Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PPCSP1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:136419429-136420374  UCSC
Coordinates (T2T) chr6:137607592-137608537  UCSC
Coordinates (hg19) chr6:136740567-136741512  UCSC
Strand -
Parental Sequence NM_001287508.2
Parental seq. overlap 447 bp
Parental seq. overlap (%) 19.7%
Genomic Region Intragenic (MAP7)
Retrocopy Summary PPCSP1, located on chr6:136419429-136420374, is a retrocopy of the parental gene PPCS. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PPCS
Full Name phosphopantothenoylcysteine synthetase
Also known as CMD2C
Coordinate chr1:42456341-42473417
Strand +
Gene summary Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PPCSP1
Bonobo Pan paniscus PPCSP1
Gorilla Gorilla gorilla PPCSP1
Orangutan Pongo abelii PPCSP1
Gibbon Nomascus leucogenys PPCSP1
Green monkey Chlorocebus sabaeus LOC103225003P1
Crab-eating macaque Macaca fascicularis PPCSP1
Rhesus Macaca mulatta PPCSP1
Baboon Papio anubis PPCSP1
Golden snub-nosed monkey Rhinopithecus roxellana PPCSP1
Marmoset Callithrix jacchus PPCSP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PPCSP1
ATTGGATAATCCTCAGTCTTGACACACAGCTTTAATATGTGACAAAAACTGAAGTAAAAAGCCCTTACAGGATCAAAAATTGTCCAGGGCTCTTACAGATGGTGAAAACTTTAATAAAACTTTTGCTTTCCTATGAACAGAGAAAATGAAGGAAAGGGAAAAGGCAGTGGTGCGCAGGCAAATATGCTTTGTTATTCATCTTTTAATGACATGTGATACACTCACCTGAATGTCATCTTGATTTTGAAATTGAACCCTAGAACTGTTTCTCACCTTTAAAAATAAGAGCTTATTGGGAAATATATATTACTTAAGGTACACATGGGGGCCTGAATATCAGCCTTCTTTATACTATAAAAAGAGGATTATGGATGCATGAATGGTCATGCTTTGGAAATCTGAGGTTATGGCCCACTTCGCGGCCGGGCTGGGCACGCAGGGCAAGCGGGTGGTGTTGGTCACGTCAGGCAGCACCAAGGTCCCTCTGGAAGCATGGCCGGCTCTTCTGCGATGTTTTACCTGGCGCGGCCCTGTCAGATTTCTATGTTCCTGGCTCTGAAATGCCTGAACACAAGATCCAGTCATCTGGGGGCCCACTGCAGATAACAATGAAGATGGTGCCAAAAATACTTTCTTCTTTGATTAAAGATTGTGCTCCCAAAGCATTTATAATTTCCTTTAAGTTGGAGACTGACCCCTCCATTGTAATTAATCGAGCTCAGAAGGCTTTGGAAGTTTATCAGCATCAAGTGGTGGTGGCTAATATCCTTGAGTCACAACAGTCCTTTGCAGTTATTGTAACCAGACACTCAGAAACCAAGTTATAGCTATCAGAGGAa
>NM_001287508.2
aggcgccggccgctgcgctgcAGATGGCGGAAATGGATCCGGTAGCCGAGTTCCCCCAGCCTCCCGGTGCTGCGCGCTGGGCTGAGGTTATGGCTCGCTTCGCGGCCAGGCTGGGCGCGCAGGGCCGGCGGGTGGTGTTGGTTACGTCAGGCGGCACCAAGGTCCCACTGGAAGCGCGGCCGGCCCTTCTGCGATGTTTTACCTGGCTGCGGCTGTGTCAGATTTCTATGTTCCTGTCTCTGAAATGCCTGAACACAAGATCCAGTCATCTGGGGGCCCACTGCAGATAACAATGAAGATGGTGCCAAAACTGCTTTCTCCTTTGGTTAAAGATTGGGCTCCCAAAGCATTTATAATTTCCTTTAAGTTGGAGACTGACCCCGCCATTGTAATTAATCGAGCTCGGAAGGCTTTGGAAATTTATCAGCATCAAGTGGTGGTGGCTAATATCCTTGAGTCACGACAGTCCTTTGTGTTTATTGTAACCAAAGACTCGGAAACCAAGTTATTGCTATCAGAGGAAGAAATAGAAAAAGGCGTAGAGATAGAAGAGAAGATAGTGGATAATCTTCAGTCTCGACACACAGCTTTTATAGGTGACAGAAACTGAAGTAAAAAGCCCTTATAGGATCAAAAATTGTTCAGGGCTCTTAGAGATGGTGAAAACTACAAAAAAAACCATGGCTTTCATATGGACAGATAAAATGAAAGAAAGGGAAAAGGCAGTGGTGTGTAGGCAAATATGGTTTGGCATTTGTCTTTTAATGACACCTGATATGATGTCATTTTGATTTTGAAATTGAACACTAGAACTGTTAATCACCTTTAAAAAGAAGAGCTTATTGGGAATTATATATTCCTTAAAATATACATGGGGGCCTGAATGTCAGCCATCTTTATACTATAGAAAAAGGATTATGGATGCATGAATGGTCATGCTTTGGAGATcaaatattggttgaatgcctatgtatgtcaggccctgtgctgagccatgaggattaaaaagatgaataaacatatcttgtTTAGGAAATGGATGTATAAAAAAATCAAGTGCAATAAAGTGTGTGTCCAAAAGCTGACACAATGGAAAGGATGTTTTGTTTTGTTTGAAATTTATCAAATATAGTAGTAGGAAAGAAGGATACCTCCCTGAAGATAGATTGTAGAATGGTGAGCTTTTCACTGCATTTACTTTTTGCTTCTTATTGTAGATTCACCTCATGTTTGGGTAATAGTTTACATTTCAAGTATTTTAGGACTGCTTTTCAGTTTAACTTAATATGTCCTTCCACCTGGGACCAGGCAGGGGCCACTTGGTGATCTCTGTCCTgagggatgcattacagtgtggtagagtatgggctagaagtcaacttagccagctgtgccacctattagctttataaacttaggcatttgacttaatctcagtgtccacatgcataaaatgaggataatctctctgcaaagtaatgccatttattgtgaggatcaaatgaaatagcaaaaagaaagcatcagtctggtgcctagcatttgattcacactcactaaatggttgcaattattGTTTTTCTCACTTAGCAAAGCAGTGTTACACCACTGCCCTGCTTAATCTTTGAATCCTTGAGAATCTTTGAAAAACTTTCAATACTTCTCTTGCTGTCCTACGTTTTGGGTTTGGAGTGCACAAGTAGCATAGTGCAAAAAAATTCCCTAAATGATCTGTAGGATAGTCCAGGTGCAATTTGAAAAATTAGCATTGATGACTAAGGTAGAAGCAGGTACTGTGTTTCACATAAATATTTGACTTAAAATACAATTCATGGTGTTTCATGGAGTAGGGAAGGGTAGCCCCTGTGTCTGTCTGATAATAGAAGTACAATAAATTTAATTGAGAAGATTTGACAGAAA

Publications

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