Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HNRNPH1P1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:159710473-159714117  UCSC
Coordinates (hg19) chr6:160131505-160135149  UCSC
Strand -
Parental Sequence NM_001032393.3
Parental seq. overlap 1766 bp
Parental seq. overlap (%) 45.5%
Genomic Region Intragenic (SOD2)
Retrocopy Summary HNRNPH1P1, located on chr6:159710473-159714117, is a retrocopy of the parental gene HNRNPH2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HNRNPH2
Full Name heterogeneous nuclear ribonucleoprotein H2
Also known as FTP3|HNRPH'|HNRPH2|MRXSB|NRPH2|hnRNPH'
Coordinate chrX:101408222-101414133
Strand +
Gene summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HNRNPH2P1
Bonobo Pan paniscus HNRNPH2P1
Orangutan Pongo abelii HNRNPH2P1
Gibbon Nomascus leucogenys HNRNPH2P1
Green monkey Chlorocebus sabaeus HNRNPH2P1
Crab-eating macaque Macaca fascicularis HNRNPH2P2
Rhesus Macaca mulatta HNRNPH2P1
Baboon Papio anubis HNRNPH2P2
Golden snub-nosed monkey Rhinopithecus roxellana HNRNPH2P1
Gorilla Gorilla gorilla Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HNRNPH1P1
GCTTATGTGAGCAGAAGTAGTTCTGCTTGTCATCTTGCTATAGCCCATTTGAAGGCAGAAGGAGGATAATTGCCCACTACACCAAAATTGCATTCCGCCAAACTTGCCACCAAGAGCTCAACAGTCGCCACGATGCTGAGCACGGAAGGCAGGGAGGGGTTCGTGGTGAAGGTCCAGGGCCTATCCTGGTCCTGCTCAGCTGATGAAGTGATGCACTTCTCTGATTGCAAAATACAAAATGGCACATCAGGTATTTGTTTCATCTACACCGGAGAAGGCAGACCAAGTGGTGAAGCATTTGTTGAACTTGAATCTGCAGATGAAGCGAAATTGGCTTTAAAGACAGAGAAACCATGGGACACAGATACGTTGAAGTATTCAAGTCTAATAGTGTTGAAATGGATTGGGTATCGAAGCACACAGGTCTGAATAGTCCTGATACTGCCAACGATGGCTTCGTCTGGCTTAGAGGACTTCCATTTGGCTGTCCAAGGAAGAGATTGTTCATTTCTTTTCAGGGTTGGAAATTGTGCCAAATGGGATAACACTGTGAGTGGACTTTCAGGGCAGAAGCACAGGGGAAGCCTTTGTGCAGTTGGCTTCGCAGGAGATAGCTGAGACGGCATTGAAGAAACACAGGGAAAGAATAGGGCACAGGTACATTGAAATCTTCTAGAATAGCCAAGCTGAAGTTCATACCTACTATGATCCCTCTCAGAAGCTCATGGCTGTGCAGTGGCCAGGTCCCAGTGATAGGCCAGGGGCTGGCTGAGGTGTAATAGCATTGGCAGAGGAGCTGGGTTTGAAAAGATGAGGCAGGGTCCCTATGGTGGAGGGTATAGAGGCTATGATGACTATCGTGGCTGTAATGATGGATATGGCTTTAGGTCTGATAGATTTGGAAAAGACCGCAATTACTGTTTTTCAGGAATGTCTGATCATAGATACGGAGATAGTGGGTCCAGTTTCCAGAGCACCACAGGGCACTGTGTACACACGAGGGGTTTACCTTACAGAGCCACTAAGAATGTTATAATTTCTATTCACCTCTTAACCTCATGAGAGTACATATTGAAATTGGACACGATGACAGAGTTTACTGGTAGGGCAGATGTTGAGTTTGCTGCTCACGAAGATGCAGTGGCAGCTATGGCAAAAGACAAAGCTAATATGCAGCACAGGTACAGGGAGACCTTTTTAAATGCTATAGGAACAAGTAGGGGGGTTTATGAACACACCTATGTAGAACTTTTCTTGAATCTACAGCAGGGGCAAGTGGTGGTGCTTATGGTAGGCAAATGATGGGAGAGATGGGCTTACCCAACCAGTCTAGTTATGCAGCTGAGTGGTGGTTGTGGAGGTGGTTATGGTGGTCTGAGTAGTGTGAGTggtggttatggaggtggttatggaggtCAGAGCAGCTGAGTCGTGGTTATGGAGGTGGTTAGGGTGATCAGAGCATTGTGAGTggtggttatggaggtggttatggaggtCAGAGCAGCTGAGTGGTCGTTGTGGAGGCGGTTAGGGTGATCAGAGTAGTGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAGTGTGAGTggtggttatggaggtggttatggaggtcagagcagctgagtggtggttatggaggtggttatggaggtCTGAGCAGTGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAGTGTGAGTggtggttatggaggtggttatggaggtCAGAGCAGCTGAGTGGTGGTTATGGAGGTGGTTAGGGTGATCAGAGCAGTGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTATGGAGGTGGTTAGGGTGATCAGAGCAATGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAATGTGGGTGGTGGTTGTGGAGGTGGTTATGGTGGTCAGAGCAGCTGAGTggtggttatggaggtggttatggaggtctgagcagctgagtggtggttatggaggtggttatggaggtCTGAGCAGCCGAGTggtggttatggaggtggttatggaggtctgagcagtgtgagtggtggttatggaggtggttatggaggtCTGAGCAGTGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTGTGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTATGGAGATCAGAGCAGTGTGACTGGTGGTTATGGAGGTGGTTATGGTGGTCAGAGCAGCTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTGTGGAGGTGGTTATGGTGATCAGAGCAGTGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTATTGGAGGTGGTTATGGTGGTCAGAGCAGCTGAGTGGTGGTTATGGAGGTGGTTATGGTGGTCAGAGCAGTGTGAGTGGTGGTTGTGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTGTGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTGTGGAGGCGGTTATGGTGATCAGAGCTGTTGAGTggtggttatggaggtggttatggaggtcagagcagtgtgagtggtggttatggaggtggttatggaggtCAGAGCAGTGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTGTGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTGTGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTGTGGAGGCGGTTATGGTGATCAGAGCTGTTGAGTggtggttatggaggtggttatggaggtcagagcagtgtgagtggtggttatggaggtggttatggaggtCAGAGCAGTGTGAGTGGTGGTTATGGAGGTGGTTATGGTGATCAGAGCAATGTAAGTGGTGGTTGTCGAGGCGGTTATGGAGGTCAGAGCAGCTGAGTGGTGGTTATGAGGTGGTTATGGTGATCAGAGCAATGTGAGTGGTGGTTGTGGAGGCGGTTATGGAGGTCAGAGCAGCTGAGTGGTGGTTATGGAGGTCAGAGCAGTATGAGTGGTGGTTATGGTGGTCAGAGCAGTGTGACTGGTGGTTATGGAGGTGGTTAGGGTGATCAGAGCAGTATGAGGGGATATGACCACGTTCTGGAGGAAAACTCCAGTGACTGTCAGTCAAAGCTTGGTTAGGTAGAGAAGGAGCACTAAAGAGCTACTCCAGATATAAAAGCAGTGCACTTATGGGAGTTGAATAGAATGGGAGGGATGTCTAGTATATCCCGTATAATGGGTAAATGAGAAATATAATTTATTCTGATCACTCTTGGTCAGCTTCTCTG
>NM_001032393.3
ACTCGCTTACGTGAGCAGAAGTAGTTCTGGTCGTCGTCTACCGTCTCGCTATAGCCGTTTGAGGGAAGAAGGAGGAAAATTACCCGCTACACCAAAATTGCATTGAGCCAAACTTGCCACCAAGAGCCCAACAATCACCATGATGCTGAGCACGGAAGGCAGGGAGGGGTTCGTGGTGAAGGTCAGGGGCCTACCCTGGTCCTGCTCAGCCGATGAAGTGATGCGCTTCTTCTCTGATTGCAAGATCCAAAATGGCACATCAGGTATTCGTTTCATCTACACCAGAGAAGGCAGACCAAGTGGTGAAGCATTTGTTGAACTTGAATCTGAAGAGGAAGTGAAATTGGCTTTGAAGAAGGACAGAGAAACCATGGGACACAGATACGTTGAAGTATTCAAGTCTAACAGTGTTGAAATGGATTGGGTGTTGAAGCATACAGGTCCGAATAGCCCTGATACTGCCAACGATGGCTTCGTCCGGCTTAGAGGACTCCCATTTGGCTGTAGCAAGGAAGAGATTGTTCAGTTCTTTTCAGGGTTGGAAATTGTGCCAAATGGGATGACACTGCCAGTGGACTTTCAGGGGCGAAGCACAGGGGAAGCCTTTGTGCAGTTTGCTTCACAGGAGATAGCTGAGAAGGCCTTAAAGAAACACAAGGAAAGAATAGGGCACAGGTACATTGAGATCTTCAAGAGTAGCCGAGCTGAAGTTCGAACCCACTATGATCCCCCTCGAAAGCTCATGGCTATGCAGCGGCCAGGTCCCTATGATAGGCCGGGGGCTGGCAGAGGGTATAATAGCATTGGCAGAGGAGCTGGGTTTGAAAGGATGAGGCGTGGTGCCTATGGTGGAGGGTATGGAGGCTATGATGACTATGGTGGCTATAATGATGGATATGGCTTTGGGTCTGATAGATTTGGAAGAGACCTCAATTACTGTTTTTCAGGAATGTCTGATCATAGATACGGAGATGGTGGGTCCAGTTTCCAGAGCACCACAGGGCACTGTGTACACATGAGGGGGTTACCTTACAGAGCCACTGAGAATGATATTTATAATTTCTTCTCACCTCTTAATCCCATGAGAGTACATATTGAAATTGGACCCGATGGCAGAGTTACCGGTGAGGCAGATGTTGAATTTGCTACTCATGAAGATGCTGTGGCAGCTATGGCAAAAGACAAAGCTAATATGCAACACAGATATGTGGAGCTCTTCTTAAATTCTACTGCAGGAACAAGTGGGGGTGCTTACGATCACAGCTATGTAGAACTTTTTTTGAATTCTACAGCAGGGGCAAGTGGTGGCGCTTATGGTAGCCAAATGATGGGAGGGATGGGCTTATCCAACCAGTCTAGTTATGGAGGTCCTGCTAGCCAGCAGCTGAgtggtggttatggaggtggttatggtggtCAGAGCAGTATGAGTGGATATGACCAAGTTCTGCAGGAAAACTCCAGTGACTATCAGTCAAACCTTGCTTAGGTAGAGAAGGAGCACTAAATAGCTACTCCAGATATAAAAGCTGTACATTTGTGGGAGTTGAATAGAATGGGAGGGATGTTTAGTATATCCAGTATGATTGGTAAATGGGAAATATAATTGATTCTGATCACTCTTGGTCAGCTTCTCTTTCTTTATCTTTCTTTCTCCTTTTTTAAGAAAACGAGTTAAGTTTAACAGTTTTGCATTACAGGCTTGTGATTCATGCTTACTGTAAAGTGGAAGTTGAGATTATTTTAAAACTTCAAGCTCAGTAATTTTGAACACTGAAACATTCATCTAGGACATAATAACAAAGTTCAGTATTGACCATAACTGTTAAAACAATTTTTAGCTTTCCTCAAGTTAGTTATGTTGTAGGAGTGTACCTAAGCAGTAAGCGTATTTAGGTTAATGCAGTTTCACTTATGTTAAATGTTGCTCTTATACCACAAATACATTGAAAACTTCGGATGCATGTTGAGAAACATGCCTTTCTGTAAAACTCAAATATAGGAGCTGTGTCTACGATTCAAAGTGAAAACATTTGGCATGTTTGTTAATTCTAGCTTTTTGGTTTAATATCCTGTAAGGCACGTGAGTGTACACTTTTTTTTTTTTTAAGGATACGGGACAATTTTAAGATGTAATACCAATACTTTAGAAGTTTGGTCGTGTCGTTTGTATGAAAATCTGAGGCTTTGGTTTAAATCTTTCCTTGTATTGTGATTTCCATTTAGATGTATTGTACTAAGTGAAACTTGTTAAATAAATCTTCCTTTTAAAAACTGGAAAAAA

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