Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name WTAPP1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:51409028-51410750  UCSC
Coordinates (T2T) chr6:51252350-51254072  UCSC
Coordinates (hg19) chr6:51273826-51275548  UCSC
Strand -
Parental Sequence NM_152858.3
Parental seq. overlap 759 bp
Parental seq. overlap (%) 29.5%
Genomic Region Intergenic
Retrocopy Summary WTAPP1, located on chr6:51409028-51410750, is a retrocopy of the parental gene WTAP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name WTAP
Full Name WT1 associated protein
Also known as Mum2
Coordinate chr6:159726696-159756319
Strand +
Gene summary The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes WTAPP1
Bonobo Pan paniscus WTAPP1
Gorilla Gorilla gorilla WTAPP1
Orangutan Pongo abelii WTAPP1
Gibbon Nomascus leucogenys WTAPP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>WTAPP1
CATCGCTCTTAACCTTGAGCATAGTGACTTAGAGACACTGTGTATCAGTTTTGCCAATAAGACTGTGGACTTCATGATTGTTGTACTTCTGGGTCAAAACTCAAATGAGGTGAATTTTGCCTTTAAAGGTTTTATTTGCTGAGAAACAACTTTTGATAGTCATGAGAGAATCAAATAATAGATGTCCGTACAAGTAGCACATATATTTAACCATTTAGTTTGGGGCTCTGTATTACTTGCTTGAGCCTTAATCAATGTGGTTTTATTCAATGGTTTGTTCTTTGAATGGCTGCAAAAACTGTAGATAAACTTACTGAGGACTGTACAGACATGAAGGTGTGGTATCAAACTTCAGGTTGAAACTGTTTGAAGCATTATAAACATTCATTTCACAACTAGATTGTATAAGGATATTAGCTGTGATGAGACTCACTGCATTTTTTTTTAGTGAATTTTATGAAATCCCCATTCCATTCAACAGGCACATGTTTGAAAGAGCATTGTCGTTGGTGTTAATGGGGGAATGTGTTCCTTCATTGTATTTGGGCCTTTTGTATTGCACTCTTGATATTAAATTAAATGTGCCTTGAAATGCCACATTCTTACACTGTCCAGCTTGTAATGTTTAATGTAAAACTTACCAGATGAACCTTGTGTTTCAGCTTTTTTCTTTTCCCCTTCCCCTTGCTTCAGACGCCTGATGGCATCGGACTATTCCGAAGAAGTGGCCACCTCCGAAAAATTCCCCTTCTAGAACATGTAGACACTTGAGAAATGTTTCTGTTTGAAGAAAATAGAGGGAGAAACAGAAGTCTTAAGTCTGTGGCACACTGTGTCTTCAGACAGTTTGAAGGGCTTGCTGAGCTCCGGCGCCCGCGGAGCTCGCACCAGGCTCCCCGGAAAGGACGGGGCGTGTTACCGGGGAGCAGCTGCTCTATTGCGCCTCGAGGCTCCGATCGGGCTAGGCCGGCGGCCTCGCTCCCTCCCTTCACCTTTCCTCTCCTGGCGGGCCCGGCGGCGGGCAAGTGACTGCCCGCCATGCCTGAAAGGCGACTCTTCGATTCAAGATGACCAGAGAAGAACCTCTTCCCAAGAAAGTTCGACTGAGTGAAACAGACTTCAAAGTTATGGCAACAGATGAGTTAATTCTAAGATGGAAACAATATGAAGCATACGTACAAGCTTTGGAGGGCAAGTATACAGATCTTAAACTCTAATGATGTAACTGGCCTAAGAGAGTCTGAAGAAAAACTAAAGCAACAACAGCAAGAGTCTGCACGCAGGGAAAACATCCTTGTAATGCGACTAGCAACCAAGGAACAAGAGATGCAAGAGTGTACTACTCAAATCCAGTACCTCAAGCAAGTCCAGCAGCCGAGCGTTGCCCAACTGAGATCAACAATGGTAGACCCAGCGATCAACTTGTTTTTCCTAAAAATGAAAGGTGAACTGGAACAGACTAAAGACAAACTGGAACAAGCCCAAAATGAACTGAGTGCCTGGAAGTTTACGCCTGATAGGTAAACAAATCATCCTCCCCAGTTAAGACTTCCCTGACAGTCCCACTACGAGAAAGCTGTGGTGGGACAACCAAGTACTCGTTTCCACACCAAGACTCAGACTTTTTGAGCCa
>NM_152858.3
CGCTTCCCTTACTGAGCTTGCTGAGCTCCGGGGCCCGCGGAGCTCGCGCCAGGCTCCTGGGAAAGGACGGGGAGTGTTACCGGGGAGCAGCTGCTCCATTGTGCCTCGAGGCCCCGATCGGGCTAGGCCGACGGCCTCCCTCCCTTCACCTTTCCTCTCCTGGCGGGGTTCGGCGGCGGGCGAGTGACTGCGGCCACGCCTGAAAGGCGACTCTCCTGATTCAAGATGACCAACGAAGAACCTCTTCCCAAGAAgGTTCGATTGAGTGAAACAGACTTCAAAGTTATGGCAAGAGATGAGTTAATTCTAAGATGGAAACAATATGAAGCATATGTACAAGCTTTGGAGGGCAAGTACACAGATCTTAACTCTAATGATGTAACTGGCCTAAGAGAGTCTGAAGAAAAACTAAAGCAACAACAGCAGGAGTCTGCACGCAGGGAAAACATCCTTGTAATGCGACTAGCAACCAAGGAACAAGAGATGCAAGAGTGTACTACTCAAATCCAGTACCTCAAGCAAGTCCAGCAGCCGAGCGTTGCCCAACTGAGATCAACAATGGTAGACCCAGCGATCAACTTGTTTTTCCTAAAAATGAAAGGTGAACTGGAACAGACTAAAGACAAACTGGAACAAGCCCAAAATGAACTGAGTGCCTGGAAGTTTACGCCTGATAGGTAAACAAATCATACTCCCCAGTCAAGACTTCCCTGACAGTCCCACTACGAGAAAGCTGTGGTGGGACAGCCAAGTACTCGTTTCCACACCAAGACTCAGACTTTTTGAGCCAAAAAAAAGCCACATTCTTACACTGTCCAGCTTGTAATGGTTAATGTAAAACTTACCAGATGAACCTTGTGTTTCAGCTTTTTTCTTTTCCCCTTCCCCTTGCTTCAGAGGCCTGATGGCGTCGGACTATTCCGAAGAAGTGGCCACCTCCGAAAAATTCCCCTTCTAGAACATGTAGACACTTGAGAAATGTTTCTGTTTGAAGAAAATAGAGGGAGAAACAGAAGTCTTAAGTCTGTGGCACACTGTGTCTTCAGACAGTTTGAAGGAATGAAAACCTAGAGATTTTAAATCATGAATTGAACATGTAAAATTCCAGTAAAATGTAAAAACGGAATATGCATCGCTCTTAACCTTGAGCATAGTGACTTAGAGACACTGTGTATCAGTTTTGCCAATAAGACTGTGGACTTCATGATTGTTGTTGAACTTCTGGGTCAAAACTCAAATGAGGTGAATTTTGCCTTTAAAGGGTTTATTTGCTGAGAACCAACTTTCAATAGTCATGAGAGAATCAAATAATAGATGTCCGTACAAGTAGCGCATATATTTAACCATTTAGTTTGGGGCTCTATATTACTTGCTTGAGCCTTAATCAATGTGGTTTTATTCAATGGTTTGTTCTTTGAATGGTTGCAAAAACTGTAGATAATCTTACTGAGGACTGTACAAACATGAAGGTGTGGTATCAAACTTCAGGTTGAAACTGTTTGAAGCATTATAAACATTCATTTCACAACTAGATTGTATAAGGATATTAGCTGTGATGAGACTCACTGCATTATTTTTTTTAGTGAATTTTATGAAATCCCCGTTCCATTCAACAGGCACATGTTTAAAAGAGCTTTGTCGTTGGTGTTAATGGGGGAATGTGTTCCTTCATTGTATTTGGGCCTTTTGTATTGCACTCTTGATATTAAATTAAATGTGCCTTGAAA

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