Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MAD2L1P2
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:160839524-160840363  UCSC
Coordinates (T2T) chr6:162196219-162197065  UCSC
Coordinates (hg19) chr6:161260556-161261395  UCSC
Strand -
Parental Sequence NM_002358.4
Parental seq. overlap 734 bp
Parental seq. overlap (%) 14%
Genomic Region Intergenic
Retrocopy Summary MAD2L1P2, located on chr6:160839524-160840363, is a retrocopy of the parental gene MAD2L1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MAD2L1
Full Name mitotic arrest deficient 2 like 1
Also known as HSMAD2|MAD2
Coordinate chr4:120055623-120066848
Strand -
Gene summary MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MAD2L1P1
Bonobo Pan paniscus MAD2L1P1
Gorilla Gorilla gorilla MAD2L1P1
Orangutan Pongo abelii MAD2L1P1
Green monkey Chlorocebus sabaeus MAD2L1P2
Crab-eating macaque Macaca fascicularis MAD2L1P2
Rhesus Macaca mulatta MAD2L1P3
Baboon Papio anubis MAD2L1P2
Gibbon Nomascus leucogenys Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MAD2L1P2
GTGACATTTCTGACACTGGTGGAAGTTTCTTGTTCATTTGATCTTTGATTTATGCAAAGATCTGGTTGTACCTGGAAGACGGGAAGAGTGGGGACCACAGTTCATAACCATTCTGAGGAAGTTTGCCTTTATTCATTTACTGCTACATCCACACAGCTCACAGCATGACAAAATCTTGTCAATGACCAAGGATGACACTAGGAAGATAATGTAATTTTCAAATGTGGTTTTCCTGAAACCAAGTCAACTATAGCTGATATGTTTCATTTCATTGATTAATGTTTACATGGGAAAAACCAATATTATACTTTACTGAACTTTGTGTAATTGTTCCGATTTTTTGATATCTGTTTGACTTACCATGGGGTTGACATAATGAATTTATTGCACATTGTTCAAAAGGAACCAGGAGGTTTTTGTCAGCACTGTAATGTAAATTCCTTTGCAGATGGTAACTGTAGATGGAAAAACTTTTGCTATAAAATGAAATGCTTCCTTAAATCAGACATTTTGGTCAAGTAGCTTGACTCAGTACAGGTAGGGAGATATTTAAATATAAAATACAATGAAAGAAGCCTAAATATTTAGAATCTTTGTTTAGATCCTGTAAGTAACTAATAATCCATAAGCAATGCAATATTGCTCTATTGGGTCCTTTTGACATTTATTTCATCATATAGCTTTCCATATTGAATAAATTTACAGATTTAATTTATATAACTTGAACCTATGAAGCAATGGATATTTCTGCGGTTTAATGTCTTGTGATACAGAACTCTTGAAAAAATTTATGTTTTATAAAATCAAGCTTTAAGTGAAAAATGAAGAAATAAAGTTAAA
>NM_002358.4
CTGACGACGTGCTGCGTCGTTACTTTTGAAACGCTTGGCGGGGAAGTGCTGTTGGAGCCGCTGTGGTTGCTGTCCGCGGAGTGGAAGCGCGTGCTTTTGTTTGTGTCCCTGGCCATGGCGCTGCAGCTCTCCCGGGAGCAGGGAATCACCCTGCGCGGGAGCGCCGAAATCGTGGCCGAGTTCTTCTCATTCGGCATCAACAGCATTTTATATCAGCGTGGCATATATCCATCTGAAACCTTTACTCGAGTGCAGAAATACGGACTCACCTTGCTTGTAACTACTGATCTTGAGCTCATAAAATACCTAAATAATGTGGTGGAACAACTGAAAGATTGGTTATACAAGTGTTCAGTTCAGAAACTGGTTGTAGTTATCTCAAATATTGAAAGTGGTGAGGTCCTGGAAAGATGGCAGTTTGATATTGAGTGTGACAAGACTGCAAAAGATGACAGTGCACCCAGAGAAAAGTCTCAGAAAGCTATCCAGGATGAAATCCGTTCAGTGATCAGACAGATCACAGCTACGGTGACATTTCTGCCACTGTTGGAAGTTTCTTGTTCATTTGATCTGCTGATTTATACAGACAAAGATTTGGTTGTACCTGAAAAATGGGAAGAGTCGGGACCACAGTTTATTACCAATTCTGAGGAAGTCCGCCTTCGTTCATTTACTACTACAATCCACAAAGTAAATAGCATGGTGGCCTACAAAATTCCTGTCAATGACTGAGGATGACATGAGGAAAATAATGTAATTGTAATTTTGAAATGTGGTTTTCCTGAAATCAAGTCATCTATAGTTGATATGTTTTATTTCATTGGTTAATTTTTACATGGAGAAAACCAAAATGATACTTACTGAACTGTGTGTAATTGTTCCTTTTATTTTTTTGGTACCTATTTGACTTACCATGGAGTTAACATCATGAATTTATTGCACATTGTTCAAAAGGAACCAGGAGGTTTTTTTGTCAACATTGTGATGTATATTCCTTTGAAGATAGTAACTGTAGATGGAAAAACTTGTGCTATAAAGCTAGATGCTTTCCTAAATCAGATGTTTTGGTCAAGTAGTTTGACTCAGTATAGGTAGGGAGATATTTAAGTATAAAATACAACAAAGGAAGTCTAAATATTCAGAATCTTTGTTAAGGTCCTGAAAGTAACTCATAATCTATAAACAATGAAATATTGCTGTATAGCTCCTTTTGACCTTCATTTCATGTATAGTTTTCCCTATTGAATCAGTTTCCAATTATTTGACTTTAATTTATGTAACTTGAACCTATGAAGCAATGGATATTTGTACTGTTTAATGTTCTGTGATACAGAACTCTTAAAAATGTTTTTTCATGTGTTTTATAAAATCAAGTTTTAAGTGAAAGTGAGGAAATAAAGTTAAGTTTGTTTTAAATTTGTCTTAAAACATTTTGATACTGGTTTGGTGTTGATATAGTTAAATGGTAATTAGAATTGATTCAGCATAGCTAATGAATTCTTGTTCCTACGAAGTTATAGAACTTAAGGGTCCAAAGTTGAGTGAGTCTTGAGGTGTCTTCAATCTAATGGATAAACTTTGATCACATCCTGTTCATCTCATAGCAATAGACTTAAGGCTATTACTTCATCATTGTGAAAAGATAAATGTCCTTTGGAATTAGTCCAACAATTCCAGTTGAACAAGTGTTGATTTTAGTACTTTACTATACTCTTAGCCTTATTGTCAGCCTACTTTTCCTTATATACTTAAATACTATGCTTATTCCTGTGCTTTCATTAATACCCTCATCTGGTACATGCTTTCTATCCAGTTCTCACCTGTTTTTCCAAGGTCAGTTTAAGGCAGATTTGTAAAGTCTTCTCTAATCTCTAATCTAAATCTGACCTCATTTTGTAAAAATTCAGtttattaatgtttattattagacactaagttctttatgtgtattaacttatttaaccttcacTATTTTTAAGTAATTGCACATAGTCTGAATCTGTTCATTCAGAAATTACATATTGAGCAAATACTGTGGATCAGTGGCAGTTTCTGGGTTCTCAGTGACAAATTTGTAGACTCTTCATATCTTTATGGAATAAGTGGACCACTGGTGTTACCAACCTAGATGATTTCAAGAAAAGTGGCAATTAAATGCTTCATTTGTATTTTAACTATTTGAGAAGTCAGACTAAATTCTGCGAAATCACTTTTCCCCCCCAagatggagtcttattctgtcgcccaggctggagtacagtgacgcagctcagctcactacagcctctgcctcccggattccagccattcttccgtctcagcctcctgagtagctgggattacaggcacgtgccaccacacctggctaatttttatatttttagtagagagagggtttcaccatgttggccaggctagtcttgaactcctgacctcatgatctgcccgccttgacctcacaaagcattgggattacaggcgtgagccactgcgcccggcTGAAAtcacatttttaaaggttgtgtgtatactctggtcatttcaactcagctaccaatattaacaggattaaattcttagatttttgtatcatttgcatgctactatttacTCTGAGGTTTCTGGAGAGCTAGTCATGATGAGTCATTTTACCCCTTACAGATTATATAATCAATTAAGAAATACACATTTTGggctgggcgcagtggctcgcgcctgtaatcccagcactttgggaggccgaggcaggtggatcacgagatcaggagtttgagaccagcctggccaagatggtcaaaccccgtctctactaaaaatataaaaattagctgggcgtggtggcgggcgcatctcagctacttgggaggctgaggcaggagaaatcgcttgaacccatgaggtggaggttgcggtgagccaagaccgtgccactgtactctagcctgggcgacagagcaaggctccatctcaaaaaataataaataaaaaagaaaTACACATTTTGGAGCTGAGTGGGAGCCAAACTATGAGTTTTATTGAGGTGAAGCTATACTGGAAAAGCTTTGCCCTGTAGCTCCAAGTGGACTGTCCCATCCTCTTTCTAGACCTTGAGGCTTACCTCAGGAGGATGATGTTTAAATCAACAGCTGAAAGACTTGTGAGTGGTTTCTACACCATGTTAAAGAGAAGGTTCTAAGACAGCATGATAGGCCTCTAGGCCTGGCCTGGACTCTGGCTCAGTGTTGCTTACCATATGTAGAGGATGAACAGAGGTTAAGCCCATCAAGGTCTGAAGTAGAGCCCAGGAGGAACTGAACTGTATCTGGCTTTCAGGATCCTTTTCCCAGTGTCATCAATCAGAGAAGTCAAACCTCTGTGAGAATGCTTGTGCAGAGGTATAACAGTCTCATGTATTGGTTGGCTTTTGCTGCACCTTTCTCATTCTGTTGGAGGGACATTGGTTAGTCAGGACTCTGAAGGCCAGCTTTTTCAcactgaccaaagcaagtgaaggtcaagcctaactttaatgggaccaggaagtatactcctcccatgGAGGTGGTGGGAATGGCACCGAGAAGTTTGATGACAGTTATCTAATGGACTagaggttggcaaactttctgtaaatggccaggtagtaaatagttctgcttttgaaggcatatggtctcttgcacctactcgaggctgaaagcagctatagacaatacataaatgaatgagcgtgagtgtgttccaataagaaaaaaacatggctgtttgcttcggccccagggttgtagcttaccagtccTGTAACAGATCACAGTTTGCTCTTTTGGTCACAAATACTTGAACCCCTCCCTAGTTCAGAGCATTTGATACCGTAATATTTAAAGCTCACTTGTAAAACATCGTTTGTTGCCTCCATCCATAGTATCTCAAACAGAATGTCTCTCCCAAATATACCTAAATTCCATATTCTCTGAAGCACAACCAGCTATTTTCTTGACATACTTCCTAACACACCCCACAGTTCACAATTTGATCTGAAAACTTGTTAAGGGAGGTTCTTTGGCATGTGATGCCATAAAAAGAGAGGTATGGGCTCTCCTTTAAAAAAGAGACCCTTTTTATGAGACTCACAATAGGATAAAGAGCCCATGCCTATTTTTAATCATTTTTTCACTATATAGACATGCATGCTGAAAAATGTTTTTATTAGTATAATGCTAATTATACTGACTTCCTATATATTTTAGCATATAGATTCAAAGATTATTAGCACAATAAGGTAGATAACTTCATAGACCATTTCTTCATCTTGTTTTCATTTAGTATGTAAAATTTATCTAAAATTTACATGAAAGATCAGAATAGCTATGTAATGCTACTTTGTAACTCTTATATTTTCCACCAGATGTCACTAATGCTGTAATATTCAAATTAAGATGACTTTCTTTTGGTTCTAAAGGCTGTAAGCTTATTGGAAAAGCAAGGTTACTCAGCATTGGAATTCCTGGCAACAAATATATAAATACATTAGGGGAATAAACACTTAGCATTTATTATTTACTAGTCACTTCACATGAATTTTTATTTAATTCTCATGCTTTTGTGCACAAGTAAAACTGGGGGTCAATGGGCATGCAAATTGTGTCGTGGTTTTTGAAGTTTAGTGGTCTCTCCTATCCCTGGCCAAGGAAGTATGCAAATTGTATTGTGGTTTTTGAAGTTTAGGTGATCTCTTCCTTCTATCCCTAGCCAAGGAAGTTCATCCTGACTCCCCAACAAGCATATCAAAAGGAGTGTTTCGTCACCTTTTTCCTCTTACCCTTTACATCCTTTTAGCAATAAAGTGTTCAGAACAAACTGGTTTTCCTTTACTGTGCTTTGCAAAACTTATTCATGTTTTATTGGGTGACTTTGTATTTACACTTTCCTCAGATAGTCTGTTGTCAGATGACTTTGACCAATGATTGGGAGGAACCAAATACAGAGGATTTTATCCTATGCCTAATCTATATTGTCTACAGAGTAAATCAGGTATGAATTTGTGAACAGTAATGAAACAATTTTCCAACTAATCAGAAGAATTGTTTGTTAAGTAACCTTAATTACTCAGTTTTTGGTGAATTGTTTGCGGCTTAACTTGTAAATAATTTCTTATTCTTTTTTTAAATGTATGAAATATTTCTAGTTATTTTGTTCAATGTGACTGATAAAAGTTTATATTGGAATA

Publications

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