Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TMPOP1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:30466681-30471117  UCSC
Coordinates (T2T) chr6:30330915-30335346  UCSC
Coordinates (hg19) chr6:30434458-30438894  UCSC
Strand +
Parental Sequence NM_001032283.3
Parental seq. overlap 1496 bp
Parental seq. overlap (%) 34.8%
Genomic Region Intergenic
Retrocopy Summary TMPOP1, located on chr6:30466681-30471117, is a retrocopy of the parental gene TMPO. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TMPO
Full Name thymopoietin
Also known as CMD1T|LAP2|LEMD4|PRO0868|TP
Coordinate chr12:98515573-98550351
Strand +
Gene summary Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TMPOP1
Bonobo Pan paniscus TMPOP1
Gorilla Gorilla gorilla TMPOP1
Orangutan Pongo abelii TMPOP1
Gibbon Nomascus leucogenys TMPOP2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TMPOP1
AGCAGGAAAGCCACGAAGAAAACAGTTCAACTCAGACCAAAAGATAAAGCTGATCTCGAGGTAACCGCGCTCACTAATGAAGATCTCGTGGACCCGCTTGCGAGGTATAAAGAGAAACCTAGTCCTACTGGAGAACAACCAGGAAGCGATGTGAGAAAAAAACCTTGAAACCGAAGGAACGAGGAGGATTAACAATTTAATCTTCAGCAGAAAATGGAAGGCAGAATTGAAATAAAGGTTCTAATAGATACTGTGACAATGAAGAAGACTAGAGTAAAGATCAAGCTTGAGAAGACAGAACCACTAAAGGGCAGAGCAAAGACTCCAGTAACACTGAAGAAAAGAAGACTTGAGATAGTCAGAGCTATTCTCACGCTGGAATAACTGAGGCTGAACGCACAAGTGGAGCTTCAGAAGGCGGAGCTCTGCAGGCCTGGAGTAGGGAGTCTACCAGAGACCGGAGGAGAAGGCCAAGGAAGAGGGTGGAAACCAGAACATTTTCCAATAGACAGTGCAGTAATTTCAGAGAGTGCTCCCACAGCTGAAACTCTAATGGCTTCAGGACACAAAACCTTCGTTGTCAGTAGGATGACTGGAAATTTCAAGCATGCAGCTCCTATTCTGCAACTCAGTAAATTTTCAAACATACCCCAAACTCCAAAGAGACCACTGGGGTTGGGGGGGAACAGAATAAAGAAGAGTAGAAAGGGATATTCTTAAGGAAATGTTGCCCTATGAAGCATCTACACCAACAGGAATTGCTGCAGACCAGTCAAAGGGGCTACAGGCAGGCCATTAGAACTCACTGAGTTCAGGATGGCAGAATCTTTTTCATCTAAATATGTTCCTAAGTGTGTTCCCTTGGCAGATGTCAAGTCAGAAAAGACAAAAAAAGAATGAGCCATTTCTGTATGGACAAAAATTTTGCGTCTATCAAGCTATAGAAACCAAACAAGGAAATCTTTTCTCTAACGTTCTTCCTGATGACTCTAGAAACCCAACTGAATGGAATCCATCTGGCACATTCAAGTTGGCCTCCTATTTTTAATAACTGTATTGAAAAACACTTGTGTACCCTTGTTGACTTAAATAGCTAAAAAAAAAAAAACAGGTGATTTCACCTCAATAAATGTAGTATTCCATGAAAAGCAAACAAAATATATATAAATGAACTTCATTAGAGTGTTTTTGAACTCTGGACTAGCAGGAGATCACTTCATGCCATATGAAAATCTTTTATAGCTCTGAAACTTTTTTGTAGGCTTTTTAAAATTTTTTCTTCTCATTGTCCAAACCCATGCAGGGTTTCTTTAAAATGTGGACACCTGGTTTCCTTTTTGAAAAATGAGGAAACAAGAAGGGAAAAACATGGTAATATAGTATGAAGTTACACATTTAAATACTTTGAATTCTTACAGAAAAGAGTGGAAGAATTATCTTCTACTGAATAAAAACTTTACAGACATGGAAGACAATGAAATTTGGTAAGAGAAAAAGTAACATGGTTGTACTTTTTGTAACTGCAACGAAATTTGATGGTGTTTATGAGGAAAACTACAGCAATAATCTCTTCTGTAACTTTTATTAATAGTAATGTTAGACTCAGAAATGGTGGCCTCCATGTTCTTCCGCCCGCTGTTGGTGGCCGCCACCCTTCGGACCACACTGGAAAAAAATAGTAATGTTATTATTGTAGCCCTATCATATTCACTTTTTAAACGACTGGCTTTTAAAAGTATCATGAAAGTCCTACTTCAGTAAAACCCATTTAAGTACAGTTGATGTTTAGCAGGGATCTTTTAGTGCAGCATAAACATGCTTTAGAGAACTGTTGGCTGGCTGTACATGTTTTTAAAAGCTGTTAGCTAGCTATGAGGCTA
>NM_001032283.3
GAAGCAGGCTGCTCGCCTCCTGCCTGTAGTGTGTGGGCTGGGGTTGGTGCGAGCTTCCAGCTTGGCCGCAGTTGGTTCGTAGTTCGGCTCTGGGGTCTTTTGTGTCCGGGTCTGGCTTGGCTTTGTGTCCGCGAGTTTTTGTTCCGCTCCGCAGCGCTCTTCCCGGGCAGGAGCCGTGAGGCTCGGAGGCGGCAGCGCGGTCCCCGGCCAGGAGCAAGCGCGCCGGCGTGAGCGGCGGCGGCAAAGGCTGTGGGGAGGGGGCTTCGCAGATCCCCGAGATGCCGGAGTTCCTGGAAGACCCCTCGGTCCTGACAAAAGACAAGTTGAAGAGTGAGTTGGTCGCCAACAATGTGACGCTGCCGGCCGGGGAGCAGCGCAAAGACGTGTACGTCCAGCTCTACCTGCAGCACCTCACGGCTCGCAACCGGCCGCCGCTCCCCGCCGGCACCAACAGCAAGGGGCCCCCGGACTTCTCCAGTGACGAAGAGCGCGAGCCCACCCCGGTCCTCGGCTCTggggccgccgccgcgggccggagccgagcagccgtcggcaggAAAGCCACAAAAAAAACTGATAAACCCAGACAAGAAGATAAAGATGATCTAGATGTAACAGAGCTCACTAATGAAGATCTTTTGGATCAGCTTGTGAAATACGGAGTGAATCCTGGTCCTATTGTGGGAACAACCAGGAAGCTATATGAGAAAAAGCTTTTGAAACTGAGGGAACAAGGAACAGAATCAAGATCTTCTACTCCTCTGCCAACAATTTCTTCTTCAGCAGAAAATACAAGGCAGAATGGAAGTAATGATTCTGACAGATACAGTGACAATGAAGAAGACTCTAAAATAGAGCTCAAGCTTGAGAAGAGAGAACCACTAAAGGGCAGAGCAAAGACTCCAGTAACACTCAAGCAAAGAAGAGTTGAGCACAATCAGAGCTATTCTCAAGCTGGAATAACTGAGACTGAATGGACAAGTGGATCTTCAAAAGGCGGACCTCTGCAGGCATTAACTAGGGAATCTACAAGAGGGTCAAGAAGAACTCCAAGGAAAAGGGTGGAAACTTCAGAACATTTTCGTATAGATGGTCCAGTAATTTCAGAGAGTACTCCCATAGCTGAAACTATAATGGCTTCAAGCAACGAATCCTTAGTTGTCAATAGGGTGACTGGAAATTTCAAGCATGCATCTCCTATTCTGCCAATCACTGAATTCTCAGACATACCCAGAAGAGCACCAAAGAAACCATTGACAAGAGCTGAAGTGGGAGAAAAAACAGAGGAAAGAAGAGTAGAAAGGGATATTCTTAAGGAAATGTTCCCCTATGAAGCATCTACACCAACAGGAATTAGTGCTAGTTGCCGCAGACCAATCAAAGGGGCTGCAGGCCGGCCATTAGAACTCAGTGATTTCAGGATGGAGGAGTCTTTTTCATCTAAATATGTTCCTAAGTATGTTCCCTTGGCAGATGTCAAGTCAGAAAAGACAAAAAAGGGACGCTCCATTCCCGTATGGATAAAAATTTTGCTGTTTGTTGTTGTGGCAGTTTTTTTGTTTTTGGTCTATCAAGCTATGGAAACCAACCAAGTAAATCCCTTCTCTAATTTTCTTCATGTTGACCCTAGAAAATCCAACTGAATGGTATCTCTTTGGCACGTTCAACTTGGTCTCCTATTTTCAATAACTGTTGAAAAACATTTGTGTACACTTGTTGACTCCAAGAACTAAAAATAATGTGATTTCGCCTCAATAAATGTAGTATTTCATTGAAAAGCAAACAAAATATATATAAATGGACTTCATTAAAATGTTTTTGAACTTTGGACTAGTAGGAGATCACTTTGTGCCATATGAATAATCTTTTTTAGCTCTGGAACTTTTTGTAGGCTTTATTTTTTTAATGTGGGCATCTTATTTCATTTTTGAAAAAATGTATATGTTTTTTGTGTATTTGGGAAACGAAGGGTGAAACATGGTAGTATAATGTGAAGCTACACATTTAAATACTTAGAATTCTTACAGAAAAGATTTTAAGAATTATTCTCTGCTGAATAAAAACTGCAAATATGTGAAACATAATGAAATTCAGTAAGAGGAAAAGTAACTTGGTTGTACTTTTTGTAACTGCAACAAAGTTTGATGGTGTTTATGAGGAAAAGTACAGCAATAATCTCTTCTGTAACCTTTATTAATAGTAATGTTGTTGTAGCCCTATCATACTCACTTTTTAAGACACAGTATCATGAAAGTCCTATTTCAGTAAGACCCATTTACATACAGTAGATTTTTAGCAGAGATCTTTTAGTGTAACATACATATTTTAGAGAATTGTTGGCTAGCTGTACATGTTTTGAAAAGCTGTTTAGCTAGCTATAAGGCTATAATTGGAAATTTGTATTTTTTATTTACAGCAAAACATTTATTCAGTCATCCAGTTTGCTACCAAAATATGTTTTAGATAAGTGTGTGTATGTTTGTTTAGAAGTTAGAAATTGTAAACACTGGTCTTATGTTTCATTTGGATTCATTATTGCATTGTCTTGTTACCAGAAACAAATTTTGCCGAGCTTTTTTTGCCCTATATTTCCCAGCATAATTTGATTAGAAAGTACAAAAAGggccaggcgcggtggcttacgcctgtaatcccagcactttgggaggccagggcgggtggatcacgaggtcaagagatcaagaccatcctggccaacatggtgaaaccccgtctctactaaaaatacaaaaaaattagctgggcgtgatgatgtgcgcctgtagtcctgtctactagggagactgaggcaggagaatcgtttgaacccaggaggcagaggttgcagtgagcagagattacgtcactgcactgtagcctggcgacagagcaagactccatctcaaaaaaaataaaaaagtacaaaaaGTACTTGCTTTTATATTACATCATAAGCAGTAGTTAATAAAGTTGTATACTCTTAAGAGGTGGGCATTATGATTATTTtttatttttttattttttatgagatggagtctcactcttgtcacccagactgtagtgcagtggcacgatctgggctcgatgcaacctctgcctcccaggttcaagcaattttcctgcctcggcagagacggggtttcaccatgttggccaggctggtctcgaacccctgacctcaagtgatcagcccacctcagcttcccaaagtgctgggattacaggtgtgatccactgcacccggccGGCATTATGATTTTGTGTACTCTTGAAATGGTTATCTTTGTGGATGATTTTTTTTTTTAAGCTGAAACTTACCTCATGAATAACTTGATTAAAGTAGTAGGTGATTAAAATTTCAATAGAATCAAATGAGACAAAAATTTTAAACTGACTCATTTGAGTTTCAACTTTACAGTCATTGACCATAAAGCACACTAAAAATGTAAGTTATTTTTAAATACATCTGAAATAAAAATACTTACTAAAAAGGAAGAAGCCGAAGATGTATATTTAGACCAGCACACAATTTTGATTTCAATTAGCCTTATTCTAATATTTAGCTTTTAGATCTTTCATACACATTTTCACGTACTTTGCAATTGAGACCAGAAAGACTTGTAGGTCTTTCTGCAGAATGAGTGGGTCCTTGCAAAGTGAGTGGGAAACTTACTCCTAGATCAGAAATGTTTGCCTCTCTGAGTAAAATGTTTCTTTCAGATGAGCCATAGAGGGGGCACCTTTTACTCAACTTTTCTTTGTTTTGAAACTTTGTTTCCCATACTGTTTTCAGCCTTTTGTTTATAATTAGAAATTGTGAGAAGCTTCATTTAGTGTTTAAAAATGTGGGGAGATAAATCAGACTTAACATGTATGTAAGATCAATTCACTTAAAAGTATGGTCCAAATAGCAAAAATAGGACCAGGTGAAACATGTAGTCATTTTTTAAAAACATGTACTTGGTCTTTTGTGTGTGTCTGTTTTATTCCATTAGAATAAATGTGTCCTTGATGTAAATGCAAAGCATTTCTTCCTGATTAAATTGTAGATGTAGACTTTACAATATAATTCAATAATAAAAAGTAATTAACCTCTAGTTTTGTCGTTGCAATAAATGGTTTTCAGATAGCACAAA

Publications

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