Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RHBDD1P1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:144397983-144398822  UCSC
Coordinates (T2T) chr6:145590598-145591437  UCSC
Coordinates (hg19) chr6:144719119-144719958  UCSC
Strand +
Parental Sequence NM_001349071.2
Parental seq. overlap 713 bp
Parental seq. overlap (%) 15%
Genomic Region Intragenic (UTRN)
Retrocopy Summary RHBDD1P1, located on chr6:144397983-144398822, is a retrocopy of the parental gene RHBDD1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RHBDD1
Full Name rhomboid domain containing 1
Also known as RHBDL4|RRP4
Coordinate chr2:226800159-226999210
Strand +
Gene summary Enables serine-type endopeptidase activity. Involved in several processes, including cellular response to unfolded protein; membrane protein proteolysis; and positive regulation of protein catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RHBDD1P1
Bonobo Pan paniscus RHBDD1P1
Gorilla Gorilla gorilla RHBDD1P1
Orangutan Pongo abelii RHBDD1P1
Gibbon Nomascus leucogenys RHBDD1P1
Green monkey Chlorocebus sabaeus RHBDD1P1
Crab-eating macaque Macaca fascicularis RHBDD1P1
Rhesus Macaca mulatta RHBDD1P1
Baboon Papio anubis RHBDD1P1
Golden snub-nosed monkey Rhinopithecus roxellana RHBDD1P1
Marmoset Callithrix jacchus RHBDD1P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RHBDD1P1
AGTTACCAGCAGAAAGACTGGCAGCATTGCCTGCTGTCTCCTGCTCACCATTGCTGATGATTGGCATTTGTATTTCAATATGGCGTCCGTGCTCTGGAAAGGAATAATCTGGAAAGATGACTGGGAAGTAGATGGTTTGCCTGTGTCATCACCACGTTTTCCCTGTTCCCTGGGGTGGTGTACCTGCTCTTGCAATATTCTCTAATTTCTGGATGAACCTGGCTTTGGAAGGTACTGTGCTGTAGGTTTTTCCAGGAGTTTTGTTTGCTTTGGAGTTTCTTAACAACCATCATTGCCTTGGAGGCTTTGTCAACATTTTGGGCTTCCTTGTCCTCAATAGATTTGCTTGTTGGGCCACACTTGTGCCTTTTCACTTATTCTCACCAGGGACTTCCTTCACTGGGCATCTGGCTGGGATTCTTCTTGCATTAATGCACACTCAAGGGCCTCTGAAGAACATCATGGAAGCATGTGCTGGCATTTTTTTCCCTCCAATTATTGGTTATCCAGGACAGTGATATTACTTCAATTGTTCAGGCTAGTCTGGATATCAGGATCATTATCTTTATGGCAGGCCAGGTTATTATGAAGAAGCACCCAGGAGCTATGATACATACACAGCAGTACGGAGAGAAAAAGAACAGCTTGTGAGAGCATGAAGAGCCAGCCCCTGGGATCAAGAAAATACCAGGAATAGCTCACTGCCCTGCGGGCTTCTTCTCTCAGAAGAAATGAGACTATAATGGCTTCACAGGTTTGATAGCCAGTGAGGTGACACAGCATCTTGGGAAGACATGGTCCACTTGTGTTATTATTGCCCATCGGATTCATTCCCCAAGC
>NM_001349071.2
GAAGACGTGGGGACGCAGGCGGGTCGTAGAGAGCATACCTGAAACTGACCACCTGAGTACGTTTTCCCATTGCTGAGCTGTTTCCCTGATATCTGGCCATGCAACGGAGATCAAGAGGGATAAATACTGGACTTATTCTACTCCTTTCTCAAATCTTCCATGTTGGGATCAACAATATTCCACCTGTCACCCTAGCAACTTTGGCCCTCAACATCTGGTTCTTCTTGAACCCTCAGAAGCCACTGTATAGCTCCTGCCTTAGTGTGGAGAAGTGTTACCAGCAAAAAGACTGGCAGCGTTTACTGCTCTCTCCCCTTCACCATGCTGATGATTGGCATTTGTATTTCAATATGGCATCCATGCTCTGGAAAGGAATAAATCTAGAAAGAAGACTGGGAAGTAGATGGTTTGCCTATGTTATCACCGCATTTTCTGTACTTACTGGAGTGGTATACCTGCTCTTGCAATTTGCTGTTGCCGAATTTATGGATGAACCTGACTTCAAAAGGAGCTGTGCTGTAGGTTTCTCAGGAGTTTTGTTTGCTTTGAAAGTTCTTAACAACCATTATTGCCCTGGAGGCTTTGTCAACATTTTGGGCTTTCCTGTACCGAACAGATTTGCTTGTTGGGTCGAACTTGTGGCTATTCATTTATTCTCACCAGGGACTTCCTTCGCTGGGCATCTGGCTGGGATTCTTGTTGGACTAATGTACACTCAAGGGCCTCTGAAGAAAATCATGGAAGCATGTGCAGGCGGTTTTTCCTCCAGTGTTGGTTACCCAGGACGGCAATACTACTTTAATAGTTCAGGCAGCTCTGGATATCAGGATTATTATCCGCATGGCAGGCCAGATCACTATGAAGAAGCACCCAGGAACTATGACACGTACACAGCAGGACTGAGTGAAGAAGAACAGCTCGAGAGAGCATTACAAGCCAGCCTCTGGGACCGAGGAAATACCAGAAATAGCCCACCACCCTACGGGTTTCATCTCTCACCAGAAGAAATGAGGAGACAGCGGCTTCACAGATTCGATAGCCAGTGAGGTGGCATCTTGGGAAGACATGGCCTATTCGTGTAATTATTGCCCATTTGGCTCATTCCCCAAGCCCCTAATTCATTTTAATTCATTTTAAACAAAAGCAGAGTACACCGGTATTGCTCCAGATCGCTCACATCACCTGGGACAGTCCCATGGCCCCTATGAGTCAACTCACAGCTTGCGGGGAGTGGGCCTTCTCCTGGCCTTGTTCTTGCTCATAAACAGGTCACTTCCTCCATGAAGAGACCAGTTTCCACGCTCCCATCTCTCACTGCTGACTCAGCGATGCCTCTGCCTCGGTCTGCTTTTGAAGACTGTGACCTTCACCAGGAGGTTTTACTTACACCAGTCGGGAAGATTAGTCCCTCATTCTGCCTGGAGTGCCCCGTGTTTGACTTGGCAGCGGGTGTGGAGCCATCCCCGCGTCCTCCTGGCGCATTGCCACTGTGGCTGTCCAGGAACAGGATGTGGCTGCCTTGGCCGAATGTTGTCCTACTCTCCCCAACCCCGGCGCCTCAGCTCCTCAGCTCCTCGGGCCCCTGCGTCTGGCTGGTGTTTGCAGGGCTTTCGCTCTGCTCTGGTATTGCTCTGCCTTTATAGAAAGTCTTATTGAAGAAGTGTAAGAAAGACCTAAGGTGGGGAAGACTCCTACACACACCATTAGTATCAGTGACACCAGCAATGTAGGTTCCCAGCCCCTTCCCAGTGGCAGCTTGTGTGTCCAGGAGATAGGACATCATTTAACGCATCAGCAAAGTAGCAGCAGATGCCACATACAGAGTAGAGCGAAGGCATTTGGTGGATCGGTCACTAGAGATCTATCTTGCAGAAAGTATGTTTTTCCTCATAAAAGTGCCTCTTAATTGGCCATTGTACCAGCCACTTGTCCTAGCCAAATGTCCAAAACACGCCCTTGGGCCCCGCCACGTTACAATCCACAGATTGTCTGTCTGAGTCGTTTAAGGCATTTCCTGGTGCTTGTGTTCCATGAATAAAAGGACAAAGTCAGAAGATCACTGATGTCTTACTGTCAACAGAGATATTTTAAAAGAGAGAAGCAGGAAAAGATCTTCCTTTTTTGATCTACAACTTATATAGTTTTCTGATTATGCACATAATAGATATGCCTTCCAGatgcataaggcaaacatctggaaagaaatatacccaaatcttagcaggggttatctttgggagtggagtacatgggattttgctttcttcatttttataattttatattactgtcttggaagatgtgtttatgtgtgtgtgttacttttacaatcaggaaaaCATATTTAATAACATATAGTCAAGAAAACAGACTtaaaaataaatactatgtgtccattgagaaaattcacaatataaacagaaatacaaataaatacatacacaattttaaagtcacctgtagccctacccttagaggtacccagggttaacattttggtggtattgtcttatcaatttttCCGTTGATACATTCAGCAAATTTGGAGCACATTGACCATGGAGTTTTGTGTCCAAATCCAATCTGAATTTACCTGGAAGAGGCCTTGACACCTGCATGGAAATGAGCTAAGAAAACCACTGGAGCCTTGGGAGCTCTTTGGCCTCCTGGCTGGCCCAGTAATATCTGAGCTCCTTTGGTTAATTTATAACTGATATAAAACTACATCTTCTTTATAATATAAATTGTACCTGTGAGTCTAGAAGCTTTAAATGTGTTTAAATTAAAATATTCAAGCTAAATGTTACTGCTCTCTCCCAAATTCTGTAAGTTTGACTCCCGTTACCCCAATTAGAAGTAACTTCTTTGTTTCATGCCACTTTTATAGCATTTGGTAATTCTGCTATAACACATCTTGCCCCTATTATTAACTGTGCACAGCTACACAAAGGTGTGCCTTCTACGTGGGAACATGGATTGTGAATGACTCTGTAATGAGGCCTGAGTCTTAGTTATCTTTCCACTCACTCCCCGTCTCCCCTTTCCAACCCCAAAGGCTCACGATAGGGGCTCACTAAATGTCAGTGTTTCACCAAAGTATTTTTTCCATTGTATTAAGAGTCCAGTCACTGTATATGGAAGTATTTTATTTTTTATTTTTTTATATCACTTGAGTCCACTAGTAGTACTTCCTTGCTCTGTTTGACTTGTCAGATACAAAGACACGGGATTAGATTTTGGGTGGTAAAATTGTGATACGCATGGCTGTTGATGGAGTGGAACATCTTAGTGATGTGAGAAAGGTCATTTTAGTTATAAATGTAAACCAATTACTTTAGCACAACAATAAAGATGTTCTGGAAATTATTATAATTATTTTAGTTAATGGACTTGCCTGTAACAAGTGCTTATGTTTGGAATGTCCATTTTATTTTATTTTCCTCTACAATAAGGAATCCCTAAAGTTATGCCAACAAACTGGAATTGGATTGAGAAAGACAAAAGCAAGTGAGCAAGTGTATTAGACTAATTATCTCTAGTAGGGAATAAGCACTTAGAGCTAATTTTTTAATTTGGTTTATTTATTAGTAGCTCCCTGATTGTCTGTTAAGCCCCTGGTTCCCACAGTTTGGTGTGGTCAGTCAACTTAAGCGACCTTTTAATGCAGAATCTTTACTTGGTTCTGAAGAGGAGGCAGTAGTTAAAATTGCTTCCTCTTAATGACTCTGAATGTATTGCCTGTGATTCCAAAGTTGTACATAATTGTTCAGACCTCCTCCATCCTTTTAAATTGCCTGCTGCAGTAAATAACTAGTTTGAGTAGAACTAGATCCTGTCTATCTATTTGGCACATGTTCTGCTGCCTGGGGAGTAAGCAAGCTAAAGGGATGAGAAAGACCACCTCCCCCTACCCTGGAAATTGCACTGCAAGGCAGGGCGAGAATGGGGTAGCTGGCAGACCTGGCCTCCTTGTTCCCAGTCTTAGTTTTTCTTGAGAGATTCAGTATTCAGTAAAGAATAGCATTCAATTAGTCAAAAAATATATATATAACTTCTTCCTTTCCCTTCCCATGAATCATTGCAGTCATTCCCTAAGTTTCTTCTCTTTTTTTTTCATGGCTGCTAGTATTTTATTTTAGAATCACAGACTCTCAGCTTAGAGAGTCACAGTATCTCAATTATTTGCTCTGTTCAATACTTAACAATACCTCCTCACTCAATTCTACATAACTCCAGCTTAGTCTTCCAAAATTCACTTTCATGATGCCACTCAGCATCTCAAATACCTTTCATTGGCTCTCTGCTGCCAAAGGATAAAGGTCAAAGTCATTAGCCTCAACAGTGGGCTTCAACCAGCCTTTGGACCTCAGCCCCATTTATCCATCACAGAGGCTGGTAACTAGTCTCACTGCTCAGGCTGTGAGTGTTCCTGATCTTGTGACATTCTGTGCTGTGCTTTTACATGGAACAGCTCTTTCCTCTCTCTTGGCCCATTCAGATCCTCCTCATCCAGCCCCCATCTGAATCCTGTAACAGACACAACCACATCTACACAGTTTCCACATACCACTTGGAATTGCTGGTTATGCTGCAATGAGAGAAtgtctttgtctttaaattgtaagcttcatgagggcagggaccatctgtttctctgtctctcctcacagtgccttgagcagtacgttgtctggaatgtcagaaccaataaatacttgtggattgaaACAAAAA

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