Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SUCLA2P1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr13). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:30468940-30470905  UCSC
Coordinates (T2T) chr6:30333169-30335134  UCSC
Coordinates (hg19) chr6:30436717-30438682  UCSC
Strand +
Parental Sequence NM_003850.3
Parental seq. overlap 1849 bp
Parental seq. overlap (%) 87.3%
Genomic Region Intergenic
Retrocopy Summary SUCLA2P1, located on chr6:30468940-30470905, is a retrocopy of the parental gene SUCLA2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SUCLA2
Full Name succinate-CoA ligase ADP-forming subunit beta
Also known as A-BETA|A-SCS|LINC00444|MTDPS5|SCS-betaA
Coordinate chr13:47942656-48001273
Strand -
Gene summary Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SUCLA2P3
Bonobo Pan paniscus SUCLA2P3
Gorilla Gorilla gorilla SUCLA2P3
Orangutan Pongo abelii SUCLA2P3
Gibbon Nomascus leucogenys SUCLA2P3
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SUCLA2P1
TGCGGGCTGCTGCTCAGGTTCTGGGAAGTTCTGGATTGTTTAATAACCATGGACTCCAAGTACAGCAGCAACAGCAAAGGAATCTCTCACTACATGAATACATGAGTATGGAATTATTGCAAGAAACTGGTGTCTCTGTTCCCAAAGGATATGTGGCAAAGTGACCAGATGAAGCTTATGCAATTGCCAAAAAATTAGGTTCAAAAGATGTTGTGATGAAGGCACAGGTTTTAGCTGGTGGTAGAGGAAAAGGAACATTTGAAAGTGGCCTCAAAGGAGGAGTGAAGATGGTTTTCTCTCCAGAAGAAGCAAAAGCTGTTCCTTCACAAATGATTAGGAAACAGTTGTTTACCAAGCAAATGGGAGAAAAGGGCAGAATATGCAATCAGGTATTGGTCTGTGAGTGAAAATATCCCAAGAGAGAGTGCTACTTTGCAATAACAATGGAAAGGTCATTTCAAGGTCTTGTATTAATAGGAAGTTTACATAGTGGGGCCAACATTGAAGATGTTGCTGCTGAGACTCCTGAAGCAATAATTAAAGTACCTATTGATATTGTAGAAGGTATCAAAGAGGAATAAGCTCTCCAGCTTGCACAGAAGATGGGATTTCCATCTAATATTGTGGCTTCAGCAGCAGAAAACATGATCAAGCTTTACAGCCTTTTTCTGAAATACGATGCAACCATGATAGAAATAAATTCAATGGTGGAAGATTCAGATGGAGCTGCATTGTGTAAGGATGCAAAGATCAATTTTGACTCTAATTCAGCCTATCGCCAAAAGAAAATGTTTGATCTACAGGACTGGACCCAGGAAGATGAAAGGAACAAAGATGCTGCTAAGGCAGATCTCAACTACACTGGCCTCGATGGAAGTATAGGCTGCCTAGTAAATGGTGCTGGTTTGGCTATGGCCACAATGGATATAATAAAACTTCATGGAGAGACTCCAGCTAATTTCCTTGTTGGTGGTGGTGCTACAGTCCATCAAGTAACAGAAGCATTTAAGCCTATCACTTCAGATAAAAAGGTACTGGCTATTCTGGTCAACATTTGTGGAGGAATCATGCACTGTGATATTACAGCAAAGGGTATAGTCATGGCAGTAAAAAGTTTGGAAATTAAAATACCTGTTGTGGTACAGTTACAAGGTACACAAGTTGATGATGTTAAGGCACTAAAAGCAGACAGTGGACTTAAAATACTTGCTTGTGATGATTTGGTGGAAGCTGCTAGAGTGCTTGTAAAGCTCTCTGAAATAGTGAAGCAAAGCAAGCGCATGTGGATGTGAAATTTCAATTGCCAATATGATCTGAAAACCCAGTGATGGCTGAAGGTGTTAAATGTGCTACAATCATTAAGGATACTGTGTTCTGTGTTATTGTTCTTTTAAGTGTGTGGAGATTGTAGTTGCCATCTAGGCACACAAACATTTAAAAGCATTTGGTTTGCATTTAATTCTACCATTCAGAATGGACTGTTTGTAAGAAGCATGTATAATGCAAATATCTTCTTTATTTCGTCACAGCCAGTCTTTTTTGCTTCTACAAAATGCAACTTGCAATATGACAGTTTATTATTGTTGGATACAAAGTTCTTCATTGATAAGAGACCTACAAATAAAATAAATATGAAGATAAAGCTTTATTCTTCAGTGTTAACATACAGTATATCTAATAACTAGCCTCATTAGTAGACCAGTATATTAAAACACTGTTTTATGTAAAAAGTGTTTATCTTCAGCACCAAATACATAATAAATGTAACAATCACTATTTATAAACAGAGCTTTCAAACACTCCTCAGAAAATCAAAATACTTCTAAGTATTTTGATGAAGTAACTTTGTAATTATGTGAACATTGTTTTAATCATTAGGAAACGCTGATAACTGCAAGAATTCATGATTCCATGGTATTAAGAAGCACCTGTAGGTTTGTTTCAAATAGAGGCATATTAACCAAGG
>NM_003850.3
AGAAATGGCGGCCTCCATGTTCTACGGCAGGCTAGTGGCCGTGGCCACCCTTCGGAACCACCGGCCTCGGACGGCCCAGCGGGCTGCTGCTCAGGTTCTGGGAAGTTCTGGATTGTTTAATAACCATGGACTCCAAGTACAGCAGCAACAGCAAAGGAATCTCTCACTACATGAATACATGAGTATGGAATTATTGCAAGAAGCTGGTGTCTCCGTTCCCAAAGGATATGTGGCAAAGTCACCAGATGAAGCTTATGCAATTGCCAAAAAATTAGGTTCAAAAGATGTCGTGATAAAGGCACAGGTTTTAGCTGGTGGTAGAGGAAAAGGAACATTTGAAAGTGGCCTCAAAGGAGGAGTGAAGATAGTTTTCTCTCCAGAAGAAGCAAAAGCTGTTTCTTCACAAATGATTGGGAAAAAATTGTTTACCAAGCAAACGGGAGAAAAGGGCAGAATATGCAATCAAGTATTGGTCTGTGAGCGAAAATATCCCAGGAGAGAATACTACTTTGCAATAACAATGGAAAGGTCATTTCAAGGTCCTGTATTAATAGGAAGTTCACATGGTGGTGTCAACATTGAAGATGTTGCTGCTGAGTCTCCTGAAGCAATAATTAAAGAACCTATTGATATTGAAGAAGGCATCAAAAAGGAACAAGCTCTCCAGCTTGCACAGAAGATGGGATTTCCACCTAATATTGTGGAATCAGCAGCAGAAAACATGGTCAAGCTTTACAGCCTTTTTCTGAAATACGATGCAACCATGATAGAAATAAATCCAATGGTGGAAGATTCAGATGGAGCTGTATTGTGTATGGATGCAAAGATCAATTTTGACTCTAATTCAGCCTATCGCCAAAAGAAAATCTTTGATCTACAGGACTGGACCCAGGAAGATGAAAGGGACAAAGATGCTGCTAAGGCAAATCTCAACTACATTGGCCTCGATGGAAATATAGGCTGCCTAGTAAATGGTGCTGGTTTGGCTATGGCCACAATGGATATAATAAAACTTCATGGAGGGACTCCAGCCAACTTCCTTGATGTTGGTGGTGGTGCTACAGTCCATCAAGTAACAGAAGCATTTAAGCTTATCACTTCAGATAAAAAGGTACTGGCTATTCTGGTCAACATTTTTGGAGGAATCATGCGCTGTGATGTTATTGCACAGGGTATAGTCATGGCAGTAAAAGACTTGGAAATTAAAATACCTGTTGTGGTACGGTTACAAGGTACACGAGTCGATGATGCTAAGGCACTGATAGCGGACAGTGGACTTAAAATACTTGCTTGTGATGACTTGGATGAAGCTGCTAGAATGGTTGTAAAGCTCTCTGAAATAGTGACCTTAGCGAAGCAAGCACATGTGGATGTGAAATTTCAGTTGCCAATATGATCTGAAAACCCAGTGGATGGCTGAAGGTGTTAAATGTGCTATAATCATTAAGAATActgtgttctgtgttattgttctttttctttttagtgtgtGGAGATTGTAATTGCCATCTAGGCACACAAACATTTAAAAGGATTTGGACTGCATTTAATTGTACCATTCAGAATGGACTGTTTGTACGAAGCATGTATAATGCAGTTATCTTCTTTCTTTTGTCGCAGCCAGTCTTTTTTGCTTCTCCTACAAAACGTAACTTGCAATTTGCCAGTTTATTATTGTTGGATACAAAGTTCTTCATTGATAAGAGTCCTATAAATAAGATAAATACGAAGATAAAGCTTTATTCTTTAGTGTTAAAATACAGTATATCTAATAACTAGCCTCATTAGTAGAGCAGTATATTAAAACAATGTTTTATGTAAAAAGTGTTTATCTTCAGCACCAAATACATGATAAATGTATCAATCACTATTTATAAACAGAGCTTTCAAACACTCCTCAGAATATTCTTCTAAGTATTTTGATGAAGTAACTTTGTAATTATTTGAACATTGTTTTAATCATTAGGAAACACTGATTAACTGCAAGTCTTCATGATTCTGTCATATTAAGAAACACCTGTAGGTTTGCTTCAAATAAAGGCATATATACCAAGGACTTACAGACAAAATTAAGAATGTCAATTTAAGTTAATAAAAATCTCCCAATATGA

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