Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name STMN2P1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:154707389-154707911  UCSC
Coordinates (T2T) chr6:155909390-155909912  UCSC
Coordinates (hg19) chr6:155028523-155029045  UCSC
Strand +
Parental Sequence NM_007029.4
Parental seq. overlap 444 bp
Parental seq. overlap (%) 23.3%
Genomic Region Intergenic
Retrocopy Summary STMN2P1, located on chr6:154707389-154707911, is a retrocopy of the parental gene STMN2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name STMN2
Full Name stathmin 2
Also known as SCG10|SCGN10
Coordinate chr8:79611117-79666162
Strand +
Gene summary This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes STMN2P1
Bonobo Pan paniscus STMN2P1
Gorilla Gorilla gorilla STMN2P1
Orangutan Pongo abelii STMN2P1
Gibbon Nomascus leucogenys STMN2P1
Green monkey Chlorocebus sabaeus STMN2P1
Crab-eating macaque Macaca fascicularis STMN2P1
Rhesus Macaca mulatta STMN2P1
Golden snub-nosed monkey Rhinopithecus roxellana STMN2P1
Marmoset Callithrix jacchus STMN2P1
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>STMN2P1
aGTGAAGCAAATCAACAAATGTGCCTTTGGCCAGGCTTTTAAGCTGATTTTAAGGCCACCACCTCCATTCTGGGAAGCCCGTTGAACTTTAGCTTGTACTAAGGAGAAAGACCTGTCCCTGAAGGAGATCCAGAAGAAACTGGAGGCTGCAGAGGAAAGAAGGAAGTCTGAGGAGGTCCAGGTGCTGAAGCCATTGGCAGAGAGGAGGGAATACAAGCAAGAAGTCTTTGAGAAGGCTTTGGAAAACGACACCTTCAGCAGAATCGTGGAGGAAAAGCTGATCCTGAAAGTGGAAAAAATTAAGGAAAATGAGGAGGCTAATCTAGCTGCTACTATGTCTGAAGGAAAAGGAGGCACGCCGCGGAGGTGCGCAGGAACAAGGACGCGCAGACTCAACAGTCTGGCTGAAGTGGAGGAGGGTACGGCATGCTGCACCATCAGTAAACCCACTGCCCATATTATAATGAGTCACGCAGTATCGGTATGGGAAATGTATGACATAGTTTACAAAGGACTCATTA
>NM_007029.4
AGTCTTCTCTCTCGCTCTCTCCGCTGCTGTAGCCGGACCCTTTGCCTTCGCCACTGCTCAGCGTCTGCACATCCCTACAATGGCTAAAACAGCAATGGCCTACAAGGAAAAAATGAAGGAGCTGTCCATGCTGTCACTGATCTGCTCTTGCTTTTACCCGGAACCTCGCAACAtcaacatctatacttacgatgATATGGAAGTGAAGCAAATCAACAAACGTGCCTCTGGCCAGGCTTTTGAGCTGATCTTGAAGCCACCATCTCCTATCTCAGAAGCCCCACGAACTTTAGCTTCTCCAAAGAAGAAAGACCTGTCCCTGGAGGAGATCCAGAAGAAACTGGAGGCTGCAGAGGAAAGAAGAAAGTCTCAGGAGGCCCAGGTGCTGAAACAATTGGCAGAGAAGAGGGAACACGAGCGAGAAGTCCTTCAGAAGGCTTTGGAGGAGAACAACAACTTCAGCAAGATGGCGGAGGAAAAGCTGATCCTGAAAATGGAACAAATTAAGGAAAACCGTGAGGCTAATCTAGCTGCTATTATTGAACGTCTGCAGGAAAAGGAGAGGCATGCTGCGGAGGTGCGCAGGAACAAGGAACTCCAGGTTGAACTGTCTGGCTGAAGCAAGGGAGGGTCTGGCACGCCCCACCAATAGTAAATCCCCCTGCCTATATTATAATGGATCATGCGATATCAGGATGGGGAATGTATGACATGGTTTAAAAAGAACTCATTATaaaaaaaaaaaaacaaaaaaaatcaaaaattaaaaaaaaTCAATGCGGTCTCTTTGCAGAATGTTTTGCTTGATGTTTAAAAAATACCTTGGATCTTATTTTGTAAATACTTACATTTTTGTTAAAAAATACAAGTATTGCATTATGCAAGTTATTTCATAATCTTACATGTCCTGTAACAGGCTTTTGATGTTGTGTCTTTCCACTCAAATGAATTTGCTAGGTCTGTTCTTTTTGAAGCTCCCCATGTCTAACTCCATTCCAAAAGAAAAATGAGGTCAGTAGACAGTCTATGGTGCTAGAAACCCACCATTGCCTAATGACCTAGAAGGCTTTGTTGTCTCTGAGCTTGACTAAGACCATACCTAGATCACAGGTATTATGACTCCACATGAACCTTCACATTTGTTCGCTCATAATCTACTTACTGCCTAAAAACTACAAAACCAGGCTAAGAAATACCACCAGTCATAGCATTTACTTCTGCTTCTCCTGGATTATGTGCTACAAATGTGCTTTGGCTTTAGAAAGGGATGGATGAGAAGACAGACCTGAGACCAATCTGGGTAGAAGCAAAAAGTTGAACCTTTTAAAGTGCTGAACACAAATCCAAATTCGAATGGTTCAAGCAGCCGTGAAATCGCTCTTCATAAAGTGGGCTTAATTCTCTAGTTTAAGTTCTTTTGATGGAATGAATTAATTAATGTGTCAGGTGGCTTATTTGTGGATGCCATGATTGATGATGTTCATTTTAAGCTCTTACCTATAGTACAAGTACATGATGCTACTGAATATTTTTCCACTTGGAAACTGTGAGCTGGTTGTTGCATTAAAACACACATACAAACAAAATCAAAAACACTGCGGACTTTCACTCAAGCTGGTCTTTCTTCCCCAGTGTAAGGCAATCCTGCCTACTAACAACACCAACAACAAAACACTCCATCTGTGAAGCTGACGCAGTTAAGGGGGCTAGGCAGGGCATTTGTGCCAACTAAGAATCACCAGATACCCACCATAAGTACCTATCGCAGTTTTGAAGTCGTTTCTCCCCAACTCCCAACTCCTGAAGGTTGCTGCCTGCATATTTACTCTTCATTAGTGCTATTTTCCTGTATGTCATTGTGAGCAAGCTGTGATTAATAAAGAATTGGAGTTCTGTGAACTAA

Publications

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