Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TUBB4BP7
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:152898045-152899317  UCSC
Coordinates (T2T) chr6:154099353-154100625  UCSC
Coordinates (hg19) chr6:153219180-153220452  UCSC
Strand +
Parental Sequence NM_006088.6
Parental seq. overlap 1076 bp
Parental seq. overlap (%) 68.7%
Genomic Region Intergenic
Retrocopy Summary TUBB4BP7, located on chr6:152898045-152899317, is a retrocopy of the parental gene TUBB4B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TUBB4B
Full Name tubulin beta 4B class IVb
Also known as Beta2|LCAEOD|TUBB2|TUBB2C
Coordinate chr9:137241287-137243707
Strand +
Gene summary Enables double-stranded RNA binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in microtubule. Implicated in Leber congenital amaurosis with early-onset deafness. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TUBB4BP1
Bonobo Pan paniscus TUBB4BP1
Gorilla Gorilla gorilla TUBB4BP1
Orangutan Pongo abelii TUBB4BP1
Gibbon Nomascus leucogenys TUBB4BP1
Green monkey Chlorocebus sabaeus TUBB4BP2
Crab-eating macaque Macaca fascicularis TUBB4BP1
Rhesus Macaca mulatta TUBB4BP1
Baboon Papio anubis TUBB4BP2
Golden snub-nosed monkey Rhinopithecus roxellana TUBB4BP2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TUBB4BP7
GGGTGATCAGTGATGAGCATGCCATCGAGCCTACTGGCACTTAGCATGCGGATAGCAACCTGCAGCTGGAGTGCATCAGTGTGTACTGCAATGAGACCACAGGTGGCAAGTATGTGCCCCACGCTGAGCTCATGGATCTGGAGCCCAGCACCGGGGACTCTGGTGTGCTCAGGCTCCTTCGTGCAGATCTTACGGCTGGACAACTTCATCTTCCATCAGAGTGGTGCCGGAAACAACTGGGCCAATGGGCACTACGCAGAAGGTGCGGAGCTGGTGGATTCGGTACTGGACATTGTGAGGAGGGAGGCTGAGAGCTGTGACTGCCTGCAGGATTTCCAGCTGACCCACTCCCTAGGAGCAGGGACTGGGCCTAAGAGGGGTACCCCTCTCATCAGCAAGATCCCAGAGAAGTATCCAGACAGGATCTTGAACAAGTTCAGTGTGCCCTTACGCAAGGTGTCAGACATGGGGGTGGAGCCCTAAAACATCACCTTCTCAGTCCACCAACTGGTAGAAAACACAGATATGACCTATTGCATTGATAATGAAACTCTCCATAACGTCTGCTTCAGAACCCTAAAGCTGACCACACCCACCTATGGTGACTTGAACCACTTGGTGTCTGCCGCCATAAGTGGGGTCACTACCTGCCTAGGCTTCCCCAACCAGCTCAATGCTGACCTGCAGAAGCTGGCTATGTACATGGTCCCATTCCCTACCTGCACTTCTTTATGCCTGTCTTCACCCTGCTGACCATCCACAGCAGCCAGCACTACCAGGCCCTCATAGTGCCTGAGCTCACCCAGCAGATGGTTGATGCCAAGAACATGATGGTTCCCTGAGACCCCTGCCATGGCCACTACCTAAAGGTGGCCACAGTGTTCACGGACTACATGTCCATGAAGGAGTTGGATGAGCAAATGCTTAATGTCCAAAACAAGAACAGCAGCTACTTTGTTGAGTGAATCCCCAACTATGTGAAAACAGCTGTCTGTGACATCCCACTCTTGGGGCTATAAATGTCTGCCACCTTCAACATCAACAGCGTGGCCATCCAGGAGCTGTTCAAGCACATCTCTGAGTGGTCATGTTTCGGTGCAAAGCCTTTCTGCACTGGCACATGGGCAAGAGCATGGACTAGATGGAGTTCACCAAGGCTGAGAGCAACATGAACAACCTGGTGTCCCGGTACCAGTAATACCAGGACACCTCAGCCAAGGAGGAGAGAAAGGTTGAGAAGGAGGCCAAGAAGAAGGTGGCCTAGAGCCTTCAG
>NM_006088.6
AGCACTCTGCGCGCCCGCTCTTCTGCTGCTGTTTGTCTACTTCCTCCTGCTTCCccgccgccgccgccgccATCATGAGGGAAATCGTGCACTTGCAGGCCGGGCAGTGCGGCAACCAAATCGGCGCCAAGTTTTGGGAGGTGATCAGCGATGAGCACGGCATCGACCCCACGGGCACCTACCACGGGGACAGCGACCTGCAGCTGGAACGCATCAACGTGTACTACAATGAGGCCACCGGCGGCAAGTACGTGCCCCGCGCCGTGCTCGTGGATCTGGAGCCCGGCACCATGGACTCCGTGCGCTCGGGGCCCTTCGGGCAGATCTTCCGGCCGGACAACTTCGTTTTCGGTCAGAGTGGTGCTGGGAACAACTGGGCCAAGGGGCACTACACAGAAGGCGCGGAGCTGGTGGACTCGGTGCTGGATGTTGTGAGAAAGGAGGCTGAGAGCTGTGACTGCCTGCAGGGTTTCCAGCTGACCCACTCCCTGGGTGGGGGGACTGGGTCTGGGATGGGTACCCTCCTCATCAGCAAGATCCGGGAGGAGTACCCAGACAGGATCATGAACACGTTTAGTGTGGTGCCTTCGCCCAAAGTGTCAGACACAGTGGTGGAGCCCTACAACGCCACCCTCTCAGTCCACCAGCTCGTAGAAAACACAGACGAGACCTACTGCATTGATAACGAAGCTCTCTACGACATTTGCTTCAGAACCCTAAAGCTGACCACGCCCACCTATGGTGACCTGAACCACCTGGTGTCTGCTACCATGAGTGGGGTCACCACCTGCCTGCGCTTCCCAGGCCAGCTCAATGCTGACCTGCGGAAGCTGGCTGTGAACATGGTCCCGTTTCCCCGGCTGCACTTCTTCATGCCCGGCTTTGCCCCACTGACCAGCCGGGGCAGCCAGCAGTACCGGGCGCTGACCGTGCCCGAGCTCACCCAGCAGATGTTTGATGCCAAGAACATGATGGCTGCCTGCGACCCCCGCCATGGCCGCTACCTGACGGTTGCCGCCGTGTTCAGGGGCCGCATGTCCATGAAGGAGGTGGATGAGCAAATGCTTAATGTCCAAAACAAAAACAGCAGCTATTTTGTTGAGTGGATCCCCAACAATGTGAAAACGGCTGTCTGTGACATCCCACCTCGGGGGCTAAAAATGTCCGCCACCTTCATTGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGCATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGCGAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGACCTGGTGTCCGAGTACCAGCAGTACCAGGATGCCACAGCCgaggaggagggcgagttcgaggaggaggctgaggaggaggtggCCTAGAGCCTTCAGTCACTGGGGAAAGCAGGGAAGCAGTGTGAACTCTTTATTCACTCCCAGCCTGTCCTGTGGCCTGTCCCACTGTGTGCACTTGCTGTTTTCCCTGTCCACATCCATGCTGTACAGACACCACCATTAAAGCATTTTCATAGTG

Publications

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