Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GLRX3P2
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:3978158-3979366  UCSC
Coordinates (T2T) chr6:3847786-3848994  UCSC
Coordinates (hg19) chr6:3978392-3979600  UCSC
Strand +
Parental Sequence NM_006541.5
Parental seq. overlap 1098 bp
Parental seq. overlap (%) 79.5%
Genomic Region Intergenic
Retrocopy Summary GLRX3P2, located on chr6:3978158-3979366, is a retrocopy of the parental gene GLRX3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GLRX3
Full Name glutaredoxin 3
Also known as GLRX4|GRX3|GRX4|PICOT|TXNL2|TXNL3
Coordinate chr10:130136391-130182877
Strand +
Gene summary This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GLRX3P1
Bonobo Pan paniscus GLRX3P1
Gorilla Gorilla gorilla GLRX3P1
Orangutan Pongo abelii GLRX3P1
Green monkey Chlorocebus sabaeus GLRX3P1
Crab-eating macaque Macaca fascicularis GLRX3P1
Rhesus Macaca mulatta GLRX3P1
Baboon Papio anubis GLRX3P1
Golden snub-nosed monkey Rhinopithecus roxellana GLRX3P1
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GLRX3P2
GTCCACAATGTGCACAGATGAACGAAGTTATGGCAGAGTTAGCTAAAGAACACCCTCAAGTTTCATTTGTGAAGTTGGAAGCTGAAGGTGTTCCTGAAGTATCTGAAAAATATGAAATTGGCTCTGTTCCCACTTTTCTGTTTTTCAATAATTCTCAGAAAATTGACCGATTAGATGGTGCACACATCCCAGAGTTGACCAAAAAAGCTCAGCGACATCTAGTGGCTCCTTCCCACCCAGCACTGATGAACATCTTAAAGACCAAAAAAGCTCAGCGACATGCATCTAGTGGCTCCTTCCCACCCAGCACTGACGAACATCTTAAAGAAGATCTCAACCTTCGCTTACAGAAACTGACTCATGCTGCCCCCTGCATGCTGTTTATGAAAGGAACTCCTCAAGAACCACTCTGTGGTTTCAGCAAGCAGATGGTGGAAATTGTTCACAAACATAATATTTAGTTTAGCAGTTTTGATGTCTTTAGATCAAGAGGTTCGACAGGGGCTCAAAGCCTATTCCAATTGGCCTACCTATCCTCAGCTCTACGTTTCTGGAGAGCTCATAGGAGGACTTGATATAATTAAGGAGATACACGCATCTGAAGAACTAGATATAATTTGTCCCAAAGCTCCCAAATTAGAGGAAAGGCTCAAAGTGCTGACAAATGAAGCTTCTATGATGCTCTTTATGAAAGGAAACAAACAGGAAGCAAAATGTGGATTCAGCAAACAAATTCTGGAAATACTAAATAGTACTGGTGGTGAATATGAAACATTCGATATATTGGAGGATGAAGGAGATCGGCAAGGATTAAAAGCTTACTCAAATTGGCCAACATACCCTCAGCTGTATGTGAAAGGGGAGCTGGTGGGAGGATTGGATATTGTGAAAGAGCTGAAAGAAAATGGTGAATTGCTGCCTATACTGAGAGGAGAAAATTAATAAATCTTAAACTTGGTGCCCAACTATTGCAAGAAATACTTAATTACATTGGGAGCAGTTCATGATTTAGTCCTCAGAAATGGGCTAGGAATAGAAAAATCCTGCTTACTCAGTTACATGTTTTTTGTATTTCACAATGTCGTGCTAAATAAAAGTATGTTACATGTTTTCCCACTAAAAATAGAATGCAATAAACATCTTCAAATTATTAACAATAACTGTATAAAAAAGTGTATCTTTACAGCAATATTAAACATACAGCTACTA
>NM_006541.5
ACTGGATTGCTTCTGTCTggcggcggcagcatggcggcgggggcggctgaggcagctgtagcggccgtggaggaggtcggcTCAGCCGGGCAGTTTGAGGAGCTGCTGCGCCTCAAAGCCAAGTCCCTCCTTGTGGTCCATTTCTGGGCACCATGGGCTCCACAGTGTGCACAGATGAACGAAGTTATGGCAGAGTTAGCTAAAGAACTCCCTCAAGTTTCATTTGTGAAGTTGGAAGCTGAAGGTGTTCCTGAAGTATCTGAAAAATATGAAATTAGCTCTGTTCCCACTTTTCTGTTTTTCAAGAATTCTCAGAAAATCGACCGATTAGATGGTGCACATGCCCCAGAGTTGACCAAAAAAGTTCAGCGACATGCATCTAGTGGCTCCTTCCTACCCAGCGCTAATGAACATCTTAAAGAAGATCTCAACCTTCGCTTGAAGAAATTGACTCATGCTGCCCCCTGCATGCTGTTTATGAAAGGAACTCCTCAAGAACCACGCTGTGGTTTCAGCAAGCAGATGGTGGAAATTCTTCACAAACATAATATTCAGTTTAGCAGTTTTGATATCTTCTCAGATGAAGAGGTTCGACAGGGACTCAAAGCCTATTCCAGTTGGCCTACCTATCCTCAGCTCTATGTTTCTGGAGAGCTCATAGGAGGACTTGATATAATTAAGGAGCTAGAAGCATCTGAAGAACTAGATACAATTTGTCCCAAAGCTCCCAAATTAGAGGAAAGGCTCAAAGTGCTGACAAATAAAGCTTCTGTGATGCTCTTTATGAAAGGAAACAAACAGGAAGCAAAATGTGGATTCAGCAAACAAATTCTGGAAATACTAAATAGTACTGGTGTTGAATATGAAACATTCGATATATTGGAGGATGAAGAAGTTCGGCAAGGATTAAAAGCTTACTCAAATTGGCCAACATACCCTCAGCTGTATGTGAAAGGGGAGCTGGTGGGAGGATTGGATATTGTGAAGGAACTGAAAGAAAATGGTGAATTGCTGCCTATACTGAGAGGAGAAAATTAATAAATCTTAAACTTGGTGCCCAACTATTGTAAGAAATATTTAATTACATTGGGAGCAGTTCATGATTTAGTCCTCAGAAATGGACTAGGAATAGAAAATTCCTGCTTTCTCAGTTACATGTTTTGTGTATTTCACAATGTCGTGCTAAATAAATGTATGTTACATTTTTTTCCCACCAAAAATAGAATGCAATAAACATCTTCAAATTATTAACAATAATTGTATGAAAAAAGTGTATCTTTACAGCAGTATTAAACATACAGCTACTATAATTAACCCA

Publications

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