCAGAATTTTTCACCATATGTATACTGAGAAATACAAATATTTTAATCTGCGTTGCCGTATGATATGATTGCACTTAGAACACCCAATTTACTTAAATCTTGGTTTACTTTTGACTTGATACCATAATCTTTAAAATCATTTGTCATCtttttttttttttttttgagacggagtctcgctctgtcgcccaggctggactgcggactgcagtggcgcaatctcggctcactgcaagctccgcttcccgggttcacgccattctcctgcctcagcctcccgagtagctgggactacaggcgcccgccaccgcgcccggctaattttttgtatttttagtagagacggggtttcaccttgttagccaggatggtctcaatctcctgacctcatgatccacctgcctcggcctcccaaagtTCATTTGTCATCTTAATAAAAATATAAAGACAGGCAAAGTTTATTGGAAATGTTCAAATGGTGTGTGGAAGCAAAAAATTACAGCCAGTATATGAGACCACTATTATGGTTTTTTAAAATTAACTTGGTCTAGTAAAAGTGATATCAAGAGTTAATCTTAGAAACTTGCTCAGTAAAAACATTTTCTAGTATAACATGTTCTTTAAAAAGCAAATGCTGCCGTCTTTGGAATCTTAATCTAAAAATGTggccgggcgcggtggctcacgcctgtaatcccaacactttgggaggctgaggcgggtggatcacaaggtcaggagttcaagaccagcctggccaacatggtgaaaccccatctctactaaaaataaaaaactcagccaggcgtggtggcgggtgcctgtaatcccagctactcgggaggctgaagcaggagaattgcttaaaatcagaaggtggaggttgcagtgagctgagatcgtgtcactgcactccagcctgggcaaaagagcgaaactccatctcaaataaacaaacaaataaataacaaaaaaCAAAAATGTTGCATTAAACTTAGTTCTTGTCTCTCCTTTCCACTCTTATTCTTAAATCTGAAGCTCATCGACTAAGTGAAATATTTAAAGAATATGATAGGCCAGCAAGAAGAAGTATTATGTAGTACCATAGTTAGTAAATTCGTAAAACCTTGGAAGCCATTATTTGGTCCCACTTGCAATTTAGTGTTTTTGAAGTGTGTAGCTTCATTCAGATAGCTCTTTAAATAATTAAAATATAAAAGCAAACAACCCAAACTACCTGACTATAAACAGGAAAAGTTAACCCTCAAAGAGAGTTCTTGTGAATTCTCTTTATGCTGGCAAATAGCTCTAGGATTAAAGGCACATTAGGGTTTCCTTCAGTTTGTTTATTCTAAGCTTTTACTGTGCTTTTTACTGAACAAGTTTCTGATGTATAAAACTTGCATCTGATTTCTTTGGAAATATTTTCACAAAAGTTATTTTAATCAGTATTTTTACATTGCCTTTCCAGTGTCCAGAAGTGTTTCTAAACTTAGAAAGTGACCTATAGTTTTTTAAAATTATGTTTTCCTAGAACGTGCCAAATTTTGATTTACTCTAACAATCAGTACTTTTCTTCAGATGCTTTGTTCTGTTTAGAACAAAAATGCACTATAGTTTTTAAAGAATCATGCATCTTTGGGTTGGCCCAGGATCAAATTTGATATTGAATAATTTATTCCAGGGCAGCTTTCATAAACATACTTCATAGATGTTGTTTTGAAATGTTTCTAAATATCTAAAATCATTTCAACAGCAGAAATGATTTTTATTTTAACAAAAGATTATGATAGCCCTTGTAGTGTTTAAAAGTGGTCATATTTATTACTGACTTTGAGTCAGGTGTTAAAATAGCAGTGCCACAGCTCGTCTCTTGCCTTAGTGTGCTGCTGTGAGAGTCACAGTGGAAACTGCAGGGAGGAGGTGTGTTCCTAAGAACCAAAATCCAGCACAGCATCCTGTGAAGCCACGTGTAATGATGGTCCCATAAGGAAAGTATGTGAATATGGCTCTTGTAAAGGATTAACTATTGTAATTTTAGCTTATGCTCTGTATTCTGTTTTCTATGGAATTATTTAAGCCCTTTTAGTGACCTTTGTCCTGGCCCATTTAAAAACTAAAATGTAGTATATATTGTATAAAATGGAAATATCATTATTGCTTCATTAGGGGAAACTGTACATAGGCATTGAAAGAAGGGTAAAAGCAAGCAGTTTTATCAGGCAGTTGTAAAACACCAAAAATATAGATTCGTCTTTGACGTGTAACACACTAAATGTATTTTGTACAGCATCTGGTTTAAAAGGTGCCTTAAGAGTTTACCATTACTTGCTTTGTTCTATATACAGATTATGTCCAATGTATCATTTTGAAGTAAATAACCTTATTTTAGTATA

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