Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name IQCB2P
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:28010694-28012931  UCSC
Coordinates (T2T) chr6:27880356-27882593  UCSC
Coordinates (hg19) chr6:27978472-27980709  UCSC
Strand +
Parental Sequence XM_024453833.1
Parental seq. overlap 2003 bp
Parental seq. overlap (%) 69.9%
Genomic Region Intergenic
Retrocopy Summary IQCB2P, located on chr6:28010694-28012931, is a retrocopy of the parental gene IQCB1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name IQCB1
Full Name IQ motif containing B1
Also known as NPHP5|PIQ|SLSN5
Coordinate chr3:121769761-121835060
Strand -
Gene summary This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Jan 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes IQCB1P1
Bonobo Pan paniscus IQCB1P1
Gorilla Gorilla gorilla IQCB1P1
Orangutan Pongo abelii IQCB1P1
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>IQCB2P
TGGTGGCCCAGCAACAGGTAATACGAGAAATGAAGCCAACAGGTGCAGACCCAAGGATCTTATCTCTAGCTGCTGAAGTTGCAAAAAGCCCTGAGTGGAATGTCCCTGTTATACTGTTGAAGTTAAAAGCCATTGCTGTGCAGGCTTGGAGCCAGGAGAAGATGCAGAGGAACTTTCCAATGAATTACTTCCATCAGCTGCAGAAAATTTTCTAGTTTTGGGGAGATAATGGCAAACATGTTTTATCAATGCAGCTAAGGCTGAAGAAAAAGATGAGTTACTAAAAATTGTGACTGATTGGCTCTTCTGGCTTTTGGGAGGCCATGTTGAACTTATTCAGAATGTACTACAAAGTGATCATTTCTTACACTTACTGCAAGTTGACAATGTCCAAATAGGATCAGCACTCATGATGATGCTACAGAATATACTATAGAGCAACAGTGGTGATTTACTCAGAACAGGAGGAAAAGCCGTGCATTCAATTTTAGATGAAGTTATTTTCAAGCTTTTTTCAACTCCTAGTCCAGTCATAAGAAGTACTGCTGCAAAACTCCTACTGTTGATGGCTGAATCCTATCAGGAAATTTTGATTTTACTGAGACAAAGTGCCTGCTACAAAGGACTCAGAAGTCTACTAAGTAAACAGGAAACTGGGACAGAATTCAGTCAAGAACTTAGACAGCTCATTGGCCTTTTAAGCCCAACGGTCTATCAGGAAGTAGAAAAGCAGAAACTACATCAAGCAGCATGCTTGATTCAAGCCTATTGGAAGGGTTTTCAGACAAGAAAGAGATTAAAGAAGCTTCCATCTGCTGTGATTGCTTTGCAGAGGAGTTTCAGATCTAAACGAGCAAAGATGTTGCTGGAGATAAATAGGAAGAAGGAAGAAGAGGACCTCAGATTGTGATTGCAACTTCAAAGACAGAGAGCCATGAGACTTTCCCAAGAATTGTGGCTGAGTATGCTCAAAGTAGTTCATCCAGGTCAAGTGGAGAAACACAATTGGGAAATGGAAGAGAAATCAGCACTGATTATCCAGAAACATTGGAGAGGGTACAGGGAAAGGAAAAATTTTTGCCAACAGAGGCAGTCTCTCACAGAATATAAAGCAGCTGTCATACTTCAAAGAGCAGTGTTTAAATTCCTAGCAAAGTGCCGTAAGAAACAGAAACTATTTGTTCCTTGGTGAGGACTCCAAGAACTCACTGATGCATGCCGAGCTGAACTGAAGCAACAAGCGGATGACTATGTCAGAAGACATTCGGGCTCTCCAATGTCAGATGTGGTCAGTAGCGAGCCCCATGCCCGAGCTTAAGAACGACTGCAACACTACTTTATGGGCAGGGCCCTGGAAGAGTGAGCCCAGCAACACAGAGAAGCTCTGATGGTACAGATCAGCACTAACGTTGAACAGCTAATGAAGGCACCAAGTCTGAAGGAAGCAGAAGGGAAAGAACCTGAGCTCTTCCTAAGATCCAGGCCTGTGGCAGCCAAGGCCAAGCAGGCCCATCTCACCACCCTGAAGCATATACAACCCACGCCGGTTGAAGAAGCTTGGGGAAGAATCTGGAGATGAGATTGATGTTCCAAAGGATGAGCTTAGTGTGGAATTAGAAACTTTATTCATTGGTGTAACCAAACCACCTAGTGAGTTACCCTAAGAATTGACACAAATCTCATATTTTAGGAGATTATATTGGTTCTGCCTCTGGCATGCTGGTAGACTAGGGCCATCTCAACTTATTGTTTTCCAGAGGTTCTCCTCCAGACAAGATTTGCAGTAAGCAAAGAGTTATACTCTACCTGTCTCTAAAGGCCACACACACACAGATTTGTGTGGCTTTTATTGTAGAACTAAACTTAGCATAGTGTTCTGTTGTTTACATGAAGTGTGAGTTTTCTTTTGTTTCTGCTGTTTTCCAACTAAAGATTTTTTTCTAAGTAAATATTTTCAACAATTGATTTGAAAAAATTTGTCAGGATTATTTCAGCTTTTCACATTTATTATCTGAAATTCCTATTTCCTATTAATGTAGGAGGTGGATGCAGACTTTATTAATATGAGGAATCTAAAAGGAACTACATATAAAAATGCATTCTTTCTATTAAACTATGAGGACTATATA
>XM_024453833.1
AGTGGAAGAACGCGAAGCGAGGATGAGTGATCCGTGGAGGCAGTAACAGGCGCGGCGAGGGAGAAGTGATTCCCGAAGAATCAAGGCTGGGCCGGACCCGGTGGCCTGGCAACAGGGTAATAAGAGAAATGAAGCCAACAGGTACAGACCCAAGGATCTTATCTATAGCTGCTGAAGTTGCAAAAAGCCCTGAGCAGAATGTCCCTGTTATACTGTTGAAGTTAAAAGAAATAATAAACATCACACCTTTAGGAAGCTCAGAGTTGAAGAAAATCAAACAAGATATATATTGTTATGATCTCATTCAATATTGCCTCTTGGTCCTCAGTCAAGATTATTCTCGAATCCAGGGTGGTTGGACTACAATTTCCCAGCTTACACAGATATTAAGCCATTGCTGTGTGGGCTTGGAGCCAGGAGAAGATGCAGAGGAATTTTACAATGAATTACTTCCATCAGCTGCAGAAAATTTTCTAGTTTTGGGGAGACAATTACAAACATGTTTTATCAATGCAGCTAAGgtctgctggagtttgctggaggtccactccagaccctgtttgcctgggtatcagcagcagaggctgtagaacagcaaatattactcacacctccttcctctggaagcttcgtctcagagtggcacctgcctgattcctgccagagctctcctgtttggaggtgtctcccagtctggaggcacagggtcagggacccacttgaggaggcattctgttccttagcagagctctagcactaacaaattcaaattcagtatatcaactgtgctgggagatgcgccgctctcttcagcgctggcaggcaggaacatttaagtctgctgaaactgcacccacagtctcccctgtccccagGCTGAAGAAAAAGATGAATTACTACACTTTTTCCAAATTGTGACTGATTCTCTCTTCTGGCTTTTGGGAGGCCATGTTGAACTTATTCAGAATGTACTACAAAGTGATCATTTCTTACATTTACTGCAAGCTGACAATGTCCAAATAGGATCTGCAGTCATGATGATGCTACAGAATATACTACAGATCAACAGTGGTGATTTACTCAGAATAGGAAGAAAAGCCCTGTATTCAATTTTAGATGAAGTTATTTTCAAGCTTTTTTCAACTCCTAGTCCAGTTATAAGAAGTACTGCTACAAAACTCCTACTGTTGATGGCTGAATCCCATCAGGAAATTTTGATTTTACTGAGACAAAGTACCTGCTACAAAGGACTCAGACGTCTACTAAGTAAACAGGAAACTGGGACTGAATTCAGTCAAGAACTTAGACAGCTTGTTGGCCTTTTAAGCCCAATGGTCTATCAGGAAGTAGAAGAGCAGAAACTACATCAAGCAGCATGCTTGATTCAAGCCTATTGGAAGGGTTTTCAGACAAGAAAGAGATTAAAGAAGCTTCCATCTGCTGTGATTGCTTTGCAGAGGAGTTTCAGATCCAAACGATCAAAGATGTTGCTGGAGATAAATAGGCAGAAGGAAGAAGAGGACCTCAAATTACAATTGCAACTTCAAAGACAGAGAGCCATGAGACTTTCCCGAGAATTGCAGCTGAGTATGCTCGAAATAGTTCATCCAGGTCAGGTGGAGAAACACTATCGGGAAATGGAAGAGAAATCAGCACTGATTATCCAGAAACATTGGAGAGGGTACAGGGAAAGGAAAAATTTTCACCAACAGAGGCAGTCTCTCATAGAGTATAAAGCAGCTGTCACACTTCAAAGAGCAGCGCTTAAATTCCTAGCGAAGTGCCGTAAGAAAAAGAAACTATTTGCTCCTTGGCGAGGACTCCAAGAACTCACTGATGCACGCCGAGTTGAACTGAAGAAACGAGTGGATGACTATGTCAGAAGACATTTGGGCTCTCCAATGTCAGATGTGGTCAGTAGGGAGCTCCATGCCCAAGCTCAAGAACGACTGCAACACTACTTTATGGGCAGGGCCCTAGAAGAGCGAGCCCAGCAGCACAGAGAAGCTCTGATAGCACAGATCAGCACCAACGTTGAACAGCTAATGAAGGCACCAAGTCTGAAGGAGGCAGAAGGGAAAGAACCTGAGCTCTTCCTAAGTAGATCCAGGCCTGTGGCAGCCAAGGCCAAGCAGGCCCATCTCACAACCCTGAAGCACATACAAGCACCCTGGTGGAAGAAGCTTGGAGAAGAATCTGGAGATGAGATTGATGTTCCAAAGGATGAGCTTAGTATAGAATTAGAAAATTTATTCATTGGTGGAACCAAACCACCTTAGTGAGTAACCCTAAGAATTGACACAAATCTCATATTTTAGGAGATTATATTGGTTCTGCCTCTGGCATGCTGGTAGACTAGGGCCATCCTAACTTATTATTTTCCAGAGGTTCTCCTCCAGACAAGACCTGCAGTAAGCAAAGAGTTATATTCTACCTCTCTCTCAATTTTCTTTTTCTTTTCTCTGTATCCTCATCGTTAGCCACACACAGATTTGTGTGGCTTTTATTGTAGAACTAAACTTAGCATAGTGTTCTGTTGTTTACATGAAGTGTGTTTTTCTTTGGTTTCTTCTGTTTTCCAACTAAATATTTTTTTCTAAATAAATATTTTCAACAATTGATTTGAAAAATTTGTCAGGATTATTTCAACTTTTCACATTTGTTATCTGAAATTCCTATTTCCTGTTAACATAGGAGGTGTGTGCAGACTTTATTAATGTGAGGAAAAGAAATGCTCAATTGAAGGACATTTCCCTGTTTTCTATAAAGCAATGGTTGAACTCATTTTCTATTTTGTTATTTCTAAAAGGAACTGCATACCAAAAAAatgcattctttctattaaactgtgagaactacataa

Publications

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