Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DHFRP2
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:31363470-31366960  UCSC
Coordinates (T2T) chr6:31219348-31222841  UCSC
Coordinates (hg19) chr6:31331247-31334737  UCSC
Strand -
Parental Sequence NM_000791.4
Parental seq. overlap 1089 bp
Parental seq. overlap (%) 25%
Genomic Region Intergenic
Retrocopy Summary DHFRP2, located on chr6:31363470-31366960, is a retrocopy of the parental gene DHFR. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DHFR
Full Name dihydrofolate reductase
Also known as DHFR1|DHFRP1|DYR
Coordinate chr5:80626226-80654983
Strand -
Gene summary Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DHFRP3
Bonobo Pan paniscus DHFRP3
Gorilla Gorilla gorilla DHFRP2
Orangutan Pongo abelii DHFRP3
Gibbon Nomascus leucogenys DHFRP4
Green monkey Chlorocebus sabaeus DHFRL1P1
Baboon Papio anubis DHFRP6
Golden snub-nosed monkey Rhinopithecus roxellana DHFRP4
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DHFRP2
CTCTATCATAATAAAAAGTCACACTTGTTCTAATAATAGGTTATGGCCAGATTTGGGGCATTTGGAAAGTAGTTCATTGAAGATAAAGCAAAAGTTAAAAAAAAAAAACAAGGGGGAAGGGTGGTTTATTCCAGCTATGGAGCTGGCTTTAAAAAGAAACAGTAAAAATATTAATAGGTTAGTTTGCCCTGGGTTTGGGCCCACTGAGTTTGAGATGCCTTTGAGAAATGAAGAAAGTAGAGAGAGAATAAAAGAAAAACTCCAGATCTTTATTCTTTTTATGTAGTAAAAAGTATAAAGCCACGCATGGTTTATTTGAAATATTTTATGTTTTAAAAAAATACATTCTGTCTTTTGGGGAACCCAAAGCAGGTTCCAAGACTGCAATTTCAGTGAAAGCAGTTTATTTTCTAGGTCTTACCAGAAATCATCAATTGAGGTACGGAGAAATGGAACTGAGAAGGTAAGAAAACCAGTTTAAAGCCAGTGAGCAGGTTCTCACTGGTAACAAACTCCATACTGCTGAGATACAGGGAAACGGAGGGGAGAAAGCTGGCATATTGATCCCCCACTCCTTGGTTGTCAGCTCCCTGTCCTGTGTGTGGGCAGAATGTACTCCAGCTGCTCTATAGCAAGTCCCAGGTGTTTGCAGTAAGAAGCTGCTGGCATGCATGTGAACAGTGAATGGCAAACACTTAAAGCAATTTCATGTTTAAGTATATAAGCTCTTCATATCGCCAATCTTGGCCGCGCGTCCTGGTGTAGCGAGCGGGCTTGGAGGAGCTCACCGCTGCTGTCATGGTTCGTTTGCTAAACTGCATCGTCGCTGTGTCTCAGAACATGGGCATCGGCAAGAACGGGGACCTGCCCTGACCGCCGCTCAGGAATGAATTTAGGTATTTCCAGAGAATGACACAATCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTTTGTGTAGGAAGACCTGGTTCTCCATTCCTGGGAAGAATCGACCTTCAAAGGATAGAATTAATTTAGTTCTCAGCAGAGAACTCAAGGAACCTCCACAACGAGCTCATTTTCTTGCCAGAAGTCTGGTTGAGATCTTAAAACTTACTTAACAACCAGAATTAGCAAATAGAGTAGACATGATTTGGATAGTTGGTGGCAGTTCTGTTTATAAGGAAGCCATGAGTCGCCCAGGCCATCTTAAACTATTTGTGACAAAGATCATGCAGGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAAATTCTGCCAGAATATCCAGGCGTTCTCTCGGATGTATTAAGTACAAATTTCAAGTATATGAGAAGAATGATTAATATGAAGGTGTTTTCTGGTTTATTTTAAGTTGTTCCCCCTCCCTCTGAAAAAAAGTTTATATTTTTACATTAGAAAAAAAGACTTTTGTTGACTTTAGATCTTTGGATAATTATTTCTAAGCAACATGTTTTTACTCCCCACTAATCTTGACTATATCAGATACCACTTATGAAATATTCTTGCTATAATTAAGTGCCTCTCCAAGACCCTGACTGAGTCCCCAGCACCTGCTACAGTGAGCTGCCATTCCACACCCATCGCATATGGGACTCTTGCCAGTCCTTGACATTGTCGGGCTTTTCAAATGt
>NM_000791.4
AGTCCCAGACAGAACCTACTATGTGCGGCGGCAGCTGGGGCGGGAAGGCGGGAGCTGGGGGCGCTGGGGGcgctgcggccgctgcggccgctgcagccgctgcAGCGCCAGGGTCCACCTGGTCGGCTGCACCTGTGGAGGAGGAGGTGGATTTCAGGCTTCCCGTAGACTGGAAGAATCGGCTCAAAACCGCTTGCCTCGCAGGGGCTGAGCTGGAGGCAGCGAGGCCGCCCGACGCAGGCTTCCGGCGAGACATGGCAGGGCAAGGATGGCAGCCCGGCGGCAGGGCCTGGCGAGGAGCGCGAGCCCGCGGCCGCAGTTCCCAGGCGTCTGCGGGCGCGAGCACGCCGCGACCCTGCGTGCGCCGGGGCGGGGGGGCGGGGCCTCGCCTGCACAAATGGGGACGAGGGGGGCGGGGCGGCCACAATTTCGCGCCAAACTTGACCGCGCGTTCTGCTGTAACGAGCGGGCTCGGAGGTCCTCCCGCTGCTGTCATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAACATGGGCATCGGCAAGAACGGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTCCAGAGAATGACCACAACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGACCTGGTTCTCCATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAGAGAACTCAAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAACTTACTGAACAACCAGAATTAGCAAATAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCTGTTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATGCAAGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTGCCAGAATACCCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTTGAAGTATATGAGAAGAATGATTAATATGAAGGTGTTTTCTAGTTTAAGTTGTTCCCCCTCCCTCTGAAAAAAGTATGTATTTTTACATTAGAAAAGGTTTTTTGTTGACTTTAGATCTATAATTATTTCTAAGCAACTAGTTTTTATTCCCCACTACTCTTGTCTCTATCAGATACCATTTATGAGACATTCTTGCTATAACTAAGTGCTTCTCCAAGACCCCAACTGAGTCCCCAGCACCTGCTACAGTGAGCTGCCATTCCACACCCATCACATGTGGCACTCTTGCCAGTCCTTGACATTGTCGGGCTTTTCACATGttggtaatatttattaaagatgaagatccacatacccttcaactgagcagtttcactagtggaaataccaaaagcttcctacgtgtatatccagaggtttgtagataaatgttgccaccttgtttgtaacagtgaaaaattgaaaacaacctggaagtccagtgatgggaaaatgagtaTGTTTctgtcttagattggggaacccaaagcagattgcaagactgaaatttcagtgaaagcagtgtatttgctaggtcataccagaaatcatcaattgaggtacggagaaactgaactgagaaggtaagaaaagcaatttaaagTCAGCGAGCAGGTTCTCATTGATAACAAGCTCCATACTGCTGAGATACAGGGAAATGGAGGGGGGAAAGCTGGAGTATTGATCCCGCCCCCCTCCTTGGTTGTCAGCTCCCTGTCCTGTGTGTGGGCGGAACATAGTCCAGCTGCTCTATAGCAAGTCTCAGGTGTTTGCAGTAAGAAGCTGCTGGCATGCACGGGAACAGTGAATGCCAAACACTTAAAGCAATTCGATGTTTAAGTATGTAAGttcttttttttttagacagcgtttcgctcttgttgcccaggctagcatgcaatggtgtgacctcggcttactgcaacctccgccttcccagattcaagcgattctcctgcctcaggctcccaagtagctaggaccaggtgcgcgccaccacgcccggctaatttttgtattttgtatttttagtagagatggggtttcaccatgttggtcaggctagtctcgaactcgtgaccgcaagcgattcacccacctcagcctcccaaagtgctgggattaccggcttgagccaccacacccggcACATCTTCATTCTTTTTATGTAGTAAAAAGTATAAGGCCACACATGGTTTATTTGAAGTATTTTATAATTTAAAAAAATACAgaagcaggaaaaccaattataagttcaagtgagggatgatggttgcttgaaccaaagggttgcatgtagtaagaaattgtgatttaagatatattttaaagttataagtagcaggatattctgatggagtttgactttggTTTTGGGCCCAGGGAGTTTCAGATGCCTTTGAGAAATGAATGAAGTAGAGAGAAAATAAAAGAAAAACCAgccaggcacagtggctcacacctgtaatcccagcgctttgggaggctaaggcaggcagatcacttgagaccagcttgggcaacatggcaaagccccatctctacaaaaaacacaaaaattagctgggcattgtggcgcacacctgtattcccatctagtcaggaagctgagatggaagaattaattgagcccacgagttcaaggctgcagtgagtcgtgattgtgccactgcactccagccggggtgacagaagagaccttgtctcgaaaaggaatctgaaaacaatggaaccatgccttcataattctagaaagttattttcaactgataaatctatattcacccaaataatcaagggtgaaggtaaaataatacatttttagacaagcaaagactcaggggttacctccatgtgccctttttagggaagctgttggagaaaatactccagcaaaatgaaggagtacacaaaccagagaatgacatgaatccagcaaataggatccaacacaggCAATATTCCAGCTATGGAGCTAGCTTTAAAAAGGAACAGTAAAAATATTAATCGGTTAgctgggtggaatggcccatgcctgtagtcccagctactcaggaggctcagcagcaggacgacttgagcccaagagttccagaccagcctggccaccttagtgagatcccttctcttaaaaaTAATAACTTATTGCCAGATTTGGGGCATTTGGAAAGAAGTTCATTGAAGATAAAGCAAAAGTAAAAAAAAAaaaaaaaaaaacaaggggaaagggttggttaggcaatcattctagggcagaaagaagtacaggataggaagagcataatacactgtttttctcaacaaggagcagtatgtacacagtcataatgatgtgactgcttagcccctaaatatggtaactactctgggacaatatgggaggaaaagtgaagattgtgatggtgtaagagctaaatcctcatctgtcatatccagaaatcactatataatatataataatgaaatgactaagttatgtgaggaaaaaaacagaagacattgctaaaagagttaaaagtcattgctctggagaattaggagggatggggcaggggactgttaggatgcattataaactgaaaagcctttttaaaattttatgtattaatatatgcattcacttgaaaaactaaaaaaaaacaataatttggaaaaacccatgaaggtaactaacggaaggaaaaactaagagaatgaaaagtatttgcctctggaaagaacaactggcaggactgttgttttcattgtaagacttttggagccatttaattgtacttaaccattttcatctatttctttaataagaacaaTTCCATCTTAATAAAGAGTTACACTTGTTAATAAGT

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