Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name EXOSC8P1
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Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr13). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:43705855-43706757  UCSC
Coordinates (T2T) chr6:43534589-43535491  UCSC
Coordinates (hg19) chr6:43673592-43674494  UCSC
Strand -
Parental Sequence NM_181503.3
Parental seq. overlap 777 bp
Parental seq. overlap (%) 65.7%
Genomic Region Intergenic
Retrocopy Summary EXOSC8P1, located on chr6:43705855-43706757, is a retrocopy of the parental gene EXOSC8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EXOSC8
Full Name exosome component 8
Also known as CIP3|EAP2|OIP2|PCH1C|RRP43|Rrp43p|bA421P11.3|p9
Coordinate chr13:37000373-37009614
Strand +
Gene summary This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EXOSC8P1
Bonobo Pan paniscus EXOSC8P1
Gorilla Gorilla gorilla EXOSC8P1
Orangutan Pongo abelii EXOSC8P1
Gibbon Nomascus leucogenys EXOSC8P1
Green monkey Chlorocebus sabaeus EXOSC8P1
Crab-eating macaque Macaca fascicularis EXOSC8P1
Rhesus Macaca mulatta EXOSC8P1
Baboon Papio anubis EXOSC8P1
Golden snub-nosed monkey Rhinopithecus roxellana EXOSC8P1
Marmoset Callithrix jacchus EXOSC8P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>EXOSC8P1
GGGAAGATGGTAGCTGGGTTCAAAACCACGGAACCTCTGGTAATTACAGGAGATTTCTGAAAGAGATCTGCCTTGCTGATGAAAGAGAACTTGGTGAATTCAGAACCACAACTGTCAACACAGGTTCAATTAGTACTGCAGTCGGTTCTCCTTTAGTGAAGCTGGGAAATACTACAGTAATGTGTAAGGTTAAAGCAGAGTTTGCAGCACCATCCACAGATGCTTCCATAAAGGATCTGTGGCTCCCACTGGGGCTCTGCCACCCTTGTGTTCCACTGAGATTTCAGTCTGGACCTCCTGGAGAAGAGATCCAAGCCACTAGCCAGATCACTGAAGATATCACTGAAAATTCACAGATAATTCAGAAAAGGAATTTATGCATTTCTCCAGGAAAGCGTGCTTGAATTCTATGCTATGATCTCATTCGCCTCTCTCATTTGCCTATTATGGAAGCATTTTGGATGCCTGCACATTTGCTTTGTAAGCAGCTTTTTAAAATGTACAGTTGCCTGAAGTTGCTAGAAAGAGACTATTTTAGCAGAAGTTAAGAAGAGAAGTTATTTGAATACTAGAACTTACCCAGCTGCAACTTCCTTTGCCGTGTTTGATGACACTTTGCTCATAGCTGACCTGACTGGAGAGGAGGAACATCTGGCAACTGGAATCTTAATAACAGTAATGGAAGAGGAAGCAGGCTCTGGTGTCCTCACCAAGCAGGTAAAAGTGGGCTGACTGGAGCTAGACTCCAGGACTAGATGAACCGAGCTGTTACAAGACACAAAGCTATTTAAAATGCAATGGATGAAGTAAATAGTATGAAACCCGAAGAAATGACCACCACATTTTCAAAGCAGATTTGTAAAAATTGTATTTGTTACACTGTGCACAAAACTTTTATACTa
>NM_181503.3
gcagacgcGCGGGCGGGAAGATGGCGGCTGGGTTCAAAACCGTGGAACCTCTGGAGTATTACAGGAGATTTCTGAAAGAGAACTGCCGTCCTGATGGAAGAGAACTTGGTGAATTCAGAACCACAACTGTCAACATCGGTTCAATTAGTACCGCAGATGGTTCTGCTTTAGTGAAGTTGGGAAATACTACAGTAATCTGTGGAGTTAAAGCAGAATTTGCAGCACCATCAACAGATGCCCCTGATAAAGGATACGTTGTTCCTAATGTGGATCTACCACCCCTGTGTTCATCGAGATTCCGGTCTGGACCTCCTGGAGAAGAGGCCCAAGTGGCTAGCCAGTTCATTGCAGATGTCATTGAAAATTCACAGATAATTCAGAAAGAGGACTTATGCATTTCTCCAGGAAAGCTTGTCTGGGTTCTATACTGTGATCTCATTTGCCTCGACTACGATGGAAACATTTTGGATGCCTGCACATTTGCTTTGCTAGCGGCTTTAAAAAATGTACAGTTGCCTGAAGTTACTATAAATGAAGAAACTGCTTTAGCAGAAGTTAATTTAAAGAAGAAAAGTTATTTGAATATTAGAACTCATCCAGTTGCAACTTCCTTTGCTGTGTTTGATGACACTTTGCTTATAGTTGACCCTACTGGAGAGGAGGAACATCTGGCAACAGGAACCTTAACAATAGTAATGGATGAGGAAGGCAAACTCTGTTGTCTTCACAAACCAGGTGGAAGTGGGCTAACTGGAGCTAAACTTCAGGACTGTATGAGCCGAGCAGTTACAAGACACAAAGAAGTTAAAAAACTGATGGATGAAGTAATTAAGAGTATGAAACCCAAATAAACAGCCACCACATTTTCAAAACAGATTTGTAAAAATTGTATTTGTTAACACTGTGCACAAACGTTTTATACTAAATAAATATCAAACTACATTCTTCTGAAAGATGTTTCTATTATTTCTTAGGTCACTTCCATATATATTATGTATAGTGAAACCATTTTTAAAAAGCAATGACTTAGGCAAACCAACCCTAGTTTGTTAAACCATTTCCCTGTTTTTATTTAAAAATGATAAGGTTGTGCTTCTGTATAAAGTTTGTACATCTAGCAATGTAAAATACTGACACATTAAAAAAAACAAAAAGTAGAAACTCAA

Publications

PMID - Link Title
No publications available for this retrocopy