Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name NUDT5P1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:36091870-36092808  UCSC
Coordinates (T2T) chr6:35912192-35913130  UCSC
Coordinates (hg19) chr6:36059647-36060585  UCSC
Strand -
Parental Sequence NM_014142.4
Parental seq. overlap 834 bp
Parental seq. overlap (%) 26.1%
Genomic Region Intragenic (MAPK14)
Retrocopy Summary NUDT5P1, located on chr6:36091870-36092808, is a retrocopy of the parental gene NUDT5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NUDT5
Full Name nudix hydrolase 5
Also known as YSA1|YSA1H|YSAH1|hNUDT5
Coordinate chr10:12165330-12195891
Strand -
Gene summary This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NUDT5P1
Bonobo Pan paniscus NUDT5P1
Gorilla Gorilla gorilla NUDT5P1
Orangutan Pongo abelii NUDT5P1
Gibbon Nomascus leucogenys NUDT5P1
Green monkey Chlorocebus sabaeus NUDT5P1
Crab-eating macaque Macaca fascicularis NUDT5P1
Rhesus Macaca mulatta NUDT5P1
Baboon Papio anubis NUDT5P1
Golden snub-nosed monkey Rhinopithecus roxellana NUDT5P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NUDT5P1
CATCCTTTCATCACCTCGGGAGGTGCCGATGTCTTGAGTCGTGACACCGGCGTATGCTGACACTGCTGCCTCCAGTAGTTCTTTTGTCCTCTTCCCTTTGTCACCCCTACACTTTGGAGGTGAACTTCTCTCCTGAGGGCTGTAAAGACTAGTTTGAAAAGGGAGAGCCAAGAACCAACTGAATTGTCTCAGAATGGAAACACTATATTATTTCAGAGGAGTTAATTTCAGAAGGAAAATGGGTCAAACTTGAAAAAACAACATACATGGCTCCTATTGGTAAAACTGGAACTTGGGACTCAGTGAAACATACAACCAGGAAAGAACAGACTGGTGATGATGTAGCGGTCATCCCTGTGCTGCAGAGAACGCTTCACTACGAGTGTATCGTTCTGGTGAAACAGTCCTGACCACCAATGGGTGGCTACTGCATAGAGTTCCCTGCAGGGAACTCATAGAAGATGGTGAAACCCCAGGAGCAGCTGCTCTTTGGGAGCTTGAGGAAGAAACTGGCTACAAAGGGGACGCTGCTGAATGTTCTCCAGTGGTCTATATGGACCCAGGTTTGTCAAACTGTACCACACACATCGTGACAGTAATCATTAACGGAGATGACGCAGAAAATGTAAGGCCCAAGCCAAAGCCAGGGGATGGAGAATTTGTGGAAGTCATTTCGTTACCCAAGAATGACCTGCTGCAGGGACTCGATGCTCTCGTAGCTGAAAAACATCTTACAGTGGATGCCAAAGTCTATTCCCATGCTCTAGCACTGAAACATGCAAATGTGAAGCCATCTGAAGTGCCCGTCCTGAAATTTTAAGGCCAAAGACGACACTGGCCATTTTTGTAAATGAGACTACCAGGCCTTCTTCACAAAGGCTTTGTATTCAACTTAGTTTAATGTAGATTTGAATTAGCTTTTTCGTa
>NM_014142.4
GCCCATCCTTTTAGCACCGCGAGAGGCGCCGGTGTTTCGAGCCGTGGCACCGGCATCGGCTGACACTGCTGCCTCCAGCTAGTTATTTCGTCCTCTTCCGTTCTTCACCCCTACACCTTGGAGGTGAACTTCTCACCTGAGGGCTGTAAAGACTCGTTTGAAAATGGAGAGCCAAGAACCAACGGAATCTTCTCAGAATGGCAAACAGTATATCATTTCAGAGGAGTTAATTTCAGAAGGAAAATGGGTCAAGCTTGAAAAAACAACGTACATGGATCCTACTGGTAAAACTAGAACTTGGGAATCAGTGAAACGTACAACCAGGAAAGAGCAGACTGCGGATGGTGTCGCGGTCATCCCCGTGCTGCAGAGAACACTTCACTATGAGTGTATCGTTCTGGTGAAACAGTTCCGACCACCAATGGGGGGCTACTGCATAGAGTTCCCTGCAGGTCTCATAGATGATGGTGAAACCCCAGAAGCAGCTGCTCTCCGGGAGCTTGAAGAAGAAACTGGCTACAAAGGGGACATTGCCGAATGTTCTCCAGCGGTCTGTATGGACCCAGGCTTGTCAAACTGTACTATACACATCGTGACAGTCACCATTAACGGAGATGATGCCGAAAACGCAAGGCCGAAGCCAAAGCCAGGGGATGGAGAGTTTGTGGAAGTCATTTCTTTACCCAAGAATGACCTGCTGCAGAGACTTGATGCTCTGGTAGCTGAAGAACATCTCACAGTGGACGCCAGGGTCTATTCCTACGCTCTAGCACTGAAACATGCAAATGCAAAGCCATTTGAAGTGCCCTTCTTGAAATTTTAAGCCCAAATATGACACTGGCCATTTTTGTAAACGAGACCACCAGGCCTTCTTCACTAAGACTTTGTATTCAACTTAGTTTAATGTAGATTTGCCATTAGCTTTTTCGTAAAATAAAAGCACAGAACAGATGTGGTGGTGGTATGGAATTGTAATTACAGGTAGGTTGTGACCTTCCTTTAAATTTGTTATAACTCCAGCTAAAATTAACAAAGAATATAAATGCAAGTATGTTTACTCCAATTTTTTTAAAGCTCAACAGCAGTTAACTACAGCTCAGTTACTTTTCTAGTCCAGTCTGGTAGACAGGGGTATTTGTATAGAGAAATAGACCTGAGTTCTCAATTAGGTCATTTCCACTCTCAACCCCCAATATAAAATTCTAAGCTGGGTATGCAAATAACCATGTACTCCGTTAGTGTTTAAAACAGCGTTAAAAAGAAAAAAAAGGCTTTTTGGCCTCTTCTAATTGAATTTTTACTATGCAAAATTTATCTAGGGTAGTTGAATCCAACTAGGGTAGGGTTCGATAGAATCCTCTACTAGTTTTCAGTTCATCTATTTACTGAGGCTGAACCAGCTTTTAAGTAAGGAAAACGGTTGACTCCATTCACTACACCAAGGCTAGGAGACTAATGAAAATTCAGGTCCATCCCGCAAGCATCTGCACGTGCTTGAGGATCTCTTTTCCTATTCTTACCTCAAAGAGTACTTGAAGTTTCTGAAAACAAATCTGTAAGACTGACATGTTTGGGGCAGTAATATCTTGATGTTAAACCATGAACAGAACCAGCAAGATCAGCCAGTACCTGAAACCCAATACAGAGTAGTTCACAGCAAGAAGTACAGATTGATCTGGTTCCCATGCCTGAAACCCTGTCATCTAGCAGTTCTACCAGTGTTCCTGGGCCATTTTCTTAGCTTCTTGAGTGAGTTTAGCTCTTTTTGTGTTGACTTTTAGGGCCTCCAGCAGCTCCATGATTTTCCAGGACTTTCCAGTCTGGCCCCCACGGAATTCTCAGGATGATTCTCATCCAGCCCTAAGTCATGTTTCTAGCCTGGCTCCAGCGGGTAAGCCAGGCCCTGAGAACCATATGAAAGGGCTCTCCAGATAAAATCAGAGTGCTAATGCCAGAATGCTGCAGTAGCCTCCGTTTGTCCACAGGCTCACTGTCTGAGCCCAGGATATTTTTATGAGTGAAACTGTAAGATCTTTACACTGGACTTCCTAAAGATAAAACAATTATGGAAATACAGAACTTTACAGATGAAGCTGTCTAGCCCTATACATGTGAAAATTAAGATCCAACTACTTCCTGTAATGGTAGCCTTCCCCTATGCCTCTAACCCTTTTTTAAATCCTGATTTCAATCACAGGCATTGTGATTCTCCAAAGCTCTAACTCTTCCTTAGGTCTGAAAGCCACATGCTATCAATCATTGAAATCAAGAGAGAAGGCATCCGTAGACGGGCGCAGCCCAGTCTTTCCACATAGCCCAGTTCCTCCCCAGCCACTCCCCATGGGAATGACCTCTGCAGCTGACCTAAGCTTATCCTCTCCTTCTTCCTAAGAGTGCAACTTAGAAGTCAGAGCCAAATCCTAGAATGTATCCCTAAATGCCATTTCTATTTTTTATAAACATGAAAAGGTTGTGCTTTGGAAATTCAGTCTGTTTGAGAACTGGCAgtctggctggcactgtttaaaaatgtttatttgccctgcatttaaaaactgaaggtttcctatgtattaaaagccatatttccaccttcttaagggaaaaaaaaatcggacgtcataacactgggtggatgtttttatggtaacagtggtctgaggcCCTTGGCGGATGCTCACCGAGCCACTGTCACTATCCTGCCTGCCTTTATCTGCCTTGCCCTGCGATTATTTGGCTTTGTAAGCATAAGCTACGTAAGACATACCACACCTAAGAAACTAAACAGCAATGAAAACCCATACTTCTGAAAAGGGTGTCTTTTAAAAATTAAGTTTGATCTTTTGGGAAATAAAGCACATAGTTTTCAAAATGATTTACCAAGATCTATGCTCTTTCAAATGGAGACTGGGATATTGTTGTTTTGAGACCACTGTTTTCCTGTTTCCTCCCAAATGTTAGTCACATATATGATTACCCTTAAGTTGGTCACTATCTATCTATCTGTCAATAATTTAGGATTAAAGTTTGAAGTGTAATTACATTTGACTTTTACAGGCATCTCAGGGTGGACTTCTTATGAATACACTGAACCTATACAAATGATCTTAGAAAACGTTTAATATCAGATTTCTTTATTTTTTCCAACACAACTGAATCAGTTTTCTTAAATAAAAGTTTATTGTCTACTGTTTA

Publications

PMID - Link Title